Latest & greatest articles for side effects

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Top results for side effects

1. The efficacy of intravenous lidocaine and its side effects in comparison with intravenous morphine sulfate in patients admitted to the ED with right upper abdominal pain suspected of biliary colic

The efficacy of intravenous lidocaine and its side effects in comparison with intravenous morphine sulfate in patients admitted to the ED with right upper abdominal pain suspected of biliary colic The efficacy of intravenous lidocaine and its side effects in comparison with intravenous morphine sulfate in patients admitted to the ED with right upper abdominal pain suspected of biliary colic - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete (...) -6757(20)30238-2. doi: 10.1016/j.ajem.2020.04.010. Online ahead of print. The efficacy of intravenous lidocaine and its side effects in comparison with intravenous morphine sulfate in patients admitted to the ED with right upper abdominal pain suspected of biliary colic , , , , Affiliations Expand Affiliations 1 Emergency Medicine Department, Tehran University of Medical Sciences, Tehran, Iran. 2 Pre-Hospital and Hospital Emergency Research Center, Emergency Medicine Department, Tehran University

2020 EvidenceUpdates

2. Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma. (Abstract)

Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma. Gliomas are brain tumours arising from glial cells with an annual incidence of 4 to 11 people per 100,000. In this review we focus on gliomas with low aggressive potential in the short term, i.e. low-grade gliomas. Most people with low-grade gliomas are treated with surgery and may receive radiotherapy thereafter. However, there is concern about the possible long-term effects (...) of radiotherapy, especially on neurocognitive functioning.To evaluate the long-term neurocognitive and other side effects of radiotherapy (with or without chemotherapy) compared with no radiotherapy, or different types of radiotherapy, among people with glioma (where 'long-term' is defined as at least two years after diagnosis); and to write a brief economic commentary.We searched the following databases on 16 February 2018 and updated the search on 14 November 2018: Cochrane Central Register of Controlled

2019 Cochrane

3. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects

Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports (...) of disabling and potentially long-lasting or irreversible side effects Disabling, long-lasting or potentially irreversible adverse reactions affecting musculoskeletal and nervous systems have been reported very rarely with fluoroquinolone antibiotics. Fluoroquinolone treatment should be discontinued at the first signs of a serious adverse reaction, including tendon pain or inflammation. Published 21 March 2019 From: Therapeutic area: , , , , , , , , , , , , , Contents Advice for healthcare professionals

2019 MHRA Drug Safety Update

4. Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial Full Text available with Trip Pro

Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial To evaluate the effectiveness of automated symptom and side effect monitoring on quality of life among individuals with symptomatic diabetic peripheral neuropathy.We conducted a pragmatic, cluster randomized controlled trial (July 2014 to July 2016) within a large healthcare system. We randomized (...) 1834 primary care physicians and prospectively recruited from their lists 1270 individuals with neuropathy who were newly prescribed medications for their symptoms. Intervention participants received automated telephone-based symptom and side effect monitoring with physician feedback over 6 months. The control group received usual care plus three non-interactive diabetes educational calls. Our primary outcomes were quality of life (EQ-5D) and select symptoms (e.g. pain) measured 4-8 weeks after

2019 EvidenceUpdates

5. Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study

Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study | Evidence-Based Mental Health Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study Article Text Original article Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study Catherine Henshall , Andrea Cipriani , David Ruvolo , Orla Macdonald , Leona Wolters , Ivan Koychev Statistics from Altmetric.com

2019 Evidence-Based Mental Health

6. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature (Abstract)

Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature This review provides an overview of the role of long-term treatment of severe asthma with oral corticosteroids (OCS) and its associated side-effects in adults. It is based on a systematic literature search conducted in MEDLINE, Embase and the Cochrane Library to identify relevant studies. After a short overview of severe asthma and its (...) treatment we present studies showing a dose-response relationship in asthmatic patients treated with OCS and then consider by organ systems the undesired effects demonstrated in clinical and epidemiological studies in patients with OCS-dependent asthma. It was found that the risk of developing various OCS-related complications, including infections, diabetes and osteoporosis as well as psychiatric disorders, was higher for patients with long-term exposure to OCS compared with control groups. In addition

2018 EvidenceUpdates

7. Safety and Side Effects of Rifampin versus Isoniazid in Children. Full Text available with Trip Pro

Safety and Side Effects of Rifampin versus Isoniazid in Children. The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been shown to be safer and to have higher (...) completion rates than 9 months of isoniazid.In this multicenter, open-label trial, we randomly assigned 844 children (<18 years of age) with latent M. tuberculosis infection to receive either 4 months of rifampin or 9 months of isoniazid. The primary outcome was adverse events of grade 1 to 5 that resulted in the permanent discontinuation of a trial drug. Secondary outcomes were treatment adherence, side-effect profile, and efficacy. Independent review panels whose members were unaware of trial-group

2018 NEJM Controlled trial quality: predicted high

8. Side effects

Side effects Top results for side effects - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for side effects The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

9. Second-generation antipsychotics and metabolic side-effects: Canadian population-based study Full Text available with Trip Pro

Second-generation antipsychotics and metabolic side-effects: Canadian population-based study Use of second-generation antipsychotics (SGA) has increased in recent years; however, their use and effect on metabolic outcomes has been poorly characterised in population-level studies.AimsThis study aimed to determine the associations between SGA use and metabolic indicators in a general population.We used data from the Canadian Health Measures Survey, a cross-sectional survey of Canadian households

2018 BJPsych open

10. Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial Full Text available with Trip Pro

Slow Infusion of Low-dose Ketamine Reduces Bothersome Side Effects Compared to Intravenous Push: A Double-blind, Double-dummy, Randomized Controlled Trial We compared the analgesic efficacy and incidence of side effects when low-dose (0.3 mg/kg) ketamine (LDK) is administered as a slow infusion (SI) over 15 minutes versus an intravenous push (IVP) over 1 minute.This was a prospective, randomized, double-blind, double-dummy, placebo-controlled trial of adult ED patients presenting with moderate (...) to severe pain (numerical rating scale [NRS] score ≥ 5). Patients received 0.3 mg/kg ketamine administered either as a SI or a IVP. Our primary outcome was the proportion of patients experiencing any psychoperceptual side effect over 60 minutes. A secondary outcome was incidence of moderate or greater psychoperceptual side effects. Additional outcomes included reduction in pain NRS scores at 60 minutes and percent maximum summed pain intensity difference (%SPID).Fifty-nine participants completed

2018 EvidenceUpdates

11. Early and Late Onset Side Effects of Photodynamic Therapy Full Text available with Trip Pro

Early and Late Onset Side Effects of Photodynamic Therapy Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases. One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects. Erythema, pain, burns, edema, itching, desquamation, and pustular formation, often in association with each other, are frequently

2018 Biomedicines

12. Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines

Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines Half-Side Application for Transdermal Patches: Clinical Effectiveness and Guidelines Last updated: March 22, 2018 Project Number: RB1203-000 Product Line: Research Type: Drug Report Type: Summary (...) of Abstracts Result type: Report Question What is the clinical effectiveness of the administration of transdermal patches using the half-side application procedure for any patient? What are the evidence-based guidelines regarding the administration of transdermal patches for any patient? Key Message No relevant literature was identified regarding the administration of transdermal patches using the half-side application procedure for any patient. Files Rapid Response Summary of Abstracts Published : March

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness

Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness | CADTH.ca Find the information you need Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Side Effect Free Chemotherapy for the Treatment of Cancer: Clinical Effectiveness Last updated: August 14, 2018 Project Number: RA0963-000 Product Line: Research Type: Drug Report Type: Reference List Result type (...) : Report Question What is the clinical effectiveness of 'side-effect-free' chemotherapy for the treatment of any type of cancer? Key Message No relevant literature was identified regarding the clinical effectiveness of 'side-effect-free' chemotherapy for the treatment of any type of cancer. Files Rapid Response Reference List Published : August 16, 2018 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter:

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. “Side effects affected my daily activities a lot”: a qualitative exploration of the impact of contraceptive side effects in Bangladesh Full Text available with Trip Pro

“Side effects affected my daily activities a lot”: a qualitative exploration of the impact of contraceptive side effects in Bangladesh In a country like Bangladesh that has made great progress in contraceptive use with one of the lowest levels of fertility and highest levels of contraceptive use, understanding what factors influence women's decisions to discontinue a contraceptive method and not switch to a new method is critical in designing interventions and programs that will help enable (...) Bangladesh to reach its FP2020 goals. Research on side effects has focused on physical manifestations like headaches, moodiness, abdominal pain, and menstrual irregularities. While physical effects alone may stop women from continuing a contraceptive method, less is known about how side effects influence women's daily activities and lives. The purpose of this study is to understand the ways that side effects affect Bangladeshi women's participation in different social settings.Thirty-five in-depth

2017 Open access journal of contraception

15. e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns

e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns - GOV.UK GOV.UK uses cookies to make the site simpler. Search e-cigarettes and refill containers (e-liquids): report suspected side effects and safety concerns Use the Yellow Card Reporting Scheme to support the safety of e-cigarettes and refill containers (e-liquids). Published 21 June 2017 From (...) : Contents What and how to report Members of the public and healthcare professionals can use the to report any suspected side effects or safety concerns with e-cigarettes and the e-liquids used for vaping. These issues could include: • suspected side-effects that occurred after the use of e-cigarettes and e-liquids • harm to children or non-users, including accidental poisoning • safety issues or defects with e-cigarette devices Your information will aid us in identifying previously unrecognised side

2017 MHRA Drug Safety Update

16. [How to evaluate side effects in a clinical trial?] (Abstract)

[How to evaluate side effects in a clinical trial?] Adverse effects of psychotropic medications must be systematically assessed during a clinical trial. This systematic and mandatory evaluation, for the patient safety first, will also allow to establish for the tested molecule, an efficiency/tolerance ratio which could be compared to preexisting medications, and guide the clinician prescriptions. These side effects are closely related to the pharmacological profile of the tested molecule (...) , in particular its monoamine binding profile. Antipsychotics are taken as an example, with a focus on classical clinical side effects related to each monoamine transmission blocking.© L’Encéphale, Paris, 2016.

2017 L'Encephale

17. Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site?

Are side effects reduced if practice nurses administer the intramuscular (IM) contraceptive injection via the ventrogluteal site compared to the dorsogluteal site? Getting Evidence in Clinical Practice: General Practice Nurse Evidence Based Practice (CAT group) Date: May 2017 CAT Lead: Gwenllian Wynne-Jones and Katherine Gatensbury Date CAT completed: May 2017 Email: g.wynne-jones@keele.ac.uk Date CAT to be reviewed: May 2018 Clinical bottom line There is no evidence regarding side effects (...) ? The use of intramuscular injections is very common in nursing practice, and is the standard method for the administration of the contraceptive injection. However, there is little guidance relating to the most appropriate intramuscular injection site and debate on whether the dorsogluteal or ventrogluteal site is associated with fewer side effects. Search timeframe From each databases inception to March 2017. Inclusion criteria Description Search terms Population and setting Adult women wanting to use

2017 Home Modification Information Clearinghouse

18. Evidence of ocular side effects of SSRIs and new warnings

Evidence of ocular side effects of SSRIs and new warnings Evidence of ocular side effects of SSRIs and new warnings | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name (...) or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Evidence of ocular side effects of SSRIs and new warnings Article Text Outcomes Evidence of ocular side effects of SSRIs and new warnings Julia Kirkham , Dallas Seitz Statistics from Altmetric.com ABSTRACT FROM: Chen H , Lin C , Lai S , et al . Association of selective

2017 Evidence-Based Mental Health

19. Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association Full Text available with Trip Pro

Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association Fatty acid amide hydrolase (FAAH) is a promising therapeutic target for the treatment of pain and CNS disorders. However, the development of potent and safe FAAH inhibitors is hindered by their off-target mediated side effect that leads to brain cell death. Its physiological off-targets (...) and their associations with phenotypes may not be characterized using existing experimental and computational techniques as these methods fail to have sufficient proteome coverage and/or ignore native biological assemblies (BAs; i.e., protein quaternary structures). To understand the mechanisms of the side effects from FAAH inhibitors and other drugs, we develop a novel structural phenomics approach to identifying the physiological off-targets binding profile in the cellular context and on a structural proteome

2016 NPJ systems biology and applications

20. Use of acupuncture to alleviate side effects in radiation oncology: Current evidence and future directions Full Text available with Trip Pro

Use of acupuncture to alleviate side effects in radiation oncology: Current evidence and future directions Several reports have shown that acupuncture is an effective method of complementary medicine; however, only a few of these reports have focused on oncological patients treated with radiation therapy. Most of these studies discuss a benefit of acupuncture for side-effect reduction; however, not all could demonstrate significant improvements. Thus, innovative trial designs are necessary (...) to confirm that acupuncture can alleviate side effects related to radiation therapy. In the present manuscript, we perform a broad review and discuss pitfalls and limitations of acupuncture in parallel with standard radiation therapy, which lead the way to novel treatment concepts.

2016 Advances in radiation oncology