Latest & greatest articles for pneumonia

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Top results for pneumonia

81. Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries: A Randomized Controlled Trial (Abstract)

Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries: A Randomized Controlled Trial Nebulized antibiotics offer high efficacy due to significant local concentrations and safety with minimal blood levels. This study evaluates the efficacy and nephrotoxicity of nebulized versus IV amikacin in postcardiothoracic surgical patients with nosocomial pneumonia caused by multidrug-resistant Gram- negative bacilli.Prospective (...) , randomized, controlled study on surgical patients divided into two groups.Postcardiac surgery ICU.The first gtroup was administered IV amikacin 20 mg/kg once daily. The second group was prescribed amikacin nebulizer 400 mg twice daily. Both groups were co-administered IV piperacillin/tazobactam empirically.Recruited patients were diagnosed by either hospital-acquired pneumonia or ventilator-associated pneumonia where 56 (42.1%) patients were diagnosed with hospital-acquired pneumonia, 51 (38.34

2017 EvidenceUpdates

82. Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette

Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette – Clinical Correlations Search Spotlight: Pneumocystis Pneumonia in a Patient Without AIDS, A Clinical Vignette September 20, 2017 6 min read By Martin Fried, MD Peer reviewed Learning Objectives Why does impaired cellular immunity increase the risk for Pneumocystis jiroveci Pneumonia (PJP)? How do acquired humoral immune deficiencies (...) of 92% on ambient air. The physical exam was notable for fine crackles and bronchial breath sounds over the right mid-lower lung field. Initial labs revealed white blood cell count of 21.9 K/uL with 80% neutrophils but was otherwise unremarkable. A rapid HIV test was negative. Chest XR demonstrated right middle and lower lobe consolidations and left basilar hazy opacities consistent with multifocal pneumonia. He was started on antibiotics for community acquired pneumonia and admitted to the hospital

2017 Clinical Correlations

83. It is possible to replace chest X-rays with pulmonary ultrasound in the diagnose of pneumonia in children?

It is possible to replace chest X-rays with pulmonary ultrasound in the diagnose of pneumonia in children? ¿Puede la ecografía pulmonar sustituir a la radiografía, para diagnosticar la neumonía en niños? - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de (...) Críticamente Boursiani C, Tsolia M, Koumanidou C, Malagari A, Vakaki M, Karapostolakis G, et al . Lung ultrasound as first-line examination for the diagnosis of community-acquired pneumonia in children. Revisores: Albi Rodríguez M.S 1 , Martínez Rubio M.V 2 . 1 Sección de Neumología y Alergia Infantil. Hospital Universitario 12 de Octubre. Madrid. España. 2 CS Los Fresnos. Torrejón de Ardoz. Madrid. España. Correspondencia: María Salomé Albi Rodríguez. Correo electrónico: Fecha de recepción: 07/06/2017

2017 Evidencias en Pediatría

84. Can we predict which children with pneumonia will have a severe prognosis?

Can we predict which children with pneumonia will have a severe prognosis? ¿Podemos predecir qué niños con neumonía van a tener un pronóstico grave? - Evidencias en pediatría Buscando, por favor espere. Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su biblioteca. | Buscar Toma de decisiones clínicas basadas en pruebas científicas Toma de decisiones clínicas basadas en pruebas científicas Mostrar menú Gestión de biblioteca Aún no ha añadido ningún artículo a su (...) , Harrell FE Jr, Reed C, et al . Predicting Severe Pneumonia Outcomes in Children. Revisores: Orejón de Luna G 1 , Cuestas Montañés E 2 . 1 CS General Ricardos. Madrid. España. 2 Servicio de Pediatría y Neonatología. Hospital Privado. Centro Formador. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina. Correspondencia: Gloria Orejón de Luna. Correo electrónico: Fecha de recepción: 23/03/2017 Fecha de aceptación: 30/03/2017 Fecha de publicación: 05/04/2017 Resumen

2017 Evidencias en Pediatría

85. Advances in the diagnosis of pneumonia in children. (Abstract)

Advances in the diagnosis of pneumonia in children. Pneumonia remains a major cause of childhood mortality and morbidity globally. Accurate diagnosis and attribution of the causes of pneumonia are important for measuring the burden of disease, implementing appropriate preventive or treatment strategies, and developing more effective interventions. This review summarizes recent diagnostic advances in radiological techniques, specimen collection, and laboratory methods. Although chest ultrasound (...) and chest magnetic resonance imaging are promising modalities for radiological diagnosis, their role in clinical management and their impact on outcomes need further study. Rapid, highly sensitive, multiplex laboratory tests performed on upper respiratory tract samples or induced sputum can detect nucleic acid from potential pathogens in most children with pneumonia. However, it may be difficult to attribute causality because it is often impossible to distinguish between organisms colonizing

2017 BMJ

86. Predictive value of copeptin as a severity marker of community-acquired pneumonia Full Text available with Trip Pro

Predictive value of copeptin as a severity marker of community-acquired pneumonia Pneumonia is the leading cause of death in children. Few studies have explored the predictive value of copeptin in pediatric pneumonia.This study aimed to assess the role of copeptin as a marker of severity of community-acquired pneumonia (CAP).This prospective case-control study was carried out at Minia University Children's Hospital in Minia (Egypt) from January to December 2016. Eighty children aged from 2 (...) months to 42 months were enrolled in this study and were classified into group 1 (40 children with clinical, laboratory and radiological evidence of pneumonia) and group 2 (40 apparently healthy control). Serum copeptin level was assayed for all enrolled children.Mean serum copeptin level was significantly higher in pneumonic patients (985.7±619) pg/ml compared to controls (519±308.2) pg/ml (p<0.001). Serum copeptin was significantly elevated in survivors of pneumonia more than non-survivors (p=0.001

2017 Electronic physician

87. Advances in the causes and management of community acquired pneumonia in adults. (Abstract)

Advances in the causes and management of community acquired pneumonia in adults. Community acquired pneumonia remains a common cause of morbidity and mortality. Usually, the causal organism is not identified and treatment remains empiric. Recent computed tomography and magnetic resonance imaging studies have challenged the accuracy of the clinical diagnosis of pneumonia, and epidemiologic studies are changing our perspective of what causes community acquired pneumonia, especially the role (...) of viral pathogens and the frequent finding of multiple pathogens. The past decade has seen increasing overuse of empiric coverage of meticillin resistant Staphylococcus aureus and antibiotic resistant Gram negative pathogens owing to inappropriate application of guidelines for healthcare associated pneumonia. Optimal treatment remains a matter for debate, especially in very sick patients, including the role of combination antibiotic therapy and corticosteroids. Pneumonia care bundles are being defined

2017 BMJ

88. Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis Full Text available with Trip Pro

Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis 29657883 2018 11 30 2147-9720 5 1 2018 Mar European journal of rheumatology Eur J Rheumatol Tropical pyomyositis caused by Klebsiella pneumoniae with rheumatoid arthritis. 83-84 10.5152/eurjrheum.2017.160126 Carneiro Juliana Brandão Pinto JBP http://orcid.org/0000-0001-7184-0582 Department of Rheumatology, Getúlio Vargas University Hospital (HUGV), Federal University of Amazon School of Medicine (UFAM), Manaus

2017 European journal of rheumatology

89. Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population Full Text available with Trip Pro

Evaluation of the Yale New Haven Readmission Risk Score for Pneumonia in a General Hospital Population The Yale New Haven Readmission Risk Score (YNHRRS) for pneumonia is a clinical prediction tool developed to assess risk for 30-day readmission. This tool was validated in a cohort of Medicare patients; generalizability to a broader patient population has not been evaluated. In addition, it lacks indicators of functional status or social support, which have been shown in other studies (...) to be predictors of readmission. The objective of this study was to evaluate the generalizability of the YNHRRS for pneumonia in a general population of hospitalized patients, and assess the impact of incorporating measures of functional status and social support on its predictive value.This retrospective chart review comprised all patients admitted to a 563-bed academic medical center with a primary diagnosis of pneumonia between March 2014 and March 2015. Abstraction of clinical variables allowed calculation

2017 EvidenceUpdates

90. The impact of blood glucose on community-acquired pneumonia: a retrospective cohort study Full Text available with Trip Pro

The impact of blood glucose on community-acquired pneumonia: a retrospective cohort study Hyperglycaemia is common in patients with community-acquired pneumonia (CAP) and is a predictor of severe outcomes. Data are scarce regarding whether this association is affected by diabetes mellitus (DM) and also regarding its importance for severe outcomes in hospital. We determined the impact of blood glucose on severe outcomes of CAP in hospital. We studied 1318 adult CAP patients hospitalised at three

2017 ERJ open research

91. The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions Full Text available with Trip Pro

The Protein Interactome of Streptococcus pneumoniae and Bacterial Meta-interactomes Improve Function Predictions The functions of roughly a third of all proteins in Streptococcus pneumoniae, a significant human-pathogenic bacterium, are unknown. Using a yeast two-hybrid approach, we have determined more than 2,000 novel protein interactions in this organism. We augmented this network with meta-interactome data that we defined as the pool of all interactions between evolutionarily conserved (...) proteins in other bacteria. We found that such interactions significantly improved our ability to predict a protein's function, allowing us to provide functional predictions for 299 S. pneumoniae proteins with previously unknown functions. IMPORTANCE Identification of protein interactions in bacterial species can help define the individual roles that proteins play in cellular pathways and pathogenesis. Very few protein interactions have been identified for the important human pathogen S. pneumoniae. We

2017 mSystems

92. Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia

Solithromycin Triskel - community-acquired pneumonia, anthrax and tularaemia 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Un on Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2017. Reproduction is authorised provided the source is acknowledged. 15 December 2016 EMA/CHMP/226929/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment (...) -acquired bacterial pneumonia CE clinically evaluable CFU colony-forming unit CI confidence interval CL/F clearance CLd1, CLd2 distributional clearances Cmax maximum plasma concentration CrCL creatinine clearance CSR clinical study report CV% percent coefficient of variation CYP human cytochrome P450 ECG electrocardiogram ECR Early Clinical Response eGFR estimated glomerular filtration rate ELF epithelial lining fluid EOT end of therapy F absolute bioavailability GI gastrointestinal GMR geometric mean

2017 European Medicines Agency - EPARs

93. CRACKCast E076 – Pneumonia

CRACKCast E076 – Pneumonia CRACKCast E076 - Pneumonia - CanadiEM CRACKCast E076 – Pneumonia In , by Adam Thomas May 8, 2017 This episode of CRACKCast covers Rosen’s Chapter 76, Pneumonia. This episode tackles high yield information on diagnosis and management of pneumonia, one of the most common emergency department presenting illnesses. Shownotes – Rosen’s in Perspective This is a common disease – thankfully most cases can be managed as an outpatient, however, this is expected to change (...) 10,000 L of air each day!! Pneumonia develops when: Host defences are overwhelmed A Virulent organism shows up A large amount of oropharyngeal organisms is aspirated Typical vs Atypical infections Typical ones: Streptococcus pneumoniae (very virulent) Haemophilus influenzae Staphylococcus aureus CA MRSA can commonly be associated with influenzae IVDU’s Look for the cavitation, and necrosis on the CXR Atypicals Legionella Mycoplasma Chlamydophila Virals: Influenzae Parainfluenza Usually named

2017 CandiEM

94. Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias Full Text available with Trip Pro

Study on Perioperative Administration of a Neutrophil Elastase Inhibitor for Interstitial Pneumonias Although acute exacerbation of idiopathic interstitial pneumonias (IIPs) is a lethal complication after pulmonary resection for lung cancer with IIPs, there are no established methods to prevent its occurrence. This prospective randomized study was conducted to evaluate whether perioperative administration of the neutrophil elastase inhibitor sivelestat prevents acute exacerbation after

2017 EvidenceUpdates

95. Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease Full Text available with Trip Pro

Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease Knowledge regarding whether benzodiazepines and similarly acting non-benzodiazepines (Z-drugs) are associated with an increased risk of pneumonia among older adults is lacking. We sought to investigate this association among community-dwelling adults with Alzheimer disease, a condition in which both sedative/hypnotic use and pneumonia are common.We obtained data on all community (...) -dwelling adults with a recent diagnosis of Alzheimer disease in Finland (2005-2011) from the Medication use and Alzheimer disease (MEDALZ) cohort, which incorporates national registry data on prescriptions, reimbursement, hospital discharges and causes of death. Incident users of benzodiazepines and Z-drugs were identified using a 1-year washout period and matched with nonusers using propensity scores. The association with hospital admission or death due to pneumonia was analyzed with the Cox

2017 EvidenceUpdates

96. Procalcitonin and CRP as Biomarkers in Discrimination of Community-acquired Pneumonia and Exacerbation of COPD Full Text available with Trip Pro

Procalcitonin and CRP as Biomarkers in Discrimination of Community-acquired Pneumonia and Exacerbation of COPD Serum procalcitonin (PCT) and C-reactive protein (CRP) are markers of systemic inflammation and bacterial infection. We aimed to compare the usefulness of procalcitonin and CRP in patients with community-acquired pneumonia and exacerbations of chronic obstructive pulmonary disease (COPD).A total of 116 consecutive patients were included in the study: 76 with chronic obstructive (...) pulmonary disease in group 1, and 40 with pneumonia in group 2.Median serum CRP level was 44 mg/L in the COPD group and 132 mg/L in the pneumonia group. Median value of serum PCT was found to be 0.07 in the COPD group and 0.14 ng/mL in the pneumonia group. Serum PCT and CRP levels were significantly higher in the pneumonia group compared to the COPD group (p<0.001). The area under the ROC curve was 0.788 (CI: 0.704-0.872) for CRP and 0.699 (CI: 0.599-0.800) for procalcitonin to identify

2017 Journal of medical biochemistry

97. The mask of acute bacterial pneumonia may disguise the face of tuberculosis Full Text available with Trip Pro

The mask of acute bacterial pneumonia may disguise the face of tuberculosis Pulmonary tuberculosis (TB) can present as acute pneumonia. Differentiation of tuberculous from non-tuberculous community-acquired pneumonia (CAP) is an important challenge in endemic areas. The purpose of this study was the comparison between characteristics of tuberculous and non-tuberculous CAP patients.In this prospective and observational study, all adult patients (aged ≥16 years) who were admitted to Imam Reza (...) Hospital in Mashhad (Iran) with the diagnosis of CAP, between February 2013 and January 2014, were enrolled. Clinical, radiological, and microbiological data of the patients were collected and reviewed. Statistical analyses were performed using SPSS 14 software and R programming language.We studied 120 patients with diagnosis of acute CAP including 21 (17.5%) tuberculous and 99 (82.5%) non-tuberculous CAP. The etiologies of CAP in the latter group were as follow: S. pneumoniae 29 (29.3%), followed by S

2017 Electronic physician

98. Increased incidence of adult pneumococcal pneumonia during school holiday periods Full Text available with Trip Pro

Increased incidence of adult pneumococcal pneumonia during school holiday periods Child contact is a recognised risk factor for adult pneumococcal disease. Peaks in invasive pneumococcal disease incidence observed during winter holidays may be related to changes in social dynamics. This analysis was conducted to examine adult pneumococcal community-acquired pneumonia (CAP) incidence during school holiday periods. Between September 2008 and 2013, consecutive adults admitted to hospitals covering (...) the Greater Nottingham area with a diagnosis of CAP were studied. Pneumococcal pneumonia was detected using culture and antigen detection methods. Of 2221 adults studied, 575 (25.9%) were admitted during school holidays and 643 (29.0%) had pneumococcal CAP. CAP of pneumococcal aetiology was significantly more likely in adults admitted during school holidays compared to term time (35.3% versus 26.7%; adjusted OR 1.38, 95% CI 1.11-1.72, p=0.004). Over the 5-year period, the age-adjusted incidence

2017 ERJ open research

99. Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up. Full Text available with Trip Pro

Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up. Objective To determine the attributable risk of community acquired pneumonia on incidence of heart failure throughout the age range of affected patients and severity of the infection.Design Cohort study.Setting Six hospitals and seven emergency departments in Edmonton, Alberta, Canada, 2000-02.Participants 4988 adults with community acquired pneumonia and no history of heart (...) failure were prospectively recruited and matched on age, sex, and setting of treatment (inpatient or outpatient) with up to five adults without pneumonia (controls) or prevalent heart failure (n=23 060).Main outcome measures Risk of hospital admission for incident heart failure or a combined endpoint of heart failure or death up to 2012, evaluated using multivariable Cox proportional hazards analyses.Results The average age of participants was 55 years, 2649 (53.1%) were men, and 63.4% were managed

2017 BMJ

100. Bedside lung ultrasound for the diagnosis of pneumonia in children

Bedside lung ultrasound for the diagnosis of pneumonia in children BestBets: Bedside lung ultrasound for the diagnosis of pneumonia in children Bedside lung ultrasound for the diagnosis of pneumonia in children Report By: Louis-David Audette - PGY-4, emergency medicine Search checked by Marc-Charles Parent - MD, FRCPC Institution: Emergency Medicine Residency Program, Laval University Date Submitted: 20th January 2016 Date Completed: 10th February 2017 Last Modified: 10th February 2017 Status (...) : Green (complete) Three Part Question In [children] presenting with suspected pneumonia), can [bedside lung ultrasound] be used to diagnose [pneumonia]? Clinical Scenario A 4 year-old child presents to your local ED with respiratory symptoms and fever. In order to confirm your suspicion of pneumonia, you plan to order a chest radiograph, but a quick look into the child's medical record shows he has already undergone several X-rays in the last few years for the evaluation of upper respiratory tract

2017 BestBETS