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Latest & greatest articles for osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.
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) on articular cartilage in postmenopausal women. The authors concluded that there was weak evidence to suggest that ERT may protect against large jointosteoarthritis. However, a negative effect was seen on cartilage volume in postmenopausal women. The review conclusions are unlikely to be robust given concerns about the review methodology and the poor quality of the studies. Authors' objectives To assess the effect of oestrogen replacement therapy (ERT) on articular cartilage in postmenopausal women (...) . The review also examined the effect of ERT on the incidence and prevalence of osteoarthritis (OA) in perimenopausal women, but these data are outside the scope of this abstract. Searching MEDLINE was searched from 1966 to March 2003; the search terms were reported. The reference lists from retrieved articles were also checked to identify additional studies. Study selection Study designs of evaluations included in the review The authors stated that epidemiological studies were eligible. Specific
Patellar resurfacing in total knee arthroplasty for osteoarthritis: a systematic review Patellar resurfacing in total knee arthroplasty for osteoarthritis: a systematic review Patellar resurfacing in total knee arthroplasty for osteoarthritis: a systematic review Forster M C CRD summary This review assessed the advantages and disadvantages of patellar resurfacing during total knee replacement for osteoarthritis. The author concluded that resurfacing reduces the reoperation rate, although (...) there is no benefit for revision rates and any reduction in anterior knee pain is unconfirmed. Poor reporting of the review process makes it difficult to verify the findings. Authors' objectives To determine the advantages and disadvantages of patellar resurfacing during total knee replacement for osteoarthritis. Searching MEDLINE (from 1966) and the Cochrane Library were searched. The bibliographies of potentially relevant papers were also checked. Study selection Study designs of evaluations included
Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Corticosteroid injections for osteoarthritis of the knee: meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Three treatment strategies for osteoarthritis (OA) of the knee were studied: 250 mg naproxen, 3 times daily for 26 weeks; 100 mg celecoxib, twice daily for 26 weeks; and 25 mg hyaluronan (HA) by intraarticular injection, once weekly for 5 weeks, followed by conventional outpatient treatment for 21 weeks. Conventional treatment may include non-pharmacologic (...) Cost-effectiveness of treatment strategies for osteoarthritis of the knee in Taiwan Cost-effectiveness of treatment strategies for osteoarthritis of the knee in Taiwan Cost-effectiveness of treatment strategies for osteoarthritis of the knee in Taiwan Yen Z S, Lai M S, Wang C T, Chen L S, Chen S C, Chen W J, Hou S M Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods
osteoarthritis (OA). Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised adult patients with symptomatic OA of the knee, hip or hands with pain, who had less than 30 minutes of morning stiffness with no evidence of other rheumatic diseases (e.g. rheumatoid arthritis or chondrocalcinosis). In addition, the patients had to be uncertain whether current NSAID therapy was helpful. Patients were excluded if they had contraindications (...) in the conventional group. In the N of 1 group, the mean age was 59 (+/- 2.3) years and the duration of OAdisease was 12.7 (+/- 2.2) years). In the conventional group, the mean age was 54 (+/- 2.4) years and the duration of OAdisease was 14 (+/- 2.3) years. The baseline HAQ score was 0.84 (+/- 0.12) in the N of 1 group versus 0.92 (+/- 0.12) in the conventional group. It was not stated whether any patients were excluded from the initial study sample for any reason. Study design This was a double-blind, parallel
Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of osteoarthritis and rheumatoid arthritis patients in the UK Moore A, Phillips C, Hunsche E, Pellissier J, Crespi S Record Status (...) analysis and cost-utility analysis. Study population The study population comprised a cohort of patients with osteoarthritis or rheumatoid arthritis. Setting The setting was primary care. The economic study was carried out in the UK. Dates to which data relate The effectiveness data and most resource use data were derived from studies published between 1995 and 2003. The costs came from a database published in 2001. The price year was 2002. Source of effectiveness data The effectiveness evidence
Bone marrow edema and its relation to progression of knee osteoarthritis. While factors affecting the course of knee osteoarthritis are mostly unknown, lesions on bone scan and mechanical malalignment increase risk for radiographic deterioration. Bone marrow edema lesions on magnetic resonance imaging correspond to bone scan lesions.To determine whether edema lesions in the subarticular bone in patients with knee osteoarthritis identify knees at high risk for radiographic progression (...) as an increase over follow-up in medial or lateral joint space narrowing, based on a semi-quantitative grading. Generalized estimating equations were used to evaluate the relation of medial bone marrow edema lesions to medial progression and lateral lesions to lateral progression, before and after adjustment for limb alignment.Of 256 patients, 223 (87.1%) participated in at least one follow-up examination. Medial bone marrow lesions were seen mostly in patients with varus limbs, and lateral lesions were seen
Methodological differences in clinical trials evaluating nonpharmacological and pharmacological treatments of hip and knee osteoarthritis. Randomized controlled trials have been developed essentially in the context of pharmacological treatments (ie, oral drugs; intra-articular injection; and topical, intramuscular, and intravenous treatments), but assessment of the effectiveness of nonpharmacological treatments (ie, surgery, arthroscopy, joint lavage, rehabilitation, acupuncture, and education (...) ) presents specific issues.To compare the quality of articles of nonpharmacological and pharmacological treatments of hip and knee osteoarthritis and to identify specific methodological issues related to assessment of nonpharmacological treatments.We searched MEDLINE and the Cochrane Central Register of Controlled Trials for articles of randomized controlled trials published between January 1, 1992, and February 28, 2002, in 28 general medical and specialty journals with high impact factors and assessing
Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Quadriceps muscle strengthening is a common goal in the management of knee osteoarthritis. In healthy knees, strength protects against new osteoarthritis. In arthritic knees, greater strength may protect joints and thereby delay osteoarthritis progression. Alternatively, in certain joint environments, such as malalignment or laxity, greater strength may translate into damaging joint reaction forces. The relationship (...) of tibiofemoral osteoarthritis progression in malaligned knees and lax knees. Subset-specific approaches beyond strengthening exercises should be developed to enhance joint-protective muscle activity.
Exercise for osteoarthritis of the hip or knee. Biomechanical factors, such as reduced muscle strength and joint mal-alignment, have an important role in the initiation and progression of osteoarthritis (OA) of the hip or knee. Currently, there is no known cure for OA, however, disease-related factors, such as impaired muscle function and reduced fitness, are potentially amenable to therapeutic exercise.To determine whether land-based therapeutic exercise is beneficial for people with OA (...) of the hip or knee in terms of reduced joint pain, improved physical function and/or the patient's global assessment of therapeutic effectiveness.Five databases (the Cochrane Controlled Trials Register, the Cochrane Musculoskeletal Group Trials Register, MEDLINE, CINAHL, PEDro) were searched up until November 2002.All randomized controlled trials comparing some form of land-based therapeutic exercise (as opposed to exercises conducted in the water) with a non-exercise group.Two reviewers independently
Acetaminophen for osteoarthritis. Osteoarthritis (OA) is the most common form of arthritis. Published guidelines and expert opinion are divided over the relative role of acetaminophen (also called paracetamol or Tylenol) and non-steroidal anti-inflammatory drugs (NSAIDs) as first-line pharmacologic therapy. The comparative safety of acetaminophen and NSAIDs is important to consider as NSAIDs have the potential for serious gastrointestinal, renal, and cardiovascular toxicities, and acetaminophen (...) searched.Published randomized controlled trials (RCTs) evaluating the efficacy and safety of acetaminophen alone in OA were considered for inclusion.Pain, physical function and global assessment outcomes were reported. Results for continuous outcome measures were expressed as standardized mean differences. Dichotomous outcome measures were pooled using relative risk and the number needed to treat was calculated.Six RCTs and 1689 participants were included in the review. One study compared acetaminophen
Intensity of exercise for the treatment of osteoarthritis. Therapeutic exercise is used as one modality to treat people with osteoarthritis (OA).To evaluate the effectiveness of therapeutic exercise of differing intensities on objective and subjective measures of disease activity in people with OA.We searched MEDLINE, EMBASE, Pedro, Current Contents, Sports Discus and CINAHL up to and including December 2002. The Cochrane Field of Rehabilitation and Related Therapies and the Cochrane (...) Musculoskeletal Review Group were also contacted for a search of their specialized registers. Handsearching was conducted on all retrieved articles for additional studies.Comparative controlled studies, such as randomized controlled trials, controlled clinical trials, cohort studies or case/control studies, of therapeutic exercises compared to control or active interventions in people with OA were eligible. No language restrictions were applied. Abstracts were also accepted.Two independent reviewers
Thermotherapy for treatment of osteoarthritis. Osteoarthritis is a degenerativejointdisease that affects mostly the weight-bearing joints in the knees and hips. As the affected joint degenerates pain and restriction of movement often occur. Inflammation can also occur sometimes resulting in edema of the joint with OA. Treatment focuses on decreasing pain and improving movement.To determine the effectiveness of thermotherapy in the treatment of OA of the knee. The outcomes of interest were (...) relief of pain, reduction of edema, and improvement of flexion or range of motion (ROM) and function.Two independent reviewers selected randomized and controlled clinical trials with participants with clinical and/or radiological confirmation of OA of the knee; and interventions using heat or cold therapy compared with standard treatment and/or placebo. Trials comparing head to head therapies, such as two different types of diathermy, were excluded.Randomized and controlled clinical trials including
Efficacy of knee tape in the management of osteoarthritis of the knee: blinded randomised controlled trial. To test the hypotheses that therapeutic taping of the knee improves pain and disability in patients with osteoarthritis of the knee and that benefits remain after stopping treatment.Randomised single blind controlled trial with three intervention arms (therapeutic tape, control tape, and no tape) of three weeks' duration and three week follow up.Outcome assessment was performed (...) in a university based laboratory. Taping interventions were applied by eight physiotherapists in metropolitan private practice.87 patients with symptoms of knee osteoarthritis as defined by the American College of Rheumatology.Primary outcome measure was pain as measured by visual analogue scale and participant perceived rating of change. Secondary measures of pain and disability included the Western Ontario and MacMaster Universities osteoarthritis index, knee pain scale, and the SF-36.The therapeutic tape
-specific inhibitors, oral celecoxib (Celebrex, Pharmacia Corporation) and oral rofecoxib (Vioxx, Merck & Co., Inc.), for the treatment of osteoarthritis (OA) in hypertensive patients aged 65 years or older. Celecoxib was administered at 200 mg/day and rofecoxib at 25 mg/day. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged 65 years or older who had OA and hypertension, and who were members of a Medicare Choice (...) sensitive combination was the costs of the cyclooxygenase-specific inhibitors and the physician visits. These could make the celecoxib costs slightly higher ($0.01 higher per patient per day) than those associated with rofecoxib. Synthesis of costs and benefits The health benefits and costs were not combined. Authors' conclusions The results suggested that celecoxib was a lower cost alternative to rofecoxib when treating osteoarthritis (OA) patients with hypertension, primarily because of the lower
Acupuncture for osteoarthritis Acupuncture for osteoarthritis Acupuncture for osteoarthritis Agency for Healthcare Research and Quality Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Agency for Healthcare Research and Quality. Acupuncture for osteoarthritis. Rockville: Agency for Healthcare Research and Quality (AHRQ). Technology (...) Assessment. 2003 Authors' objectives This review contains: a) A review of recent (1995 to present) systematic reviews on the use of acupuncture for osteoarthritis, updated with any RCTs published since the date of the last systematic review (2000 to present). b) Information available in the literature on training for persons performing this therapy and the number of physicians certified to perform this therapy. Authors' conclusions A key issue in studies of acupuncture is the effect of sham acupuncture
Arthroscopic lavage for knee osteoarthritis Arthroscopic lavage for knee osteoarthritis Arthroscopic lavage for knee osteoarthritis Allgood P Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Allgood P. Arthroscopic lavage for knee osteoarthritis. London: Bazian Ltd (Editors), Wessex Institute for Health Research and Development, University of Southampton 2003: 10 (...) Authors' objectives This study aims to assess the effects of arthroscopic lavage, with or without debridement, in people with osteoarthritis of the knee. Authors' conclusions We found one good quality randomised controlled trial that was directly relevant to the question. It found that arthroscopic debridement and lavage did not improve pain and function compared with placebo in people with knee osteoarthritis. We found limited evidence that full arthroscopic lavage improves pain compared with low
Services Advisory Committee. Intra-articular viscosupplementation for treatment of osteoarthritis of the knee. Canberra: Medical Services Advisory Committee (MSAC) 2003: 88 Authors' objectives This review aims to provide a systematic review of literature on intra-articular viscosupplementation for treatment of osteoarthritis (OA) of the knee. Authors' conclusions MSAC recommended that on the strength of evidence pertaining to intra-articular viscosupplementation for treatment of osteoarthritis (...) Intra-articular viscosupplementation for treatment of osteoarthritis of the knee Intra-articular viscosupplementation for treatment of osteoarthritis of the knee Intra-articular viscosupplementation for treatment of osteoarthritis of the knee Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Medical