Latest & greatest articles for otitis media

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Top results for otitis media

141. Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview

Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview Otitis media with effusion and s-carboxymethylcysteine and/or its lysine salt: a critical overview Pignataro O, Pignataro L D, Gallus G, Calori G, Cordaro C I Authors' objectives To evaluate the therapeutic relevance of the medical treatment with S-carboxymethylcysteine (SCMC) and its monohydrate (...) lysine salt (SCMC-LYS) in patients with otitis media with effusion (OME). Searching EMBASE, BIOSIS Previews and MEDLINE were searched from 1972 to 1993 using the keywords 'carbocysteine', 'S-carboxymethylcysteine', 'double blind controlled' and 'otitis media'. No other restrictions or sources are discussed. Study selection Study designs of evaluations included in the review Only randomised placebo-controlled trials with double-blinded outcome assessment and complete follow-up were included. Studies

1996 DARE.

142. Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media

Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media Brodimoprim in upper respiratory tract infections: two meta-analyses of randomised, controlled clinical trials in acute sinusitis and otitis media Rahlfs V W, Macciocchi A, Monti T Authors' objectives (...) The authors aimed to assess the clinical efficacy of brodimoprim and standard comparator agents in adults with acute bacterial sinusitis, and in children with acute otitis media. Searching All clinical studies performed during the development of brodimoprim up to 1994 were reviewed for inclusion. MEDLINE and Excerpta Medica were also searched for relevant literature. Study selection Study designs of evaluations included in the review Individual patient data (IPD) from randomised controlled trials (RCTs

1996 DARE.

143. A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children

A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children A cost-utility analysis of second-line antibiotics in the treatment of acute otitis media in children Oh P, Maerov P, Pritchard D, Knowles S, Einarson T, Shear N Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Second-line antibiotic treatment used to treat acute otitis media in children. Type of intervention Treatment. Economic study type Cost-utility analysis. Study population Male and female children with acute otitis media. Ages ranged from 2 months to 18 years, but the majority of patients were between 6 months and 12

1996 NHS Economic Evaluation Database.

144. Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials

Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials Rosenfeld R M, Vertrees J E, Carr J, Cipolle R J, Uden D L, Giebink G S, Canafax D M Authors' objectives (...) To review the clinical effectiveness of antimicrobial drugs for acute otitis media (glue ear) in children. Searching MEDLINE was searched from 1966 to June 1992 using the MeSH (explode) 'otitis media' or (explode) 'drug therapy', and limiting the search by: (1) use of MeSH 'prospective studies', 'placebos', 'random allocation', 'double-blind method' or (explode) 'clinical trials'; (2) check tag comparative study; or (3) publication-type clinical trial. Current Contents (1992;35(13-26)), and references

1994 DARE.

145. A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media

A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media Landholt T F, Kotschwar T R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion (...) on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Treatment of acute otitis media in children with amoxicillin/ clavulanate potassium or cefpodoxime proxetil. Type of intervention Treatment Economic study type Cost-effectiveness analysis. Study population Children (males and females) were divided equally into two groups with an average

1994 NHS Economic Evaluation Database.

146. Co-amoxiclav in recurrent acute otitis media: placebo controlled study. Full Text available with Trip Pro

Co-amoxiclav in recurrent acute otitis media: placebo controlled study. To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media.A randomised double blind placebo controlled clinical trial.General practice in the Netherlands.121 children with recurrent acute otitis media, defined by onset of otalgia and otoscopic signs of middle ear infection within four to 52 weeks after the previous attack. Confirmation of diagnosis and randomisation (...) for irregular course of the disease (odds ratio 5.9; 1.8 to 19.1). Among children aged below 2 years, 28% (4/14) in the co-amoxiclav group and 58% (7/12) in the placebo group had irregular courses. For children 2 years and older these percentages were 13% (7/52) and 7% (3/41).Children with recurrent acute otitis media are at greater risk of an irregular clinical course of the disease than children with a first episode of acute otitis media. Co-amoxiclav has no significant benefit over placebo in treating

1991 BMJ Controlled trial quality: predicted high

147. Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). (Abstract)

Antimicrobial therapy for otitis media with effusion ('secretory' otitis media). To determine the effectiveness of antimicrobial treatment for otitis media with effusion ("secretory" otitis media) in children.We report the reexamination of a previously published study by Mandel et al that evaluated the efficacy of a 2-week course of antimicrobials (amoxicillin trihydrate) with and without a 4-week course of an oral decongestant-antihistamine combination in a double-blind, placebo-controlled (...) , randomized trial involving 518 infants and children with otitis media with effusion.At 4 weeks, amoxicillin efficacy as determined by a tympanometric criterion (P = .121) or by a measure of improvement in hearing (P = .311) was insignificant. Only by otoscopic judgment, which is shown to contain a systematic bias as used in this clinical trial, could an argument be made for a marginal efficacy of amoxicillin at the 4-week end point. Logistic regression analyses of the combined effects of treatment

1991 JAMA Controlled trial quality: predicted high

148. Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. (Abstract)

Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. We studied the efficacy of adenoidectomy in 213 children who had received tympanostomy-tube placement because of persistent and/or recurrent otitis media and had again developed otitis media after tubal extrusion. Ninety-nine of the children were assigned randomly to either an adenoidectomy group or a control group (...) in the randomized trial, where during the first and second years, respectively, adenoidectomy subjects had 47% and 37% less time with otitis media than control subjects and 28% and 35% fewer suppurative (acute) episodes than control subjects. We conclude that adenoidectomy is warranted on an individualized basis for children who develop recurrent otitis media after extrusion of tympanostomy tubes.

1990 JAMA Controlled trial quality: uncertain

149. Screening for otitis media with effusion in preschool children. (Abstract)

Screening for otitis media with effusion in preschool children. 1439 Dutch children were included in a randomised trial to evaluate the efficacy of preschool screening for otitis media with effusion (OME) by 3-monthly tympanometry. Children with bilateral OME on two consecutive occasions were referred for further investigation and then, if parents gave their consent, allocated at random to treatment or non-treatment groups. The effect of childhood screening for OME and subsequent treatment

1989 Lancet Controlled trial quality: uncertain

150. Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. (Abstract)

Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. In a prospective study, 105 infants aged 3-12 months with acute otitis media were randomly assigned to one of three treatment groups: amoxycillin/clavulanate ('Augmentin') alone (36 patients), myringotomy plus placebo (35 patients), or augmentin plus myringotomy (34 patients). The last two groups were double-blinded. Bacterial pathogens, mainly Haemophilus influenzae (of which 20% were beta

1989 Lancet Controlled trial quality: uncertain

151. Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. Full Text available with Trip Pro

Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. In a randomized, double-blind, placebo-controlled trial involving 518 infants and children who had otitis media with effusion ("secretory" otitis media), we evaluated the efficacy of a two-week course of amoxicillin (40 mg per kilogram of body weight per day) with and without a four-week course of an oral decongestant-antihistamine (...) and children with otitis media with effusion, amoxicillin treatment increases to some extent the likelihood of resolution.

1987 NEJM Controlled trial quality: predicted high

152. Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion. (Abstract)

Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion. To study the effectiveness of adenoidectomy and of the placement of tympanostomy tubes in the treatment of chronic otitis media with effusion, we randomly assigned 578 children, aged four through eight years, to receive bilateral myringotomy and no additional treatment (Group 1), placement of tympanostomy tubes (Group 2), adenoidectomy (Group 3), or adenoidectomy and placement (...) be considered when surgical therapy is indicated in children four to eight years old who are severely affected by chronic otitis media with effusion.

1987 NEJM Controlled trial quality: uncertain

153. Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. (Abstract)

Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. In a double-blind, randomized trial of 553 infants and children who had otitis media with effusion ("secretory" otitis media), we compared the efficacy of a four-week course of an oral decongestant-antihistamine combination (pseudoephedrine hydrochloride, 4 mg per kilogram of body weight per day, and chlorpheniramine (...) -antihistamine combinations do not appear to be indicated for the treatment of otitis media with effusion in infants and children.

1983 NEJM Controlled trial quality: uncertain

154. Therapy of acute otitis media: myringotomy, antibiotics, or neither? A double-blind study in children. (Abstract)

Therapy of acute otitis media: myringotomy, antibiotics, or neither? A double-blind study in children. In a double-blind study 171 children with acute otitis media (239 affected ears) were treated by four different methods: neither antibiotics nor myringotomy; myringotomy only; antibiotics only; or both antibiotics and myringotomy. All received symptomatic treatment. There were no significant differences in clinical course (pain, temperature, duration of discharge, otoscopic appearances (...) , audiography, recurrence rate) between the four groups. In the groups treated without antibiotics, the ears discharge for slightly longer and the eardrums took a little longer to heal; these differences were not significant. No complications were seen. Symptomatic therapy with nosedrops and analgesics seems a reasonable initial approach to acute otitis media in children. Myringotomy and antibiotics can be reserved for cases in which the course of otitis is irregular, there are complications

1981 Lancet Controlled trial quality: uncertain

155. Pneumococcal vaccine and otitis media. (Abstract)

Pneumococcal vaccine and otitis media. After an acute attack of otitis media 827 children aged 3 months to 6 years were assigned randomly to receive either 14-valent pneumococcal polysaccharide vaccine or a control vaccine (Haemophilus influenzae type b capsular polysaccharide). In children older than 6 months serum antibody responses to most of the vaccine polysaccharides were satisfactory. The response to type 6A was poor. Correspondingly, no clinical protection was seen below 6 months of age (...) or against otitis media caused by group 6 pneumococci. Among the children more than 6 months old, the first 6 months after vaccination saw significantly (p < 0.001) fewer attacks caused by the pneumococal types represented in the vaccine (group 6 excepted) in those who received the pneumococcal vaccine than in those who received the control vaccine. Protection against type 19F was statistically significant (p < 0.01). The overall protective efficacy was 58%--somewhat better in children older than 2 years

1980 Lancet Controlled trial quality: uncertain

156. Persistence of middle-ear effusion after acute otitis media in children. (Abstract)

Persistence of middle-ear effusion after acute otitis media in children. We observed the frequent occurrence of persistent middle-ear effusion in children with acute otitis media and followed them according to standard procedures for otologic diagnosis. We performed a life-table analysis to identify risk factors for such persistent disease. Sixty-two patients were free of middle-ear effusion at one or more clinic visits two to 13 weeks after presentation and were considered cured; 45 had (...) may be associated with impaired hearing and appears to be the most important sequela of otitis media.

1979 NEJM Controlled trial quality: uncertain

157. Ampicillin compared to other antimicrobials in acute otitis media. (Abstract)

Ampicillin compared to other antimicrobials in acute otitis media. 4964192 1967 12 21 2016 10 17 0098-7484 202 8 1967 Nov 20 JAMA JAMA Ampicillin compared to other antimicrobials in acute otitis media. 697-702 Bass J W JW Cohen S H SH Corless J D JD Mamunes P P eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Anti-Infective Agents 17R794ESYN Penicillin G Procaine 740T4C525W Sulfisoxazole 7C782967RD Ampicillin RIT82F58GK (...) Penicillin G Benzathine X20I9EN955 Oxytetracycline Z61I075U2W Penicillin V AIM IM Ampicillin therapeutic use Anti-Infective Agents therapeutic use Child Child, Preschool Humans Infant Otitis Media drug therapy Oxytetracycline therapeutic use Penicillin G Benzathine therapeutic use Penicillin G Procaine therapeutic use Penicillin V therapeutic use Sulfisoxazole therapeutic use 1967 11 20 1967 11 20 0 1 1967 11 20 0 0 ppublish 4964192

1967 JAMA Controlled trial quality: uncertain

158. Myringotomy in acute otitis media. A controlled study. (Abstract)

Myringotomy in acute otitis media. A controlled study. 4161606 1966 10 17 2016 10 17 0098-7484 197 11 1966 Sep 12 JAMA JAMA Myringotomy in acute otitis media. A controlled study. 849-53 Roddey O F OF Jr Earle R R Jr Haggerty R R eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States JAMA 7501160 0098-7484 0 Nasal Decongestants 0 Sympathomimetics 17R794ESYN Penicillin G Procaine 1WS297W6MV Phenylephrine 740T4C525W Sulfisoxazole Q42T66VG0C Penicillin G (...) RIT82F58GK Penicillin G Benzathine AIM IM Audiometry Bacteria isolation & purification Child Child, Preschool Humans Infant Infant, Newborn Myringoplasty Nasal Decongestants therapeutic use Otitis Media cytology drug therapy surgery Penicillin G surgery Penicillin G Benzathine therapeutic use Penicillin G Procaine therapeutic use Phenylephrine therapeutic use Sulfisoxazole therapeutic use Sympathomimetics therapeutic use 1966 9 12 2001 3 28 10 1 1966 9 12 0 0 ppublish 4161606

1966 JAMA Controlled trial quality: uncertain