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Latest & greatest articles for osteoporosis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on osteoporosis or other clinical topics then use Trip today.
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Zoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial. Persistent use of glucocorticoid drugs is associated with bone loss and increased fracture risk. Concurrent oral bisphosphonates increase bone mineral density and reduce frequency of vertebral fractures, but are associated with poor compliance and adherence. We aimed to assess whether one intravenous infusion (...) of zoledronic acid was non-inferior to daily oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis.This 1-year randomised, double-blind, double-dummy, non-inferiority study of 54 centres in 12 European countries, Australia, Hong Kong, Israel, and the USA, tested the effectiveness of 5 mg intravenous infusion of zoledronic acid versus 5 mg oral risedronate for prevention and treatment of glucocorticoid-induced osteoporosis. 833 patients were randomised 1:1 to receive zoledronic
2009LancetControlled trial quality: predicted high
Zoledronic acid (Aclasta) - Treatment of osteoporosis in men at increased risk of fracture, including those with a recent low-trauma hip fracture. Published 12 January 2009 Secretariat - Delta House 50 West Nile Street Glasgow G1 2NP Telephone 0141 225 6997 Fax 0141 248 3778 E-mail email@example.com Chairman Dr Kenneth R Paterson Scottish Medicines Consortium zoledronic acid 5mg/100ml solution for infusion (Aclasta ® ) (No. 535/08) Novartis Pharmaceuticals UK Ltd Statement of Advice 05 (...) December 2008 ADVICE: in the absence of a submission from the holder of the marketing authorisation. zoledronic acid 5mg (Aclasta ® ) is not recommended for use within NHSScotland for the treatment of osteoporosis in men at increased risk of fracture, including those with a recent low-trauma hip fracture. The holder of the marketing authorisation has not made a submission to SMC regarding this product in this indication. As a result we cannot recommend its use within NHSScotland. Advice context
Incorporating adherence into health economic modelling of osteoporosis Incorporating adherence into health economic modelling of osteoporosis Incorporating adherence into health economic modelling of osteoporosis Strom O, Borgstrom F, Kanis JA, Jonsson B Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment (...) on the reliability of the study and the conclusions drawn. CRD summary The objective was to examine the impact of adherence on the cost-effectiveness of drugs for patients with osteoporosis. The authors concluded that improved adherence led to relevant benefits, but that these might be offset by increased intervention costs. The study appears to have been based on valid methodology, but the data sources were only partially reported. In general, the authors’ conclusions appear to be valid. Type of economic
Using the osteoporosis self-assessment tool for referring older men for bone densitometry: a decision analysis Using the osteoporosis self-assessment tool for referring older men for bone densitometry: a decision analysis Using the osteoporosis self-assessment tool for referring older men for bone densitometry: a decision analysis Ito K, Hollenberg JP, Charlson ME Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study compared the cost-effectiveness of universal versus selective, using the Osteoporosis Self-Assessment Tool (OST), bone densitometry for the diagnosis of osteoporosis. The authors concluded that using the OST, followed by bone densitometry for those with an OST score of -2 or less, and then alendronate treatment
Osteoporosis case manager for patients with hip fractures: results of a cost-effectiveness analysis conducted alongside a randomized trial Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Risk factor assessment for osteoporosis and/or increased fracture risk in men. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding
Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. The American College of Physicians (ACP) developed this guideline to present the available evidence on various pharmacologic treatments to prevent fractures in men and women with low bone density or osteoporosis.Published literature on this topic was identified by using MEDLINE (1966 to December 2006), the ACP Journal Club database (...) , the Cochrane Central Register of Controlled Trials (no date limits), the Cochrane Database of Systematic Reviews (no date limits), Web sites of the United Kingdom National Institute of Health and Clinical Excellence (no date limits), and the United Kingdom Health Technology Assessment Program (January 1998 to December 2006). Searches were limited to English-language publications and human studies. Keywords for search included terms for osteoporosis, osteopenia, low bone density, and the drugs listed
Head-to-head comparison of risedronate vs. teriparatide on bone turnover markers in women with postmenopausal osteoporosis: a randomised trial We aimed to compare the effect of risedronate (RIS) and teriparatide (TPTD) (recombinant human parathyroid hormone 1-34) on bone turnover markers in women with postmenopausal osteoporosis.Forty-four Caucasian women (age 65.1 +/- 1.6 years) with postmenopausal osteoporosis were randomly assigned to receive either RIS 35 mg once weekly (n = 22) or TPTD 20 (...) ) and increased in TPTD group (p < 0.001) throughout the treatment. iPTH increased significantly in RIS group (p < 0.05) and decreased in TPTD group (p < 0.001). Finally, lumbar spine BMD increased significantly in both RIS (p = 0.003) and TPTD groups (p < 0.001) without significant differences between them.Our data suggest that both serum P1NP and CTx are reliable markers of RIS and TPTD action in women with postmenopausal osteoporosis. In a similar way, serum total ALP can be used as an alternative marker
Screening for osteoporosis in men: a clinical practice guideline from the American College of Physicians. The American College of Physicians developed this guideline to present the available evidence on risk factors and screening tests for osteoporosis in men.Published literature on this topic was identified by using MEDLINE (1990 to July 2007). Reference mining was done on the retrieved articles, references of previous reviews, and solicited articles from experts. The inclusion criteria (...) for the studies were measuring risk factors for low bone mineral density or osteoporotic fracture in men or comparing 2 different methods of assessment for the presence of osteoporosis in men. This guideline grades the evidence and recommendations by using the American College of Physicians' clinical practice guidelines grading system. RECOMMENDATION 1: The American College of Physicians recommends that clinicians periodically perform individualized assessment of risk factors for osteoporosis in older men
Relative effectiveness of osteoporosis drugs for preventing nonvertebral fracture. Little information is available on the comparative effectiveness of osteoporosis pharmacotherapies.To compare the relative effectiveness of osteoporosis treatments to reduce nonvertebral fracture risk among older adults.Cohort study.Enrollees in 2 statewide pharmaceutical benefit programs for persons age 65 years or older.43,135 new recipients of oral bisphosphonates, nasal calcitonin, and raloxifene who began
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density.In this genome-wide association study, we identified the most promising of 314 075 single nucleotide polymorphisms (SNPs) in 2094 women in a UK study. We then tested these SNPs for replication (...) protein) gene. A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008). Three SNPs near the TNFRSF11B gene were associated with decreased bone mineral density (top SNP, rs4355801: p=7.6x10(-10) for lumbar spine and p=3.3x10(-8) for femoral neck
Management and prevention of osteoporosis. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding for the National Guideline Clearinghouse (NGC
A comparison of the effect of alendronate and risedronate on bone mineral density in postmenopausal women with osteoporosis: 24-month results from FACTS-International To compare alendronate 70 mg once weekly (OW) with risedronate 35 mg OW with respect to change in bone mineral density (BMD), biochemical markers and upper gastrointestinal (UGI) tolerability over 24 months.This was a 12-month extension to the Fosamax Actonel Comparison Trial international study (FACTS). Postmenopausal women (...) with osteoporosis randomly assigned to either alendronate 70 mg OW or risedronate 35 mg OW for the 12-month base study continued taking the same double-blind study medication. Efficacy measurements were BMD at the hip trochanter, lumbar spine, total hip, and femoral neck and levels of four bone turnover markers at 24 months. The primary hypothesis was that alendronate would produce a greater mean per cent increase from baseline in hip trochanter BMD at 24 months.Trochanter BMD increased significantly from
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and fracture (...) affected BMD. The LRP6 Ile1062Val polymorphism was not associated with any osteoporosis phenotype. All aforementioned associations except that between Val1330 and all fractures and vertebral fractures remained significant after multiple-comparison adjustments.Common LRP5 variants are consistently associated with BMD and fracture risk across different white populations. The magnitude of the effect is modest. LRP5 may be the first gene to reach a genome-wide significance level (a conservative level
Therapeutic Brief 15 - osteoporosis: strategies to minimise fracture risk Therapeutic Brief 15 – Osteoporosis: strategies to minimise fracture risk. June 2008. Veterans’ Medicines Advice and Therapeutics Education Services Osteoporosis: strategies to minimise fracture risk Key points Osteoporosis is preventable and treatable. Evidence from clinical trials suggests that available therapies reduce the risk of fractures by as much as 30 - 50%. Consider BMD testing in high risk patients including (...) those aged over 50 years who have had a low trauma fracture and those aged 70 years and over. Ensure adequate calcium and vitamin D, as these are the cornerstone of any regimen aimed at preventing or treating osteoporosis. Consider specific antiresorptive drugs for patients with very low bone density (T-score = -3.0) Consider specific antiresorptive drugs after low trauma fracture associated with low bone density to prevent further bone loss and reduce fracture risk. Recommend strategies to prevent
How do you approach male patients with osteoporosis? How do you approach male patients with osteoporosis? – Clinical Correlations Search How do you approach male patients with osteoporosis? February 28, 2008 5 min read Commentary by Carrie Mahowald MD Case: GS, a 65 year old man with only a history of severe OA, is seen in pre-op clinic for medical clearance before his hip replacement. On his pre-op x-ray, an incidental finding of a lumbar vertebral compression fracture is noted. After his hip (...) replacement, how would you work him up for osteoporosis? Osteoporosis, defined as low bone mass and the deterioration of bone micro-architecture which leads to the compromise of bone strength and the increased risk of fracture, is the most common bone disease in humans. Osteoporosis affects millions of people and the risk increases with increasing age causing significant mortality and morbidity including chronic pain, disability and death. Osteoporosis in men is less common than in women and therefore
FRAX: A Brand New Tool For the Management of Osteoporosis FRAX: A Brand New Tool For the Management of Osteoporosis – Clinical Correlations Search FRAX: A Brand New Tool For the Management of Osteoporosis August 13, 2008 4 min read Commentary by Judith Brenner MD, Associate Editor, Clinical Correlations. Reviewed by Valerie Peck MD, NYU Division of Endocrinology. An 81 year old Caucasian woman with a history of diabetes and hypertension who was admitted to the orthopedic service with a hip (...) fracture after falling in her home. This is a typical story and represents the end stages of osteoporosis. It is the myocardial infarction of the bone world. Like cardiovascular disease, prevention and identification of at-risk individuals is the most powerful tool clinicians have available to make an impact and prevent outcomes such as these. The questions we face are: Who is most at risk? When do we intervene? What is our intervention? So, how do we quantify risk? Up until now, it has essentially
Teriparatide (Forsteo®) for the treatment of osteoporosis in men at increased risk of fracture Teriparatide (Forsteo®) for the treatment of osteoporosis in men at increased risk of fracture Teriparatide (Forsteo®) for the treatment of osteoporosis in men at increased risk of fracture All Wales Medicines Strategy Group (AWMSG) Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA (...) database. Citation All Wales Medicines Strategy Group (AWMSG). Teriparatide (Forsteo®) for the treatment of osteoporosis in men at increased risk of fracture. Penarth: All Wales Therapeutics and Toxicology Centre (AWTTC), secretariat of the All Wales Medicines Strategy Group (AWMSG). AWMSG Secretariat Assessment Report Advice No. 2108. 2008 Authors' conclusions Teriparatide (Forsteo®) is not recommended for use within NHS Wales for the treatment of osteoporosis in men at increased risk of fracture