Latest & greatest articles for pregnancy

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on pregnancy or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on pregnancy and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for pregnancy

41. Updated SOGC Committee Opinion – COVID-19 in Pregnancy

on how to prevent or manage infection with COVID-19. Due to physiologic changes that occur in pregnancy, when compared with their non-pregnant counterparts, pregnant women with lower respiratory tract infections often experience worse outcomes, including higher rates of hospital and intensive care unit admission. (3) Since 2002 there have been two other global outbreaks of highly-pathogenic coronaviruses: severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). While SARS (...) with SARS and MERS infection. The only published case-control study showed that pregnant women with SARS experienced worse outcomes than non-pregnant women of similar age.(10) Reports varied with respect to the effects of SARS and MERS on pregnancy outcomes. Spontaneous abortion has been reported among women infected with SARS and MERS in the first trimester.4 As well, stillbirth, intrauterine growth restriction, and preterm birth have been reported in pregnancies affected by SARS and MERS in the second

2020 Society of Obstetricians and Gynaecologists of Canada

42. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Full Text available with Trip Pro

Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine (...) vertical transmission potential of COVID-19 infection.Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing

2020 Lancet

43. Genome-wide microarray testing for pregnancies with major foetal structual abnormalities detected by ultrasound

) for a type of genetic testing that would be done during pregnancy. The test, called genome-wide microarray, would be done if a pregnant woman had an ultrasound that has shown the unborn baby has a major structural abnormality (sometimes called a birth defect). 2 Currently, these structural abnormalities are further assessed by a type of genetic test called karyotyping. Genome-wide microarray is a new pathology laboratory tool used to analyse large numbers of genes at one time. The evidence provided (...) Genome-wide microarray testing for pregnancies with major foetal structual abnormalities detected by ultrasound 1 Public Summary Document Application No. 1533 – Genome-wide microarray testing for pregnancies with major fetal structural abnormalities detected by ultrasound Applicant: The Royal College of Pathologists of Australasia (RCPA) Date of MSAC consideration: MSAC 77 th Meeting, 28-29 November 2019 Context for decision: MSAC makes its advice in accordance with its Terms of Reference

2020 Medical Services Advisory Committee

44. Cannabis Use During Pregnancy and Lactation: A Practice Resources for Health Care Providers

in a parenting and human-milk-feeding relationship with a child who may not self-identify as such. Health care providers may prefer to use the term “chestfeeding” rather than breastfeeding in these cases. This practice resource is intended for the use of health care providers providing clinical care and/or counselling to women and pregnant individuals in the perinatal period. The purpose of this practice resource is to help health care providers facilitate conversations on cannabis use during pregnancy (...) to avoid or reduce using any forms of cannabis during pregnancy and lactation due to the lack of information on the short- and long-term effects on women and pregnant individuals' health and children’s growth and development. THC tetrahydrocannabinol CBD cannabinol Cannabis Use During Pregnancy & Lactation I Practice Resource for Health Care Providers I February 2020 What is Cannabis? Cannabis refers to substances derived from the plant Cannabis sativa and is composed of two main compounds: delta-9

2020 British Columbia Perinatal Health Program

45. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. Full Text available with Trip Pro

Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. To assess the association between macrolide antibiotics prescribing during pregnancy and major malformations, cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder in children.Population based cohort study.The UK Clinical Practice Research Datalink.The study cohort included 104 605 children born from 1990 to 2016 (...) , genital, and urinary) after macrolide or penicillin prescribing during the first trimester (four to 13 gestational weeks), second to third trimester (14 gestational weeks to birth), or any trimester of pregnancy. Additionally, risks of cerebral palsy, epilepsy, attention deficit hyperactivity disorder, and autism spectrum disorder.Major malformations were recorded in 186 of 8632 children (21.55 per 1000) whose mothers were prescribed macrolides and 1666 of 95 973 children (17.36 per 1000) whose

2020 BMJ

46. Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study. Full Text available with Trip Pro

Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study. To evaluate the risk of adverse maternal and infant outcomes following in utero exposure to duloxetine.Cohort study nested in the Medicaid Analytic eXtract for 2004-13.Publicly insured pregnancies in the United States.Pregnant women 18 to 55 years of age and their liveborn infants.Duloxetine exposure during the etiologically relevant time window, compared with no exposure to duloxetine, exposure (...) to selective serotonin reuptake inhibitors, exposure to venlafaxine, and exposure to duloxetine before but not during pregnancy.Congenital malformations overall, cardiac malformations, preterm birth, small for gestational age infant, pre-eclampsia, and postpartum hemorrhage.Cohort sizes ranged from 1.3 to 4.1 million, depending on the outcome. The number of women exposed to duloxetine varied by cohort and exposure contrast and was around 2500-3000 for early pregnancy exposure and 900-950 for late pregnancy

2020 BMJ

47. Guidelines for the management of pregnant and breastfeeding women in the context of Ebola virus disease

in the context of Ebola virus disease 3 Executive summary The Democratic Republic of Congo is currently experiencing the second largest Ebola outbreak in history (1), following a 2014-2016 outbreak in western Africa that had an estimated 28,000 cases. Investigational treatment and vaccination trials are ongoing, but data in the context of pregnancy and breastfeeding are limited (2,3). A paucity of scientific evidence exists on how to best treat pregnant or breastfeed - ing women with suspected or confirmed (...) work with pregnant or breastfeeding women in the context of Ebola. The guidelines are relevant to the WHO goal of ensuring one billion people are better protected from health emergen- cies by impacting maternal mortality, neonatal survival, and the transmission Ebola virus in the context of an Ebola epidemic. Specific recommendations cover 6 topics. These are: (i) the management of acute EVD in pregnant women, (ii) the management of pregnancies in women who develop EVD during pregnancy and those

2020 World Health Organisation Guidelines

48. Valproate (Epilim, Depakote) pregnancy prevention programme: updated educational materials

Valproate (Epilim, Depakote) pregnancy prevention programme: updated educational materials Valproate (Epilim▼, Depakote▼) pregnancy prevention programme: updated educational materials - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search The UK has left the EU Valproate (Epilim▼, Depakote (...) ▼) pregnancy prevention programme: updated educational materials In January 2020, healthcare professionals received updated educational materials to support the valproate pregnancy prevention programme. Valproate is contraindicated in girls and women of childbearing potential, unless the conditions of the pregnancy prevention programme are met. Published 12 February 2020 From: Therapeutic area: , , , Contents Advice for healthcare professionals: valproate is contraindicated in girls and women

2020 MHRA Drug Safety Update

49. Severe vomiting in pregnancy: the priority is to rehydrate

antihistamine (despite its limitations) in mild nausea and vomiting in a pregnant woman. Priority treatment of severe vomiting during pregnancy consists of non-drug measures, chiefly parenteral rehydration combined with rest. Of the antiemetic drugs with proven efficacy in other situations, metoclopramide is the one for which we have the longest experience during the first trimester of pregnancy, with no major signal of an increased malformation rate. But after the first trimester, the long-term (...) Severe vomiting in pregnancy: the priority is to rehydrate Prescrire IN ENGLISH - Spotlight ''Severe vomiting in pregnancy: the priority is to rehydrate'', 1 February 2020 {1} {1} {1} | | > > > Severe vomiting in pregnancy: the priority is to rehydrate Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Severe vomiting in pregnancy: the priority

2020 Prescrire

50. Vaccination in pregnancy (VIP)

Vaccination in pregnancy (VIP) Vaccination in pregnancy (VIP) - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search The UK has left the EU Guidance Vaccination in pregnancy (VIP) Advice for GPs on pregnant women who are inadvertently vaccinated against measles, mumps, rubella, chicken pox (...) (varicella) or human papilloma virus. Published 1 May 2010 Last updated 21 January 2020 — From: Contents The Immunisation department at Public Health England ( ( . . Shingles vaccine administration in pregnancy Shingles vaccine (Zostavax®, Generic Name: Varicella Zoster Virus, Marketed by Sanofi Pasteur MSD) is a live viral vaccine that is not recommended for use in pregnancy. Most women of child-bearing age in the UK are known to be immune to chickenpox. You can reassure a pregnant woman immunised

2020 Public Health England

51. Towards integrated antenatal care for low-risk pregnancy

engaged in non-clinical interventions 28 3.2.4 How to improve BPPE: Literature review and stakeholders consultation 28 3.3 ICT INNOVATIONS FOR INFORMATION EXCHANGE 31 4 LEGAL FRAMEWORK OF ANC AND PROTECTIVE MEASURES FOR PREGNANT WOMEN IN BELGIUM 33 4.1 LEGAL FRAMEWORK OF ANC IN BELGIUM 33 4.2 PROTECTIVE MEASURES FOR (VULNERABLE) PREGNANT WOMEN 34 2 Towards integrated antenatal care for low-risk pregnancy KCE Report 326 5 PROVISION AND UPTAKE OF ROUTINE ANC: PARENTS’ AND HEALTHCARE PROFESSIONALS (...) Recommendations 82 4 Towards integrated antenatal care for low-risk pregnancy KCE Report 326 LIST OF FIGURES Figure 1 – Evolution of the average length of stay (in days) for deliveries with a low level of severity (SOI 1) in Belgium (2 nd semester 2013 - 2 nd semester 2017 [last data available]) 14 Figure 2 – Proportion of low-risk pregnant women who attended at least one consultation during their pregnancy by healthcare professional, in 2016 19 Figure 3 – Number of ANC consultations (2016) for clinical

2020 Belgian Health Care Knowledge Centre

52. Pregnancy Health: Exercise Programs to Prevent Gestational Hypertension

: Exercise Programs to Prevent Gestational Hypertension Tabs Snapshot Summary of CPSTF Finding The exercise programs for pregnant women to reduce the development of gestational hypertension. Intervention Programs engage women in regular exercise from before their 16th week of pregnancy through birth. Exercise programs must include one or both of the following: Supervised exercise classes that meet at least three times each week and include 30-60 minutes of moderate-intensity aerobic exercise Regular (...) . Exercise during pregnancy protects against hypertension and macrosomia: randomized clinical trial. Am J Obstet Gynecol . 2016;214:649.e1–8. de Oliveria Melo AS, Silva JL, Tavares JS, Barros VO, Leite DF, Amorim MM. Effect of a physical exercise program during pregnancy on uteroplacental and fetal blood flow and fetal growth: a randomized controlled trial. Obstet Gynecol . 2012;120:302–10. Haakstad LAH, Bo K. Exercise in pregnant women and birth weight: a randomized controlled trial. BMC Pregnancy

2020 Community Preventive Services Task Force

53. Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study. Full Text available with Trip Pro

Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study. To study the impact of maternal smoking during pregnancy on fractures in offspring during different developmental stages of life.National register based birth cohort study with a sibling comparison design.Sweden.1 680 307 people born in Sweden between 1983 and 2000 to women who smoked (n=377 367, 22.5%) and did not smoke (n=1 302 940) in early pregnancy. Follow-up was until 31 (...) December 2014.Fractures by attained age up to 32 years.During a median follow-up of 21.1 years, 377 970 fractures were observed (the overall incidence rate for fracture standardised by calendar year of birth was 11.8 per 1000 person years). The association between maternal smoking during pregnancy and risk of fracture in offspring differed by attained age. Maternal smoking was associated with a higher rate of fractures in offspring before 1 year of age in the entire cohort (birth year standardised

2020 BMJ

54. Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial. Full Text available with Trip Pro

Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial. Preterm birth remains a common cause of neonatal mortality, with a disproportionately high burden in low-income and middle-income countries. Meta-analyses of low-dose aspirin to prevent pre-eclampsia suggest that the incidence of preterm birth might also be decreased, particularly if initiated before 16 weeks (...) of gestation.ASPIRIN was a randomised, multicountry, double-masked, placebo-controlled trial of low-dose aspirin (81 mg daily) initiated between 6 weeks and 0 days of pregnancy, and 13 weeks and 6 days of pregnancy, in nulliparous women with an ultrasound confirming gestational age and a singleton viable pregnancy. Participants were enrolled at seven community sites in six countries (two sites in India and one site each in the Democratic Republic of the Congo, Guatemala, Kenya, Pakistan, and Zambia). Participants

2020 Lancet

55. Diabetes in Pregnancy

Diabetes in Pregnancy Guideline No. 393-Diabetes in Pregnancy - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 41, Issue 12, Pages 1814–1825.e1 Guideline No. 393-Diabetes in Pregnancy x Howard Berger Correspondence Corresponding author: Dr. Howard Berger , MD x Howard Berger Correspondence Corresponding author: Dr. Howard Berger Toronto, ON x Robert Gagnon , MD Montréal, QC x Mathew Sermer , MD Toronto, ON No. 393 (...) , December 2019 (replaces No. 334, July 2016) DOI: To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Figures Appendix A Gestational Diabetes Mellitus Screening and Diagnosis Appendix B Gestational Diabetes Mellitus Postpartum Testing Abstract Objectives This guideline reviews the evidence relating to the diagnosis and obstetrical management of diabetes in pregnancy. Outcomes The outcomes evaluated were short and long-term maternal outcomes

2020 Society of Obstetricians and Gynaecologists of Canada

56. Maternal Collapse in Pregnancy and the Puerperium Full Text available with Trip Pro

Maternal Collapse in Pregnancy and the Puerperium Maternal Collapse in Pregnancy and the Puerperium - Chu - - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library

2020 Royal College of Obstetricians and Gynaecologists

57. Antiepileptics and pregnancy: potential long-term effects in children

and pregnancy: potential long-term effects in children FEATURED REVIEW Many women who could become pregnant are exposed to antiepileptic drugs. Yet most of the antiepileptic drugs taken by pregnant women expose the unborn child to the risk of malformations, fetotoxic effects and neonatal disorders. What are the long-term effects of the most widely used antieleptics on children exposed in utero, and how do they compare? Full review (8 pages) available for download by subscribers. Abstract What are the main (...) Antiepileptics and pregnancy: potential long-term effects in children Prescrire IN ENGLISH - Spotlight ''Antiepileptics and pregnancy: potential long-term effects in children'', 1 January 2020 {1} {1} {1} | | > > > Antiepileptics and pregnancy: potential long-term effects in children Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Antiepileptics

2020 Prescrire

58. Tuberculosis and pregnant women

Tuberculosis and pregnant women Tuberculosis and pregnant women - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Tuberculosis and pregnant women Guidance for patients and the public and for clinical staff involved in treating pregnant women. Published 1 November 2013 Last (...) . Please tell us what format you need. It will help us if you say what assistive technology you use. Details One set of guidance is for pregnant women and members of the public. The other is for clinical staff treating pregnant women who have had contact with a person with infectious tuberculosis ( 17 December 2019 Updated to reflect changes in national guidance and availability of services. 1 November 2013 First published. Related content Collection Explore the topic Is this page useful? Thank you

2020 Public Health England

59. Are healthy weight management interventions effective before, during and after pregnancy?

management interventions before, during and after pregnancy, including those that reduce gestational weight gain (GWG) or prevent poor maternal and child health outcomes, from January 1 st 2010 to 19 th Sept 2019. Key messages • There were many systematic reviews addressing this topic, but there was no overall consensus on which interventions are the most effective for healthy weight management in pregnant or postpartum women • Some reviews found that dietary interventions alone were significantly more (...) interventions before, during and after pregnancy? KLS Evidence Briefing 2 nd October 2019 Background The prevalence of obesity in pregnancy is increasing, rising from 9–10% in the early 1990s to 16–19% in the 2000s. Pregnant women who are obese are at greater risk of pregnancy-related complications compared with women of normal BMI, including pre-eclampsia, gestational diabetes and increased risk of caesarean birth (1). There is still a lack of consensus on the optimal gestational weight gain for obese

2020 Public Health England - Evidence Briefings

60. Guidance on self-monitoring of blood pressure in pregnancy

Guidance on self-monitoring of blood pressure in pregnancy 1 Information for healthcare professionals Version 1: Published Monday 30 March 2020 Self-monitoring of blood pressure in pregnancy2 1. Introduction The COVID-19 pandemic has required the NHS to urgently consider blood pressure (BP) self-monitoring in order to reduce face to face consultations for pregnant and postnatal women, whilst maintaining adequate safety for the woman and her baby. BP self-monitoring in pregnancy can either (...) with chronic hypertension, based on their care outside of pregnancy. 1.1 Scope This guidance covers pregnant women who currently require blood pressure monitoring (at varying frequencies) throughout the antenatal and postnatal period, during the period of COVID-19 pandemic. For women with chronic hypertension, gestational hypertension or pre-eclampsia, more frequent BP monitoring is required, over and above standard antenatal care. Other groups of women may also require increased frequency if they have

2020 Royal College of Obstetricians and Gynaecologists