Latest & greatest articles for pressure ulcer

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Top results for pressure ulcer

161. A randomized trial of low-air-loss beds for treatment of pressure ulcers. (Abstract)

A randomized trial of low-air-loss beds for treatment of pressure ulcers. To assess the effectiveness of low-air-loss beds for the treatment of pressure ulcers in nursing homes.Prospective, randomized, clinical trial.Three teaching nursing homes in Los Angeles, Calif.Eighty-four nursing home residents with trunk or trochanter pressure ulcers (Shea stage > or = 2).Subjects were randomly assigned to use either a low-air-loss bed (n = 43) or a 10-cm corrugated foam mattress (n = 41) throughout (...) substantial improvement compared with foam mattresses despite other factors in pressure ulcer healing.

1993 JAMA Controlled trial quality: uncertain

162. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. (Abstract)

Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. A randomised, phase I/II, double-blind, placebo-controlled study was designed to assess the effect of topically applied recombinant human BB homodimeric platelet-derived growth factor (rPDGF-BB) on healing of chronic pressure ulcers. Twenty patients were randomly allocated daily treatment for 28 days with 1, 10, or 100 micrograms/ml rPDGF-BB (0.01, 0.1, or 1.0 micrograms per cm2 ulcer area) or placebo. Patients (...) treated with 100 micrograms/ml rPDGF-BB showed a greater healing response than the placebo group, but the lower doses had little effect. After 28 days, ulcers treated with 100 micrograms/ml rPDGF-BB were smaller than those treated with placebo (mean [SE] volume 6.4 [4.0] vs 21.8 [5.6]% of day 0 volume). There were no toxic effects. These preliminary findings suggest that rPDGF-BB is a potent wound-healing agent in soft tissue.

1992 Lancet Controlled trial quality: uncertain