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Latest & greatest articles for stroke
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on stroke or other clinical topics then use Trip today.
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Are Aerobic Programs Similar in Design to Cardiac Rehabilitation Beneficial for Survivors of Stroke? A Systematic Review and Meta-Analysis. Background Survivors of stroke face movement disability and increased cardiovascular disease and stroke risk. Treatment includes rehabilitation focused on functional movement with less emphasis on aerobic capacity. After rehabilitation, survivors of stroke must self-manage activity with limited appropriate community programs. Lack of structured activity (...) contributes to sedentary behavior. The objective of this systematic review and meta-analysis is to review aerobic programs for stroke survivors similar in activity and dosage to cardiac rehabilitation programs to determine their efficacy for improving aerobic and walking capacity. Methods and Results Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to review 5 databases. Group interventions for survivors of stroke with a primary aerobic component and dosage from 18
The association between pulmonary hypertension and stroke: a systematic review and meta-analysis. 31864793 2020 04 20 2020 04 20 1874-1754 303 2020 03 15 International journal of cardiology Int. J. Cardiol. The association between pulmonary hypertension and stroke: a systematic review and meta-analysis. 78 S0167-5273(19)35735-3 10.1016/j.ijcard.2019.12.020 Shah Trushil G TG Division of Pulmonary and Critical Care Medicine, The University of Texas Southwestern, Dallas, Texas, USA. Sutaria Jaini (...) M JM Parkland Health and Hospital System, Department of Internal Medicine, The University of Texas Southwestern, Dallas, Texas, USA. Vyas Manav V MV Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address: firstname.lastname@example.org. eng Letter Comment 2019 12 12 Netherlands Int J Cardiol 8200291 0167-5273 IM Int J Cardiol. 2019 Nov 15;295:21-24 31402157 Int J Cardiol. 2020 Mar 15;303:79 32063282 Humans Hypertension, Pulmonary Stroke
Stroke epidemiology and stroke policies in China from 1980 to 2017: A systematic review and meta-analysis. Stroke is the leading cause of death and years of life lost in China, and this problem is growing because stroke risk factors such as hypertension and hypercholesteremia have been on the rise as China experiences the demographic transition. The Chinese government has created public health initiatives in the form of guidelines, policies and programs to combat this problem (...) , but the dissemination and effectiveness of these policies are not well known.The aim of this study was to determine trends in stroke incidence, prevalence, and stroke-related mortality in China and to report these trends in the context of stroke initiatives that have been enacted by the Chinese government.We systematically reviewed articles on stroke rates and stroke initiatives from 1980 to 2017. A meta-regression including 11 studies showed that stroke incidence remained stable at 128.3 per 100,000 per year from
the search results for studies reporting the correlation between sNfL and stroke outcome in ischemicstroke or transientischemicattack patients. The Newcastle-Ottawa Scale was adopted to evaluate the quality of the included studies. The pooled odds ratio (OR) of sNfL for stroke functional outcome was calculated with the Comprehensive Meta-Analysis software, version 2. Heterogeneity and publication bias were assessed with the I2 test and funnel plot, respectively.Seven studies met the inclusion criteria (...) Serum Neurofilament Light Chain as a Predictive Biomarker for IschemicStroke Outcome: A Systematic Review and Meta-analysis. Stroke is the leading cause of death and long-term disability worldwide. The purpose of the study is to examine the role of serum neurofilament light chain (sNfL) as a predictive biomarker for ischemicstroke outcome.We searched PubMed, Web of Science, and EMBASE for potential studies published in English previous to November 15, 2019. Two independent reviewers screened
Aspirin or anticoagulation after cryptogenic stroke with patent foramen ovale: systematic review and meta-analysis of randomized controlled trials. Since closure has restrictive eligibility criteria, the vast majority of patients with cryptogenic stroke and patent foramen ovale (PFO) receive medical treatment. However, the optimal antithrombotic strategy is still unclear. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to define risk/benefit profile (...) of anticoagulation compared with antiplatelet treatment in PFO-related stroke.Systematic review protocol was registered in PROSPERO (CRD42019117559). Following PRISMA guidelines, we searched MEDLINE, EMBASE, and Cochrane CENTRAL database (2000-2019) for RCTs randomly allocating patients with cryptogenic stroke and PFO to medical treatment. Risk of bias was assessed with Cochrane RoB tool. Main outcomes were stroke recurrence and major bleeding. RoPE score-dependent analysis was implemented to define a possible
, and the probable neuroprotective mechanisms in experimental ischemic strokes.Studies of G-Rb1 on ischemicstroke animal models were identified from 7 databases. No clinical trials were included in the analysis. The primary outcome measures were neurological function scores, infarct volume, evans blue content and/or brain water content (BWC). The second outcome measures were the possible neuroprotective mechanisms. All the data were analyzed by Rev Man 5.3.Pooled preclinical data showed that compared (...) Ginsenoside-Rb1 for IschemicStroke: A Systematic Review and Meta-analysis of Preclinical Evidence and Possible Mechanisms. Ischemicstroke is the most common type of stroke, while pharmacological therapy options are limited. Ginsenosides are the major bioactive compounds in Ginseng and have been found to have various pharmacological effects in the nervous system. In the present study, we sought to evaluate the effects of Ginsenoside-Rb1 (G-Rb1), an important ingredient of ginsenosides
Endovascular thrombectomy for low ASPECTS large vessel occlusionischemicstroke: a systematic review and meta-analysis. 32299532 2020 04 17 0317-1671 2020 Apr 17 The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Can J Neurol Sci Endovascular thrombectomy for low ASPECTS large vessel occlusionischemicstroke: a systematic review and meta-analysis. 1-21 10.1017/cjn.2020.71 Diestro Jose Danilo B JDB https://orcid.org/0000-0001-8450-2021 Dmytriw Adam
Inherited Thrombophilia and the Risk of Arterial IschemicStroke: A Systematic Review and Meta-Analysis. Background Inherited thrombophilias are well-established predisposing factors for venous thromboembolism, but their role in arterial thrombosis, such as arterial ischemicstroke, remains uncertain. We aimed to evaluate the association between inherited thrombophilia (factor V Leiden, prothrombin G20210A mutation, protein C deficiency, protein S deficiency, and antithrombin deficiency (...) ) and risk of arterial ischemicstroke in adults. Methods and Results We searched PubMed, EMBASE, and Cochrane Library Databases from inception to December 31, 2018. We included case-control or cohort studies of adults reporting the prevalence of inherited thrombophilias in those with arterial ischemicstroke and subjects without arterial ischemicstroke. Two reviewers (T.C., E.D.) independently searched the literature and extracted data. Pooled odds ratios (ORs) and 95% CIs were calculated using random
Clinical prognosis of FLAIR hyperintense arteries in ischaemicstroke patients: a systematic review and meta-analysis. We performed a systematic review and meta-analysis to determine the association of fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-HAs) on brain MRI and prognosis after acute ischaemicstroke (AIS).We searched Medline, Embase and Cochrane Central Register of Controlled Trials for studies reporting clinical or imaging outcomes with presence of FLAIR-HAs (...) after AIS. Two researchers independently assessed eligibility of retrieved studies and extracted data, including from the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Outcomes were unfavourable functional outcome (primary, modified Rankin scale scores 3-6 or 2-6), death, intermediate clinical and imaging outcomes. We performed subgroup analyses by treatment or types of FLAIR-HAs defined by location (at proximal/distal middle cerebral artery (MCA), within/beyond
Response by Siegerink et al to Letter Regarding Article, "Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-Analysis". 32295507 2020 04 16 1524-4628 2020 Apr 16 StrokeStroke Response by Siegerink et al to Letter Regarding Article, "Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-Analysis". STROKEAHA120029610 10.1161/STROKEAHA.120.029610 Siegerink Bob B Center for Stroke Research Berlin (...) (CSB) and Klinik für Neurologie mit Experimenteller Neurologie, Charité Universitätsmedizin Berlin, Germany. Broersen Leonie H A LHA Center for Stroke Research Berlin (CSB) and Klinik für Neurologie mit Experimenteller Neurologie, Charité Universitätsmedizin Berlin, Germany. Scheitz Jan F JF Center for Stroke Research Berlin (CSB) and Klinik für Neurologie mit Experimenteller Neurologie, Charité Universitätsmedizin Berlin, Germany. eng Letter 2020 04 16 United States Stroke 0235266 0039-2499 IM
. The primary endpoints were recurrent stroke or transientischemicattack (TIA). The secondary outcomes were all-cause death, atrial fibrillation (AF), and hemorrhagic events.Five randomized trials and fourteen observational studies (6301 participants) were eligible. PFO closure was superior to medical therapy for stroke prevention risk ratios ([RR], 0.38; 95% CI, 0.24-0.60), but showed increased risk of AF (RR, 4.96; 95% CI, 2.31-10.7). There was no significant difference in TIA recurrence, death (...) Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies. Previous review from randomized controlled trials (RCT) showed that patients with cryptogenic stroke may benefit from patent foramen ovale (PFO) closure. However, the findings from the systematic review were not clear when observational studies were also included.We searched MEDLINE, Embase, and Cochrane databases
Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemicstroke: A meta-analysis. Recently, associations between intercellular adhesion molecule-1 (ICAM-1) rs5498 polymorphism and ischemicstroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta-analysis was performed to better assess the relationship between ICAM-1rs5498 polymorphism and IS.PubMed, Medline, Embase, and CNKI were searched for eligible studies. We
Letter by Noubiap et al Regarding Article, "Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-Analysis". 32295505 2020 04 16 1524-4628 2020 Apr 16 StrokeStroke Letter by Noubiap et al Regarding Article, "Association Between High-Sensitivity Cardiac Troponin and Risk of Stroke in 96 702 Individuals: A Meta-Analysis". STROKEAHA120029565 10.1161/STROKEAHA.120.029565 Noubiap Jean Jacques JJ Centre for Heart Rhythm Disorders, University (...) of Adelaide and Royal Adelaide Hospital, Australia. Thomas Gijo G Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Australia. Sanders Prashanthan P Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Australia. eng Letter 2020 04 16 United States Stroke 0235266 0039-2499 IM 2020 4 17 6 0 2020 4 17 6 0 2020 4 17 6 0 aheadofprint 32295505 10.1161/STROKEAHA.120.029565
Cognitive rehabilitation for attention deficits following stroke. Many survivors of stroke report attentional impairments, such as diminished concentration and distractibility. However, the effectiveness of cognitive rehabilitation for improving these impairments is uncertain.This is an update of the Cochrane Review first published in 2000 and previously updated in 2013.To determine whether people receiving cognitive rehabilitation for attention problems 1. show better outcomes (...) in their attentional functions than those given no treatment or treatment as usual, and 2. have a better functional recovery, in terms of independence in activities of daily living, mood, and quality of life, than those given no treatment or treatment as usual.We searched the Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, Embase, CINAHL, PsycINFO, PsycBITE, REHABDATA and ongoing trials registers up to February 2019. We screened reference lists and tracked citations using Scopus.We included controlled
Association between Lys198Asn polymorphism of endothelin-1 gene and ischemicstroke: A meta-analysis. Endothelin (ET)-1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single-nucleotide polymorphism (SNP) of gene encoding ET-1 (EDN1). It is hypothesized that it might have a role in altering ET-1 and ultimately leading to vascular dysfunction and ischemicstroke. We therefore conducted a meta (...) (Egger test: p = .79; Begg test: p = .85). A subgroup analysis based on subtypes of ischemicstroke showed that Lys198Asn SNP was only associated with large vessel infarction but not with lacunar infarction caused by small vessel disease. A subgroup analysis based on ethnicity revealed that the Lys198Asn polymorphism of the EDN1 gene was associated with ischemicstroke only in Caucasians.The present meta-analysis suggests that Lys198Asn polymorphism of EDN1 gene is associated with an increased risk
Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta-analysis. Nurses and other nonspecialists in dysphagia are often trained to screen swallowing poststroke. There are many basic tools that test water only, they are usually conservative, and patients that fail the test remain nil by mouth until a speech and language therapy assessment. More comprehensive tests also allow nonspecialists to recommend modified oral intake (...) . Little is known about the accuracy, clinical utility and cost-effectiveness of these tests.Following PRISMA guidelines, a systematic review was conducted to describe comprehensive swallowing tests that are available for use in acute stroke by nurses or other nonspecialists in dysphagia. A meta-analysis was performed to evaluate accuracy and the clinical utility of the tests was considered. Searches and analyses, conducted by two reviewers, included MEDLINE, Embase, trial registries and grey
Impact of quality improvement strategies on the quality of life of individuals post-stroke: a systematic review. Purpose: The purpose of this systematic review was to synthesize and appraise the evidence regarding the impact of quality improvement strategies on quality of life as well as physical and psychological well-being of individuals with stroke.Materials and methods: Studies were identified by searching MEDLINE (OVID interface, 2000 onwards), CINAHL (EBSCO interface, 2000 onwards (...) was self-management. Other studies included patient education, team changes, and case management. Only 5 of the 12 studies reported statistically significant improvements in some component of quality of life.Conclusions: There is a lack of evidence to demonstrate efficacy/effectiveness of patient education, self-management, team changes, and case management approaches on improving the quality of life of stroke survivors. Identifying the essential features of effective and ineffective strategies
Carotid Plaque With High-Risk Features in Embolic Stroke of Undetermined Source: Systematic Review and Meta-Analysis. Background and Purpose- An ipsilateral mild carotid stenosis, defined as plaque with <50% luminal narrowing, is identified in nearly 40% of patients with embolic stroke of undetermined source and could represent an unrecognized source of atheroembolism. We aimed to summarize data about the frequency of mild carotid stenosis with high-risk features in embolic stroke (...) of undetermined source. Methods- We searched Pubmed and Ovid-Embase for studies reporting carotid plaque imaging features in embolic stroke of undetermined source. The prevalence of ipsilateral and contralateral mild carotid stenosis with high-risk features was pooled using random-effect meta-analysis. Results- Eight studies enrolling 323 participants were included. The prevalence of mild carotid stenosis with high-risk features in the ipsilateral carotid was 32.5% (95% CI, 25.3-40.2) compared with 4.6% (95
Association of E-Selectin gene rs5361 polymorphism with ischemicstroke susceptibility: a systematic review and Meta-analysis. Background: Over the years, a number of published studies showed that E-Selectin gene rs5361 (S128R, Ser128Arg, A561C) variants were associated with the risk of ischemicstroke (IS). However, the results of those case-control studies were still equivocal. Therefore, we performed this meta-analysis to clarify the relationship between E-Selectin gene rs5361 polymorphism