Latest & greatest articles for sepsis

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Top results for sepsis

141. Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis Full Text available with Trip Pro

Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding (...) protein 7 in this population.In this ancillary analysis, we included patients with sepsis who were enrolled in either of two trials including 39 ICUs across Europe and North America. The primary endpoint was moderate-severe acute kidney injury (equivalent to Kidney Disease Improving Global Outcome stage 2-3) within 12 hours of enrollment. We assessed biomarker performance by calculating the area under the receiver operating characteristic curve, sensitivity, specificity, and negative and positive

2016 EvidenceUpdates

142. Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial Full Text available with Trip Pro

Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear.To determine whether high-dose intravenous sodium selenite treatment and procalcitonin (...) -guided anti-infectious therapy in patients with severe sepsis affect mortality.The Placebo-Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT), a multicenter, randomized, clinical, 2 × 2 factorial trial performed in 33 intensive care units in Germany, was conducted from November 6, 2009, to June 6, 2013, including a 90-day follow-up period.Patients were randomly assigned to receive an initial intravenous loading dose of sodium selenite, 1000 µg

2016 EvidenceUpdates Controlled trial quality: predicted high

143. Clinical Criteria to Identify Patients With Sepsis Full Text available with Trip Pro

Clinical Criteria to Identify Patients With Sepsis 27458952 2016 08 22 2018 12 02 1538-3598 316 4 2016 Jul 26 JAMA JAMA Clinical Criteria to Identify Patients With Sepsis. 453 10.1001/jama.2016.6407 Makam Anil N AN Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Nguyen Oanh Kieu OK Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. eng KL2 TR001103 TR NCATS NIH HHS United States R24 HS022418 HS AHRQ HHS United (...) States Letter Comment United States JAMA 7501160 0098-7484 AIM IM JAMA. 2016 Jul 26;316(4):454 27458955 JAMA. 2016 Feb 23;315(8):762-74 26903335 Female Hospital Mortality Humans Male Organ Dysfunction Scores Sepsis diagnosis mortality 2016 7 27 6 0 2016 7 28 6 0 2016 8 23 6 0 ppublish 27458952 2536624 10.1001/jama.2016.6407 PMC5349293 NIHMS850954 Circulation. 2007 Feb 20;115(7):928-35 17309939 Circ Cardiovasc Qual Outcomes. 2014 Sep;7(5):778-9 25097213 JAMA. 2016 Feb 23;315(8):762-74 26903335 JAMA

2016 JAMA

144. Sepsis: the LightCycler SeptiFast Test MGRADE©, SepsiTestT and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi - a systematic review and economic evaluation

Sepsis: the LightCycler SeptiFast Test MGRADE©, SepsiTestT and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi - a systematic review and economic evaluation Sepsis: the LightCycler SeptiFast Test MGRADE®, SepsiTest™ and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi – a systematic review and economic evaluation Sepsis: the LightCycler SeptiFast Test MGRADE®, SepsiTest™ and IRIDICA BAC BSI assay for rapidly identifying bloodstream (...) , McMullan R, Dark P. Sepsis: the LightCycler SeptiFast Test MGRADE®, SepsiTest™ and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi – a systematic review and economic evaluation. Health Technology Assessment 2016; 20(46) Authors' objectives To determine the clinical effectiveness and cost-effectiveness of three tests [LightCycler SeptiFast Test MGRADE® (Roche Diagnostics, Risch-Rotkreuz, Switzerland); SepsiTestTM (Molzym Molecular Diagnostics, Bremen, Germany

2016 Health Technology Assessment (HTA) Database.

145. Sepsis: recognition, diagnosis and early management

Sepsis: recognition, diagnosis and early management Sepsis: recognition, diagnosis and early Sepsis: recognition, diagnosis and early management management NICE guideline Published: 13 July 2016 nice.org.uk/guidance/ng51 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration (...) be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Sepsis: recognition, diagnosis and early management (NG51) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 50Contents Contents Overview 4 Who

2016 National Institute for Health and Clinical Excellence - Clinical Guidelines

146. Hypopyon and Klebsiella Sepsis. (Abstract)

Hypopyon and Klebsiella Sepsis. 27355556 2016 07 07 2016 06 30 1533-4406 374 26 2016 Jun 30 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Hypopyon and Klebsiella Sepsis. e33 10.1056/NEJMicm1509932 Mustafa Osama M OM Alfaisal University, Riyadh, Saudi Arabia omustafa@alfaisal.edu. Aduriz-Lorenzo Patricio M PM Dubai Hospital, Dubai, United Arab Emirates. eng Case Reports Journal Article United States N Engl J Med 0255562 0028-4793 AIM IM Anterior Eye Segment

2016 NEJM

147. Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. Full Text available with Trip Pro

Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial. Survivors of sepsis face long-term sequelae that diminish health-related quality of life and result in increased care needs in the primary care setting, such as medication, physiotherapy, or mental health care.To examine if a primary care-based intervention improves mental health-related quality of life.Randomized clinical trial conducted between (...) February 2011 and December 2014, enrolling 291 patients 18 years or older who survived sepsis (including septic shock), recruited from 9 intensive care units (ICUs) across Germany.Participants were randomized to usual care (n = 143) or to a 12-month intervention (n = 148). Usual care was provided by their primary care physician (PCP) and included periodic contacts, referrals to specialists, and prescription of medication, other treatment, or both. The intervention additionally included PCP and patient

2016 JAMA Controlled trial quality: predicted high

148. Liver Abscess Associated Sepsis Caused by Fish Bone Ingestion Full Text available with Trip Pro

Liver Abscess Associated Sepsis Caused by Fish Bone Ingestion 28868489 2018 11 13 2341-4545 23 6 2016 Nov-Dec GE Portuguese journal of gastroenterology GE Port J Gastroenterol Liver Abscess Associated Sepsis Caused by Fish Bone Ingestion. 322-323 10.1016/j.jpge.2016.03.006 Peixoto Armando A Gastroenterology Department, Centro Hospitalar de São João, Porto, Portugal. Gonçalves Regina R Gastroenterology Department, Centro Hospitalar de São João, Porto, Portugal. Macedo Guilherme G (...) Gastroenterology Department, Centro Hospitalar de São João, Porto, Portugal. eng Journal Article 2016 06 21 Switzerland GE Port J Gastroenterol 101685861 2387-1954 Fishes Foreign Bodies Liver Abscess Sepsis 2016 02 12 2016 03 13 2017 9 5 6 0 2016 6 21 0 0 2016 6 21 0 1 epublish 28868489 10.1016/j.jpge.2016.03.006 S2341-4545(16)30024-2 PMC5580013 Lancet. 2002 Mar 16;359(9310):977 11918943 Klin Khir. 1992;(11):75-6 1296086 Clin Infect Dis. 2005 Dec 1;41(11):1689-90 16267752 ANZ J Surg. 2011 Mar;81(3):206

2016 GE Portuguese journal of gastroenterology

149. Risk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study (Abstract)

Risk of Recurrence After Surviving Severe Sepsis: A Matched Cohort Study To examine the risk of recurrence in adults who survived first-episode severe sepsis for at least 3 months.A matched cohort study.Inpatient claims data from Taiwan's National Health Insurance Research Database.We analyzed 10,818 adults who survived first-episode severe sepsis without recurrence for at least 3 months in 2000 (SS group; mean age, 62.7 yr; men, 54.7%) and a group of age/sex-matched (1:1) population controls (...) who had no prior history of severe sepsis. All subjects were followed from the study entry to the occurrence of end-point, death, or until December 31, 2008, whichever date came first.None.Primary end-point was severe sepsis that occurred after January 1, 2001 (the study entry). Relative risk of the end-point was assessed using competing risk regression model. During the follow-up period, severe sepsis and death occurred in 35.0% and 26.5% of SS group and in 4.3% and 18.6% of controls

2016 EvidenceUpdates

150. A Multicenter Randomized Trial of Continuous versus Intermittent ?-Lactam Infusion in Severe Sepsis

A Multicenter Randomized Trial of Continuous versus Intermittent ?-Lactam Infusion in Severe Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

151. Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient Full Text available with Trip Pro

Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient A 61-year-old man with an unremarkable medical history was admitted with fever 7 days after being bitten by his dog. On day 3, he showed altered mental status, and laboratory data showed progressive hemolytic anemia, thrombocytopenia, hyperbilirubinemia, renal dysfunction, coagulopathy, and schistocytosis. Severe sepsis complicated with thrombotic microangiopathy caused (...) by Capnocytophaga canimorsus was suspected.Plasma exchange was applied to treat the thrombotic microangiopathy and resulted in platelet count increase and improved renal function, hyperbilirubinemia, and schistocytosis. Blood culture results confirmed the presence of C. canimorsus. The patient was discharged in good condition.Capnocytophaga canimorsus is rare cause of severe sepsis, and should be suspected even in immunocompetent patients with dog-bite history. Capnocytophaga canimorsus infection may

2016 Acute medicine & surgery

152. Sepsis: pathophysiology and clinical management. Full Text available with Trip Pro

Sepsis: pathophysiology and clinical management. Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune dysfunction and catabolism. Much has been learnt (...) about the pathogenesis of sepsis at the molecular, cell, and intact organ level. Despite uncertainties in hemodynamic management and several treatments that have failed in clinical trials, investigational therapies increasingly target sepsis induced organ and immune dysfunction. Outcomes in sepsis have greatly improved overall, probably because of an enhanced focus on early diagnosis and fluid resuscitation, the rapid delivery of effective antibiotics, and other improvements in supportive care

2016 BMJ

153. Late mortality after sepsis: propensity matched cohort study. Full Text available with Trip Pro

Late mortality after sepsis: propensity matched cohort study.  To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself. Observational cohort study. US Health and Retirement Study. 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients admitted with non-sepsis infection, and 504 (...) patients admitted with acute sterile inflammatory conditions. Late (31 days to two years) mortality and odds of death at various intervals. Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute increase relative to patients admitted with sterile inflammatory conditions (P

2016 BMJ

154. Splenic volume in severe sepsis is associated with disease severity and pneumococcal infection Full Text available with Trip Pro

Splenic volume in severe sepsis is associated with disease severity and pneumococcal infection A small spleen, which is occasionally found in patients with pneumococcal sepsis, may increase pneumococcal susceptibility because of splenic malfunction. However, a small spleen may also originate from severe disease. We carried out a retrospective study to evaluate the association between splenic volume and severe pneumococcal sepsis or disease severity.We reviewed the medical records of 23 patients (...) with severe pneumococcal sepsis treated at our institution between January 2004 and September 2015 (pneumococcal group) and 61 patients with severe non-pneumococcal bacteremia treated between April 2011 and September 2015 (control group). Splenic volume measured by abdominal computed tomography on admission was compared between the two groups. Correlations between Acute Physiology and Chronic Health Evaluation (APACHE) II scores and splenic volume on admission and the change in splenic volume from the non

2016 Acute medicine & surgery

155. Delayed Antimicrobial Therapy Increases Mortality and Organ Dysfunction Duration in Pediatric Sepsis

Delayed Antimicrobial Therapy Increases Mortality and Organ Dysfunction Duration in Pediatric Sepsis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

156. Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis

Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

157. Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. Full Text available with Trip Pro

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. Sepsis is considered to induce immune suppression, leading to increased susceptibility to secondary infections with associated late mortality.To determine the clinical and host genomic characteristics, incidence, and attributable mortality of intensive care unit (ICU)-acquired infections in patients admitted to the ICU with or without sepsis.Prospective (...) observational study comprising consecutive admissions of more than 48 hours in 2 ICUs in the Netherlands from January 2011 to July 2013 stratified according to admission diagnosis (sepsis or noninfectious).The primary outcome was ICU-acquired infection (onset >48 hours). Attributable mortality risk (fraction of mortality that can be prevented by elimination of the risk factor, acquired infection) was determined using time-to-event models accounting for competing risk. In a subset of sepsis admissions (n

2016 JAMA

158. Modified early warning scoring (MEWS): evaluating the evidence for tool inclusion of sepsis screening criteria and impact on mortality and failure to rescue (Abstract)

Modified early warning scoring (MEWS): evaluating the evidence for tool inclusion of sepsis screening criteria and impact on mortality and failure to rescue To evaluate current research evidence reporting outcomes from modified early warning scoring system tools utilisation to prevent failure to rescue in hospitalised adult medical-surgical/telemetry patients.Early sepsis detection exhibits clinical significance to practitioners and patients. Thorough and timely clinical observations, along (...) in detection of inpatients at-risk for clinical deterioration, limited high-level data and no clinical trials linking use of modified early warning scoring system tool usage to robust outcomes were found. Established criteria for validating modified early warning scoring system criteria, organisational-specific reliability testing and multi-site trials are recommended.Development of all-cause illness screening tools, including sepsis, is imperative. The clinical picture may be quantified with scoring tools

2016 EvidenceUpdates

159. Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock

Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club

160. The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis

The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2016 PedsCCM Evidence-Based Journal Club