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Latest & greatest articles for prostate cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on prostate cancer or other clinical topics then use Trip today.
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The impact of PTEN deletion and ERG rearrangement on recurrence after treatment for prostatecancer: a systematic review and meta-analysis. The specific association between PTEN deletion or ERG rearrangement and the recurrence of prostatecancer (PC) treated with radical prostatectomy (RP) or brachytherapy is still unelaborated. Therefore, we performed a comprehensive meta‑analysis to understand the impact of these factors on cancer recurrence.A comprehensive literature search was performed (...) of 6744 patients from 17 studies were included in this analysis Overall, The pooled results showed that PTEN loss predict pooled BRF (HR 1.79, 95% CI 1.49-2.16, P < 0.001) and RFS (HR 1.71, 95% CI 1.50-1.95, P < 0.001) in patients after radical prostatectomy or brachytherapy for prostatecancer. Subgroup analysis revealed that PTEN deletion significantly predicted poor BRF or RFS in heterozygous studies group (HR 1.70, 95% CI 1.31-2.21, P < 0.001). The PTEN deletion also significantly predicted poor
The relationship between inguinal hernia and minimally-invasive surgery for prostatecancer: A systematic review of the literature. We aimed to perform a systematic review about the relationship between inguinal hernia and surgery for prostate cancer.Diagnosis of abdominal wall defects and prostatecancer may be either synchronous or metachronous. The convenience and safety of combined prostatectomy and hernioplasty, the incidence of hernias after prostatectomy and the feasibility (...) to patients suffering from an inguinal hernia and a prostatecancer amenable of radical prostatectomy. Sixteen studies addressing the potential increase in the occurrence of inguinal hernia after radical prostatectomy were evaluated. Approximately 15% of patients who undergo retro-pubic radical prostatectomy will develop inguinal hernia. It is suggested that the incidence might be lower in laparoscopic prostatectomy series, particularly in case of transperitoneal approach. The median time
Effect of DNA damage response mutations on prostatecancer prognosis: a systematic review. The prognosis of men with prostatecancer (PC) with mutations in DNA damage response (DDR) genes undergoing different treatments is unclear. This systematic review compared clinical outcomes in PC patients with DDR mutations (DDR+) versus no mutations (DDR-). 14 resources plus gray literature were searched for studies in PC and subgroups (castration-resistant PC, metastatic PC and metastatic castration
Systematic Review of Commercially Available Mobile Phone Applications for ProstateCancer Education. Prostatecancer is the most commonly diagnosed non-skin cancer among all men and the second most common cause of death. To ameliorate the burden of prostatecancer, there is a critical need to identify strategies for providing men with information about prostatecancer screening and the importance of informed decision making. With mobile phones becoming more ubiquitous, many individuals (...) are adopting their phones as sources for health information. The objective of this systematic review is to identify and evaluate commercially available apps for promoting informed prostatecancer screening decisions. Two keywords "prostatecancer screening" and "prostatecancer" were entered into the search engines of Google and iOS app stores in May 2017. Evaluations were conducted on apps' (a) quality, (b) grade-level readability, (c) cultural sensitivity, and (d) usability heuristics. None of the 14
Hypofractionated radiotherapy versus conventional radiotherapy in patients with intermediate- to high-risk localized prostatecancer: a meta-analysis of randomized controlled trials. Prostatecancer is one of the most common cancers in the world. The results of treatment after hypofractionated radiotherapy only have been reported from several small randomized clinical trials. Therefore, we conducted a meta-analysis to compare clinical outcomes of hypofractionated radiotherapy versus (...) conventional radiotherapy in the treatment of intermediate- to high-risk localized prostate cancer.Relevant studies were identified through searching related databases till August 2018. Hazard ratio (HR) or risk ratio (RR) with its corresponding 95% confidence interval (CI) was used as pooled statistics for all analyses.The meta-analysis results showed that overall survival (HR = 1.12, 95% CI: 0.93-1.35, p = 0.219) and prostatecancer-specific survival (HR = 1.29, 95% CI: 0.42-3.95, p = 0.661) were similar
Predictive Factors of Missed Clinically Significant ProstateCancers in Men with Negative Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis. We systematically reviewed the literature on predictive factors for clinically significant prostatecancer diagnosis after prebiopsy negative magnetic resonance imaging in prostatecancer naïve patients.The MEDLINE® and Scopus® databases were searched up to March 2019. The review protocol was published in the PROSPERO database (...) (CRD42019125549). The clinical factors and markers studied were age, prostate specific antigen, prostate specific antigen isoforms, prostate specific antigen density, PCA3, prostate volume, family history, ethnicity and risk calculators. The primary objective was to determine their predictive ability for clinically significant prostatecancer diagnosis. Secondary objectives included meta-analysis of the negative predictive value of prebiopsy negative magnetic resonance imaging when combined
Systematic review and meta-analysis of the associations between body mass index, prostatecancer, advanced prostatecancer, and prostate-specific antigen. The relationship between body mass index (BMI) and prostatecancer remains unclear. However, there is an inverse association between BMI and prostate-specific antigen (PSA), used for prostatecancer screening. We conducted this review to estimate the associations between BMI and (1) prostatecancer, (2) advanced prostatecancer, and (3 (...) ) PSA.We searched PubMed and Embase for studies until 02 October 2017 and obtained individual participant data from four studies. In total, 78 studies were identified for the association between BMI and prostatecancer, 21 for BMI and advanced prostatecancer, and 35 for BMI and PSA. We performed random-effects meta-analysis of linear associations of log-PSA and prostatecancer with BMI and, to examine potential non-linearity, of associations between categories of BMI and each outcome.In the meta
Could aspirin be a lifesaver for prostatecancer patients in prostatecancer-specific mortality?: an update systematic review and meta-analysis. Currently, clinical studies on the prognosis of prostatecancer (PC) taking aspirin were developing, but the precise mechanism of aspirin on tumor cells was still unclear. In addition, the conclusion that aspirin can improve the prognosis of PC patients continues to be controversial. Therefore, we collected comprehensive literatures and performed our (...) study to explore the prognostic effect of aspirin on PC.A comprehensive literature search was performed in April 2019 based on PUBMED. EMBASE. Hazard Ratio (HR) as well as its 95% confidence interval (CIs) for prostatecancer specific mortality (PCSM) was extracted from eligible studies.A total of 10 eligible articles were used in our study. The pooled results showed that PC patients who used aspirin or taking aspirin did not have lower PCSM than those who had not used (HR =0.89, 95% CI: 0.73-1.08
Intricate Interplay of Entwined Metabolic and Inflammatory Life-threatening Processes in Tumor Lysis Syndrome Complicating ProstateCancer: A Systematic Review with a Single Institution Experience. Tumor lysis syndrome (TLS) occurs in rapidly proliferating tumor cells, either spontaneously or after cytotoxic therapy. It has been well-documented in hematological diseases but is extremely rare in solid neoplasms, particularly in prostatecancer (PRCA). In the presence of risk factors, it can (...) cause metabolic disturbances and be potentially fatal. We searched PubMed, Medline, ScienceDirect, and Scopus for "tumor lysis syndrome" and "prostatecancer" and conducted a systematic review with a pooled analysis for the published literature and cases from our institution. Twenty-two TLS cases were identified (18 published in the literature and four cases from our institution). The patients' median age was 68 years (range 16-82), and most cases were prostateadenocarcinoma. The median prostate
Prognostic Value of Gleason Score at Positive Surgical Margin in ProstateCancer: A Systematic Review and Meta-analysis. The individual clinical significance of a positive surgical margin (PSM) after radical prostatectomy has remained controversial. Studies have suggested that the Gleason grade (GG) at the PSM could improve predictive accuracy and decision making. Our objective was to systematically review the reported data to determine the effect of the GG at the PSM on the prognosis after (...) radical prostatectomy. A systematic review was conducted by searching MEDLINE/PubMed for studies reported by June 2019 in accordance with the Preferred Reporting Items for Systematic Review statement. The keywords used included prostatecancer, radical prostatectomy, positive surgical margin, Gleason score, and/or Gleason grade. After a systematic literature review, 10 studies were included, comprising 14,108 patients, of whom 2454 (17.4%) had a PSM and 428 (14%) eventually experienced biochemical
trial conducted at the US Department of Veterans Affairs and National Cancer Institute sites. The participants were men (n=731) ≤75yr of age with localized prostatecancer, prostate-specific antigen (PSA) <50ng/ml, life expectancy ≥10yr, and medically fit for surgery. Intervention: Radical prostatectomy versus observation. Outcome measurements and statistical analysis: All-cause mortality was assessed in the entire cohort and patient and tumor subgroups. Intention-to-treat analysis was conducted (...) with intermediate-risk disease although not in men with high-risk disease. Patient summary: In this randomized study, we evaluated death from any cause in men with early prostatecancer treated with either surgery or observation. Overall, surgery may provide small very long-term reductions in death from any cause and increases in years of life gained. Absolute effects were much smaller in men with low-risk disease, but were greater in men with intermediate-risk disease although not in men with high-risk disease
Work after prostatecancer: a systematic review. Research in the field of vocational rehabilitation, specifically for prostatecancer, remains rare despite increasing recognition of the role of vocational interventions in other cancer groups. The aim of this review was to compile and evaluate current trends, facilitators and barriers associated with returning to work after a prostatecancer diagnosis.The literature search was conducted in March 2018 using the Preferred Reporting Items (...) for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Forty-seven original research papers published in English in peer-reviewed journals were identified. The included studies comprised a total of 20,083 prostatecancer patients with a mean age of 61 years.The studies implied a good overall return to work prognosis in prostatecancer patients; however, these findings are not generalisable to those with physically demanding or low paid jobs, comorbid conditions or poor physical functioning.The limited
Systemic Management for Nonmetastatic Castration-resistant ProstateCancer: A Systematic Review and Network Meta-Analysis. To indirectly compare the efficacy and safety of systemic therapies used for patients with nonmetastatic castration-resistant prostatecancer (nmCRPC).The relevant randomized controlled trials were retrieved from PubMed and the Cochrane Library. Network meta-analyses were used to compare multiple drugs simultaneously for the outcomes of nmCRPC. Direct evidence in trials (...) and indirect evidence across trials were combined by the network meta-analyses to estimate the treatment efficiency.Eight studies were included in our research. For prostate-specific antigen progression-free survival, the rate of progression was significantly decreased following apalutamide, enzalutamide, bicalutamide+dutasteride, and bicalutamide treatment compared with placebo. Compared with placebo treatment, metastases-free survival was significantly increased in patients who received apalutamide
Effectiveness of Platinum-Based Chemotherapy in Patients With Metastatic ProstateCancer: Systematic Review and Meta-analysis. Taxanes are the only cytotoxic drugs that have demonstrated a survival benefit for patients with castration-resistant prostatecancer (CRPC), but there is some evidence that platinum compounds may also benefit such patients.We performed a systematic search on electronic databases. We sought prospective clinical studies testing platinum compounds for CRPC. Platinum (...) compounds could be delivered alone or in combination with other drugs. Both randomized and nonrandomized studies were included for qualitative synthesis, only randomized studies were included for meta-analyses. Clinical overall response rate (cORR), prostate-specific antigen overall response rate (sORR), progression-free survival (PFS), overall survival (OS), and toxicity were the outcomes of interest.We identified 53 studies delivering platinum agents for patients with CRPC. cORR varied from 0 to 82
Longitudinal model-based meta-analysis for survival probabilities in patients with castration-resistant prostatecancer. The aims of this longitudinal model-based meta-analysis (MBMA) were to indirectly compare the time courses of survival probabilities and to identify corresponding potential significant covariates across approved drugs in patients with castration-resistant prostatecancer (CRPC).A systematic literature review for monotherapy studies in patients with CRPC was conducted up (...) , Gleason score, and baseline prostate-specific antigen (BLPSA), while OS probability was associated with chemotherapy, Gleason score, visceral metastasis, Eastern Cooperative Oncology Group performance status, and BLPSA.Our modeling and simulation framework can be applied to support indirect comparison, dose selection, and go/no-go decision-making for new agents targeting CRPC.
Comparison of PSMA-PET/CT, choline-PET/CT, NaF-PET/CT, MRI, and bone scintigraphy in the diagnosis of bone metastases in patients with prostatecancer: a systematic review and meta-analysis. A systematic review and meta-analysis to compare the diagnostic performance of prostate-specific membrane antigen (PSMA)-PET/CT, choline-PET/CT, Sodium Fluoride (NaF) PET/CT, MRI, and bone scintigraphy (BS) in detecting bone metastases in patients with prostate cancer.We searched PubMed and Embase (...) , respectively.According to the meta-analysis, PSMA-PET/CT had the highest per-patient sensitivity and specificity in detecting bone metastases with prostatecancer. The sensitivities of NaF-PET/CT and MRI were better than those for choline-PET/CT and BS. The specificity of PSMA-PET/CT was significantly better than BS. Others were similar. For per-lesion, NaF-PET/CT had the highest sensitivity, PSMA-PET/CT had higher sensitivity than choline-PET/CT and MRI, and BS had the lowest sensitivity.
Prognostic value of the bone scan index in patients with metastatic castration-resistant prostatecancer: a systematic review and meta-analysis. Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostatecancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis.The PubMed, Cochrane, and Embase databases were searched systematically for relevant