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Latest & greatest articles for prostate cancer screening
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Periodic PSA-based screening in men 55 to 69 years of age reduced prostatecancer mortality. 22801696 2012 09 24 2012 07 17 1539-3704 157 2 2012 Jul 17 Annals of internal medicine Ann. Intern. Med. ACP Journal Club. Periodic PSA-based screening in men 55 to 69 years of age reduced prostatecancer mortality. JC2-4 10.7326/0003-4819-157-2-201207170-02004 Hoffman Richard M RM eng Comment Journal Article United States Ann Intern Med 0372351 0003-4819 N Engl J Med. 2012 Mar 15;366(11):981-90
for prostatecancer using prostate-specific antigen (PSA) testing. STATEMENT OF THE CLINICAL ISSUE Section: Prostatecancer is the second leading cause of cancer deaths among men in the United States, , with the estimated number of deaths exceeding 28,000 in 2012. The rationale for screening asymptomatic men for prostatecancer in the general population is the potential for reducing mortality rates through early detection of the disease. However, much controversy exists between the potential harms (...) that a patient's age and level of comorbidity need to be considered when deciding whether to screen for prostatecancer. – Assessing risk for prostatecancer has been achieved through development of prostatecancer risk calculators. These factor not only PSA but other risk factors and tumor markers for prostatecancer as well. Rather than using a cutoff value, individual probabilities for any and aggressive prostatecancers are calculated, with the decision for biopsy based on patient and physician views
detected by screening) prostatecancer were eligible. Studies had to report all-cause or prostatecancer mortality or prespecified adverse events. Observational studies had to adjust mortality estimates for age at diagnosis and have tumour grade as a minimum. Non-controlled observational studies of perioperative mortality and surgical complications were eligible if they included at least 1,000 patients. Included studies enrolled men with localised prostatecancer, but it was unclear how many (...) Screening for prostatecancer: a review of the evidence for the U.S. Preventive Services Task Force Screening for prostatecancer: a review of the evidence for the U.S. Preventive Services Task Force Screening for prostatecancer: a review of the evidence for the U.S. Preventive Services Task Force Chou R, Croswell JM, Dana T, Bougatsos C, Blazina I, Fu R, Gleitsmann K, Koenig HC, Lam C, Maltz A, Rugge B, Lin K CRD summary This review concluded that it was uncertain whether prostate-specific
Stratifying risk - the u.s. Preventive services task force and prostate-cancerscreening. 22029756 2011 12 09 2011 11 24 1533-4406 365 21 2011 Nov 24 The New England journal of medicine N. Engl. J. Med. Stratifying risk--the U.S. Preventive Services Task Force and prostate-cancerscreening. 1953-5 10.1056/NEJMp1112140 Schröder Fritz H FH Erasmus University Medical Center, Rotterdam, The Netherlands. eng Journal Article 2011 10 26 United States N Engl J Med 0255562 0028-4793 EC 22.214.171.124 (...) Prostate-Specific Antigen AIM IM Advisory Committees Humans Male Mass Screening standards Practice Guidelines as Topic Preventive Health Services standards Prostate-Specific Antigen blood ProstaticNeoplasms blood diagnosis prevention & control Risk Factors United States 2011 10 28 6 0 2011 10 28 6 0 2011 12 14 6 0 ppublish 22029756 10.1056/NEJMp1112140
Screening for prostatecancer. 22029754 2011 12 09 2011 11 24 1533-4406 365 21 2011 Nov 24 The New England journal of medicine N. Engl. J. Med. Clinical practice. Screening for prostatecancer. 2013-9 10.1056/NEJMcp1103642 Hoffman Richard M RM Department of Medicine, University of New Mexico School of Medicine, and the Medicine Service, New Mexico Veterans Affairs Health Care System, Albuquerque, USA. firstname.lastname@example.org eng Journal Article Review 2011 10 26 United States N Engl J Med 0255562 0028 (...) -4793 EC 126.96.36.199 Prostate-Specific Antigen AIM IM Biopsy Decision Making Humans Male Mass Screening adverse effects Middle Aged Patient Participation Practice Guidelines as Topic Prostate-Specific Antigen blood ProstaticNeoplasms diagnosis epidemiology mortality Risk Factors Sensitivity and Specificity United States epidemiology 2011 10 28 6 0 2011 10 28 6 0 2011 12 14 6 0 ppublish 22029754 10.1056/NEJMcp1103642
Prostate-cancerscreening - what the u.s. Preventive services task force left out. 22029759 2011 12 09 2011 11 24 1533-4406 365 21 2011 Nov 24 The New England journal of medicine N. Engl. J. Med. Prostate-cancerscreening--what the U.S. Preventive Services Task Force left out. 1949-51 10.1056/NEJMp1112191 Brett Allan S AS Department of Medicine, University of South Carolina School of Medicine, Columbia, USA. Ablin Richard J RJ eng Journal Article 2011 10 26 United States N Engl J Med 0255562 (...) 0028-4793 EC 188.8.131.52 Prostate-Specific Antigen AIM IM Advisory Committees Direct Service Costs Humans Male Mass Screening economics standards Practice Guidelines as Topic Preventive Health Services standards Prostate-Specific Antigen blood ProstaticNeoplasms blood diagnosis prevention & control United States 2011 10 28 6 0 2011 10 28 6 0 2011 12 14 6 0 ppublish 22029759 10.1056/NEJMp1112191
was restricted to studies published in English. The search queries were based on a combination of exploded and non-exploded subject headings and free-text keywords. These terms included prostatecancer, prostaticneoplasms, prostatetumour, prostate-specific antigen (PSA), digital rectal examination (DRE), DRE, mass screening, screening test, early detection of cancer, cancerscreening, screening, PSA, transrectal ultrasound (TRUS), TRUS, ran- domized, false-negative and false-positive; we used alterna- tive (...) . Introduction The goal of prostatecancer (PCa) screening is to reduce the morbidity and mortality from this disease through early detection. There has been a steady decline in PCa mortality following the introduction of PSA testing in the late 1980s. 1 However, phase III trials on PCa screening have demon- strated a high number needed to treat, suggesting many PCas diagnosed were not destined to have an impact on a patient’s overall survival. 2,3 (Level 1 Evidence.) We review the literature on PCa
Cost-effectiveness of prostate specific antigen screening in the United States: extrapolating from the European study of screening for prostatecancer Cost-effectiveness of prostate specific antigen screening in the United States: extrapolating from the European study of screening for prostatecancer Cost-effectiveness of prostate specific antigen screening in the United States: extrapolating from the European study of screening for prostatecancer Shteynshlyuger A, Andriole GL Record Status (...) This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the cost-effectiveness of screening for prostatecancer using prostate-specific antigen, compared with no screening, using the preliminary results of the European Randomized Study of Screening
PSA Test to Screen for ProstateCancer PSA Test to Screen for ProstateCancer – TheNNTTheNNT Prostate Specific Antigen (PSA) Test to Screen for ProstateCancer 5 for unneeded biopsy In Summary, for those who got the PSA test: Benefits in NNT 100% saw no benefit 0% were helped by preventing death from any cause 0% were helped by preventing death from prostatecancer None were helped (preventing death from any cause, preventing death from prostatecancer) Harms in NNT 20% were harmed (...) with prostate CA in their lifetime and a 3% chance of dying from prostatecancer. Autopsy studies have shown that up to 2/3 of elderly men die with asymptomatic prostatecancer. It appears that if they live long enough most men will develop prostatecancer, though it will not affect their longevity. Given the high incidence of prostatecancer, there have been aggressive efforts to screen patients with the hopes of diagnosing local (non-metastatic) cancer that can be treated before it progresses. Elevated
Population screening act: prostatecancerscreening using MRI Population screening act: prostatecancerscreening using MRI Population screening act: prostatecancerscreening using MRI Health Council of the Netherlands Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Health Council of the Netherlands. Population screening act: prostatecancerscreening using MRI (...) . The Hague: Health Council of the Netherlands Gezondheidsraad (GR). 2011/37. 2011 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Humans; Magnetic Resonance Imaging; Mass Screening; ProstaticNeoplasms Language Published English Country of organisation Netherlands English summary An English language summary is available. Address for correspondence Postbus 16052, 2500 BB Den Haag, The Netherlands. Tel: +31 70 340 7520;Fax: +31 70 340 7523 Email: email@example.com AccessionNumber
Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. The effect on mortality of screening for lung cancer with modern chest radiographs is unknown.To evaluate the effect on mortality of screening for lung cancer using radiographs in the Prostate, Lung, Colorectal, and Ovarian (PLCO) CancerScreening Trial.Randomized controlled trial that involved 154,901 participants aged 55 through 74 years, 77,445 of whom were assigned (...) % at years 1 through 3; the rate of screening use in the usual care group was 11%. Cumulative lung cancer incidence rates through 13 years of follow-up were 20.1 per 10,000 person-years in the intervention group and 19.2 per 10,000 person-years in the usual care group (rate ratio [RR]; 1.05, 95% CI, 0.98-1.12). A total of 1213 lung cancer deaths were observed in the intervention group compared with 1230 in usual care group through 13 years (mortality RR, 0.99; 95% CI, 0.87-1.22). Stage and histology were
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) CancerScreening Randomized Controlled Trial. Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality.To evaluate the effect of screening for ovarian cancer on mortality in the Prostate, Lung, Colorectal and Ovarian (PLCO) CancerScreening Trial.Randomized controlled trial of 78,216 women aged 55 to 74 years assigned to undergo (...) ultrasound but received their usual medical care. Participants were followed up for a maximum of 13 years (median [range], 12.4 years [10.9-13.0 years]) for cancer diagnoses and death until February 28, 2010.Mortality from ovarian cancer, including primary peritoneal and fallopian tube cancers. Secondary outcomes included ovarian cancer incidence and complications associated with screening examinations and diagnostic procedures.Ovarian cancer was diagnosed in 212 women (5.7 per 10,000 person-years
sixth man from a list of dates of birth. These men were invited to be screened every third year from 1987 to 1996. On the first two occasions screening was done by digital rectal examination only. From 1993, this was combined with prostate specific antigen testing, with 4 µg/L as cut off. On the fourth occasion (1996), only men aged 69 or under at the time of the investigation were invited.Data on tumour stage, grade, and treatment from the South East Region ProstateCancer Register. Prostatecancer (...) Randomised prostatecancerscreening trial: 20 year follow-up. To assess whether screening for prostatecancer reduces prostatecancer specific mortality.Population based randomised controlled trial.Department of Urology, Norrköping, and the South-East Region ProstateCancer Register.All men aged 50-69 in the city of Norrköping, Sweden, identified in 1987 in the National Population Register (n = 9026).From the study population, 1494 men were randomly allocated to be screened by including every
Patient-centered discussions about prostatecancerscreening: a real-world approach. National guidelines recommend that primary care providers discuss the risks and benefits of prostatecancerscreening with their patients but give little guidance on how to fit such a complex discussion into a busy clinic encounter. The authors propose a process-oriented approach (Ask-Tell-Ask) that promotes tailored conversations and value-based recommendations. The Ask-Tell-Ask approach includes diagnosing (...) a patient's informational needs, providing targeted education based on those needs, and making a shared decision about testing. This time-efficient model emphasizes the provider's role as an interactive guide rather than a one-way supplier of information. Although there is no way to make these discussions simple, this streamlined strategy can help patients and providers efficiently negotiate the complex and important decision of screening for prostatecancer.
Mortality results from the Goteborg randomised population-based prostate-cancerscreening trial Prostatecancer is one of the leading causes of death from malignantdisease among men in the developed world. One strategy to decrease the risk of death from this disease is screening with prostate-specific antigen (PSA); however, the extent of benefit and harm with such screening is under continuous debate.In December, 1994, 20,000 men born between 1930 and 1944, randomly sampled from (...) the population register, were randomised by computer in a 1:1 ratio to either a screening group invited for PSA testing every 2 years (n=10,000) or to a control group not invited (n=10,000). Men in the screening group were invited up to the upper age limit (median 69, range 67-71 years) and only men with raised PSA concentrations were offered additional tests such as digital rectal examination and prostate biopsies. The primary endpoint was prostate-cancer specific mortality, analysed according
Screening for prostatecancer: systematic review and meta-analysis of randomised controlled trials Screening for prostatecancer: systematic review and meta-analysis of randomised controlled trials Screening for prostatecancer: systematic review and meta-analysis of randomised controlled trials Djulbegovic M, Beyth RJ, Neuberger MM, Stoffs TL, Vieweg J, Djulbegovic B, Dahm P CRD summary This review found that screening for prostate specific antigen with or without digital rectal examination (...) increased prostatecancer diagnosis but did not reduce mortality. The authors concluded that current evidence did not support the routine use of screening. The review was well-conducted and the conclusions appear reliable. Authors' objectives To assess the benefits and harms of screening for prostatecancer. Searching The authors searched PubMed, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) from January 2005 to July 2010 to identify trials published since a Cochrane review
-specific antigen (PSA). PSA is a protease produced in the prostate which is believed to liquefy seminal fluid. 5 In general, prostatecancerscreening both through PSA and DRE are inexpensive, safe tests. The rationale behind using PSA as a screening tool is that prostatecancer causes PSA to be released in the blood; the tumor does not, however, produce PSA. 5 Although there is evidence that prostatecancer risk varies with the levels of PSA circulating in the blood, 5 it is important to consider (...) , decreased urinary stream, and urinary urgency. Patients with metastatic disease experienced weight loss, loss of appetite, bone pain, lower extremity pain and edema, as well as uremic symptoms. 3 The use of PSA resulted in identification of patients with earlier-stage, organ- localized disease. 3 PSA screening has led to an overall increase in the incidence of prostatecancer, but its effect on the mortality of prostatecancer still remains unanswered. 6 Two randomized control trials have recently been