Latest & greatest articles for osteoarthritis

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on osteoarthritis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for osteoarthritis

461. Topical treatments for osteoarthritis of the knee

Topical treatments for osteoarthritis of the knee Topical treatments for osteoarthritis of the knee Topical treatments for osteoarthritis of the knee Haynes S, Gemmell H CRD summary This review assessed the effectiveness of topical treatments for knee osteoarthritis and concluded that the treatments provided pain and stiffness relief and improved levels of functional disability. The authors' conclusions should be interpreted with some caution, since relevant studies may have been omitted (...) . Authors' objectives To investigate the efficacy of topically applied treatments for osteoarthritis of the knee. Searching MEDLINE, MANTIS, NCCAM (National Centre for Complementary and Alternative Medicine), AMED, CINAHL, Science Direct and The Cochrane Library were searched for studies published in English from inception to May 2005; search terms were reported. Reference lists of relevant papers were handsearched. Study selection Randomised controlled trials (RCTs) of topical treatments in patients

2007 DARE.

462. Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review

should also investigate how long the beneficial effects of exercise therapy that includes booster sessions last for, and what is required to maintain the beneficial effects of exercise therapy in the long term. Funding Not stated. Bibliographic details Pisters M F, Veenhof C, van Meeteren N L, Ostelo R W, de Bakker D H, Schellevis F G, Dekker J. Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review. Arthritis and Rheumatism (Arthritis Care (...) Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review Pisters M F, Veenhof C, van Meeteren N L, Ostelo R W, de Bakker D H, Schellevis F G, Dekker J CRD summary The authors concluded that positive post

2007 DARE.

463. Effectiveness of physiotherapy exercise after knee arthroplasty for osteoarthritis: systematic review and meta-analysis of randomised controlled trials

Effectiveness of physiotherapy exercise after knee arthroplasty for osteoarthritis: systematic review and meta-analysis of randomised controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

464. Unicompartmental knee arthroplasty for the treatment of unicompartmental osteoarthritis: a systematic study Full Text available with Trip Pro

of the medial or lateral compartments of the knee were eligible for inclusion. The inclusion criteria were not specified in terms of participants but it was clear that studies of patients with unicompartmental osteoarthritis undergoing UKA, TKA and HTO were eligible. In the full systematic review, the inclusion criteria concerning participants were specified in more detail; patients with rheumatoid arthritis were not eligible (see Other Publications of Related Interest). Outcomes assessed in the review (...) for unicompartmental osteoarthritis: a systematic review. Adelaide: Royal Australian College of Surgeons, ASERNIP-S; 2005. Report No.: 44. Indexing Status Subject indexing assigned by NLM MeSH Arthroplasty, Replacement, Knee /methods; Disease Progression; Humans; Knee Prosthesis; Osteoarthritis, Knee /surgery; Osteotomy; Postoperative Complications; Range of Motion, Articular; Recovery of Function; Reoperation; Survival Analysis AccessionNumber 12007008208 Date bibliographic record published 31/03/2008 Date

2007 DARE.

465. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis Full Text available with Trip Pro

. Research: The authors stated that intra-articular hylan should not be used in clinical research on patients with osteoarthritis of the knee. Funding Swiss National Science Foundation, grant numbers 4053-40-104762/3, 3200-066378 and 3233-066377. Bibliographic details Reichenbach S, Blank S, Rutjes A W, Shang A, King E A, Dieppe P A, Juni P, Trelle S. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Arthritis and Rheumatism (Arthritis Care and Research (...) Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis Reichenbach S, Blank S, Rutjes A W, Shang A, King E A, Dieppe P A, Juni P, Trelle S CRD summary This review found that hylan appears unlikely to be more effective than hyaluronic acid for treating pain

2007 DARE.

466. The value of individual or collective group exercise programs for knee or hip osteoarthritis: elaboration of French clinical practice guidelines

(six-minute walk test, timed get-up-and-go test, ascending and descending stairs), self-reported measures (Western Ontario and McMaster Universities Osteoarthritis Index, Arthritis Impact Measurement Scale, Activities of Daily Living) or non-steroidal anti-inflammatory drug therapy. Some studies evaluated individual and group exercises separately; others used a combination of group and individual sessions. Some of the exercise programmes were delivered in the community or in the home. The frequency (...) synthesised narratively. Results of the review Twenty-nine studies (n=4,762) were included: 21 on knee osteoarthritis; one on hip arthritis; and seven on knee and hip arthritis. Of these, 12 were of evidence level 1. The authors did not report the specific aspects of quality assessment. There was low to moderate benefit of individual exercise in improving pain (up to 36% on visual analogue scale), walking ability and muscle strength following treatment (11 studies). One year after treatment these benefits

2007 DARE.

467. Meta-analysis: chondroitin for osteoarthritis of the knee or hip

commentary may also be of interest. Lane N. Review: based on evidence from higher-quality trials, chondroitin does not reduce pain in knee or hip osteoarthritis. ACP J Club 2007;147:44. Indexing Status Subject indexing assigned by NLM MeSH Aged; Chondroitin Sulfates /adverse effects /therapeutic use; Female; Hip Joint /radiography; Humans; Knee Joint /radiography; Male; Middle Aged; Osteoarthritis, Hip /drug therapy /physiopathology /radiography; Osteoarthritis, Knee /drug therapy /physiopathology (...) Meta-analysis: chondroitin for osteoarthritis of the knee or hip Meta-analysis: chondroitin for osteoarthritis of the knee or hip Meta-analysis: chondroitin for osteoarthritis of the knee or hip Reichenbach S, Sterchi R, Scherer M, Trelle S, Burgi E, Burgi U, Dieppe P A, Juni P CRD summary This well-conducted and reliable review concluded that evidence from large and methodologically sound trials suggests that the symptomatic benefit of chondroitin is minimal or non-existent. However, it should

2007 DARE.

468. Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence

Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence Splinting for osteoarthritis of the carpometacarpal joint: a review of the evidence Egan M Y, Brousseau L CRD summary This review concluded that splinting may help to relieve pain and improve function in patients with carpometacarpal osteoarthritis, but there was no clear evidence of the superiority of one type of splint over (...) International were searched up to June 2006. Studies published in English or French were sought. The search terms used are available on request from the authors. Study selection Study designs of evaluations included in the review All studies that addressed the study question, regardless of design, were eligible for inclusion. Specific interventions included in the review Studies investigating splinting for osteoarthritis of the CMC joint were eligible for inclusion. Studies were excluded if they reported

2007 DARE.

469. Meta-analysis: acupuncture for osteoarthritis of the knee

Meta-analysis: acupuncture for osteoarthritis of the knee Meta-analysis: acupuncture for osteoarthritis of the knee Meta-analysis: acupuncture for osteoarthritis of the knee Manheimer E, Linde K, Lao L, Bouter L M, Berman B M CRD summary This review concluded that acupuncture showed clinical benefits compared to usual care and waiting-list for the treatment of knee osteoarthritis, and clinically irrelevant short-term benefits compared to sham. This was a generally well-conducted piece (...) of research. The authors' cautious conclusions reflected the limitations of the evidence and appeared reliable. Authors' objectives To assess the safety and effects of acupuncture for the treatment of knee osteoarthritis. Searching MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched to January 2007 for publications in any language. Search terms were broadly stated. Study selection Studies eligible for inclusion were: randomised controlled trials (RCTs) with an observation

2007 DARE.

470. Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis

Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2007 DARE.

471. Glucosamine for pain in osteoarthritis: why do trial results differ? Full Text available with Trip Pro

-07598. Bibliographic details Vlad S C, LaValley M P, McAlindon T E, Felson D T. Glucosamine for pain in osteoarthritis: why do trial results differ? Arthritis and Rheumatism 2007; 56(7): 2267-2277 PubMedID DOI Indexing Status Subject indexing assigned by NLM MeSH Clinical Trials as Topic; Glucosamine /therapeutic use; Humans; Osteoarthritis /physiopathology; Pain /drug therapy; Patient Selection; Reproducibility of Results AccessionNumber 12007002654 Date bibliographic record published 09/08/2008 (...) Glucosamine for pain in osteoarthritis: why do trial results differ? Glucosamine for pain in osteoarthritis: why do trial results differ? Glucosamine for pain in osteoarthritis: why do trial results differ? Vlad S C, LaValley M P, McAlindon T E, Felson D T CRD summary This review concluded that glucosamine hydrochloride is not effective in treating osteoarthritic pain, and that definitive conclusions could not be drawn on the efficacy of glucosamine sulphate because of significant variation

2007 DARE.

472. Tramadol for osteoarthritis. Full Text available with Trip Pro

Tramadol for osteoarthritis. Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of benefit and the safety of oral tramadol in people with osteoarthritis.We searched the Cochrane Central Register (...) of Controlled Trials (CENTRAL), MEDLINE, EMBASE and LILACS databases up to August 2005.We included randomized controlled trials (RCTs) that evaluated the effect of tramadol or tramadol plus paracetamol on pain levels and/or physical function in people with osteoarthritis. No language restriction was applied.We analyzed separately placebo-controlled and active-controlled studies. We used fixed-effect models for the meta-analyses as the results across studies were similar.We included eleven RCTs with a total

2006 Cochrane

473. Posterior versus lateral surgical approach for total hip arthroplasty in adults with osteoarthritis. (Abstract)

Posterior versus lateral surgical approach for total hip arthroplasty in adults with osteoarthritis. Osteoarthritis (OA) of the hip is a progressive condition that has no cure and often requires a total hip arthroplasty (THA). The principal methods for THA are the posterior and direct lateral approaches. The posterior approach is considered to be easy to perform, however, increased rates of dislocation have been reported. The direct lateral approach facilitates cup positioning which may (...) decrease rates of hip dislocation and diminishes the risk of injury to the sciatic nerve. However, there is an increased risk of limp. Dislocation of a hip prosthesis is a clinically important complication after THA, in terms of morbidity implications and costs.To determine the risks of prosthesis dislocation, postoperative Trendelenburg gait and sciatic nerve palsy after a posterior approach, compared to a direct lateral approach, for adult patients undergoing THA for primary OA and to update

2006 Cochrane

474. Patients who wore standard magnetic bracelets reported reduced pain from osteoarthritis of the hip or knee compared with patients wearing placebo bracelets Full Text available with Trip Pro

or knee (diagnosed by an orthopaedic surgeon, rheumatologist, or general practitioner and confirmed by radiological evidence) and scores of 8–20 on the Western Ontario and McMaster University osteoarthritis index (WOMAC A). Exclusion criteria were use of cardiac pacemakers, current use of magnetic bracelets, surgery to the index joint (except arthroscopy), haemophilia, pregnancy, and breast feeding. Intervention: 66 patients were allocated to standard neodymium magnets set in a steel backing cup (...) Patients who wore standard magnetic bracelets reported reduced pain from osteoarthritis of the hip or knee compared with patients wearing placebo bracelets Patients who wore standard magnetic bracelets reported reduced pain from osteoarthritis of the hip or knee compared with patients wearing placebo bracelets | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn

2006 Evidence-Based Nursing

475. Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee Full Text available with Trip Pro

% women, mean age 62 y) and had primary OA in ⩾1 knee (verified radiologically within the previous 6 mo) and at least moderate pain (identified with the Western Ontario and McMaster Universities [WOMAC] LK3.0 OA Index pain subscale). Exclusion criteria included secondary arthritis related to syphilitic neuropathy; ochronosis; metabolic bone disease or acute trauma; sensitivity to intervention ingredients; and active renal, hepatic, or peptic ulcer disease. Intervention: patients were allocated to TD (...) Therapeutics Topical diclofenac improved pain and physical function with no systemic side effects in primary osteoarthritis of the knee Free Ann Cranney , MD, MSc , Siobhan O’Donnell , PT, MSc Statistics from Altmetric.com Bookman AA, Williams KS, Shainhouse JZ. Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004 ; 171 : 333 –8. Q In patients with primary osteoarthritis (OA) of the knee, is a topical diclofenac (TD

2006 Evidence-Based Medicine

476. Review: intra-articular corticosteroid injections are better than placebo for improving symptoms of knee osteoarthritis Full Text available with Trip Pro

to –10.03). View this table: Intra-articular corticosteroid injections (ICI) v placebo for osteoarthritis of the knee* CONCLUSION In patients with osteoarthritis of the knee, intra-articular corticosteroid injections are more effective than placebo for improving symptoms in the short and long term. Commentary The biological mechanism of corticosteroids suggests that they should be effective in joint disease with significant inflammation—a fact established in the treatment of rheumatoid arthritis (...) : intra-articular corticosteroid injections are better than placebo for improving symptoms of knee osteoarthritis Free Stanford Shoor , MD Statistics from Altmetric.com Arroll B, Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ 2004 ; 328 : 869 . Q In patients with osteoarthritis (OA) of the knee, are intra-articular corticosteroid injections more effective than placebo for improving symptoms? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ IM

2006 Evidence-Based Medicine

477. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. Full Text available with Trip Pro

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis.We randomly assigned 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg (...) that in the placebo control group (P=0.008). For patients with moderate-to-severe pain at baseline, the rate of response was significantly higher with combined therapy than with placebo (79.2 percent vs. 54.3 percent, P=0.002). Adverse events were mild, infrequent, and evenly distributed among the groups.Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Exploratory analyses suggest that the combination

2006 NEJM Controlled trial quality: predicted high

478. Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A meta-analytic review

Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A meta-analytic review Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A meta-analytic review Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A meta-analytic review Devos-Comby L, Cronan T, Roesch SC CRD summary This review examined the effectiveness of patient education and exercise regimens on the well (...) -being of patients with knee osteoarthritis; it concluded that both regimens had a modest, yet clinically important influence on patients' well-being. The review had serious flaws in its conduct and analysis, meaning that the authors' conclusions are not likely to be reliable. Authors' objectives To examine the effectiveness of patient education and exercise regimens on the well-being of patients with knee osteoarthritis. Searching MEDLINE and PsycINFO were searched for peer-reviewed articles

2006 DARE.

479. Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review

Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2006 DARE.

480. Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis Full Text available with Trip Pro

, Sharifi H, Kominski G, Lieberman J R. Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis. Journal of Bone and Joint Surgery. American volume 2006; 88A(9): 1975-1982 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Arthroplasty, Replacement, Knee /economics /methods; Cost-Benefit Analysis; Decision Support Techniques; Humans; Multivariate Analysis; Osteoarthritis, Knee (...) Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis Cost-effectiveness analysis of unicompartmental knee arthroplasty as an alternative to total knee arthroplasty for unicompartmental osteoarthritis SooHoo N F, Sharifi H, Kominski G, Lieberman J R Record

2006 NHS Economic Evaluation Database.