Latest & greatest articles for sepsis

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Top results for sepsis

301. Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock

Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2008 PedsCCM Evidence-Based Journal Club

302. Thymosin alpha(1)- and Ulinastatin-Based Immunomodulatory Strategy for Sepsis Arising from Intra-Abdominal Infection Due to Carbapenem-Resistant Bacteria Full Text available with Trip Pro

Thymosin alpha(1)- and Ulinastatin-Based Immunomodulatory Strategy for Sepsis Arising from Intra-Abdominal Infection Due to Carbapenem-Resistant Bacteria The aim of this study was to evaluate the potential efficacy of therapy with thymosin alpha(1) and ulinastatin for patients with sepsis due to carbapenem-resistant bacteria.Prospective, randomized, parallel controlled clinical study.A total of 120 patients received a diagnosis of sepsis caused by infection with carbapenem-resistant bacteria

2008 EvidenceUpdates Controlled trial quality: uncertain

303. Outcome of severe sepsis in pediatric oncology patients

Outcome of severe sepsis in pediatric oncology patients PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2008 PedsCCM Evidence-Based Journal Club

304. Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2008 PedsCCM Evidence-Based Journal Club

305. Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study

Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2008 PedsCCM Evidence-Based Journal Club

306. Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients (Abstract)

Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients To assess the diagnostic utility of combining measurement of blood procalcitonin (PCT) concentrations with the presence of a biphasic transmittance waveform (BPW) from the activated partial thromboplastin time (aPTT) to identify sepsis in critically ill patients.Prospective observational study.Thirty-one-bed university hospital department of medico-surgical intensive (...) care.Two hundred consecutive adult patients admitted to the department during a 3-month period.aPTT waveform analysis was performed on admission and daily throughout the intensive care unit (ICU) stay. Receiver operating characteristic curves were created to determine the best threshold values of BPW and PCT for prediction of sepsis. Of the 200 patients, 63 (32%) had sepsis during the ICU stay; 29 (15%) patients were diagnosed with sepsis at admission. Using a threshold value of BPW slope_1 = -0.075%T

2008 EvidenceUpdates

307. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. Full Text available with Trip Pro

Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. Concern exists that current guidelines for care of patients with severe sepsis and septic shock are followed variably, possibly due to a lack of adequate education.To determine whether a national educational program based on the Surviving Sepsis Campaign guidelines affected processes of care and hospital mortality for severe sepsis.Before and after design in 59 medical-surgical intensive (...) care units (ICUs) located throughout Spain. All ICU patients were screened daily and enrolled if they fulfilled severe sepsis or septic shock criteria. A total of 854 patients were enrolled in the preintervention period (November-December 2005), 1465 patients during the postintervention period (March-June 2006), and 247 patients during the long-term follow-up period 1 year later (November-December 2006) in a subset of 23 ICUs.The educational program consisted of training physicians and nursing

2008 JAMA

308. Probable early-onset group B streptococcal neonatal sepsis: a serious clinical condition related to intrauterine infection (Abstract)

Probable early-onset group B streptococcal neonatal sepsis: a serious clinical condition related to intrauterine infection The estimated incidence of true early-onset group B streptococcal (GBS) neonatal infection is based on positive GBS blood or cerebrospinal fluid (CSF) culture results, but the real burden of disease is underestimated owing to the high incidence of culture-negative sepsis possibly because of antibiotic administration to the mother.To examine the rate of probable early-onset (...) GBS neonatal sepsis and to assess its impact on total GBS neonatal disease.A multicentre longitudinal prospective surveillance of 107,021 deliveries.The rates of culture-proven and probable early-onset GBS sepsis were 0.39 and 0.47 per 1000 live births, respectively. Of great concern was the finding of three deaths related to the infection in the group with probable early-onset GBS sepsis.The use of chemoprophylaxis in GBS-colonised pregnant women, especially when it is incomplete, may

2008 EvidenceUpdates

309. Validation of the Mortality in Emergency Department Sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS). (Abstract)

Validation of the Mortality in Emergency Department Sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS). To prospectively and externally validate the Mortality in Emergency Department Sepsis (MEDS) score as a predictor of 28-day mortality in patients who present to the emergency department with a systemic inflammatory response syndrome.Multicentered prospective cohort study.Emergency departments at the University of Colorado Hospital and Denver Health Medical

2008 EvidenceUpdates

310. Guidelines for the prevention of sepsis in asplenic and hyposplenic patients (Abstract)

Guidelines for the prevention of sepsis in asplenic and hyposplenic patients Asplenic or hyposplenic patients are at risk of fulminant sepsis. This entity has a mortality of up to 50%. The spectrum of causative organisms is evolving as are recommended preventive strategies, which include education, prophylactic and standby antibiotics, preventive immunizations, optimal antimalarial advice when visiting endemic countries and early management of animal bites. However, there is evidence (...) that adherence to these strategies is poor. Consensus-updated guidelines have been developed to help Australian and New Zealand clinicians and patients in the prevention of sepsis in asplenic and hyposplenic patients.

2008 Clinical Practice Guidelines Portal

311. Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke”

Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke” Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke” – Clinical Correlations Search Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke” January 28, 2009 3 min read | | Sites We Follow: Useful Links: Questions? Comments? Contact us! © New York University. All rights reserved. Electronic ISSN 1944-0030. The content of this site is intended

2008 Clinical Correlations

312. Corticosteroids in Sepsis Now Less Stimulating

Corticosteroids in Sepsis Now Less Stimulating Corticosteroids in Sepsis Now Less Stimulating – Clinical Correlations Search Corticosteroids in Sepsis Now Less Stimulating April 30, 2008 4 min read Commentary by Joe Philip MD, PGY-2 CORTICUS was the long-awaited trial addressing the use of corticosteroids in sepsis that was this past January. Months prior to the leading auther Charles Sprung publishing it, the Tisch and Bellevue intensive care units halted corticotropin stimulation testing (...) . Corticosteroids have warranted much publicity since CORTICUS came out—and rightly so as practice across the country has changed because of it. The Survinig Sepsis Campaign has now downgraded the recommendation on the use of corticosteroids in sepsis from C down to 2C based on this trial, which did not show a mortality benefit in those with septic shock. Should practice change as a result? Don’t get me wrong, I was thrilled as an intern when I realized that I didn’t have to jump from bed 1 to bed 6 to bed 13

2008 Clinical Correlations

313. Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis

Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2008 DARE.

314. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. Full Text available with Trip Pro

Intensive insulin therapy and pentastarch resuscitation in severe sepsis. The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids.In a multicenter, two-by-two factorial trial, we randomly assigned patients with severe sepsis to receive either intensive insulin therapy to maintain euglycemia or conventional insulin (...) renal failure and renal-replacement therapy than was Ringer's lactate.The use of intensive insulin therapy placed critically ill patients with sepsis at increased risk for serious adverse events related to hypoglycemia. As used in this study, HES was harmful, and its toxicity increased with accumulating doses. (ClinicalTrials.gov number, NCT00135473.)2008 Massachusetts Medical Society

2008 NEJM Controlled trial quality: uncertain

315. REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial

REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2008 PedsCCM Evidence-Based Journal Club

316. Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker (Abstract)

Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker The goal was to determine the utility of neutrophil CD64 as a diagnostic marker for sepsis in neonates.A prospective study that enrolled consecutive infants with suspected sepsis was performed. Complete blood count with differential, blood culture, and CD64 index measurement were performed, and neutrophil CD64 indices were correlated with the diagnoses of confirmed and suspected sepsis.There were 293 episodes (...) of sepsis evaluations for 163 infants. Infants with sepsis episodes (confirmed or suspected; n = 40) were of greater gestational age (34.7 +/- 0.9 weeks), compared with those (n = 123) with no sepsis (32.6 +/- 0.5 weeks), but had similar birth weights (2325 +/- 200 vs 1969 +/- 94 g) and Apgar scores at 1 and 5 minutes. There was no difference in the duration of hospitalization for the 2 groups. As expected, the hematologic profiles of sepsis episodes (n = 128) were characterized by higher white blood

2008 EvidenceUpdates

317. Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients.

Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients. PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2007 PedsCCM Evidence-Based Journal Club

318. Drotrecogin alfa (activated protein C) use for adult patients with sepsis.

Drotrecogin alfa (activated protein C) use for adult patients with sepsis. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines and Measures Funding

2007 University of Pennsylvania Health System

319. Decreased a disintegrin-like and metalloprotease with thrombospondin (ADAMTS)-13 is associated with a poor prognosis in sepsis-induced organ failure*. (Abstract)

Decreased a disintegrin-like and metalloprotease with thrombospondin (ADAMTS)-13 is associated with a poor prognosis in sepsis-induced organ failure*.

2007 EvidenceUpdates

320. Selenium in Intensive Care (SIC) study: Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock

Selenium in Intensive Care (SIC) study: Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2007 PedsCCM Evidence-Based Journal Club