Latest & greatest articles for rheumatoid arthritis

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Top results for rheumatoid arthritis

161. Physical activity and sedentary behavior in patients with systemic lupus erythematosus and rheumatoid arthritis Full Text available with Trip Pro

Physical activity and sedentary behavior in patients with systemic lupus erythematosus and rheumatoid arthritis Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are at increased risk of cardiovascular disease (CVD). As sedentary behavior and lack of physical activity are known cardiovascular risk factors, we compared habitual activity between SLE patients, RA patients, and healthy control participants.For this cross-sectional study, RA and SLE patients were

2017 Open access rheumatology : research and reviews

162. Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center Full Text available with Trip Pro

Mortality in Italian patients with rheumatoid arthritis: evidence for a low mortality rate from cancer and infections in patients followed up at a tertiary center Mortality in patients with rheumatoid arthritis (RA) has never been investigated in Italy. This study is devoted to investigating all the distinct causes of mortality in Italian RA patients.Clinical charts of patients consecutively admitted to an Italian tertiary center, from January 1, 2008 to December 31, 2014, were reviewed (...) by the National Institute of Statistics was observed. All-cause and neoplasm IMRs in our series were found to be significantly lower than that reported in the Norfolk Arthritis Registry, while no difference was detected in cardiovascular (CV) mortality. On the other hand, all causes and CV SMRs in our series were found to be higher than that reported in the general Italian population, while cancer and infectious SMRs were found to be lower.In our series, RA patients had an increased all-cause mortality

2017 Open access rheumatology : research and reviews

163. Sarilumab for moderate to severe rheumatoid arthritis

Sarilumab for moderate to severe rheumatoid arthritis Sarilumab for moder Sarilumab for moderate to se ate to sev vere ere rheumatoid arthritis rheumatoid arthritis T echnology appraisal guidance Published: 1 November 2017 nice.org.uk/guidance/ta485 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived (...) . Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Sarilumab for moderate to severe rheumatoid arthritis (TA485) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 22Contents Contents 1 Recommendations 4 2 The technology 6 3 Committee discussion 7

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

164. Promonitor for monitoring response to biologics in rheumatoid arthritis

Promonitor for monitoring response to biologics in rheumatoid arthritis Promonitor for monitoring response to biologics Promonitor for monitoring response to biologics in rheumatoid arthritis in rheumatoid arthritis Medtech innovation briefing Published: 27 October 2017 nice.org.uk/guidance/mib126 pathways Summary Summary The technology technology described in this briefing is Promonitor. It is used to monitor response to biologic therapies. The inno innovativ vative aspect e aspect (...) is that each sample only needs to be run once, potentially allowing for a higher throughput of tests. The intended place in ther place in therap apy y would be in addition to current methods of monitoring drug response in people with rheumatoid arthritis. The main points from the e main points from the evidence vidence summarised in this briefing are from 4 prospective studies (2 in Europe and 2 in Asia) and 1 study comparing 3 devices, including a total of 495 adults in specialist centres. They show

2017 National Institute for Health and Clinical Excellence - Advice

165. Initial Serological Response after Prime-boost Pneumococcal Vaccination in Rheumatoid Arthritis Patients: Results of a Randomized Controlled Trial (Abstract)

Initial Serological Response after Prime-boost Pneumococcal Vaccination in Rheumatoid Arthritis Patients: Results of a Randomized Controlled Trial To evaluate the initial serological responses to pneumococcal vaccination with the 13-valent protein-conjugated pneumococcal vaccine (PCV13) followed by the 23-valent polysaccharide pneumococcal vaccine (PPV23) among patients with rheumatoid arthritis (RA) treated with biological disease-modifying antirheumatic drugs (bDMARD) according to dosing

2017 EvidenceUpdates

166. Mortality following new-onset Rheumatoid Arthritis: has modern Rheumatology had an impact? (Abstract)

Mortality following new-onset Rheumatoid Arthritis: has modern Rheumatology had an impact? To investigate if, and when, patients diagnosed with rheumatoid arthritis (RA) in recent years are at increased risk of death.Using an extensive register linkage, we designed a population-based nationwide cohort study in Sweden. Patients with new-onset RA from the Swedish Rheumatology Quality Register, and individually matched comparators from the general population were followed with respect to death

2017 EvidenceUpdates

167. Malignant Neoplasms in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors, Tocilizumab, Abatacept, or Rituximab in Clinical Practice: A Nationwide Cohort Study From Sweden Full Text available with Trip Pro

Malignant Neoplasms in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors, Tocilizumab, Abatacept, or Rituximab in Clinical Practice: A Nationwide Cohort Study From Sweden Considering the widespread and increasing use of biological immunomodulators (biological disease-modifying antirheumatic drugs [bDMARDs]) to treat chronic inflammatory conditions, and the concern that immunomodulation may alter cancer risk and progression, the limited available data on use (...) of these therapies as used in clinical practice and cancer risks are a concern.To assess the risk of incident malignant neoplasms in patients with rheumatoid arthritis (RA) treated with bDMARDs.This was a national register-based prospective cohort study of the public health care system in Sweden from 2006 to 2015. Cohorts of patients with RA initiating treatment with tocilizumab (n = 1798), abatacept (n = 2021), and rituximab (n = 3586), a tumor necrosis factor inhibitor (TNFi) as first-ever (n = 10 782

2017 EvidenceUpdates

168. A Phase III Study Evaluating Continuation, Tapering, and Withdrawal of Certolizumab Pegol After One Year of Therapy in Patients With Early Rheumatoid Arthritis Full Text available with Trip Pro

A Phase III Study Evaluating Continuation, Tapering, and Withdrawal of Certolizumab Pegol After One Year of Therapy in Patients With Early Rheumatoid Arthritis In disease-modifying antirheumatic drug-naive patients with early rheumatoid arthritis (RA) who had achieved sustained low disease activity (a Disease Activity Score in 28 joints using the erythrocyte sedimentation rate of ≤3.2 at both week 40 and week 52) after 1 year of treatment with certolizumab pegol (CZP) at a standard dose (200 mg (...) disability index score of ≤0.5; 71.4% and 70.6% of patients, respectively, versus 57.0%). Safety profiles were similar between all groups, with no new safety signals identified for continuing CZP to week 104. No deaths were reported.The study failed to meet its primary end point. However, there were no clinically meaningful differences between the standard and reduced frequency doses of CZP plus MTX; both controlled RA more effectively than stopping CZP.© 2017 The Authors. Arthritis & Rheumatology

2017 EvidenceUpdates Controlled trial quality: uncertain

169. Case series: Monoarticular rheumatoid arthritis Full Text available with Trip Pro

Case series: Monoarticular rheumatoid arthritis Monoarticular presentation of rheumatoid arthritis is infrequent and has been previously reported to involve large joints such as the hip and knee joints. Here we report a case series of four patients presenting to the University of Michigan in 2015 with monoarticular rheumatoid arthritis, one with small and three with large joint involvement.In total, four patients with monoarticular rheumatoid arthritis were treated in the Division (...) of Rheumatology, University of Michigan. All the patients were retrospectively reviewed with permission from our Institutional Review Board; informed consent was provided by the patients for enrollment in a clinical trial for patients with rheumatoid arthritis. All the patients were assessed using the 2010 ACR/EULAR classification criteria for rheumatoid arthritis.All the patients presented with monoarthritis; three patients had large joint involvement and one had small joint involvement. Serologies were

2017 European journal of rheumatology

170. Tocilizumab (RoACTEMRA) [subcutaneous injection with an auto injector device] for adult patients with moderate to severe active rheumatoid arthritis - after DMARD failure

Tocilizumab (RoACTEMRA) [subcutaneous injection with an auto injector device] for adult patients with moderate to severe active rheumatoid arthritis - after DMARD failure Tocilizumab (RoACTEMRA) [subcutaneous injection with an auto injector device] for adult patients with moderate to severe active rheumatoid arthritis – after DMARD failure | Innovation Observatory toggle menu Menu Search View All Filter by Speciality Filter by Year Filter by Category This search function provides links (...) to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required for our stakeholders. > > > Tocilizumab (RoACTEMRA) [subcutaneous injection with an auto injector device] for adult patients with moderate to severe active rheumatoid arthritis – after DMARD failure Tocilizumab (RoACTEMRA) [subcutaneous injection with an auto injector

2017 NIHR Innovation Observatory

171. Adalimumab impact on fatigue measured by FACIT-F: a study of rheumatoid arthritis patients in Saudi Arabia Full Text available with Trip Pro

Adalimumab impact on fatigue measured by FACIT-F: a study of rheumatoid arthritis patients in Saudi Arabia The objective of the study was to assess the effectiveness of adalimumab as a treatment for fatigue in patients with rheumatoid arthritis (RA).Fatigue was monitored in patients with RA who were already on an adalimumab treatment regimen. Fatigue, general well-being, comorbidities, and disease activity were measured at baseline and ~8, 16, and 24 weeks, thereafter.Significant reductions

2017 Open access rheumatology : research and reviews Controlled trial quality: uncertain

172. Tofacitinib for moderate to severe rheumatoid arthritis

Tofacitinib for moderate to severe rheumatoid arthritis T T ofacitinib for moder ofacitinib for moderate to se ate to sev vere ere rheumatoid arthritis rheumatoid arthritis T echnology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta480 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent the view of NICE, arrived (...) . Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. T ofacitinib for moderate to severe rheumatoid arthritis (TA480) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 22Contents Contents 1 Recommendations 4 2 The technology 6 3 Committee discussion 7

2017 National Institute for Health and Clinical Excellence - Technology Appraisals

173. Similar efficacy and safety of initial COBRA-light and COBRA therapy in rheumatoid arthritis: 4-year results from the COBRA-light trial Full Text available with Trip Pro

Similar efficacy and safety of initial COBRA-light and COBRA therapy in rheumatoid arthritis: 4-year results from the COBRA-light trial To assess the efficacy and safety of initial COBRA-light vs COBRA therapy in RA patients after a 4-year follow-up period.In the COBRA-light trial, 162 consecutive patients with recent-onset RA were randomized to either COBRA-light (prednisolone and MTX) or COBRA therapy (prednisolone, MTX and SSZ) for 1 year. After 1 year, treatment was continued without

2017 EvidenceUpdates

174. [Tofacitinib (rheumatoid arthritis) - benefit assessment according to õ35a Social Code Book V]

[Tofacitinib (rheumatoid arthritis) - benefit assessment according to õ35a Social Code Book V] Tofacitinib (Rheumatoide Arthritis): Nutzenbewertung gemäß § 35a SGB V; Dossierbewertung; Auftrag A17-18 [Tofacitinib (rheumatoid arthritis) - benefit assessment according to §35a Social Code Book V] Tofacitinib (Rheumatoide Arthritis): Nutzenbewertung gemäß § 35a SGB V; Dossierbewertung; Auftrag A17-18 [Tofacitinib (rheumatoid arthritis) - benefit assessment according to §35a Social Code Book V (...) ] Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. Tofacitinib (Rheumatoide Arthritis): Nutzenbewertung gemäß § 35a SGB V; Dossierbewertung; Auftrag A17-18. [Tofacitinib (rheumatoid arthritis) - benefit assessment

2017 Health Technology Assessment (HTA) Database.

175. Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial Full Text available with Trip Pro

Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial High adalimumab serum concentrations do not result in better response in patients with rheumatoid arthritis (RA), suggesting overexposure. We investigated whether patients with adalimumab concentrations >8 µg/mL can prolong their dosing interval by 50% without a clinically relevant change in disease activity.Consecutive

2017 EvidenceUpdates

176. Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid Arthritis Full Text available with Trip Pro

Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid Arthritis Tocilizumab (TCZ) monotherapy has been proven as an effective treatment for rheumatoid arthritis (RA) in clinical trials. However, there are limited data available regarding the effectiveness of TCZ monotherapy in real-world clinical settings in the United States. The objective of this study was to evaluate the impact of TCZ monotherapy on disease activity

2017 Rheumatology and therapy

177. Single-Arm Study of Etanercept in Adult Patients with Moderate to Severe Rheumatoid Arthritis Who Failed Adalimumab Treatment Full Text available with Trip Pro

Single-Arm Study of Etanercept in Adult Patients with Moderate to Severe Rheumatoid Arthritis Who Failed Adalimumab Treatment To evaluate the efficacy and safety of etanercept treatment in adult patients with moderate to severe rheumatoid arthritis (RA) who failed to respond (primary failure) or lost a satisfactory response (secondary failure) to adalimumab.All patients discontinued prior adalimumab treatment and continued methotrexate with etanercept 50 mg once weekly for 24 weeks. The primary

2017 Rheumatology and therapy

178. Rheumatoid arthritis - musculoskeletal ultrasound

Rheumatoid arthritis - musculoskeletal ultrasound Rheumatoid arthritis - musculoskeletal ultrasound Search the full site Search keywords Our on-going projects: SHTG: 006-17 SHTG: 006-17 Contact the SHTG team Contact Healthcare Improvement Scotland with any SHTG questions: Email: Musculoskeletal ultrasound for diagnosis to confirm or rule out a diagnosis of rheumatoid arthritis SHTG advice issued: Date Publication September 2017 Advice Statement 006-17 Evidence Note 69 Downloads Latest advice (...) summary: Advice Statement 006-17 Why is SHTG looking at this topic? This advice has been produced following completion of evidence note 69 by Healthcare Improvement Scotland, in response to an enquiry from the Scottish Society for Rheumatology. Advice for NHSScotland There is evidence from a systematic review of a small number of studies to support the addition of MSUS to clinical assessment and laboratory testing to diagnose rheumatoid arthritis at an earlier stage of the disease. Use of ultrasound

2017 SHTG Advice Statements

179. Clinically stable rheumatoid arthritis - musculoskeletal ultrasound

Clinically stable rheumatoid arthritis - musculoskeletal ultrasound Clinically stable rheumatoid arthritis - musculoskeletal ultrasound Search the full site Search keywords Our on-going projects: SHTG: 007-17 SHTG: 007-17 Contact the SHTG team Contact Healthcare Improvement Scotland with any SHTG questions: Email: Clinically stable rheumatoid arthritis - musculoskeletal ultrasound SHTG advice issued: Date Publication September 2017 Advice Statement 007-17 Evidence Note 70 Downloads Latest (...) advice summary: Advice Statement 007-17 Why is SHTG looking at this topic? This advice has been produced following completion of evidence note 70 by Healthcare Improvement Scotland, in response to an enquiry from the Scottish Society for Rheumatology. Advice for NHSScotland A meta-analysis based on seven observational studies suggests that MSUS is clinically effective in predicting relapse or progression of joint damage in rheumatoid arthritis patients in clinical remission. Evidence from three

2017 SHTG Advice Statements

180. Long-term outcomes and secondary prevention after acute coronary events in patients with rheumatoid arthritis (Abstract)

Long-term outcomes and secondary prevention after acute coronary events in patients with rheumatoid arthritis Patients with rheumatoid arthritis (RA) are at increased risk of acute coronary syndrome (ACS) and suffer from poorer short-term outcomes after ACS. The aims of this study were to assess long-term outcomes in patients with RA with ACS compared with non-RA patients with ACS, and to investigate whether the use of secondary preventive drugs could explain any differences in ACS outcome.We

2017 EvidenceUpdates