Latest & greatest articles for osteoarthritis

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Top results for osteoarthritis

161. A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis Full Text available with Trip Pro

A Prospective Randomized Trial of Prognostic Genicular Nerve Blocks to Determine the Predictive Value for the Outcome of Cooled Radiofrequency Ablation for Chronic Knee Pain Due to Osteoarthritis Genicular nerve radiofrequency ablation is an effective treatment for patients with chronic pain due to knee osteoarthritis; however, little is known about factors that predict procedure success. The current study evaluated the utility of genicular nerve blocks to predict the outcome of genicular nerve (...) cooled radiofrequency ablation (cRFA) in patients with osteoarthritis.This randomized comparative trial included patients with chronic knee pain due to osteoarthritis. Participants were randomized to receive a genicular nerve block or no block prior to cRFA. Patients receiving a prognostic block that demonstrated ≥50% pain relief for six hours received cRFA. The primary outcome was the proportion of participants with ≥50% reduction in knee pain at six months.Twenty-nine participants (36 knees) had

2017 EvidenceUpdates

162. Hip Pain and Mobility Deficits ? Hip Osteoarthritis

and global audience via www.jospt.org CLASSIFICATION The primary International Classification of Diseases 10th Revision (ICD-10) code and condition associated with hip pain and mobility deficits is M16.1 Primary coxarthrosis, unilateral. In the ICD, the term OA is used as a synonym for arthrosis or osteoarthrosis. Other, secondary codes associated with hip OA are M16.0 Primary coxarthrosis, bilateral; M16.2 Coxarthrosis resulting from dysplasia, bilateral; M16.3 Dysplastic coxarthrosis, unilateral; M16.4 (...) of rural China, the preva- lence of symptomatic hip OA was estimated at 0.6%. 77 2017 Summary Osteoarthritis is the most common cause of hip pain in older adults (older than 50 years of age). Prevalence rates for adult hip OA range from 0.4% to 27%. The reported prevalence of hip OA continues to show great variability, with men showing higher prevalence of radiographic hip OA. PATHOANATOMICAL FEATURES 2009 Summary Clinicians should assess for impairments in mobility of the hip joint and the strength

2017 The Orthopaedic Section of the American Physical Therapy Association (APTA), Inc.

163. Intra-articular Corticosteroids for Osteoarthritis of the Knee. Full Text available with Trip Pro

Intra-articular Corticosteroids for Osteoarthritis of the Knee. Are intra-articular corticosteroids associated with improvement in pain and physical function compared with sham injection or no intervention in patients with knee osteoarthritis?Intra-articular corticosteroids may be associated with moderate improvement in pain and a small improvement in physical function up to 6 weeks after injection. However, the quality of the evidence is low.

2016 JAMA

164. Predictive capacity of thigh muscle strength in symptomatic and/or radiographic knee osteoarthritis progression – data from the FNIH OA Biomarkers Consortium Full Text available with Trip Pro

Predictive capacity of thigh muscle strength in symptomatic and/or radiographic knee osteoarthritis progression – data from the FNIH OA Biomarkers Consortium Thigh muscle weakness is a risk factor for incident radiographic and symptomatic knee osteoarthritis (KOA). The role of thigh muscle weakness in radiographic and/or symptomatic KOA progression remains elusive. Five hundred twenty-seven knees of 527 Osteoarthritis Initiative participants with baseline Kellgren-Lawrence grades 1 to 3 were (...) included in this nested case-control study evaluating whether baseline muscle strength predicted symptomatic and/or radiographic KOA progression. Case knees (n = 173) displayed both medial tibiofemoral joint space loss (≥0.7 mm) and a persistent increase in Western Ontario McMasters Osteoarthritis Index pain (≥9 on a 0- to 100-point scale) over 24 to 48 months from baseline. Control knees (n = 354) included 174 with neither radiographic nor symptomatic progression, 91 with radiographic progression only

2016 American journal of physical medicine & rehabilitation

165. Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Full Text available with Trip Pro

Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. The prevalence of knee osteoarthritis (OA)/degenerative joint disease (DJD) is increasing in the USA. Systematic reviews of treatment efficacy and adverse events (AEs) of hyaluronic acid (HA) injections report conflicting evidence about the balance of benefits and harms. We review evidence on efficacy and AEs of intraarticular (...) viscosupplementation with HA in older individuals with knee osteoarthritis and account for differences in these conclusions from another systematic review.We searched PubMed and eight other databases and gray literature sources from 1990 to December 12, 2014. Double-blind placebo-controlled randomized controlled trials (RCTs) reporting functional outcomes or quality-of-life; RCTs and observational studies on delay/avoidance of arthroplasty; RCTs, case reports, and large cohort studies and case series assessing

2016 Systematic Reviews

166. Efficacy of Cabbage Leaf Wraps in the Treatment of Symptomatic Osteoarthritis of the Knee: A Randomized Controlled Trial Full Text available with Trip Pro

Efficacy of Cabbage Leaf Wraps in the Treatment of Symptomatic Osteoarthritis of the Knee: A Randomized Controlled Trial Osteoarthritis (OA) of the knee is one of the most common chronic diseases among older adults. This study aimed to test the effects of cabbage leaf wraps (CLWs) in the treatment of symptomatic OA.Patients with OA of the knee at stages II to III (Kellgren-Lawrence) were randomly assigned to 4 weeks of treatment with CLWs (daily for at least 2h), topical pain gel (TPG) (10 mg (...) diclofenac/g, at least once daily), or usual care (UC). The primary outcome measure was pain intensity (VAS) after 4 weeks. Secondary outcomes included functional disability Western Ontario and McMaster Universities Arthritis Index (WOMAC), quality of life (SF-36), self-efficacy (Arthritis Self-Efficacy Scale-D), physical function (30 s Chair Stand Test), pressure pain sensitivity (PPT), satisfaction, and safety after 4 and 12 weeks.In total, 81 patients were included in this study (42 women, 65.9±10.3 y

2016 EvidenceUpdates

167. Anxiety and depression in patients with osteoarthritis: impact and management challenges Full Text available with Trip Pro

Anxiety and depression in patients with osteoarthritis: impact and management challenges Anxiety and depression are common psychological comorbidities that impact the quality of life (QoL) of patients. In this systematic review, we 1) determined the impact of anxiety and depression on outcomes in patients with osteoarthritis (OA) and 2) summarized unique challenges these comorbidities present to current OA management.A systematic literature search was performed using the OVID Medline and EMBASE (...) databases until April 2016. Full-text research articles published in English from the year 2000 onward with a sample size of >100 were included in this review. Eligible research articles were reviewed and the following data were extracted: study author(s), year of publication, study design, and key findings.A total of 38 studies were included in the present review. The present study found that both anxiety and/or depression were highly prevalent among patients with OA. Patients with OA diagnosed

2016 Open access rheumatology : research and reviews

168. Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. Full Text available with Trip Pro

Unique aspects of pain reduction in osteoarthritis of the knee with LMWF-5A. Osteoarthritis of the knee (OAK) is a common form of arthritis that can lead to substantial pain and disability. This commentary highlights key aspects of the recently published phase 3 A Efficacy and Safety Study of Two Doses of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee (SPRING) study. SPRING (NCT01839331) was a multicenter, randomized, vehicle-controlled, double-blind (...) trial that evaluated the safety and efficacy of the low-molecular-weight fraction of 5% human serum albumin (LMWF-5A) for treatment of pain, measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain scale, in patients with symptomatic OAK (N=329). Patients in this study reflected many characteristics of "real-world" individuals with OAK, with a broad range of disease severity and disability. The most important finding from this study was that treatment with a single intra

2016 Open access rheumatology : research and reviews Controlled trial quality: uncertain

169. Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone. Full Text available with Trip Pro

Clinical efficacy of intra-articular injections in knee osteoarthritis: a prospective randomized study comparing hyaluronic acid and betamethasone. Osteoarthritis (OA) is the most common joint disease and leading cause of disability. Intra-articular (IA) administration of hyaluronic acid (HA) or corticosteroids (CS) have been previously studied, though using insufficient number of patients or short follow-up periods.We evaluate HA and CS in patients with knee OA in terms of clinical efficacy (...) over 12 months.We used a prospective, randomized study with parallel groups. Randomized patients received IA injections of HA or betamethasone (BM). The primary outcomes were improvement in pain using Visual Analog Scale and function in the Western Ontario and McMaster University Osteoarthritis Index (Likert scale). Follow-up visits were scheduled at 3 months, 6 months, 9 months, and 12 months.A total of 200 patients were included. Pain was significantly reduced in both groups at the first follow

2016 Open access rheumatology : research and reviews Controlled trial quality: uncertain

170. Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study. Full Text available with Trip Pro

Efficacy of a natural mineral complex in North American adults with osteoarthritis of the knee: a randomized double-blind placebo-controlled study. This study evaluated the efficacy of a hydrothermal mineral complex (HMC) supplement in participants with knee osteoarthritis.This was a double-blind, placebo-controlled, 12-week crossover study with 150 participants receiving either placebo or HMC for 4 weeks, with a 4-week washout period. The primary endpoint was WOMAC™ pain, and secondary

2016 Open access rheumatology : research and reviews Controlled trial quality: predicted high

171. Gait analysis of patients with knee osteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions Full Text available with Trip Pro

Gait analysis of patients with knee osteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions Knee osteoarthritis (OA) is a painful and incapacitating disease affecting a large portion of the elderly population, for which no cure exists. There is a critical need to enhance our understanding of OA pathogenesis, as a means to improve therapeutic options.Knee OA is a complex disease influenced by many factors, including the loading environment (...) in OA development, and to design therapeutic interventions. Multidisciplinary research is necessary to relate the biomechanical alterations to the structural and biological components of OA. Cite this article: Favre J, Jolles BM. Analysis of gait, knee biomechanics and the physiopathology of knee osteoarthritis in the development of therapeutic interventions. EFORT Open Rev 2016;1:368-374. DOI: 10.1302/2058-5241.1.000051.

2016 EFORT open reviews

172. Effects of High- and Low-Velocity Resistance Training on Gait Kinematics and Kinetics in Individuals with Hip Osteoarthritis: A Randomized Controlled Trial. (Abstract)

Effects of High- and Low-Velocity Resistance Training on Gait Kinematics and Kinetics in Individuals with Hip Osteoarthritis: A Randomized Controlled Trial. The aim of this study was to investigate the effects of high-velocity (HV) and low-velocity (LV) resistance training on gait kinematics and kinetics in patients with hip osteoarthritis.This was a single-blind, randomized controlled trial. Forty-six women with hip osteoarthritis were randomly allocated to the HV (n = 23) or LV (n = 23

2016 American journal of physical medicine & rehabilitation Controlled trial quality: uncertain

173. Occupational Exposures and Osteoarthritis

by pain and reduced joint function. Osteoarthritis affects more people than any other joint disease and it is a major cause of physical disability. The disease has a multifactorial aetiology and complex pathogenesis. Objective The objective of this review was to assess the scientific basis describing the influence of occupational expos­ures on osteoarthritis. Conclusions This systematic literature review has uncovered a substantial body of evidence in support of in­creased risk of hip and knee (...) of the evidence may have changed. Since 2011, the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) has had a mandate from the Swedish government to systematically assess the evidence for associations between occupational exposures and health issues. A wide range of occupational exposures were investigated, including physical work load, vibration, noise and other work-related environmental factors. Background Osteoarthritis is a chronic joint disorder characterized

2016 Swedish Council on Technology Assessement

174. Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee Full Text available with Trip Pro

Simultaneous anterior cruciate ligament reconstruction and dome-shaped high tibial osteotomy for severe medial compartment osteoarthritis of the knee The optimal surgical procedure to address both anterior cruciate ligament (ACL) deficiency and medial compartment osteoarthritis (OA) has been controversial.A 49-year-old woman with a 30-year history of chronic anterior cruciate ligament (ACL) deficiency, medial compartment osteoarthritis, and varus deformity presented with medial knee pain (...) reconstruction combined with a dome-shaped high tibial osteotomy using a locking plate is one option for treating an aged athlete with ACL deficiency and severe medial compartment osteoarthritis, and can allow the athlete to return to sports activity.

2016 Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology

175. Basic science of osteoarthritis Full Text available with Trip Pro

Basic science of osteoarthritis Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral (...) bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option

2016 Journal of experimental orthopaedics

176. Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study (Abstract)

Economic Impact of Ketorolac vs Corticosteroid Intra-Articular Knee Injections for Osteoarthritis: A Randomized, Double-Blind, Prospective Study Knee osteoarthritis is a disabling disease that costs billions of dollars to treat. Corticosteroid gives varying pain relief and costs $12 per injection, whereas ketorolac costs $2 per injection, per institutional costs. The aim of this study was to compare ketorolac with corticosteroid based on pain relief using patient outcome measures and cost (...) data.A total of 35 patients were randomized to ketorolac or corticosteroid intra-articular knee injection in a double-blind, prospective study. Follow-up was 24 weeks. Osteoarthritis was evaluated using Kellgren-Lawrence grading. Visual analog scale (VAS) was the primary outcome measure. A query of the institutional database was performed for International Classification of Diseases, Ninth Revision codes 715.16 and 719.46, and procedure code 20610 over a 3-year period. Two-way, repeated measures

2016 EvidenceUpdates Controlled trial quality: uncertain

177. FLEXISEQ for osteoarthritis

surgery is recommended for people if osteoarthritis has a substantial impact on quality of life and does not respond to non-surgical treatment. Population, setting and intended user Osteoarthritis is one of the most common chronic diseases in the UK, with 8.75 million people having sought treatment (Arthritis Research UK). An estimated 4 million people in England have osteoarthritis of the knee and 2.5 million have osteoarthritis of the hip (Arthritis Research UK). FLEXISEQ is promoted for use (...) . It consists of an aqueous gel containing hydrophilic, nanoscale lipid vesicles made from phospholipid bilayer (Sequessome vesicles), which are designed to pass through the skin into the joint. FLEXISEQ is regulated as a medical device. The intended place in ther intended place in therap apy y is as a pain-relieving treatment for people with all stages of osteoarthritis, especially those for whom non-steroidal anti-inflammatory drugs (NSAIDS) are not suitable. It would be used in addition to core

2016 National Institute for Health and Clinical Excellence - Advice

178. Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect Full Text available with Trip Pro

Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect Interleukin-1 receptor antagonist (IL-1 ra) can be disease-modifying in posttraumatic osteoarthritis (PTOA). One limitation is its short joint residence time. We hypothesized that IL-1 ra encapsulation in poly (lactide-co-glycolide) (PLGA) microspheres reduces IL-1 ra systemic absorption and provides an enhanced anti-PTOA (...) 7, 14, 21 and 28 following ACLT. Cartilage and synovial histopathology: On day 35, animal ACLT joints were harvested and tibial cartilage and synovial histopathology scoring was performed.Percent IL-1 ra content in the supernatant at 6 h was 13.44 ± 9.27 % compared to 34.16 ± 12.04 %, 47.89 ± 12.71 %, 57.14 ± 11.71 %, and 93.90 ± 8.50 % at 12, 24, 48 and 72 h, respectively. PLGA IL-1 ra inhibited lymphocyte proliferation and cartilage degradation similar to IL-1 ra. Serum IL-1 ra levels were

2016 Journal of experimental orthopaedics

179. Functional outcome measures in a surgical model of hip osteoarthritis in dogs Full Text available with Trip Pro

Functional outcome measures in a surgical model of hip osteoarthritis in dogs The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip (...) , and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis. The purpose of this study was to evaluate a surgical model of hip osteoarthritis in a large laboratory animal model and to evaluate functional and end-point outcome measures.Seven dogs were subjected to partial surgical debridement of cartilage from one femoral head. Pre- and postoperative pain and functional scores

2016 Journal of experimental orthopaedics

180. Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis Full Text available with Trip Pro

Brief time-based activity pacing instruction as a singular behavioral intervention was not effective in participants with symptomatic osteoarthritis Osteoarthritis (OA) of the lower extremities is a prevalent cause of disability in which symptoms interfere with mobility and activity participation. Behavioral self-management for OA symptomatology is commonly recommended; but these interventions are underutilized, unstandardized in application, and at times, unavailable in the context of clinical (...) , fatigue, and physical function in people with symptomatic knee or hip OA. A 3-arm randomized controlled trial was conducted in which 193 people were randomized into tailored activity pacing, general activity pacing, or usual care arms. Assessments were done at 10 weeks and 6 months after baseline. Using linear mixed models, Western Ontario and McMaster Universities Osteoarthritis Index pain scores changed over time, decreasing the most in the general and usual care groups; only the usual care group

2016 EvidenceUpdates Controlled trial quality: uncertain