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Latest & greatest articles for osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.
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-3,200 mg per day), piroxicam (10-20 mg per day) and naproxen (500-1000 mg for patients with osteoarthritis and 1,500 mg per day for those with rheumatoid arthritis). Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Patients at least 18 years of age with either rheumatoid arthritis or osteoarthritis. Individuals were excluded if they had either a history of liver disease, blood dyscrasia, uncontrolled hypertension, abnormal laboratory values, recent (...) Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK Choice of NSAID and management strategy in rheumatoid arthritis and osteoarthritis: the impact on costs and outcomes in the UK McCabe C J, Akehurst R L, Kirsch J, Whitfield M, Backhouse M, Woolf A D, Scott D L, Emery P, Haslock I Record Status
Medico-economic analysis of diacerein with or without standard therapy in the treatment of osteoarthritis Medico-economic analysis of diacerein with or without standard therapy in the treatment of osteoarthritis Medico-economic analysis of diacerein with or without standard therapy in the treatment of osteoarthritis Fagnani F, Bouvenot G, Valat J, Bardin T, Berdah L, Lafuma A, Bone I, Eschwege E, Dresier R Record Status This is a critical abstract of an economic evaluation that meets (...) the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Standard therapy with or without diacerein used in the treatment of osteoarthritis. Type of intervention Treatment Economic study type Cost-effectiveness analysis. Study population The study population was defined as outpatients, aged over 50 years, with radiologically
A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). To determine the effects of structured exercise programs on self-reported disability in older adults with knee osteoarthritis.A randomized, single-blind clinical trial lasting 18 months conducted at 2 academic medical centers.A total of 439 community-dwelling adults, aged 60 years or older (...) , with radiographically evident knee osteoarthritis, pain, and self-reported physical disability.An aerobic exercise program, a resistance exercise program, and a health education program.The primary outcome was self-reported disability score (range, 1-5). The secondary outcomes were knee pain score (range, 1-6), performance measures of physical function, x-ray score, aerobic capacity, and knee muscle strength.A total of 365 (83%) participants completed the trial. Overall compliance with the exercise prescription
be hypothesized that the costs associated with adverse effects of OA treatment could be considerably reduced. Source of funding Grants from Boehringer Ingelheim. Bibliographic details Jansen, Capri S, Nuijten M J, Burrell, Marini M G, Hardens M. Economic evaluation of meloxicam (7.5mg) versus sustained release diclofenac (100mg) treatment for osteoarthritis: a cross-national assessment for France, Italy and the UK. British Journal of Medical Economics 1997; 11: 9-22 Other publications of related interest (...) Economic evaluation of meloxicam (7.5mg) versus sustained release diclofenac (100mg) treatment for osteoarthritis: a cross-national assessment for France, Italy and the UK Economic evaluation of meloxicam (7.5mg) versus sustained release diclofenac (100mg) treatment for osteoarthritis: a cross-national assessment for France, Italy and the UK Economic evaluation of meloxicam (7.5mg) versus sustained release diclofenac (100mg) treatment for osteoarthritis: a cross-national assessment for France
Acupuncture as a symptomatic treatment of osteoarthritis: a systematic review Acupuncture as a symptomatic treatment of osteoarthritis: a systematic review Acupuncture as a symptomatic treatment of osteoarthritis: a systematic review Ernst E Authors' objectives To assess the effectiveness of acupuncture as a complementary treatment for osteoarthritis (OA). Searching MEDLINE from 1966 to 1996, and CISCOM were searched. IN addition, the bibliographies of the retrieved studies were examined (...) of axial and peripheral jointOA. CRD commentary This was a generally methodologically sound review. Although the studies were not critically appraised in detail, aspects of the methodological quality were assessed and the author's conclusions were based on the most robust studies. It is unclear whether additional relevant trials would have been identified by searching other databases, e.g. CINAHL, EMBASE, and the Cochrane Controlled Trials Register. Bibliographic details Ernst E. Acupuncture
in Arthritis and Rheumatism 1997; 26(5): 755-770 PubMedID Other publications of related interest Gotzche P. Methodology and overt hidden bias in reports of 196 double-blind trials of non-steroidal anti-inflammatory drugs in rheumatoid arthritis. Control Clin Trials 1989;10:31-56. Indexing Status Subject indexing assigned by NLM MeSH Humans; Knee Joint; Osteoarthritis /drug therapy; Randomized Controlled Trials as Topic /methods; Research Design AccessionNumber 11997000656 Date bibliographic record (...) To compare the efficacy of pharmacological agents for the treatment of osteoarthritis of the knee. Searching MEDLINE was searched from 1966 to 1994, using MeSH terms 'osteoarthritis', 'knee', 'knee joint'. Only English language publications were included. Reference lists of publications retrieved were also searched. Study selection Study designs of evaluations included in the review Only randomised controlled trials (RCTs) were included. Specific interventions included in the review Nonsteroidal anti
Authors' objectives To compare the effects of education interventions and non-steroidal anti-inflammatory drug (NSAID) treatment on pain and functional disability in patients with osteoarthritis, and on pain, functional disability, and tender joint counts in patients with rheumatoid arthritis. Searching Studies of educational interventions: MEDLINE was searched from 1966 to 1993 (the search terms are provided); bibliographies of relevant articles and of a previous meta-analysis were examined. Studies (...) in the review Patients with osteoarthritis or rheumatoid arthritis were included. Outcomes assessed in the review Pain, functional disability and tender joint counts were assessed. How were decisions on the relevance of primary studies made? The authors do not state how the papers were selected for the review, or how many of the authors performed the selection. Assessment of study quality The authors do not state that they assessed quality. Data extraction The standardised gain difference was used
the Arthritis Foundation. Bibliographic details Chang R W, Pellissier J M, Hazen G B. A cost-effectiveness analysis of total hip arthroplasty for osteoarthritis of the hip. Journal of the American Medical Association 1996; 275(11): 858-865 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Age Factors; Aged; Aged, 80 and over; Cost-Benefit Analysis; Data Collection; Decision Trees; Disease Progression; Female; Hip Prosthesis /economics /mortality; Humans; Male; Middle Aged; Models, Economic (...) all the requirementsof a quality cost-effectiveness analysis. Implications of the study Further research is needed to determine whether this procedure is actually being used in this cost-effective manner, especially in older age groups. Source of funding The study was supported by National Institutes of Health, National Institute of Arthritis, Musculoskeletal, and Skin Diseases Multipurpose Arthritis and Musculoskeletal Diseases grant, National Science Foundation grant, and a grant form
commentary Overall, this is a poorly designed review, constructed from 3 RCTs that suffer from methodological problems such as a potential sampling bias (i.e. use of volunteers) and failure to blind outcome assessors. One study included patients with both osteoarthritis and rheumatoid arthritis of both the hip and knee joint, and it is unclear if the data relevant to this review was available separately. Since the search strategy was limited to English language papers, relevant literature may have been (...) The efficacy of aerobic exercises for treating osteoarthritis of the knee The efficacy of aerobic exercises for treating osteoarthritis of the knee The efficacy of aerobic exercises for treating osteoarthritis of the knee La Mantia K, Marks R Authors' objectives To critically examine the efficacy of aerobic exercise for treating osteoarthritis of the knee. Searching MEDLINE was searched from 1985 to 94 with search terms (explode) 'arthritis', (explode) 'osteoarthritis', 'exercise', (explode
Taping the patella medially: a new treatment for osteoarthritis of the knee joint? To test the hypothesis that medial taping of the patella reduces the symptoms of osteoarthritis of the knee when the patellofemoral joint is affected.Randomised, single blind, crossover trial of three different forms of taping of the knee joint. Each tape (medial, lateral, or neutral) was applied for four days, with three days of no treatment between tape positions.14 patients with established, symptomatic (...) in patients with osteoarthritis of the patellofemoral joint.
, Australia.25 patients (median age 64 years) with pain of osteoarthritis (median duration of disease eight years) considered by their general practitioners to require regular treatment. 20 were already taking non-steroidal anti-inflammatory drugs.Diary of pain and stiffness, function, and side effects.15 patients completed the study, five withdrew early but had made a therapeutic decision, and five dropped out very early. Results from 20 patients were analysed. Several patterns of response evolved. Eight (...) n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis. To evaluate the efficacy of paracetamol and a non-steroidal anti-inflammatory drug for symptom relief in osteoarthritis.Double blind, randomised, controlled trials in individual patients (n of 1 trials). Three treatment cycles with two weeks' each of paracetamol (1 g twice daily) and diclofenac (50 mg twice daily) prepared in identical gelatin capsules.General practices in metropolitan Sydney
for hip and knee osteoarthritis. Annals of Internal Medicine 1994; 121(2): 133-140 PubMedID Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Clinical Trials as Topic; Humans; Knee Joint; Osteoarthritis /therapy; Osteoarthritis, Hip /therapy AccessionNumber 11994008036 Date bibliographic record published 31/01/1998 Date abstract record published 31/01/1998 Record Status This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each (...) Published trials of nonmedicinal and noninvasive therapies for hip and knee osteoarthritis Published trials of nonmedicinal and noninvasive therapies for hip and knee osteoarthritis Published trials of nonmedicinal and noninvasive therapies for hip and knee osteoarthritis Puett D W, Griffin M R Authors' objectives To review the efficacy of nonmedicinal, noninvasive therapies in knee and hip osteoarthritis. Searching MEDLINE was searched from 1966 to 1993 by cross-referencing the medical therapy
Nabumetone in elderly patients with osteoarthritis: economic benefits versus ibuprofen alone or ibuprofen plus misoprostol Nabumetone in elderly patients with osteoarthritis: economic benefits versus ibuprofen alone or ibuprofen plus misoprostol Nabumetone in elderly patients with osteoarthritis: economic benefits versus ibuprofen alone or ibuprofen plus misoprostol Bentkover J D, Baker A M, Kaplam H Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) type Cost-effectiveness analysis Study population Elderly patients (> 60 years of age) with osteoarthritis. Setting Primary care. The economic study was carried out in the USA. Dates to which data relate Cost data was calculated for 1992 US dollars, and effectiveness data was gathered from a trial conducted in 1993. Source of effectiveness data The evidence for effectiveness was derived from a single study. Link between effectiveness and cost data Cost data was not collected on patients included
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. The optimal short-term, symptomatic therapy for osteoarthritis of the knee has not been fully determined. Accordingly, we compared the efficacy of a nonsteroidal antiinflammatory drug, ibuprofen, given in either an antiinflammatory dose (high dose) or an analgesic dose (low dose), with that of acetaminophen, a pure analgesic.In (...) a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day. They were evaluated after a washout period of three to seven days before the beginning of the study, and again after four weeks of treatment. The major measures of outcome included scores on the pain and disability scales of the Stanford Health Assessment Questionnaire (range of possible scores, 0 to 3), scores on the visual
Effect of non-steroidal anti-inflammatory drugs on the course of osteoarthritis. To test the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) accelerate the progression of osteoarthritis by reducing synthesis of vasodilator prostaglandins, thereby diminishing joint perfusion, 105 osteoarthritis patients awaiting hip arthroplasty were treated prospectively with a strong or weak prostaglandin synthesis inhibitor, indomethacin or azapropazone, respectively. Pain and radiological (...) joint space were monitored during the period up to arthroplasty and the condition of the excised femoral head was determined. As judged by radiological and histopathological data, the two treatment groups were at a similar pathophysiological end-point when they came to arthroplasty. In the indomethacin group the affected hips lost joint space more rapidly than did the contralateral hips, a difference not seen in the azapropazone group. The patients receiving azapropazone, who had higher
Controlled trial of homoeopathic treatment of osteoarthritis. In a double-blind, placebo-controlled crossover study to compare the homoeopathic remedy Rhus tox. 6X with fenoprofen in osteoarthritis of the hip and knee, fenoprofen was shown to have beneficial analgesic and anti-inflammatory effects which differed significantly from those of placebo. The effects of Rhus tox. 6X and placebo did not differ significantly. Patient preference was for fenoprofen. Side-effects were not severe but were
Trolamine salicylate cream in osteoarthritis of the knee. Twenty-five patients with symptomatic osteoarthritis (OA) of the knee were treated topically for one week with either 10% trolamine salicylate cream or placebo cream in a randomized double-blind crossover study. No significant difference was found in subjective or objective measures of pain relief between the treatment and control groups. Eight patients preferred "active" test cream, six preferred placebo, and 11 had no preference (...) . No side effects were reported. Topically applied 10% trolamine salicylate cream did not relieve the pain of OA of the knee any more than did placebo.