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Latest & greatest articles for stress
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The perceived stress and approach to learning effects on academic performance among Sudanese medical students There is an increasing awareness of the perceived stress and approach to learning effects on academic achievement.This study aimed to assess the educational environment and approach to learning in clinical phase medical students.This comparative cross-sectional study was conducted among fifty-nine clinical stage medical students at Omdurman Islamic University (Khartoum, Sudan) during (...) the period from June to August 2016. All the participants signed a written informed consent, then responded to a structured questionnaire to collect demographic data, the two process study questionnaires and the perceived stress questionnaire. The ethical committee of Omdurman Islamic University approved the research, and the Statistical Package for Social Sciences was used to compare the students based on sex, class, and their grades. Data were analyzed by SPSS version 22, using descriptive statistics
Secondary traumatic stress, dissociative and somatization symptoms in spouses of veterans with PTSD in Zahedan, Iran Secondary traumatic stress is a disorder which occurs in spouses and people with close relation to someone with posttraumatic stress disorder. Like PTSD, it seems that STS also occurs with other psychiatric problems like somatization and dissociation. This study aimed to determine the relationship between STS and somatization and dissociation symptoms.This cross-sectional study (...) was done in 2015 and lasted for one year. Self-report questionnaires assessing secondary traumatic stress symptoms, dissociation symptoms and somatization symptoms were distributed among spouses of veterans with PTSD in Zahedan, Iran. The relationship between STS symptoms and somatization symptoms and also between STS symptoms and dissociation symptoms were determined by Pearson correlation test. SPSS version 23 was used for data analysis.Occurrence of secondary traumatic stress symptoms were
Investigation of marital satisfaction and its relationship with job stress and general health of nurses in Qazvin, Iran Pressures in nursing can affect family life and marital problems, disrupt common social problems, increase work-family conflicts and endanger people's general health.To determine marital satisfaction and its relationship with job stress and general health of nurses.This descriptive and cross-sectional study was done in 2015 in medical educational centers of Qazvin by using (...) an ENRICH marital satisfaction scale and General Health and Job Stress questionnaires completed by 123 nurses. Analysis was done by SPSS version 19 using descriptive and analytical statistics (Pearson correlation, t-test, ANOVA, Chi-square, regression line, multiple regression analysis).The findings showed that 64.4% of nurses had marital satisfaction. There was significant relationship between age (p=0.03), job experience (p=0.01), age of spouse (p=0.01) and marital satisfaction. The results showed
Oxidative Stress Markers in GnRH Agonist and Antagonist Protocols in IVF Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles.This prospective study included 82 patients who underwent IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle (...) was higher in patients without OS while miscarriage rate was higher in patients with OS.Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.
Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress The prevalence of major depression in those with HIV/AIDS is substantially higher than in the general population. Mechanisms underlying this comorbidity are poorly understood. HIV-transactivator of transcription (Tat) protein, produced and excreted by HIV, could be involved. We determined whether conditional Tat protein expression in mice is sufficient (...) to induce depression-like behaviors and oxidative stress. Further, as oxidative stress is associated with depression, we determined whether decreasing or increasing oxidative stress by administering methylsulfonylmethane (MSM) or diethylmaleate (DEM), respectively, altered depression-like behavior.GT-tg bigenic mice received intraperitoneal saline or doxycycline (Dox, 25-100 mg/kg/day) to induce Tat expression. G-tg mice, which do not express Tat protein, also received Dox. Depression-like behavior
Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder Posttraumatic stress disorder (PTSD) is associated with hypothalamus-pituitary-adrenal (HPA) axis response to stressors, but links to neurophysiological and neuroanatomical changes are unclear. The purpose of this study was to determine whether stress-induced cortisol alters negative feedback on pituitary corticotroph function and pituitary volume.Prospective controlled study in an outpatient clinic.Subjects
F2-Isoprostanes Reflect Oxidative Stress Correlated With Lean Mass and Bone Density but Not Insulin Resistance F2-isoprostanes (F2-isoPs) are biomarkers for oxidative stress in humans and have been shown to be elevated in obesity, cardiovascular disease, and diabetes. Therefore, F2-isoPs are often implicated in oxidative stress contributing to insulin resistance, although this has not been rigorously examined.To determine whether urinary F2-isoPs are predictive of insulin sensitivity and other (...) was also not associated with body fat. However, there was a strong negative correlation between 15-F2t-IsoP and lean body mass (LBM; r = -0.46, P = 0.0001), bone mineral content (BMC; r = -0.58, P < 0.0001), bone mineral density (BMD; r = -0.65, P < 0.0001), and skeletal muscle protein 4-hydroxynonenal (4-HNE; r = -0.54, P = 0.0239), another marker of oxidative stress. 15-F2t-IsoP was also positively associated with circulating triglycerides and total cholesterol, and increased as a function
Habitat disturbance results in chronic stress and impaired health status in forest-dwelling paleotropical bats Anthropogenic habitat disturbance is a major threat to biodiversity worldwide. Yet, before population declines are detectable, individuals may suffer from chronic stress and impaired immunity in disturbed habitats, making them more susceptible to pathogens and adverse weather conditions. Here, we tested in a paleotropical forest with ongoing logging and fragmentation, whether habitat (...) disturbance influences the body mass and immunity of bats. We measured and compared body mass, chronic stress (indicated by neutrophil to lymphocyte ratios) and the number of circulating immune cells between several bat species with different roost types living in recovering areas, actively logged forests, and fragmented forests in Sabah, Malaysia. In a cave-roosting species, chronic stress levels were higher in individuals from fragmented habitats compared with conspecifics from actively logged areas
Posttraumatic Stress Disorder, Antipsychotic Use and Risk of Dementia in Veterans To examine the risk of dementia associated with posttraumatic stress disorder (PTSD) and the contribution of antipsychotic use to this risk.Retrospective cohort study SETTING: Australia. Administrative claims data from the Australian Government Department of Veterans' Affairs were used.Male Vietnam veterans aged 55 to 65 at baseline (2001-02) with no preexisting dementia diagnosis (N = 15,612).The association
The Chemical Chaperone, PBA, Reduces ER Stress and Autophagy and Increases Collagen IV Î±5 Expression in Cultured Fibroblasts From Men With X-Linked Alport Syndrome and Missense Mutations X-linked Alport syndrome (OMIM 301050) is caused by COL4A5 missense variants in 40% of families. This study examined the effects of chemical chaperone treatment (sodium 4-phenylbutyrate) on fibroblast cell lines derived from men with missense mutations.Dermal fibroblast cultures were established from 2 (...) affected men and 3 normals. Proliferation rates were examined, the collagen IV α5 chain localized with immunostaining, and levels of the intra- and extracellular chains quantitated with an in-house enzyme-linked immunosorbent assay. COL4A5 mRNA was measured using quantitative reverse transcriptase polymerase chain reaction. Endoplasmic reticulum (ER) size was measured on electron micrographs and after HSP47 immunostaining. Markers of ER stress (ATF6, HSPA5, DDIT3), autophagy (ATG5, BECN1, ATG7
Disrupted ERâ€toâ€Golgi trafficking underlies antiâ€HIV drugs and alcoholâ€induced cellular stress and hepatic injury Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) are involved in anti-human immunodeficiency virus (HIV) drugs and alcohol-induced liver disease in a significant number of patients infected with HIV. However, the precise mechanism by which the drugs and alcohol cause ER stress remains elusive. We found that ritonavir-boosted lopinavir (RL) activated two (...) canonical UPR branches without activation of the third canonical activating transcription factor 6 (ATF6) branch in either HepG2 cells or primary mouse hepatocytes. In the RL-treated cells, ATF6 localization in the Golgi apparatus required for its activation was reduced; this was followed by Golgi fragmentation and dislocation/redistribution of Golgi-resident enzymes. Severities of Golgi fragmentation induced by other anti-HIV drugs varied and were correlated with the ER stress response. In the liver
Two-Year Follow-up of a Randomized Clinical Trial of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care for Chronic Low Back Pain. 28196244 2017 03 17 2018 12 02 1538-3598 317 6 2017 02 14 JAMA JAMA Two-Year Follow-up of a Randomized Clinical Trial of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care for Chronic Low Back Pain. 642-644 10.1001/jama.2016.17814 Cherkin Daniel C DC Group Health Research Institute, Seattle, Washington (...) United States Letter Randomized Controlled Trial United States JAMA 7501160 0098-7484 AIM IM Adult Aged Chronic Pain therapy Cognitive Behavioral Therapy Disability Evaluation Follow-Up Studies Humans Low Back Pain therapy Middle Aged Mindfulness methods Mobility Limitation Outcome Assessment (Health Care) Regression Analysis Stress, Psychological therapy Surveys and Questionnaires Time Factors Treatment Outcome Young Adult 2017 2 15 6 0 2017 2 15 6 0 2017 3 18 6 0 ppublish 28196244 2601490 10.1001
The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related
Stress response to handling is short lived but may reflect personalities in a wild, Critically Endangered tortoise species We investigated the acute stress response associated with animal personalities by measuring plasma glucocorticoids throughout handling and collected ~2 years of movement and behavioural data in a wild, Critically Endangered animal, Astrochelys radiata (radiated tortoise). To determine whether our standard, brief conscientious handling procedures induce a stress response (...) changes in plasma concentrations of the stress hormone corticosterone (CORT) but did reveal tremendous individual variation in response. The CORT concentration ranged more than 200-fold after imposing the stressor and returned to near-baseline values by the following day. When we accounted for the wide variation by calculating the degree of each individual's stress response relative to its baseline over its processing time, we discovered two non-overlapping physiological response types; those in which
Increased Cardiac Sympathetic Activity and Oxidative Stress in Habitual Electronic Cigarette Users: Implications for Cardiovascular Risk Electronic cigarettes (e-cigarettes) have gained unprecedented popularity, but virtually nothing is known about their cardiovascular risks.To test the hypothesis that an imbalance of cardiac autonomic tone and increased systemic oxidative stress and inflammation are detectable in otherwise healthy humans who habitually use e-cigarettes.Cross-sectional case (...) , reflecting the cardiac sympathovagal balance. Three parameters of oxidative stress were measured in plasma: (1) low-density lipoprotein oxidizability, (2) high-density lipoprotein antioxidant/anti-inflammatory capacity, and (3) paraoxonase-1 activity.Of the 42 participants, 35% were women, 35% were white, and the mean age was 27.6 years. The high-frequency component was significantly decreased in the e-cigarette users compared with nonuser control participants (mean [SEM], 46.5 [3.7] nu vs 57.8 [3.6] nu
Evidence Brief: Effectiveness of Stellate Ganglion Block for Treatment of Posttraumatic Stress Disorder (PTSD) 4 Department of Veterans Affairs Health Services Research & Development Service Evidence-based Synthesis Program Evidence Brief: Effectiveness of Stellate Ganglion Block for Treatment of Posttraumatic Stress Disorder (PTSD) February 2017 Prepared for: Department of Veterans Affairs Veterans Health Administration Quality Enhancement Research Initiative Health Services Research (...) with stakeholders to effectively engage the program. Comments on this evidence report are welcome and can be sent to Nicole Floyd, ESP CC Program Manager, at Nicole.Floyd@va.gov. Recommended citation: Peterson K, Bourne D, Anderson J, Mackey K, Helfand M. Evidence Brief: Effectiveness of Stellate Ganglion Block for Treatment of Posttraumatic Stress Disorder. VA ESP Project #09-199; 2017. This report is based on research conducted by the Evidence-based Synthesis Program (ESP) Coordinating Center located
Physiological effects of environmentally relevant, multi-day thermal stress on wild juvenile Atlantic salmon (Salmo salar) The frequency of extreme thermal events in temperate freshwater systems is expected to increase alongside global surface temperature. The Miramichi River, located in eastern Canada, is a prominent Atlantic salmon (Salmo salar) river where water temperatures can exceed the proposed upper thermal limit for the species (~27°C). Current legislation closes the river (...) response of juvenile salmon, despite the variable thermal cycling condition. Our results suggest that relatively cooler night temperatures in the summer months may play a limited role in mitigating physiological stress throughout warm diel cycle events.
Early stress, parental motivation, and reproductive decision-making: applications of life history theory to parental behavior This review focuses on the impact of parental behavior on child development, as interpreted from an evolutionary-developmental perspective. We employ psychosocial acceleration theory to reinterpret the effects of variation in parental investment and involvement on child development, arguing that these effects have been structured by natural selection to match
Human Growth Hormone for Depression, Post-Traumatic Stress Disorder, or Fibromyalgia: Clinical Effectiveness and Guidelines Human Growth Hormone for Depression, Post-Traumatic Stress Disorder, or Fibromyalgia: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Human Growth Hormone for Depression, Post-Traumatic Stress Disorder, or Fibromyalgia: Clinical Effectiveness and Guidelines Human Growth Hormone for Depression, Post-Traumatic Stress Disorder, or Fibromyalgia (...) : Clinical Effectiveness and Guidelines Published on: February 8, 2017 Project Number: RA0891-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness of human growth hormone for patients with depression? What is the clinical effectiveness of human growth hormone for patients with post-traumatic stress disorder? What is the clinical effectiveness of human growth hormone for patients with fibromyalgia? What are the evidence-based