Latest & greatest articles for pulmonary embolism

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Top results for pulmonary embolism

281. Single-detector helical computed tomography as the primary diagnostic test in suspected pulmonary embolism: a multicenter clinical management study of 510 patients. (Abstract)

Single-detector helical computed tomography as the primary diagnostic test in suspected pulmonary embolism: a multicenter clinical management study of 510 patients. Helical computed tomography (CT) is a readily available tool for diagnosing pulmonary embolism (PE); however, its role in the management of patients with clinically suspected PE has not been fully established.To determine the effectiveness and safety of using helical CT of the pulmonary arteries as the primary diagnostic test (...) in patients with suspected PE.Multicenter, prospective clinical outcome study.Two academic hospitals and one large teaching hospital in the Netherlands.510 consecutive inpatients and outpatients with clinically suspected PE followed for 3 months.Patients underwent helical CT of the pulmonary arteries within 24 hours after presenting with signs and symptoms of PE. If CT results were normal or inconclusive, compression ultrasonography was performed on the same day as CT and repeated on days 4 and 7

2003 Annals of Internal Medicine

282. Ventilation / Perfusion Imaging for Pulmonary Embolic Disease

for Pulmonary Embolic Disease - British Nuclear Medicine Society perfusion scans in chest disease: comparison with standard radiographs. Am J Roentgenol. 130, 421-8. Alderson PO, Biello DR, Khan AR, Barth KH, McKnight RC, Siegel BA (1980). A comparison of 133 Xenon single-breath and washout imaging with scintigraphic diagnosis of pulmonary embolism. Radiology, 137, 481-6. 12. Date Agreed/Approved April 2001 13. Date for Review/Update April 2005 Initial draft first posted July 1999 Revised April 2001 Revised (...) Ventilation / Perfusion Imaging for Pulmonary Embolic Disease Ventilation / Perfusion Imaging for Pulmonary Embolic Disease - British Nuclear Medicine Society 1. Purpose This guideline must be read in conjunction with the BNMS Generic Guidelines. The purpose of this guideline is to assist specialists in Nuclear medicine and Radionuclide Radiology in recommending, performing, interpreting and reporting the results of lung scintigraphy for pulmonary embolism. This guideline will assist individual

2003 British Nuclear Medicine Society

283. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. Full Text available with Trip Pro

Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. The standard initial treatment of hemodynamically stable patients with pulmonary embolism is intravenous unfractionated heparin, requiring laboratory monitoring and hospitalization.We conducted a randomized, open-label trial involving 2213 patients with acute symptomatic pulmonary embolism to compare the efficacy and safety of the synthetic antithrombotic agent fondaparinux (...) in an international normalized ratio above 2.0. The primary efficacy outcome was the three-month incidence of the composite end point of symptomatic, recurrent pulmonary embolism (nonfatal or fatal) and new or recurrent deep-vein thrombosis.Forty-two of the 1103 patients randomly assigned to receive fondaparinux (3.8 percent) had recurrent thromboembolic events, as compared with 56 of the 1110 patients randomly assigned to receive unfractionated heparin (5.0 percent), for an absolute difference of -1.2 percent

2003 NEJM Controlled trial quality: predicted high

284. Contrast-enhanced helical computed tomography for the diagnosis of pulmonary embolism

Contrast-enhanced helical computed tomography for the diagnosis of pulmonary embolism Contrast-enhanced helical computed tomography for the diagnosis of pulmonary embolism Contrast-enhanced helical computed tomography for the diagnosis of pulmonary embolism Institute for Clinical Systems Improvement Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institute (...) for Clinical Systems Improvement. Contrast-enhanced helical computed tomography for the diagnosis of pulmonary embolism. Bloomington MN: Institute for Clinical Systems Improvement (ICSI) 2003 Authors' objectives This review aims to assess the available evidence on contrast-enhanced helical computed tomography for the diagnosis of pulmonary embolism. Authors' conclusions With regard to the use of contrast-enhanced helical computed tomography (CT) for the diagnosis of pulmonary embolism (PE), the ICSI

2003 Health Technology Assessment (HTA) Database.

285. Should the MUHC use low-molecular-weight heparin in inpatient treatment of deep vein thrombosis with or without pulmonary embolism?

Should the MUHC use low-molecular-weight heparin in inpatient treatment of deep vein thrombosis with or without pulmonary embolism? Should the MUHC use low-molecular-weight heparin in inpatient treatment of deep vein thrombosis with or without pulmonary embolism? Should the MUHC use low-molecular-weight heparin in inpatient treatment of deep vein thrombosis with or without pulmonary embolism? Chen J, Penrod J, McGregor M Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Chen J, Penrod J, McGregor M. Should the MUHC use low-molecular-weight heparin in inpatient treatment of deep vein thrombosis with or without pulmonary embolism? Technology Assessment Unit of the McGill University Health Centre (MUHC). Report #5. 2003 Authors' objectives This report compares the effectiveness and safety of low-molecular-weight heparin (LMWH

2003 Health Technology Assessment (HTA) Database.

286. Diagnosis and treatment of deep venous thrombosis and pulmonary embolism

Diagnosis and treatment of deep venous thrombosis and pulmonary embolism Diagnosis and treatment of deep venous thrombosis and pulmonary embolism Diagnosis and treatment of deep venous thrombosis and pulmonary embolism Segal JB, Eng J, Jenckes MW, Tamariz LJ Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Segal JB, Eng J, Jenckes MW (...) , Tamariz LJ. Diagnosis and treatment of deep venous thrombosis and pulmonary embolism. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 68. 2003 Authors' objectives Venous thromboembolism (VTE), thrombosis in the venous vasculature, causes considerable morbidity and mortality, and diagnosis and treatment are challenging. In this report we sought to summarize evidence on the following questions: 1) What are the efficacy and safety of low molecular

2003 Health Technology Assessment (HTA) Database.

287. D-dimer testing for deep vein thrombosis and pulmonary embolism

D-dimer testing for deep vein thrombosis and pulmonary embolism D-dimer testing for deep vein thrombosis and pulmonary embolism D-dimer testing for deep vein thrombosis and pulmonary embolism Institute for Clinical Systems Improvement Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institute for Clinical Systems Improvement. D-dimer testing for deep vein (...) thrombosis and pulmonary embolism. Bloomington MN: Institute for Clinical Systems Improvement (ICSI) 2003 Authors' objectives This review aims to assess the available evidence on the effectiveness of D-dimer testing for deep vein thrombosis and pulmonary embolism. Authors' conclusions With regard to D-dimer testing, the ICSI Technology Assessment Committee finds: Many D-dimer assays are available; they are not equivalent. It is imperative that an assay is applied only to a population in which it has been

2003 Health Technology Assessment (HTA) Database.

288. Does this patient have pulmonary embolism? Full Text available with Trip Pro

, Eikelboom J W, Attia J, Miniati M, Panju A A, Simel D L, Ginsberg J S. Does this patient have pulmonary embolism? JAMA 2003; 290(21): 2849-2858 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adult; Aged; Chest Pain; Decision Support Techniques; Dyspnea; Female; Fibrin Fibrinogen Degradation Products /metabolism; Humans; Male; Medical History Taking; Physical Examination; Probability; Pulmonary Embolism /blood /diagnosis; Reproducibility of Results; Risk Factors (...) Does this patient have pulmonary embolism? Does this patient have pulmonary embolism? Does this patient have pulmonary embolism? Chunilal S D, Eikelboom J W, Attia J, Miniati M, Panju A A, Simel D L, Ginsberg J S CRD summary This study investigated the accuracy of clinical gestalt compared with clinical prediction rules for estimating the pre-test probability of pulmonary embolism. The authors concluded that clinical gestalt of experienced clinicians and clinical prediction rules used

2003 DARE.

289. Turbidimetric D-dimer test in the diagnosis of pulmonary embolism: a metaanalysis

Turbidimetric D-dimer test in the diagnosis of pulmonary embolism: a metaanalysis Turbidimetric D-dimer test in the diagnosis of pulmonary embolism: a metaanalysis Turbidimetric D-dimer test in the diagnosis of pulmonary embolism: a metaanalysis Brown M D, Lau J, Nelson R D, Kline J A CRD summary This review found that quantitative, latex turbidimetric D-dimer tests are sensitive but non-specific for the detection of pulmonary embolism in the emergency department setting. The review was well (...) conducted and the conclusions are supported by the data presented. Authors' objectives To evaluate the test characteristics of quantitative, latex turbidimetric D-dimer tests in the diagnosis of pulmonary embolism (PE) in adults in the out-patient acute-care setting. Searching MEDLINE (1982 to 2002), EMBASE (1995 to 2002) and ISI Reference Update (1995 to 2002) were searched; some details of the search strategy were reported. The reference lists of included studies and previous systematic reviews were

2003 DARE.

290. Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies: a systematic review

Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies: a systematic review Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies: a systematic review Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies: a systematic review Kruip M J, Leclercq M G, van der Heul C, Prins M H, Buller H R CRD summary This review evaluated diagnostic strategies designed to exclude pulmonary embolism. The authors concluded (...) that there was evidence to support strategies starting with a normal perfusion lung scan or a combination of normal D-dimer levels and low clinical probability, and after initial testing the use of angiography or lung scintigraphy was warranted. The conclusions of the review were balanced and appeared to be robust. Authors' objectives To evaluate diagnostic strategies designed to exclude pulmonary embolism (PE). Searching MEDLINE (from 1966 to February 2003), EMBASE, and DARE were searched for English language

2003 DARE.

291. Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Full Text available with Trip Pro

Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Cost-effectiveness of ultrasound in preventing femoral venous catheter-associated pulmonary embolism Cox C E, Carson S S, Biddle A K Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary (...) of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Two strategies to prevent femoral venous catheter-associated pulmonary embolism (PE) were compared. The strategies were physical examination alone without ultrasound and lower extremity unilateral Doppler ultrasound-based screening, performed after 7 days of catheterisation. The ultrasound strategy included unilateral duplex Doppler examination

2003 NHS Economic Evaluation Database.

292. Cost-effectiveness of the bird's nest filter for preventing pulmonary embolism among patients with malignant brain tumors and deep venous thrombosis of the lower extremities

Cost-effectiveness of the bird's nest filter for preventing pulmonary embolism among patients with malignant brain tumors and deep venous thrombosis of the lower extremities Cost-effectiveness of the bird's nest filter for preventing pulmonary embolism among patients with malignant brain tumors and deep venous thrombosis of the lower extremities Cost-effectiveness of the bird's nest filter for preventing pulmonary embolism among patients with malignant brain tumors and deep venous thrombosis (...) ) for the prevention of pulmonary embolism (PE) in patients with malignant brain tumour, who were at high risk of developing deep venous thrombosis (DVT) in the lower extremities. Type of intervention Secondary prevention. Economic study type Cost-utility analysis. Study population The study referred to patients with malignant brain tumour who were at risk of DVT in the lower extremities. Patients with upper extremity DVT were excluded. Setting The setting was secondary care. The economic study was carried out

2003 NHS Economic Evaluation Database.

293. Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study. (Abstract)

Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study. We designed a prospective multicentre outcome study to evaluate a diagnostic strategy based on clinical probability, spiral CT, and venous compression ultrasonography of the legs in patients with suspected pulmonary embolism (PE). The main aim was to assess the safety of withholding anticoagulant treatment in patients with low or intermediate clinical probability of PE and negative (...) findings on spiral CT and ultrasonography.1041 consecutive inpatients and outpatients with suspected PE were included. Patients with negative spiral CT and ultrasonography and clinically assessed as having a low or intermediate clinical probability were left untreated. Those with high clinical probability underwent lung scanning, pulmonary angiography, or both. All patients were followed up for 3 months.PE was diagnosed in 360 (34.6%) patients; 55 had positive ultrasonography despite negative spiral CT

2002 Lancet

294. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. (Abstract)

Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Diagnostic strategies for pulmonary embolism are complex and consist of non-invasive diagnostic tests done to avoid conventional pulmonary angiography as much as possible. We aimed to assess the diagnostic accuracy of magnetic resonance angiography (MRA) for the diagnosis of pulmonary embolism, using conventional pulmonary (...) angiography as a reference method.In a prospective study, we enrolled 141 patients with suspected pulmonary embolism and an abnormal perfusion scan. Patients underwent MRA before conventional pulmonary angiography. Two reviewers, masked with respect to the results of conventional pulmonary angiography, assessed MRA images independently. Statistical analyses used chi(2) and 95% CI.MRA was contraindicated in 13 patients (9%), and images were not interpretable in eight (6%). MRA was done in two patients

2002 Lancet

295. Echocardiography in the management of pulmonary embolism. (Abstract)

Echocardiography in the management of pulmonary embolism. Echocardiography is not recommended as a routine imaging test to diagnose suspected pulmonary embolism. However, it is useful for identifying patients with pulmonary embolism who may have a poor prognosis. It can be used for rapid and accurate risk assessment. Moderate or severe right ventricular hypokinesis, persistent pulmonary hypertension, a patent foramen ovale, and free-floating right-heart thrombus are echocardiographic markers (...) that identify patients at risk for death or recurrent thromboembolism. Such patients warrant consideration for thrombolysis or embolectomy. Serial imaging of right ventricular function can help physicians monitor the effect of treatment and judge whether the selected management strategy is successful. Further research will clarify and define more precisely the utility and limitations of echocardiography in the management of pulmonary embolism.

2002 Annals of Internal Medicine

296. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. Full Text available with Trip Pro

Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. The use of thrombolytic agents in the treatment of hemodynamically stable patients with acute submassive pulmonary embolism remains controversial.We conducted a study of patients with acute pulmonary embolism and pulmonary hypertension or right ventricular dysfunction but without arterial hypotension or shock. The patients were randomly assigned in double-blind fashion to receive heparin plus 100 (...) -plus-alteplase group and 2.2 percent in the heparin-plus-placebo group, P=0.71). Treatment with heparin plus placebo was associated with almost three times the risk of death or treatment escalation that was associated with heparin plus alteplase (P=0.006). No fatal bleeding or cerebral bleeding occurred in patients receiving heparin plus alteplase.When given in conjunction with heparin, alteplase can improve the clinical course of stable patients who have acute submassive pulmonary embolism and can

2002 NEJM Controlled trial quality: predicted high

297. Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery

Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery Abdulwadud O Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation (...) Abdulwadud O. Anticoagulation therapy as prophylaxis for prevention of DVT or pulmonary embolism in neurosurgery. Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2002: 12 Authors' objectives This aim of this critical appraisal was to assess the effectiveness of anticoagulation therapy as prophylaxis for prevention of deep vein thrombosis (DVT) or pulmonary embolism in neurosurgery. Project page URL Indexing Status Subject indexing assigned by CRD MeSH Anticoagulants; Neurosurgery; Pulmonary

2002 Health Technology Assessment (HTA) Database.

298. The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis

The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis The accuracy of the enzyme-linked immunosorbent assay D-dimer test in the diagnosis of pulmonary embolism: a meta-analysis Brown M D, Rowe B H, Reeves M J, Bermingham J M, Goldhaber S Z Authors' objectives The primary objective was to determine (...) the accuracy of the enzyme-linked immunosorbent assay (ELISA) D-dimer test in the diagnosis of pulmonary embolism (PE) in adults in the hospital emergency department (ED). A secondary objective was to determine whether the test performance is affected by covariates such as age, co-morbidity and duration of symptoms. Searching MEDLINE (from January 1980 to January 1 2001) and EMBASE were searched; the search terms were reported. The reference lists of articles identified by the search, and those of previous

2002 DARE.

299. Thrombolytic therapy of pulmonary embolism: a meta-analysis

Thrombolytic therapy of pulmonary embolism: a meta-analysis Thrombolytic therapy of pulmonary embolism: a meta-analysis Thrombolytic therapy of pulmonary embolism: a meta-analysis Thabut G, Thabut D, Myers R P, Bernard-Chabert B, Marrash-Chahla R, Mal H, Fournier M Authors' objectives To assess the safety and efficacy of thrombolytic treatment in people with acute pulmonary embolism (PE). Searching MEDLINE (from 1967 to 2000), EMBASE (from 1974 to 2000) and Current Contents were searched (...) . Bibliographic details Thabut G, Thabut D, Myers R P, Bernard-Chabert B, Marrash-Chahla R, Mal H, Fournier M. Thrombolytic therapy of pulmonary embolism: a meta-analysis. Journal of the American College of Cardiology 2002; 40(9): 1660-1667 PubMedID Original Paper URL Other publications of related interest Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12. Indexing

2002 DARE.

300. Severe pulmonary embolism associated with air travel. (Abstract)

Severe pulmonary embolism associated with air travel. Air travel is believed to be a risk factor for pulmonary embolism, but the relation between pulmonary embolism and distance flown has not been documented. The aim of this study was to investigate whether the duration of air travel is related to the risk of pulmonary embolism.From November 1993 to December 2000, we systematically reviewed all cases of pulmonary embolism requiring medical care on arrival at France's busiest international (...) airport. Data on the geographic origins of all flights and the numbers of passengers were collected in order to evaluate the incidence of pulmonary embolism per 1 million passenger arrivals as a function of the distance traveled.A total of 135.29 million passengers from 145 countries or other areas arrived at Charles de Gaulle Airport during the period of the study, of whom 56 had confirmed pulmonary embolism. The incidence of pulmonary embolism was much higher among passengers traveling more than

2001 NEJM