Latest & greatest articles for pneumonia

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Top results for pneumonia

81. Pneumonia caused by proton pump inhibitors (PPI)

Pneumonia caused by proton pump inhibitors (PPI) MED CHECK - TIP December 2017 / Vol.3 No.9 · Page 27 -The Informed Prescriber C N o 9 M ED HECK D e ce m b e r 2 0 1 7 WHO downgrades Tamiflu Suvorexant : A hypnotic causing cataplexy Insomnia, Sleep Duration, Harm of hypnotics PPI causes Pneumonia Editorial WHO downgraded oseltamivir (Tamiflu) New Products Hypnotic (sleeping pill), suvorexant (brand name Belsomra) A substance that causes narcolepsy and cataplexy Teriparatide More harm than (...) benefit: Review Insomnia, Optimal Sleep Duration and Harm of Sleeping pills Pneumonia caused by proton pump inhibitors (PPI) (1) meta-analysis (2) Critical appraisal of a study CONTENTS (December 2017, Vol. 3, No. 9 ) 28 29 34 36 40 42 Volume 3 Page 28 · MED CHECK - TIP December 2017/ Vol.3 No.9 WHO downgrades Tamiflu after reviewing evidence WHO (World Health Organization) reviews their model list of essential medicines every two years. In the revision launched in June 2017, oseltamivir (Tamiflu

2018 Med Check - The Informed Prescriber

83. Primary care: Hypoxia and signs of increased work of breathing are most strongly associated with radiographic pneumonia in children

Primary care: Hypoxia and signs of increased work of breathing are most strongly associated with radiographic pneumonia in children Hypoxia and signs of increased work of breathing are most strongly associated with radiographic pneumonia in children | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log (...) in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Hypoxia and signs of increased work of breathing are most strongly associated with radiographic pneumonia in children Article Text

2018 Evidence-Based Medicine

84. Influence of environmental conditions and pollution on the incidence of Streptococcus pneumoniae infections Full Text available with Trip Pro

Influence of environmental conditions and pollution on the incidence of Streptococcus pneumoniae infections Fossil fuel derived pollutants (SO2, NO), dry air and cold increase the incidence of S. pneumoniae infections http://ow.ly/RnLW30gogb1.

2017 ERJ open research

85. Cost of treating ventilator-associated pneumonia post cardiac surgery in the National Health Service: Results from a propensity-matched cohort study Full Text available with Trip Pro

Cost of treating ventilator-associated pneumonia post cardiac surgery in the National Health Service: Results from a propensity-matched cohort study Ventilator-associated pneumonia is associated with significant morbidity, mortality and healthcare costs. Most of the cost data that are available relate to general intensive care patients in privately remunerated institutions. This study assessed the cost of managing ventilator-associated pneumonia in a cardiac intensive care unit in the National (...) Health Service in the United Kingdom.Propensity-matched study of prospectively collected data from the cardiac surgical database between April 2011 and December 2014 in all patients undergoing cardiac surgery (n = 3416). Patients who were diagnosed as developing ventilator-associated pneumonia, as per the surveillance definition for ventilator-associated pneumonia (n = 338), were propensity score matched with those who did not (n = 338). Costs of treating post-op cardiac surgery patients in intensive

2017 Journal of the Intensive Care Society

86. Evaluation of severity score-guided approaches to macrolide use in community-acquired pneumonia Full Text available with Trip Pro

Evaluation of severity score-guided approaches to macrolide use in community-acquired pneumonia International guidelines including those in the UK, Japan, Australia and South Africa recommend the avoidance of macrolides in patients with low-severity community-acquired pneumonia (CAP). We hypothesised that severity scores are poor predictors of atypical pneumonia and response to macrolide therapy, and thus, inadequate tools for guiding antibiotic prescriptions.Secondary analysis of four (...) independent prospective CAP datasets was conducted. The predictive values of the CURB-65 and pneumonia severity index (PSI) for clinically important groups of causative pathogens were evaluated. The effect of macrolide use according to risk class was assessed by multivariable analysis. Patients (3297) were evaluated, and the predictive values of CURB-65 and PSI for atypical pathogens were poor (AUC values of 0.37 and 0.42, respectively). No significant differences were noted among the effects of macrolide

2017 EvidenceUpdates

87. Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months. Full Text available with Trip Pro

Short-course versus long-course intravenous therapy with the same antibiotic for severe community-acquired pneumonia in children aged two months to 59 months. Pneumonia is a leading cause of childhood mortality from infectious disease, responsible for an estimated 1.3 million deaths annually in children under five years of age, many of which are in low-income countries. The World Health Organization recommends intravenous antibiotics for five days as first-line treatment for children (...) with severe pneumonia. Although controversy exists regarding the specific clinical features used to diagnose pneumonia, the criteria for diagnosis of severe pneumonia are better defined and are widely used to triage children for referral and second-line therapy.In 2011 it was estimated that approximately 120 million new cases of pneumonia occur globally each year in children under five years of age, of which 14 million become severe episodes. Hospitalisation for severe pneumonia in children places

2017 Cochrane

88. Bacteremia Prediction Model for Community-acquired Pneumonia: External Validation in a Multicenter Retrospective Cohort Full Text available with Trip Pro

Bacteremia Prediction Model for Community-acquired Pneumonia: External Validation in a Multicenter Retrospective Cohort Many studies have described constructing a prediction model for bacteremia in community-acquired pneumonia (CAP), but these studies were not validated in external heterogeneous groups. The objective of this study was to test the generalizability of a previous bacteremia prediction model for CAP by external validation.This multicenter retrospective cohort analysis was performed

2017 EvidenceUpdates

89. Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries: A Randomized Controlled Trial (Abstract)

Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries: A Randomized Controlled Trial Nebulized antibiotics offer high efficacy due to significant local concentrations and safety with minimal blood levels. This study evaluates the efficacy and nephrotoxicity of nebulized versus IV amikacin in postcardiothoracic surgical patients with nosocomial pneumonia caused by multidrug-resistant Gram- negative bacilli.Prospective (...) , randomized, controlled study on surgical patients divided into two groups.Postcardiac surgery ICU.The first gtroup was administered IV amikacin 20 mg/kg once daily. The second group was prescribed amikacin nebulizer 400 mg twice daily. Both groups were co-administered IV piperacillin/tazobactam empirically.Recruited patients were diagnosed by either hospital-acquired pneumonia or ventilator-associated pneumonia where 56 (42.1%) patients were diagnosed with hospital-acquired pneumonia, 51 (38.34

2017 EvidenceUpdates

90. Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette

Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette – Clinical Correlations Search Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette September 20, 2017 6 min read By Martin Fried, MD Peer reviewed Learning Objectives Why does impaired cellular immunity increase the risk for Pneumocystis jiroveci Pneumonia (PJP)? How do acquired humoral immune deficiencies (...) of 92% on ambient air. The physical exam was notable for fine crackles and bronchial breath sounds over the right mid-lower lung field. Initial labs revealed white blood cell count of 21.9 K/uL with 80% neutrophils but was otherwise unremarkable. A rapid HIV test was negative. Chest XR demonstrated right middle and lower lobe consolidations and left basilar hazy opacities consistent with multifocal pneumonia. He was started on antibiotics for community acquired pneumonia and admitted to the hospital

2017 Clinical Correlations

91. It is possible to replace chest X-rays with pulmonary ultrasound in the diagnose of pneumonia in children?

It is possible to replace chest X-rays with pulmonary ultrasound in the diagnose of pneumonia in children? ¿Puede la ecografía pulmonar sustituir a la radiografía, para diagnosticar la neumonía en niños? - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de (...) Críticamente Boursiani C, Tsolia M, Koumanidou C, Malagari A, Vakaki M, Karapostolakis G, et al . Lung ultrasound as first-line examination for the diagnosis of community-acquired pneumonia in children. Revisores: Albi Rodríguez M.S 1 , Martínez Rubio M.V 2 . 1 Sección de Neumología y Alergia Infantil. Hospital Universitario 12 de Octubre. Madrid. España. 2 CS Los Fresnos. Torrejón de Ardoz. Madrid. España. Correspondencia: María Salomé Albi Rodríguez. Correo electrónico: Fecha de recepción: 07/06/2017

2017 Evidencias en Pediatría

92. Can we predict which children with pneumonia will have a severe prognosis?

Can we predict which children with pneumonia will have a severe prognosis? ¿Podemos predecir qué niños con neumonía van a tener un pronóstico grave? - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su (...) , Harrell FE Jr, Reed C, et al . Predicting Severe Pneumonia Outcomes in Children. Revisores: Orejón de Luna G 1 , Cuestas Montañés E 2 . 1 CS General Ricardos. Madrid. España. 2 Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina. Correspondencia: Gloria Orejón de Luna. Correo electrónico: Fecha de recepción: 23/03/2017 Fecha de aceptación: 30/03/2017 Fecha de publicación: 05/04/2017 Resumen

2017 Evidencias en Pediatría

93. Advances in the diagnosis of pneumonia in children. (Abstract)

Advances in the diagnosis of pneumonia in children. Pneumonia remains a major cause of childhood mortality and morbidity globally. Accurate diagnosis and attribution of the causes of pneumonia are important for measuring the burden of disease, implementing appropriate preventive or treatment strategies, and developing more effective interventions. This review summarizes recent diagnostic advances in radiological techniques, specimen collection, and laboratory methods. Although chest ultrasound (...) and chest magnetic resonance imaging are promising modalities for radiological diagnosis, their role in clinical management and their impact on outcomes need further study. Rapid, highly sensitive, multiplex laboratory tests performed on upper respiratory tract samples or induced sputum can detect nucleic acid from potential pathogens in most children with pneumonia. However, it may be difficult to attribute causality because it is often impossible to distinguish between organisms colonizing

2017 BMJ

94. Predictive value of copeptin as a severity marker of community-acquired pneumonia Full Text available with Trip Pro

Predictive value of copeptin as a severity marker of community-acquired pneumonia Pneumonia is the leading cause of death in children. Few studies have explored the predictive value of copeptin in pediatric pneumonia.This study aimed to assess the role of copeptin as a marker of severity of community-acquired pneumonia (CAP).This prospective case-control study was carried out at Minia University Children's Hospital in Minia (Egypt) from January to December 2016. Eighty children aged from 2 (...) months to 42 months were enrolled in this study and were classified into group 1 (40 children with clinical, laboratory and radiological evidence of pneumonia) and group 2 (40 apparently healthy control). Serum copeptin level was assayed for all enrolled children.Mean serum copeptin level was significantly higher in pneumonic patients (985.7±619) pg/ml compared to controls (519±308.2) pg/ml (p<0.001). Serum copeptin was significantly elevated in survivors of pneumonia more than non-survivors (p=0.001

2017 Electronic physician

95. Advances in the causes and management of community acquired pneumonia in adults. (Abstract)

Advances in the causes and management of community acquired pneumonia in adults. Community acquired pneumonia remains a common cause of morbidity and mortality. Usually, the causal organism is not identified and treatment remains empiric. Recent computed tomography and magnetic resonance imaging studies have challenged the accuracy of the clinical diagnosis of pneumonia, and epidemiologic studies are changing our perspective of what causes community acquired pneumonia, especially the role (...) of viral pathogens and the frequent finding of multiple pathogens. The past decade has seen increasing overuse of empiric coverage of meticillin resistant Staphylococcus aureus and antibiotic resistant Gram negative pathogens owing to inappropriate application of guidelines for healthcare associated pneumonia. Optimal treatment remains a matter for debate, especially in very sick patients, including the role of combination antibiotic therapy and corticosteroids. Pneumonia care bundles are being defined

2017 BMJ

96. Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis Full Text available with Trip Pro

Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis 29657883 2018 11 30 2147-9720 5 1 2018 Mar European journal of rheumatology Eur J Rheumatol Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis. 83-84 10.5152/eurjrheum.2017.160126 Carneiro Juliana Brandão Pinto JBP http://orcid.org/0000-0001-7184-0582 Department of Rheumatology, Getúlio Vargas University Hospital (HUGV), Federal University of Amazon School of Medicine (UFAM), Manaus

2017 European journal of rheumatology

97. Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population Full Text available with Trip Pro

Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population The Yale New Haven Readmission Risk Score (YNHRRS) for pneumonia is a clinical prediction tool developed to assess risk for 30-day readmission. This tool was validated in a cohort of Medicare patients; generalizability to a broader patient population has not been evaluated. In addition, it lacks indicators of functional status or social support, which have been shown in other studies (...) to be predictors of readmission. The objective of this study was to evaluate the generalizability of the YNHRRS for pneumonia in a general population of hospitalized patients, and assess the impact of incorporating measures of functional status and social support on its predictive value.This retrospective chart review comprised all patients admitted to a 563-bed academic medical center with a primary diagnosis of pneumonia between March 2014 and March 2015. Abstraction of clinical variables allowed calculation

2017 EvidenceUpdates

98. The impact of blood glucose on community-acquired pneumonia: a retrospective cohort study Full Text available with Trip Pro

The impact of blood glucose on community-acquired pneumonia: a retrospective cohort study Hyperglycaemia is common in patients with community-acquired pneumonia (CAP) and is a predictor of severe outcomes. Data are scarce regarding whether this association is affected by diabetes mellitus (DM) and also regarding its importance for severe outcomes in hospital. We determined the impact of blood glucose on severe outcomes of CAP in hospital. We studied 1318 adult CAP patients hospitalised at three

2017 ERJ open research

99. The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions Full Text available with Trip Pro

The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions The functions of roughly a third of all proteins in Streptococcus pneumoniae, a significant human-pathogenic bacterium, are unknown. Using a yeast two-hybrid approach, we have determined more than 2,000 novel protein interactions in this organism. We augmented this network with meta-interactome data that we defined as the pool of all interactions between evolutionarily conserved (...) proteins in other bacteria. We found that such interactions significantly improved our ability to predict a protein's function, allowing us to provide functional predictions for 299 S. pneumoniae proteins with previously unknown functions. IMPORTANCE Identification of protein interactions in bacterial species can help define the individual roles that proteins play in cellular pathways and pathogenesis. Very few protein interactions have been identified for the important human pathogen S. pneumoniae. We

2017 mSystems

100. Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia

Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Un on Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. 15 December 2016 EMA/CHMP/226929/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment (...) -acquired bacterial pneumonia CE clinically evaluable CFU colony-forming unit CI confidence interval CL/F clearance CLd1, CLd2 distributional clearances Cmax maximum plasma concentration CrCL creatinine clearance CSR clinical study report CV% percent coefficient of variation CYP human cytochrome P450 ECG electrocardiogram ECR Early Clinical Response eGFR estimated glomerular filtration rate ELF epithelial lining fluid EOT end of therapy F absolute bioavailability GI gastrointestinal GMR geometric mean

2017 European Medicines Agency - EPARs