Latest & greatest articles for side effects

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Top results for side effects

81. Umbilical artery catheters in the newborn: effects of catheter design (end vs side hole). Full Text available with Trip Pro

Umbilical artery catheters in the newborn: effects of catheter design (end vs side hole). This section is under preparation and will be included in the next issue.To determine whether the design of an umbilical arterial catheter influences the frequency of ischemic events, aortic thrombosis, intraventricular hemorrhage, mortality or necrotising enterocolitis in newborn infants.Randomized and quasi randomized controlled trials of umbilical catheterization use were obtained from the following (...) sources: 1. Effective Care of the Newborn Infant, edited by JC Sinclair and MB Bracken. 2. Medline Search using Melvyl Medline Plus and the keyword headings 'Umbilic#', 'Catheter#' and subject heading 'Infant, Newborn' 3. Search of personal data filesRandomized trials in newborn infants of any birthweight or gestation. Comparison of end hole catheters with side hole catheters. Clinically important end points such as ischemic events or aortic thrombosis.There appears to be only a single trial which has

2000 Cochrane

82. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. (Abstract)

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. To assess the effects of folic acid and folinic acid in reducing the mucosal and gastrointestinal (GI) and haematologic side effects of low-dose of Methotrexate (MTX) in patients with Rheumatoid Arthritis (RA) and to determine whether or not folate supplementation alters MTX efficacy.We searched the Cochrane Controlled Clinical Trial's Register (CCTR), the Cochrane Musculoskeletal (...) criteria. The total sample included 307 patients, of which 147 were treated with folate supplementation, 80 patients with folinic acid and 67 patients with folic acid. A 79% reduction in mucosal and GI side effects was observed for folic acid [OR = 0.21 (95% CI 0.10 to 0.44)]. For folinic acid, a clinically but non-statistically significant reduction of 43% was found [OR = 0. 57 (95% CI 0.28 to 1.15)]. No major differences were observed between low and high doses of folic or folinic acid. Haematologic

2000 Cochrane

83. The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction Full Text available with Trip Pro

The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction HS Osman, HI Rashid, N Sathananthan, MC Parker Record Status This is a critical abstract of an economic evaluation that meets the criteria (...) for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study evaluated the cost-effectiveness of self-expanding metal stents to treat acute left-sided large bowel obstruction in colorectal carcinoma. The authors concluded that stenting showed reduction in hospital stay and costs, but further analysis was necessary due to small sample size

2000 NHS Economic Evaluation Database.

84. Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. (Abstract)

Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomised trial. Radical radiotherapy is commonly used to treat localised prostate cancer. Late chronic side-effects limit the dose that can be given, and may be linked to the volume of normal tissues irradiated. Conformal radiotherapy allows a smaller amount of rectum and bladder to be treated, by shaping the high-dose volume to the prostate. We assessed the ability of this new technology (...) to lessen the risk of radiation-related effects in a randomised controlled trial of conformal versus conventional radiotherapy.We recruited men with prostate cancer for treatment with a standard dose of 64 Gy in daily 2 Gy fractions. The men were randomly assigned conformal or conventional radiotherapy treatment. The primary endpoint was the development of late radiation complications (> 3 months after treatment) measured with the Radiation Therapy and Oncology Group (RTOG) score. Indicators of disease

1999 Lancet Controlled trial quality: predicted high

85. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials

Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo: a meta-analysis of randomized controlled trials Efficacy and extrapyramidal side-effects of the new (...) of drop-outs is considered in detail. The very nature of the patient population and the side-effects of the drugs means that drop-outs in these types of trials are often very common. In view of the data presented the authors' findings would appear to be valid and their suggestions for future research would seem reasonable. However, the above comments should be borne in mind when interpreting the findings. 95% CI are often not reported for individual studies and pooled effect sizes. Implications

1999 DARE.

86. Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects

Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects Hindmarch I, Shamsi Z Authors' objectives The primary aim was to identify the test which are most sensitive to the effects of antihistamines, to identify a test-battery which (...) and other side-effects. Clinical and Experimental Allergy 1999; 29(Supplement 3): 133-142 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Cognition /drug effects; Histamine Antagonists /adverse effects; Humans; Hypnotics and Sedatives /adverse effects; Psychomotor Performance /drug effects AccessionNumber 11999001555 Date bibliographic record published 31/12/2000 Date abstract record published 31/12/2000 Record Status This is a critical abstract of a systematic review that meets

1999 DARE.

87. Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice

Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily practice Honig A, Arts B M, Ponds R W, Riedel W J Authors' objectives To investigate whether lithium gives rise to cognitive side-effects and affects (...) with lithium who present themselves with memory problems and mental slowness in order to rule out lithium intoxication. Patients should be given psycho-education about cognitive deficits in an attempt to make them aware of implications of these deficits for their ability to drive, thereby decreasing the risk of road accidents'. Bibliographic details Honig A, Arts B M, Ponds R W, Riedel W J. Lithium induced cognitive side-effects in bipolar disorder: a qualitative analysis and implications for daily

1999 DARE.

88. Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects

Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects Curatolo M, Petersen-Felix S, Scaramozzino P, Zbinden A M (...) in the review Patients undergoing surgery (orthopaedic or lower abdominal) with planned epidural block, without general analgesia. Women in labour were not included unless they were having Caesarean section. Outcomes assessed in the review Inadequate analgesia and the occurrence of side-effects were assessed. Inadequate analgesia was defined as pain at any intensity at the site of surgery, occurring during operation. The side-effects included respiratory depression, nausea/vomiting, pruritis, sedation

1998 DARE.

89. Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients

Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients Cantarovich M, Besner J G, Fitchett D H, Latter D A Record Status This is a critical abstract of an economic evaluation (...) progressively decreased since its introduction into clinical practice as side-effects such as hypertension and renal dysfunction were frequently reported after heart transplantation. You, as a user of this database, should consider whether this is a widely used health technology in your own setting. Validity of estimate of measure of benefit No summary benefit measure was used in the analysis and as such the principal benefits centred around reductions in dose and therefore cost. The data have not been used

1997 NHS Economic Evaluation Database.

90. Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy and side-effects

Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy and side-effects Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy and side-effects Selective serotonin reuptake inhibitors (SSRIs) in the treatment of elderly depressed patients: a qualitative analysis of the literature on their efficacy (...) and side-effects Menting J E, Honig A, Verhey F R, Hartmans M, Rozendaal N, de Vet H C, van Praag H M Authors' objectives To assess the efficacy and side-effects of selective serotonin re-uptake inhibitors (SSRIs) for the treatment of elderly people with depression. Searching MEDLINE was searched from January 1980 until December 1994 using the keywords 'fluvoxamine', 'paroxetine', 'fluoxetine' and 'sertraline' combined with 'aged', 'elderly' or 'geriatric'. The citations in all of the identified papers

1996 DARE.

91. Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis

Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis Low-dose neuroleptic therapy and extrapyramidal side effects in schizophrenia: an effect size analysis Barbui C, Saraceno B Authors' objectives To quantify the overall extrapyramidal side-effect improvement in patients treated with low doses of neuroleptics, compared with those receiving (...) doses varied between 10, 20 and 50% of the standard dose. Participants included in the review Patients with a standardised diagnosis of schizophrenia (RDC, American Psychiatric Association DSM III) and/or schizoaffective disorder (details taken from the meta-analysis of effectiveness by the same authors, see Other Publications of Related Interest). The mean age of the patients was 34 years with a mean history of disease of over 131 months. Outcomes assessed in the review Extrapyramidal side-effects

1996 DARE.

92. Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents. (Abstract)

Avoiding unsuspected respiratory side-effects of topical timolol with cardioselective or sympathomimetic agents. Topical timolol given for the treatment or chronic simple glaucoma may cause unrecognised bronchospasm among elderly people. We recruited 80 patients aged over 60 years, who were without a history of airways disease and already used timolol, into a randomised crossover study comparing the effects on spirometry and exercise tolerance of changing to betaxolol or dipivefrine therapy

1995 Lancet Controlled trial quality: uncertain

93. Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research

Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research Cognitive side-effects of chronic antiepileptic drug treatment: a review of 25 years of research Vermeulen J, Aldenkamp A P Authors' objectives To assess the cognitive side effects of long-term anti-epileptic drug treatments. Searching Computerised and manual searches of English language literature (...) types were examined and reported separately: healthy volunteer studies, monotherapy studies, polytherapy studies, studies with a non-randomised post-test only design, studies providing insufficient information. No tests for heterogeneity were used, methodological and statistical issues were discussed. Results of the review Ninety-four articles representing 89 non-overlapping studies were included. The total patient numbers were not given. No clear results were shown on the cognitive side-effects

1995 DARE.

94. Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial. (Abstract)

Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial. To determine the incidence of side effects from short-term glucocorticoid therapy prescribed for treatment of optic neuritis in the Optic Neuritis Treatment Trial.Randomized, placebo-controlled, multicenter clinical trial.Fifteen university- or hospital-based centers throughout the United States.A total of 457 patients between the ages of 18 and 46 years with acute demyelinative optic neuritis were (...) studied.(1) Intravenous methylprednisolone (250 mg every 6 hours) for 3 days while hospitalized followed by oral prednisone (1 mg/kg per day) for 11 days; (2) oral prednisone (1 mg/kg per day) for 14 days; and (3) oral placebo for 14 days. Each regimen was followed by a short taper.Only two patients experienced major side effects, psychotic depression in one and acute pancreatitis in the other. Both of these patients were from the intravenous methylprednisolone group and both of the side effects

1993 JAMA Controlled trial quality: uncertain

95. Trial of high-dose Edmonston-Zagreb measles vaccine in the Gambia: antibody response and side-effects. (Abstract)

Trial of high-dose Edmonston-Zagreb measles vaccine in the Gambia: antibody response and side-effects. In a randomised trial, infants living in a large village in The Gambia were immunised either at 4 months of age with 40,000 plaque forming units (PFU) of the Edmonston-Zagreb (EZ) measles vaccine or at the usual age of 9 months with 6000 TCID50 of a conventional Schwarz measles vaccine. Measles developed in 2 of 119 children who received the EZ vaccine, in 1 before and in the other after 9 (...) -term morbidity as assessed by clinic attendances and weight at 18 months of age was much the same in the two groups. The EZ measles vaccine is thus safe and clinically and serologically effective when used in a high dose to immunise young Gambian infants.

1988 Lancet Controlled trial quality: uncertain

96. Efficacy and reduced metabolic side effects of a 15-mg chlorthalidone formulation in the treatment of mild hypertension. A multicenter study. (Abstract)

Efficacy and reduced metabolic side effects of a 15-mg chlorthalidone formulation in the treatment of mild hypertension. A multicenter study. We compared a new low-dose chlorthalidone formulation consisting of 15 mg of this compound and a biocompatible polymer in a double-blind placebo-controlled trial with the standard 25-mg dose of chlorthalidone in the management of mild essential hypertension. Two hundred twenty-two patients, ranging in age from 21 to 69 years, with an average standing (...) diastolic blood pressure between 91 and 104 mm Hg participated in this trial. At the end of 12 weeks, the percentage of patients who had a decrease in their standing diastolic blood pressure of 5 mm Hg or more was statistically similar in both of the active-treatment groups and significantly different from the placebo group. With the lower-dose compound, the metabolic side effect of hypokalemia was less of a problem and there was no evidence of glucose intolerance. Thus, this new 15-mg formulation

1987 JAMA Controlled trial quality: uncertain

97. beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects. (Abstract)

beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects. The antihypertensive effect and metabolic side effects of bendroflumethiazide have been compared with those of propranolol in two randomly selected groups, of 53 previously untreated middle-aged men during 6 years' treatment for mild to moderately severe essential hypertension. The blood pressure-reduction was the same in the two groups. During the follow-up 1 man (...) that the frequency of metabolic side effects during diuretic treatment of mild to moderately severe essential hypertension is low and has been grossly exaggerated. Since the antihypertensive effect and side effects were equal with both drugs, and since the diuretics are cheaper, they should be the drug of first choice in this type of hypertension.

1981 Lancet Controlled trial quality: uncertain