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Latest & greatest articles for prostate cancer
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-refractory metastatic prostatecancer only if their Karnofsky performance-status score is 60% or more. 1.2 It is recommended that treatment with docetaxel should be stopped: - at the completion of planned treatment of up to 10 cycles, or - if severe adverse events occur, or - in the presence of progression of disease as evidenced by clinical or laboratory criteria, or by imaging studies. 1.3 Repeat cycles of treatment with docetaxel are not recommended if the disease recurs after completion (...) Docetaxel for the treatment of hormone-refractory metastatic prostatecancer Docetaxel for the treatment of hormone-refractory metastatic prostatecancer Docetaxel for the treatment of hormone-refractory metastatic prostatecancer National Institute for Health and Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation National Institute for Health
Proton beam therapy for prostatecancer Proton beam therapy for prostatecancer Proton beam therapy for prostatecancer HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Proton beam therapy for prostatecancer. Lansdale: HAYES, Inc.. Directory Publication. 2006 Authors' objectives Proton beam therapy (PBT) is a type of external radiation (...) treatment in which positively charged subatomic particles (protons) are precisely targeted to a specific tissue mass by using a sophisticated stereotaxic planning and delivery system. In comparison with conventional photon irradiation, proton beam radiation may deliver a higher dose to the target tissue, while minimizing exposure to surrounding healthy tissue. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Neutrons; ProstaticNeoplasms
Neutron beam therapy for prostatecancer Neutron beam therapy for prostatecancer Neutron beam therapy for prostatecancer HAYES, Inc. Citation HAYES, Inc.. Neutron beam therapy for prostatecancer. Lansdale: HAYES, Inc.. Directory Publication. 2006 Authors' objectives Neutron beam therapy (NBT) is a form of external beam radiotherapy in which accelerated neutral subatomic particles (neutrons) are targeted to a tumor mass, with the goal of eradicating malignant cells. Unlike standard photon (x (...) -ray) radiotherapy (XRT), which is characterized by low linear energy transfer (LET), NBT involves high-LET. Compared with XRT, the high-LET of NBT is associated with greater cell killing per unit dose and, theoretically, is superior in overcoming radioresistance in slowly proliferating tumors such as prostateadenocarcinoma. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Neutrons; ProstaticNeoplasms /radiotherapy; Radiotherapy
High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostatecancer High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostatecancer High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostatecancer National Institute for Health and Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation National Institute for Health and Clinical Excellence. High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostatecancer. London: National Institute for Health and Clinical Excellence (NICE). Interventional Procedure Guidance 174. 2006 Authors' objectives This study aims to assess the current evidence on high dose rate brachytherapy in combination with external-beam radiotherapy for localised prostatecancer
Brachytherapy for the treatment of prostatecancer: assessment report May 2005 Brachytherapy for the treatment of prostatecancer: assessment report May 2005 Brachytherapy for the treatment of prostatecancer: assessment report May 2005 Medical Services Advisory Committee Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Medical Services (...) Advisory Committee. Brachytherapy for the treatment of prostatecancer: assessment report May 2005. Canberra: Medical Services Advisory Committee (MSAC). MSAC application no. 1089. 2006 Authors' objectives The aim of this report was to assess the safety, effectiveness and cost-effectiveness of brachytherapy for treating early localised prostatecancer compared with radical prostatectomy (RP), external beam radiation therapy (EBRT), and no initial treatment or deferred treatment (active surveillance
of prostatecancer (PC) in men aged 55 years and older, but it was not cost-effective except in scenarios with substantial reductions in the cost of the agent and in high-risk men. In effect, given the low prevalence of disease, a substantial proportion of the cost would be generated by giving finasteride to men who, even without chemoprevention, would never develop PC. CRD COMMENTARY - Selection of comparators The rationale for the choice of the comparators was clear since the actual pattern of care (...) The cost of prostatecancer chemoprevention: a decision analysis model The cost of prostatecancer chemoprevention: a decision analysis model The cost of prostatecancer chemoprevention: a decision analysis model Svatek R S, Lee J J, Roehrborn C G, Lippman S M, Lotan Y Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed
of the analysis cannot be extrapolated to the treatment of men with good-risk prostatecancer since epidemiological data referred to patients with intermediate-risk disease. Implications of the study The study results support the use of IMRT for the treatment of intermediate-risk prostatecancer, although this conclusion was highly dependent on the time horizon of the analysis and the improvements in QoL associated with treatment. The authors noted that further studies should investigate the potential (...) of increased second malignancies with IMRT. Source of funding None stated. Bibliographic details Konski A, Watkins-Bruner D, Feigenberg S, Hanlon A, Kulkarni S, Beck J R, Horwitz E M, Pollack A. Using decision analysis to determine the cost-effectiveness of intensity-modulated radiation therapy in the treatment of intermediate risk prostatecancer. International Journal of Radiation Oncology, Biology, Physics 2006; 66(2): 408-415 Other publications of related interest Because readers are likely
prostatecancer. Health Econ 2002;11:233-48. Sanguineti G, Agostinelli S, Foppiano F, et al. Adjuvant androgen deprivation impacts late rectal toxicity after conformal radiotherapy of prostatecarcinoma. Br J Cancer 2002;86:1843-7. Indexing Status Subject indexing assigned by NLM MeSH Adenocarcinoma /drug therapy /economics /radiotherapy; Androgen Antagonists /economics /therapeutic use; Antineoplastic Agents, Hormonal /economics /therapeutic use; Combined Modality Therapy; Cost-Benefit Analysis (...) . Modelling A Markov model was set up to assess the costs and benefits of LTAD versus STAD in a cohort of patients with locally advanced prostatecarcinoma. The time horizon of the model was 10 years and the cycle length was 1 year. The health states considered in the model were no disease progression, hormone-responsive disease progression, hormone-unresponsive disease progression and death. The allowable state transitions were from no disease progression, to hormone-responsive disease progression
Autoantibody signatures in prostatecancer. New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer.With a phage-display library derived from prostate-cancer tissue, we developed and used phage protein microarrays to analyze serum samples from 119 patients with prostatecancer and 138 controls, with the samples equally divided into training and validation sets. A phage-peptide detector that was constructed from the training set was evaluated (...) on an independent validation set of 128 serum samples (60 from patients with prostatecancer and 68 from controls).A 22-phage-peptide detector had 88.2 percent specificity (95 percent confidence interval, 0.78 to 0.95) and 81.6 percent sensitivity (95 percent confidence interval, 0.70 to 0.90) in discriminating between the group with prostatecancer and the control group. This panel of peptides performed better than did prostate-specific antigen (PSA) in distinguishing between the group with prostatecancer
Risk of prostatecancer-specific mortality following biochemical recurrence after radical prostatectomy. The natural history of biochemical recurrence after radical prostatectomy can be long but variable. Better risk assessment models are needed to identify men who are at high risk for prostatecancer death early and who may benefit from aggressive salvage treatment and to identify men who are at low risk for prostatecancer death and can be safely observed.To define risk factors for prostate (...) cancer death following radical prostatectomy and to develop tables to risk stratify for prostatecancer-specific survival.Retrospective cohort study of 379 men who had undergone radical prostatectomy at an urban tertiary care hospital between 1982 and 2000 and who had a biochemical recurrence and after biochemical failure had at least 2 prostate-specific antigen (PSA) values at least 3 months apart in order to calculate PSA doubling time (PSADT). The mean (SD) follow-up after surgery was 10.3 (4.7
-specific mortality for the 125 men with low-risk prostatecancer (clinical tumor category T1c or T2a and PSA level <10.0 ng/mL and Gleason score < or =6) and the 233 men with higher-risk disease, stratified by the PSA velocity.A PSA velocity greater than 2.0 ng/mL per year was significantly associated with a shorter time to prostatecancer-specific mortality (adjusted hazard ratio [HR], 12.0; 95% confidence interval [CI], 3.0-54.0; P = .001) and all-cause mortality (adjusted HR, 2.1; 95% CI, 1.3-3.6; P (...) = .005) when compared with men whose PSA velocity was 2.0 ng/mL per year or less. Men presenting with low-risk disease and a PSA velocity greater than 2.0 ng/mL per year had a 7-year estimate of prostatecancer-specific mortality of 19% (95% CI, 2%-39%) compared with 0% for men whose PSA velocity was 2.0 ng/mL per year or less. The corresponding values for men with higher-risk disease were 24% (95% CI, 12%-37%) and 4% (95% CI, 0%-11%), respectively.A greater than 2.0-ng/mL increase in PSA level
Androgen deprivation therapy for prostatecancer. Prostatecancer is the most common nonskin cancer and second most common cause of cancer mortality in US men. Androgen deprivation therapy (ADT), specifically surgical or medical castration, is the first line of treatment against advanced prostatecancer and is also used as an adjuvant to local treatment of high-risk disease.To review systematically the evidence on the risks and benefits of ADT for prostatecancer as well as clinical management (...) of its adverse effects.We performed MEDLINE searches of English-language literature (1966 to March 2005) using the terms androgen deprivation therapy, hormone treatment, and prostatecancer. We reviewed bibliographies of literature to extract other relevant articles. Studies were selected based on clinical pertinence, with an emphasis on controlled study design.Androgen deprivation therapy is effective for palliation in many patients with advanced prostatecancer and improves outcomes for high-risk
therapy alone, stratified by age at diagnosis and histological findings.A retrospective population-based cohort study using Connecticut Tumor Registry data supplemented by hospital record and histology review of 767 men aged 55 to 74 years with clinically localized prostatecancer diagnosed between January 1, 1971, and December 31, 1984. Patients were treated with either observation or immediate or delayed androgen withdrawal therapy, with a median observation of 24 years.Probability of mortality from (...) prostatecancer or other competing medical conditions, given a patient's age at diagnosis and tumor grade.The prostatecancer mortality rate was 33 per 1000 person-years during the first 15 years of follow-up (95% confidence interval [CI], 28-38) and 18 per 1000 person-years after 15 years of follow-up (95% CI, 10-29). The mortality rates for these 2 follow-up periods were not statistically different, after adjusting for differences in tumor histology (rate ratio, 1.1; 95% CI, 0.6-1.9). Men with low
Randomised phase III study of intravenous vinorelbine plus hormone therapy versus hormone therapy alone in hormone-refractory prostatecancer. Vinorelbine (VRL) has been shown to be active in hormone-refractory prostatecancer (HRPC) in phase II studies, alone or in combination. Its moderate toxicity profile is well tolerated in elderly patients.Patients with metastatic prostatecancer, progressive after primary hormonal therapy, were randomised to receive intravenous VRL 30 mg/m2 on days 1 (...) -morbidities, and therefore offers an active and safe therapeutic option for patients with hormone-refractory prostatecancer.
of those who received androgen-deprivation therapy had a fracture, as compared with 12.6 percent of those not receiving androgen-deprivation therapy (P<0.001). In the Cox proportional-hazards analyses, adjusted for characteristics of the patient and the tumor, there was a statistically significant relation between the number of doses of gonadotropin-releasing hormone received during the 12 months after diagnosis and the subsequent risk of fracture.Androgen-deprivation therapy for prostatecancer (...) Risk of fracture after androgen deprivation for prostatecancer. The use of androgen-deprivation therapy for prostatecancer has increased substantially over the past 15 years. This treatment is associated with a loss of bone-mineral density, but the risk of fracture after androgen-deprivation therapy has not been well studied.We studied the records of 50,613 men who were listed in the linked database of the Surveillance, Epidemiology, and End Results program and Medicare as having received
remains current, and should be read in conjunction with the clinical guideline. Description Prostatecancer is one of the most common cancers in men. It tends to affect older men, with the risk rising with age. It is not a single disease entity but may be indicated form an incidental biopsy finding to presentation with metastatic prostatecancer, which may or may not cause any symptoms or shorten life. Symptoms when they occur include urinary outflow obstruction and features of metastases (...) , such as bone pain. Prognosis with prostatecancer is variable and depends on the grade of the tumour and stage of the diagnosed cancer. Treatment options depend on the stage of the cancer. Current treatments for localised prostatecancer include watchful waiting, radiotherapy, and radical prostatectomy. Metastatic prostatecancer is usually treated with hormone therapy. Brachytherapy is a form of radiotherapy in which delivery of radiation is targeted directly to the prostate gland through the implantation
guidance on cryotherapy for recurrent prostatecancer remains current, and should be read in conjunction with the clinical guideline. Description This procedure is used to treat carcinoma of the prostate that has been unsuccessfully treated via another method, most typically radiation or hormones. The procedure is performed by inserting cryotherapeutic probes into the prostate gland. These are used to freeze the gland along with cancerous tissue, thus destroying the diseased tissue. Patients (...) Cryotherapy for recurrent prostatecancer (IPG119) Overview | Cryotherapy for recurrent prostatecancer | Guidance | NICE Cryotherapy for recurrent prostatecancer Interventional procedures guidance [IPG119] Published date: May 2005 Share Save Guidance The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on cryotherapy for recurrent prostatecancer in May 2005. Further recommendations have been made
High-intensity focused ultrasound for prostatecancer (IPG118) Overview | High-intensity focused ultrasound for prostatecancer | Guidance | NICE High-intensity focused ultrasound for prostatecancer Interventional procedures guidance [IPG118] Published date: March 2005 Share Save Guidance The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on high-intensity focused ultrasound for prostatecancer (...) in March 2005. Further recommendations have been made as part of the clinical guideline on prostatecancer published in February 2008, as follows: High intensity focused ultrasound (HIFU) and cryotherapy are not recommended for men with localised prostatecancer other than in the context of controlled clinical trials comparing their use with established interventions. Clinical and cost-effectiveness evidence was reviewed in the development of this guideline which has led to this more specific
.- are used as secondary codes to classify interventions that are percutaneous and require some form of image control: if the method of image control is unspecified, Y53.9 Unspecified approach to organ under image control is assigned. In addition the ICD-10 code C61.X Malignantneoplasm of prostate is assigned. Your responsibility This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals (...) Cryotherapy as a primary treatment for prostatecancer (IPG145) Overview | Cryotherapy as a primary treatment for prostatecancer | Guidance | NICE Cryotherapy as a primary treatment for prostatecancer Interventional procedures guidance [IPG145] Published date: November 2005 Share Save Guidance The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on cryotherapy as a primary treatment for prostate