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Latest & greatest articles for osteoarthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoarthritis or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on osteoarthritis and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
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Including people with or without: Mild to severe osteoarthritis Radiographic evidence of osteoarthritis i X-ray or MRI changes of arthritis Mechanical symptoms i Locking, clicking, catching Acute onset knee pain i Pain started suddenly or slowly Meniscal tears i Tear in knee cartilage People with degenerative knee disease Choice of intervention or Arthroscopic surgery Conservative management Any conservative management strategy (exercise therapy, injections, drugs) Arthroscopic surgery with or without (...) ? Degenerative knee disease is an inclusive term, which many consider synonymous with osteoarthritis. We use the term degenerative knee disease to explicitly include patients with knee pain, particularly if they are >35 years old, with or without: Imaging evidence of osteoarthritis Meniscus tears Locking, clicking, or other mechanical symptoms except persistent objective locked knee Acute or subacute onset of symptoms Most people with degenerativearthritis have at least one of these characteristics
(In the final document this should be a combination of your clinical and librarian search terms) Population and Setting Adults with ankle OA Adults, ankle OA, ankle osteoarthritis, degenerative changes Getting Evidence into Clinical Practice: Musculoskeletal Research Facilitation Group (CAT Group) Date: February 2018 CAT Lead: Jo Pike Date CAT completed: February 2018 email@example.com Date CAT to be reviewed: February 2021 Intervention or Exposure Surgical intervention in the form of either joint sparing (...) In adults with ankle osteoarthritis (OA), is total ankle replacement/fusion/debridement better than no treatment for pain and function, risks and harms and adverse events? Getting Evidence into Clinical Practice: Musculoskeletal Research Facilitation Group (CAT Group) Date: February 2018 CAT Lead: Jo Pike Date CAT completed: February 2018 firstname.lastname@example.org Date CAT to be reviewed: February 2021 Specific Question: In adults with ankle Osteoarthritis (OA) A is total ankle replacement/fusion
trials have been completed. Why is this important? This question was selected due to the lack of standardisation by clinicians with regards to best clinical practice. Ankle OA constitutes only 4.4% of patients referred to orthopedic clinic for the management of lower extremity OA. Search timeframe (e.g. 2006-2017) Inclusion Criteria Description Search terms Population and Setting Adults with ankle OA within any care setting Adults, OA, osteoarthritis, lower limb, talocrural joint, joint pain (...) In adults with ankle osteoarthritis is exercise/physiotherapy/rehabilitation/conservative treatment more effective than surgical options? Getting Evidence into Clinical Practice: Musculoskeletal Research Facilitation Group (CAT Group) Date: September 2017 CAT Lead: Ben Lannie Date CAT completed: August 2017 Email: email@example.com Date CAT to be reviewed: September 2020 Specific Question: In adults with ankle osteoarthritis is exercise / physiotherapy / rehabilitation / conservative
HAYES, Inc. Comparative effectiveness review of platelet-rich plasma for knee osteoarthritis: a review of reviews. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Osteoarthritis (OA) is a painful condition in which the cartilage between the bones degenerates, no longer providing a smooth, gliding surface for motion or adequate cushioning. Because OA damages the cartilage and may ultimately damage the bone, it disrupts how components work together, resulting (...) with PRP for knee OA, and how do complications compare with sham injection and other IA treatments? Have definitive patient selection criteria been established for PRP for knee OA? Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Humans; Osteoarthritis, Knee; Platelet-Rich Plasma Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc
. Comparative effectiveness review of hyaluronic acid for knee osteoarthritis: a review of reviews. Lansdale: HAYES, Inc. Directory Publication. 2017 Authors' conclusions Health Problem: Osteoarthritis (OA) is a painful condition in which the cartilage between the bones degenerates, no longer providing a smooth, gliding surface for motion or adequate cushioning. Because OA damages the cartilage and may ultimately damage the bone, it disrupts how components work together, resulting in pain, swelling (...) , inflammation, muscle weakness, impaired quality of life (QOL), and reduced function. The knee is commonly afflicted by OA. Technology Description: Hyaluronic acid (HA) is a component of synovial fluid, which lubricates the joint and absorbs shock. HA production is generally reduced and may be of poorer quality in patients with OA, which may exacerbate inflammation. Intra-articular (IA) injection of HA (IA-HA) aims to replace depleted or poor-quality HA in the joint. Controversy: Despite a large evidence
A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis Genicular nerve radiofrequency ablation is an effective treatment for patients with chronic pain due to knee osteoarthritis; however, little is known about factors that predict procedure success. The current study evaluated the utility of genicular nerve blocks to predict the outcome of genicular nerve (...) cooled radiofrequency ablation (cRFA) in patients with osteoarthritis.This randomized comparative trial included patients with chronic knee pain due to osteoarthritis. Participants were randomized to receive a genicular nerve block or no block prior to cRFA. Patients receiving a prognostic block that demonstrated ≥50% pain relief for six hours received cRFA. The primary outcome was the proportion of participants with ≥50% reduction in knee pain at six months.Twenty-nine participants (36 knees) had
and global audience via www.jospt.org CLASSIFICATION The primary International Classification of Diseases 10th Revision (ICD-10) code and condition associated with hip pain and mobility deficits is M16.1 Primary coxarthrosis, unilateral. In the ICD, the term OA is used as a synonym for arthrosis or osteoarthrosis. Other, secondary codes associated with hip OA are M16.0 Primary coxarthrosis, bilateral; M16.2 Coxarthrosis resulting from dysplasia, bilateral; M16.3 Dysplastic coxarthrosis, unilateral; M16.4 (...) of rural China, the preva- lence of symptomatic hip OA was estimated at 0.6%. 77 2017 Summary Osteoarthritis is the most common cause of hip pain in older adults (older than 50 years of age). Prevalence rates for adult hip OA range from 0.4% to 27%. The reported prevalence of hip OA continues to show great variability, with men showing higher prevalence of radiographic hip OA. PATHOANATOMICAL FEATURES 2009 Summary Clinicians should assess for impairments in mobility of the hip joint and the strength
Intra-articular Corticosteroids for Osteoarthritis of the Knee. Are intra-articular corticosteroids associated with improvement in pain and physical function compared with sham injection or no intervention in patients with knee osteoarthritis?Intra-articular corticosteroids may be associated with moderate improvement in pain and a small improvement in physical function up to 6 weeks after injection. However, the quality of the evidence is low.
Predictive capacity of thigh muscle strength in symptomatic and/or radiographic knee osteoarthritis progression â€“ data from the FNIH OA Biomarkers Consortium Thigh muscle weakness is a risk factor for incident radiographic and symptomatic knee osteoarthritis (KOA). The role of thigh muscle weakness in radiographic and/or symptomatic KOA progression remains elusive. Five hundred twenty-seven knees of 527 Osteoarthritis Initiative participants with baseline Kellgren-Lawrence grades 1 to 3 were (...) included in this nested case-control study evaluating whether baseline muscle strength predicted symptomatic and/or radiographic KOA progression. Case knees (n = 173) displayed both medial tibiofemoral joint space loss (≥0.7 mm) and a persistent increase in Western Ontario McMasters Osteoarthritis Index pain (≥9 on a 0- to 100-point scale) over 24 to 48 months from baseline. Control knees (n = 354) included 174 with neither radiographic nor symptomatic progression, 91 with radiographic progression only
Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. The prevalence of knee osteoarthritis (OA)/degenerativejointdisease (DJD) is increasing in the USA. Systematic reviews of treatment efficacy and adverse events (AEs) of hyaluronic acid (HA) injections report conflicting evidence about the balance of benefits and harms. We review evidence on efficacy and AEs of intraarticular (...) viscosupplementation with HA in older individuals with knee osteoarthritis and account for differences in these conclusions from another systematic review.We searched PubMed and eight other databases and gray literature sources from 1990 to December 12, 2014. Double-blind placebo-controlled randomized controlled trials (RCTs) reporting functional outcomes or quality-of-life; RCTs and observational studies on delay/avoidance of arthroplasty; RCTs, case reports, and large cohort studies and case series assessing
Efficacy of Cabbage Leaf Wraps in the Treatment of Symptomatic Osteoarthritis of the Knee: A Randomized Controlled Trial Osteoarthritis (OA) of the knee is one of the most common chronic diseases among older adults. This study aimed to test the effects of cabbage leaf wraps (CLWs) in the treatment of symptomatic OA.Patients with OA of the knee at stages II to III (Kellgren-Lawrence) were randomly assigned to 4 weeks of treatment with CLWs (daily for at least 2h), topical pain gel (TPG) (10 mg (...) diclofenac/g, at least once daily), or usual care (UC). The primary outcome measure was pain intensity (VAS) after 4 weeks. Secondary outcomes included functional disability Western Ontario and McMaster Universities Arthritis Index (WOMAC), quality of life (SF-36), self-efficacy (Arthritis Self-Efficacy Scale-D), physical function (30 s Chair Stand Test), pressure pain sensitivity (PPT), satisfaction, and safety after 4 and 12 weeks.In total, 81 patients were included in this study (42 women, 65.9±10.3 y
Anxiety and depression in patients with osteoarthritis: impact and management challenges Anxiety and depression are common psychological comorbidities that impact the quality of life (QoL) of patients. In this systematic review, we 1) determined the impact of anxiety and depression on outcomes in patients with osteoarthritis (OA) and 2) summarized unique challenges these comorbidities present to current OA management.A systematic literature search was performed using the OVID Medline and EMBASE (...) databases until April 2016. Full-text research articles published in English from the year 2000 onward with a sample size of >100 were included in this review. Eligible research articles were reviewed and the following data were extracted: study author(s), year of publication, study design, and key findings.A total of 38 studies were included in the present review. The present study found that both anxiety and/or depression were highly prevalent among patients with OA. Patients with OA diagnosed
Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. Osteoarthritis of the knee (OAK) is a common form of arthritis that can lead to substantial pain and disability. This commentary highlights key aspects of the recently published phase 3 A Efficacy and Safety Study of Two Doses of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee (SPRING) study. SPRING (NCT01839331) was a multicenter, randomized, vehicle-controlled, double-blind (...) trial that evaluated the safety and efficacy of the low-molecular-weight fraction of 5% human serum albumin (LMWF-5A) for treatment of pain, measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain scale, in patients with symptomatic OAK (N=329). Patients in this study reflected many characteristics of "real-world" individuals with OAK, with a broad range of disease severity and disability. The most important finding from this study was that treatment with a single intra
Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone. Osteoarthritis (OA) is the most common jointdisease and leading cause of disability. Intra-articular (IA) administration of hyaluronic acid (HA) or corticosteroids (CS) have been previously studied, though using insufficient number of patients or short follow-up periods.We evaluate HA and CS in patients with knee OA in terms of clinical efficacy (...) over 12 months.We used a prospective, randomized study with parallel groups. Randomized patients received IA injections of HA or betamethasone (BM). The primary outcomes were improvement in pain using Visual Analog Scale and function in the Western Ontario and McMaster University Osteoarthritis Index (Likert scale). Follow-up visits were scheduled at 3 months, 6 months, 9 months, and 12 months.A total of 200 patients were included. Pain was significantly reduced in both groups at the first follow