Latest & greatest articles for preeclampsia

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Top results for preeclampsia

81. Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths

Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

82. Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. Full Text available with Trip Pro

Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. To develop a predictive model for pre-eclampsia based on clinical risk factors for nulliparous women and to identify a subgroup at increased risk, in whom specialist referral might be indicated.Prospective multicentre cohort.Five centres in Auckland, New Zealand; Adelaide, Australia; Manchester and London, United Kingdom; and Cork, Republic of Ireland.3572 "healthy (...) " nulliparous women with a singleton pregnancy from a large international study; data on pregnancy outcome were available for 3529 (99%).Pre-eclampsia defined as ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg, or both, on at least two occasions four hours apart after 20 weeks' gestation but before the onset of labour, or postpartum, with either proteinuria or any multisystem complication. Preterm pre-eclampsia was defined as women with pre-eclampsia delivered before 37(+0) weeks' gestation

2011 BMJ Controlled trial quality: uncertain

83. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. Full Text available with Trip Pro

Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. To test the hypothesis that a relative deficiency in L-arginine, the substrate for synthesis of the vasodilatory gas nitric oxide, may be associated with the development of pre-eclampsia in a population at high risk.Randomised, blinded, placebo controlled clinical trial.Tertiary public hospital in Mexico City.Pregnant women (...) with a history of a previous pregnancy complicated by pre-eclampsia, or pre-eclampsia in a first degree relative, and deemed to be at increased risk of recurrence of the disease were studied from week 14-32 of gestation and followed until delivery.Supplementation with a medical food-bars containing L-arginine plus antioxidant vitamins, antioxidant vitamins alone, or placebo-during pregnancy.Development of pre-eclampsia/eclampsia.222 women were allocated to the placebo group, 228 received L-arginine plus

2011 BMJ Controlled trial quality: predicted high

84. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Full Text available with Trip Pro

Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Pre-eclampsia is a leading cause of maternal deaths. These deaths mainly result from eclampsia, uncontrolled hypertension, or systemic inflammation. We developed and validated the fullPIERS model with the aim of identifying the risk of fatal or life-threatening complications in women with pre-eclampsia within 48 h of hospital admission for the disorder.We developed and internally (...) validated the fullPIERS model in a prospective, multicentre study in women who were admitted to tertiary obstetric centres with pre-eclampsia or who developed pre-eclampsia after admission. The outcome of interest was maternal mortality or other serious complications of pre-eclampsia. Routinely reported and informative variables were included in a stepwise backward elimination regression model to predict the adverse maternal outcome. We assessed performance using the area under the curve (AUC

2010 Lancet

85. Pre-eclampsia. (Abstract)

Pre-eclampsia. Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a multiorgan cluster of varying clinical features. Poor early placentation is especially associated with early onset disease. Predisposing cardiovascular or metabolic risks for endothelial dysfunction, as part of an exaggerated systemic inflammatory (...) response, might dominate in the origins of late onset pre-eclampsia. Because the multifactorial pathogenesis of different pre-eclampsia phenotypes has not been fully elucidated, prevention and prediction are still not possible, and symptomatic clinical management should be mainly directed to prevent maternal morbidity (eg, eclampsia) and mortality. Expectant management of women with early onset disease to improve perinatal outcome should not preclude timely delivery-the only definitive cure. Pre

2010 Lancet

86. An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia (Abstract)

An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia The angiogenic and antiangiogenic factors soluble fms-like tyrosine kinase (sFlt)-1 and placental growth factor (PIGF) have been implicated in the mechanisms of disease responsible for preeclampsia (PE). Moreover, it has been proposed that the concentrations of these markers in maternal serum/plasma may have predictive value. This study evaluates a newly developed Elecsys (Roche, Penzberg

2010 EvidenceUpdates

87. The role of urinary soluble endoglin in the diagnosis of pre-eclampsia: comparison with soluble fms-like tyrosine kinase 1 to placental growth factor ratio (Abstract)

The role of urinary soluble endoglin in the diagnosis of pre-eclampsia: comparison with soluble fms-like tyrosine kinase 1 to placental growth factor ratio Endoglin, an anti-angiogenic glycoprotein expressed on endothelial cells, has been proposed recently as a biomarker of pre-eclampsia (PE). Given that PE is characterised by an imbalance of angiogenic factors, we sought to determine the clinical utility of urinary soluble endoglin, relative to the soluble fms-like tyrosine kinase 1

2010 EvidenceUpdates

88. Randomised controlled trial: Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia

Randomised controlled trial: Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) monitoring in women with gestational hypertension or mild pre-eclampsia Article Text Therapeutics Randomised controlled trial Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia Baha M Sibai Professor Baha M Sibai Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267, USA; baha.sibai{at}uc.edu Statistics from Altmetric.com Commentary

2010 Evidence-Based Medicine

89. Financial impact of a novel pre-eclampsia diagnostic test versus standard practice: a decision-analytic modeling analysis from a UK healthcare payer perspective

Financial impact of a novel pre-eclampsia diagnostic test versus standard practice: a decision-analytic modeling analysis from a UK healthcare payer perspective Financial impact of a novel pre-eclampsia diagnostic test versus standard practice: a decision-analytic modeling analysis from a UK healthcare payer perspective Financial impact of a novel pre-eclampsia diagnostic test versus standard practice: a decision-analytic modeling analysis from a UK healthcare payer perspective Hadker N, Garg S (...) , Costanzo C, Miller JD, Foster T, van der Helm W, Creeden J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the economic impact of a new in vitro test, to detect pre-eclampsia in pregnant women, compared with standard

2010 NHS Economic Evaluation Database.

90. Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Full Text available with Trip Pro

Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Results of several trials of antioxidant use during pregnancy have not shown a reduction in pre-eclampsia, but the effect in women with diabetes is unknown. We aimed to assess whether supplementation with vitamins C and E reduced incidence of pre-eclampsia in women with type 1 diabetes.We enrolled women from 25 UK antenatal metabolic clinics in a multicentre randomised (...) allocation. The primary endpoint was pre-eclampsia, which we defined as gestational hypertension with proteinuria. Analysis was by modified intention to treat. This study is registered, ISRCTN27214045.Between April, 2003, and June, 2008, 762 women were randomly allocated to treatment groups (379 vitamin supplementation, 383 placebo). The primary endpoint was assessed for 375 women allocated to receive vitamins, and 374 allocated to placebo. Rates of pre-eclampsia did not differ between vitamin (15%, n=57

2010 Lancet Controlled trial quality: predicted high

91. Cohort study: Higher BMI in pregnant women associated with a greater likelihood of pre-eclampsia, caesarian delivery and higher offspring birth weight and body fat

Cohort study: Higher BMI in pregnant women associated with a greater likelihood of pre-eclampsia, caesarian delivery and higher offspring birth weight and body fat Higher BMI in pregnant women associated with a greater likelihood of pre-eclampsia, caesarian delivery and higher offspring birth weight and body fat | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time (...) -eclampsia, caesarian delivery and higher offspring birth weight and body fat Article Text Aetiology Cohort study Higher BMI in pregnant women associated with a greater likelihood of pre-eclampsia, caesarian delivery and higher offspring birth weight and body fat Sohinee Bhattacharya Statistics from Altmetric.com Commentary on: HAPO Study Cooperative Research Group . Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study: associations with maternal body mass index . Context Although there are several

2010 Evidence-Based Medicine

92. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women (Abstract)

Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women It has been suggested that vitamin C, alone or in combination with vitamin E, may protect against pre-eclampsia, whereas the safety of high-dose vitamin E supplements has been questioned. We investigated dietary intakes of vitamins C and E to see if they correlated with the incidence of pre-eclampsia.Prospective cohort study.The Danish National Birth Cohort; a population-based pregnancy cohort (...) ; analyses were based on 57 346 pregnancies.Vitamin intake was estimated from a food frequency questionnaire completed in gestational week 25, recording intake from diet and supplements during the previous four weeks. Pre-eclampsia diagnoses were obtained from the Danish National Patient Registry; we worked with two entities, 'pre-eclampsia (all types)' and 'severe pre-eclampsia/eclampsia/HELLP'. We adjusted for confounding factors by logistic regression.A small increase in the incidence of severe

2009 EvidenceUpdates

93. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. Full Text available with Trip Pro

Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. To investigate whether pre-eclampsia is more common in first pregnancies solely because fewer affected women, who presumably have a higher risk of recurrence, go on to have subsequent pregnancies.Prospective cohort study.Swedish Medical Birth Register.763 795 primiparous mothers who had their first births in Sweden, 1987-2004.Pre-eclampsia.The risk of pre-eclampsia was 4.1% in the first pregnancy and 1.7 (...) % in later pregnancies overall. However, the risk was 14.7% in the second pregnancy for women who had had pre-eclampsia in their first pregnancy and 31.9% for women who had had pre-eclampsia in the previous two pregnancies. The risk for multiparous women without a history of pre-eclampsia was around 1%. The incidence of pre-eclampsia associated with delivery before 34 weeks' gestation was 0.42% in primiparous women, 0.11% in multiparous women without a history of pre-eclampsia, and 6.8% and 12.5

2009 BMJ

94. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries (Abstract)

World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries To determine if vitamin C and E supplementation in high-risk pregnant women with low nutritional status reduces pre-eclampsia.Multicentred, randomised, controlled, double-blinded trial.Antenatal care clinics and Hospitals in four countries.Pregnant women between 14 and 22 weeks (...) : placebo group (14.7%), vitamins group (11.8%). Previous pre-eclampsia, or its complications, was the most common risk factor at entry (vitamins 41.6%, placebo 41.3%). Treatment compliance was 87% in the two groups and loss to follow-up was low (vitamins 2.0%, placebo 1.3%). Supplementation was not associated with a reduction of pre-eclampsia (RR: 1.0; 95% CI: 0.9-1.3), eclampsia (RR: 1.5; 95% CI: 0.3-8.9), gestational hypertension (RR: 1.2; 95% CI: 0.9-1.7), nor any other maternal outcome. Low

2009 EvidenceUpdates Controlled trial quality: predicted high

95. Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study Full Text available with Trip Pro

Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study Women who develop pre-eclampsia in pregnancy are at increased risk of cardiovascular disease. The offspring from pregnancies complicated by pre-eclampsia have higher blood pressures during childhood, but little is known about their long-term health. We hypothesized that pre-eclampsia would lead to an increased risk of cardiovascular disease in the offspring.We traced 6410 babies (...) born in Helsinki, Finland, from 1934 to 1944. We used the mothers' blood pressure levels and the presence of proteinuria during pregnancy to define pre-eclampsia and gestational hypertension without proteinuria according to modern criteria.Two hundred eighty-four of the pregnancies were complicated by pre-eclampsia (120 with nonsevere and 164 with severe disease) and 1592 by gestational hypertension. The crude hazard ratio for all forms of stroke among people whose mothers had pre-eclampsia was 1.9

2009 EvidenceUpdates

96. Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan Full Text available with Trip Pro

Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan The occurrence of preeclampsia-eclampsia during pregnancy has been reported to increase the risk of stroke in mainly Western populations. However, few studies have evaluated stroke risk in Asian populations and followed women beyond the early postpartum period. Thus, the present study determined the risk of stroke in women in Taiwan during pregnancy and the first postpartum year.A population-based cohort study (...) was performed on 1,132,019 parturients during 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Stroke-free survival rates were estimated using the Kaplan-Meier method, and the log-rank test was used to examine the effect of preelampsia-eclampsia on the prevalence of stroke. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine the adjusted odds ratios of preeclampsia-eclampsia

2009 EvidenceUpdates

97. Prediction, prevention, and prognosis of preeclampsia. In: Diagnosis, evaluation and management of the hypertensive disorders of pregnancy.

Prediction, prevention, and prognosis of preeclampsia. In: Diagnosis, evaluation and management of the hypertensive disorders of pregnancy. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust

2009 Society of Obstetricians and Gynaecologists of Canada

98. The effect of recurrent miscarriage and infertility on the risk of pre-eclampsia Full Text available with Trip Pro

The effect of recurrent miscarriage and infertility on the risk of pre-eclampsia Pre-eclampsia, recurrent miscarriage and infertility may all partly be caused by unsuccessful placentation early in pregnancy. If so, one will expect these disorders to be associated in population studies. The aim of the present investigation was to estimate the risk of pre-eclampsia in women with recurrent miscarriage and infertility.Cohort study.The Norwegian Mother and Child Cohort Study (MoBa), a large (...) population-based pregnancy cohort.The sample consisted of 20,846 singleton pregnancies to nulliparous women participating in the MoBa, 1999-2005.Information on miscarriage, infertility and potential confounders was self-reported in postal questionnaires, whereas the diagnosis of pre-eclampsia was retrieved from the Medical Birth Registry of Norway. Risk estimation and confounder control was performed with multiple logistic regression.Pre-eclampsia according to history of miscarriage and infertility.An

2009 EvidenceUpdates

99. Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women (Abstract)

Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.Prospective cohort.Denmark.A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149 (...) , 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.Pre-eclampsia and severe pre-eclampsia.The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical

2009 EvidenceUpdates

100. Maternal smoking, preeclampsia, and infant health outcomes in New York City, 1995-2003 Full Text available with Trip Pro

and preeclampsia with respect to preterm delivery and birth weight; smokers who developed preeclampsia had a lower risk of preterm delivery, and a lower adjusted mean difference in birth weight, than would have been expected based on the independent effects of smoking and preeclampsia. These data suggest that smoking is only protective against preeclampsia without pre gestational hypertension, and even then principally among younger women. Additionally, smokers who develop these disorders have no increased (...) Maternal smoking, preeclampsia, and infant health outcomes in New York City, 1995-2003 A number of previous studies have reported an inverse association between maternal smoking and preeclampsia. Additionally, some have suggested that smokers who develop preeclampsia have worse maternal and fetal outcomes than nonsmokers who develop preeclampsia. The authors examined the relation of smoking to preeclampsia among 674,250 singleton pregnancies in New York City between 1995 and 2003. Although

2009 EvidenceUpdates