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Latest & greatest articles for rheumatoid arthritis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on rheumatoid arthritis or other clinical topics then use Trip today.
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The association of obesity with disease activity, functional ability and quality of life in early rheumatoidarthritis: data from the Early RheumatoidArthritis Study/Early RheumatoidArthritis Network UK prospective cohorts To examine associations between BMI and disease activity, functional ability and quality of life in RA.Data from two consecutive, similarly designed UK multicentre RA inception cohorts were used: the Early RA Study (ERAS) and the Early RA Network (ERAN). Recruitment figures
High-sensitivity cardiac troponin I is a biomarker for occult coronary plaque burden and cardiovascular events in patients with rheumatoidarthritis Patients with RA display greater occult coronary atherosclerosis burden and experience higher cardiovascular morbidity and mortality compared with controls. We here explored whether pro-inflammatory cytokines and high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, correlated with plaque burden and cardiovascular events
Serious infection across biologic-treated patients with rheumatoidarthritis: results from the British Society for Rheumatology Biologics Register for RheumatoidArthritis To compare the incidence of serious infection (SI) across biologic drugs used to treat rheumatoidarthritis (RA) using data from the British Society for Rheumatology Biologics Register for RheumatoidArthritis (BSRBR-RA).The BSRBR-RA is a prospective observational cohort study. This analysis included patients with RA starting
Glucocorticoids Are Associated with An Increased Risk for Vertebral Fracture in Patients with RheumatoidArthritis To identify the effects of glucocorticoids (GC) on various types of fractures in patients with rheumatoidarthritis (RA).We used the Korean National Healthcare Claims database from 2010 to establish a retrospective cohort of patients with RA ≥ 19 years old. We then followed those patients through December 2013. The incidence rates of total and major fractures were calculated. We
Baricitinib in Patients with RheumatoidArthritis and an Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs in United States and Rest of World: A Subset Analysis This article evaluates the efficacy and safety of baricitinib 4 mg versus placebo in United States including Puerto Rico (US) and rest of the world (ROW) subpopulations using data pooled from RA-BEAM and RA-BUILD, which enrolled patients with moderate-to-severe adult-onset rheumatoidarthritis (RA).In RA-BEAM
Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoidarthritis Adverse changes in body composition, specifically decreased muscle mass (MM) and increased fat mass, characterize rheumatoidarthritis (RA). These changes, termed rheumatoid cachexia (RC), are important contributors to the disability and elevated co-morbidity risk of RA. Recently, we observed substantial muscle loss (~2 kg) in a patient with RA
Sarilumab (Kevzara) - rheumatoidarthritis Published 9 April 2018 1 sarilumab 150mg and 200mg solution for injection in pre-filled syringe and pre-filled pen (Kevzara ® ) SMC No 1314/18 Sanofi Genzyme 9 March 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following a full submission sarilumab (Kevzara ® (...) ) is accepted for restricted use within NHS Scotland. Indication under review: in combination with methotrexate for the treatment of moderately to severely active rheumatoidarthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs (DMARDs). Sarilumab can be given as monotherapy in case of intolerance to methotrexate or when treatment with methotrexate is inappropriate. SMC restriction: in patients with severe disease
Efficacy and safety of monotherapy with sirukumab compared with adalimumab monotherapy in biologic-naive patients with active rheumatoidarthritis (SIRROUND-H): a randomised, double-blind, parallel-group, multinational, 52-week, phase 3 study This randomised, double-blind, parallel-group, phase 3 study compared monotherapy with sirukumab, an anti-interleukin-6 cytokine monoclonal antibody, with adalimumab monotherapy in patients with rheumatoidarthritis (RA).Biologic-naïve patients with active
Similar efficacy, safety and immunogenicity of adalimumab biosimilar BI 695501 and Humira reference product in patients with moderately to severely active rheumatoidarthritis: results from the phase III randomised VOLTAIRE-RA equivalence study To demonstrate clinical equivalence of adalimumab biosimilar candidate BI 695501 with Humira.Patients with active rheumatoidarthritis on stable methotrexate were randomised to BI 695501 or Humira in a double-blind, parallel-group, equivalence study
Impact of Stopping Tumor Necrosis Factor Inhibitors on RheumatoidArthritis Patients' Burden of Disease To determine the impact of stopping tumor necrosis factor inhibitor (TNFi) treatment on patient-reported outcomes (PROs) of physical and mental health status, health utility, pain, disability, and fatigue in patients with established rheumatoidarthritis (RA).In the pragmatic, 12-month POET trial, 817 RA patients with ≥6 months of remission or stable low disease activity were randomized 2:1
Effect on Risk of Stroke and Acute Myocardial Infarction of Nonselective Nonsteroidal Anti-Inflammatory Drugs in Patients With RheumatoidArthritis There are still debates on the association of increased cardiovascular risk with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatoidarthritis (RA) because of inconsistent results. Therefore, our study aims to evaluate the transient effects of selective and nonselective NSAIDs on the risk of stroke and acute
Impact of temporary methotrexate discontinuation for 2 weeks on immunogenicity of seasonal influenza vaccination in patients with rheumatoidarthritis: a randomised clinical trial To determine whether a 2-week methotrexate (MTX) discontinuation after vaccination improves the efficacy of seasonal influenza vaccination in patients with rheumatoidarthritis (RA).In this prospective randomised parallel-group multicentre study, patients with RA on stable dose of MTX were randomly assigned at a ratio
Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With RheumatoidArthritis: A Randomized Clinical Trial To determine the relative risks of cardiovascular (CV), gastrointestinal (GI), and renal adverse events during long-term treatment with celecoxib, compared with ibuprofen and naproxen, in patients with osteoarthritis (OA) and patients with rheumatoidarthritis (RA).A total of 24,081 patients with OA or RA who had a moderate or high risk
Association of serum testosterone and dehydroepiandrosterone sulfate with rheumatoidarthritis: a case control study It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoidarthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA.The aim of this study was to determine the association of serum testosterone and DHEAs with RA.This case-control study was conducted on 59 patients with RA and 61 healthy
Similar Improvements in Patient-Reported Outcomes Among RheumatoidArthritis Patients Treated with Two Different Doses of Methotrexate in Combination with Adalimumab: Results From the MUSICA Trial In patients with rheumatoidarthritis (RA), combination treatment with methotrexate (MTX) and adalimumab is more effective than MTX monotherapy. From the patients' perspective, the impact of reduced MTX doses upon initiating adalimumab is not known. The objective was to evaluate the effects of low
A Case Report of Chikungunya Fever, RheumatoidArthritis, and Feltyâ€™s Syndrome Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoidarthritis (RA).We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK (...) arthritis not only resembling RA clinically, but also associated with RA biomarkers and extra-articular features, including Felty's syndrome (FS).We describe this patient's excellent response to methotrexate and discuss the implications her case provides in understanding this important emerging rheumatic disease.
Safety, Effectiveness, and Treatment Persistence of Golimumab in Elderly Patients with RheumatoidArthritis in Real-World Clinical Practice in Japan Golimumab has been proven as an effective treatment for rheumatoidarthritis in clinical trials. However, there is a scarcity of data regarding its use in elderly patients in a real-world setting. This study aims to evaluate the safety, effectiveness, and treatment persistence of golimumab in elderly Japanese patients (≥ 75 years) with rheumatoid (...) arthritis.This study was a post hoc analysis of post-marketing surveillance data on 5137 Japanese patients with active rheumatoidarthritis who received golimumab for 24 weeks. The study population was divided into two age groups (younger: < 75 years and elderly: ≥ 75 years), and the safety, effectiveness, and treatment persistence of golimumab were assessed. Also, the reasons for discontinuing golimumab treatment were analyzed by multi-logistic regression.During golimumab treatment over 24 weeks, younger
Tele-Health Followup Strategy for Tight Control of Disease Activity in RheumatoidArthritis: Results of a Randomized Controlled Trial To test the effect of patient-reported outcome (PRO)-based tele-health followup for tight control of disease activity in patients with rheumatoidarthritis (RA), and the differences between tele-health followup performed by rheumatologists or rheumatology nurses.A total of 294 patients were randomized (1:1:1) to either PRO-based tele-health followup carried out
Cluster-Randomized Trial of a Behavioral Intervention to Incorporate a Treat-to-Target Approach to Care of US Patients With RheumatoidArthritis To assess the feasibility and efficacy of implementing a treat-to-target approach versus usual care in a US-based cohort of rheumatoidarthritis patients.In this behavioral intervention trial, rheumatology practices were cluster-randomized to provide treat-to-target care or usual care. Eligible patients with moderate/high disease activity (Clinical (...) . Arthritis Care & Research published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.
Association Between Glucocorticoid Exposure and Healthcare Expenditures for Potential Glucocorticoid-related Adverse Events in Patients with RheumatoidArthritis Oral glucocorticoid (OGC) use for rheumatoidarthritis (RA) is debated because of the adverse event (AE) profile of OGC. We evaluated the associations between cumulative doses of OGC and potential OGC-related AE, and quantified the associated healthcare expenditures.Using the MarketScan databases, patients ≥ 18 years old who have RA