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Is there any benefit to increasing the dose of tamsulosin from 0.4 mg to 0.8 mg for the treatment of benign prostatic hypertrophy? Chiefs’ Inquiry Corner – 3/9/20 – Clinical Correlations Search Chiefs’ Inquiry Corner – 3/9/20 March 9, 2020 2 min read A Cochrane review including 4122 patients from 14 studies found only a 4% absolute reduction in Boyarsky symptom score and no difference in peak urine flow in patients taking tamsulosin 0.8 mg versus those taking 0.4 mg. Further, patients taking (...) the higher dose of tamsulosin more likely to discontinue tamsulosin due to adverse events References: Fentanyl, a phenylpiperidine opioid (in the same class as meperidine, tramadol, and dextromethorphan), has been shown in case reports to induce serotonin syndrome. The mechanism is not entirely clear, but fentanyl may function as a weak serotonin reuptake inhibitor and also may enhance serotonin release. Thus in patients who develop signs of serotonin syndrome, clinicians must be vigilant in considering
Tamsulosin Top results for tamsulosin - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for tamsulosin The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms
Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial Urinary stone disease is a common presentation in the emergency department, and α-adrenergic receptor blockers, such as tamsulosin, are commonly used to facilitate stone passage.To determine if tamsulosin promotes the passage of urinary stones within 28 days among emergency department patients.We conducted a double-blind, placebo-controlled clinical trial from 2008 to 2009 (first phase) and then from (...) 2012 to 2016 (second phase). Participants were followed for 90 days. The first phase was conducted at a single US emergency department; the second phase was conducted at 6 US emergency departments. Adult patients were eligible to participate if they presented with a symptomatic urinary stone in the ureter less than 9 mm in diameter, as demonstrated on computed tomography.Participants were randomized to treatment with either tamsulosin, 0.4 mg, or matching placebo daily for 28 days.The primary
Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Recent large high-quality trials have questioned the clinical effectiveness of medical expulsive therapy using tamsulosin for ureteral stones.To evaluate the efficacy and safety of tamsulosin for distal ureteral stones compared with placebo.We conducted a double-blind, placebo-controlled study of 3296 patients with distal (...) ureteral stones, across 30 centers, to evaluate the efficacy and safety of tamsulosin.Participants were randomly assigned (1:1) into tamsulosin (0.4mg) or placebo groups for 4 wk.The primary end point of analysis was the overall stone expulsion rate, defined as stone expulsion, confirmed by negative findings on computed tomography, over a 28-d surveillance period. Secondary end points included time to stone expulsion, use of analgesics, and incidence of adverse events.Among 3450 patients randomized
Tamsulosin for the Expulsion of Ureteral Stones Emergency Medicine > Journal Club > Archive > September 2016 Toggle navigation September 2016 Tamsulosin for the Expulsion of Ureteral Stones Vignette You are working in TCC one busy evening, kicking ass and saving lives. In the middle of the primary survey of a critically ill level one trauma, you are suddenly hit by a sharp, 10 out of 10 pain in your right side. Thinking that Doug Schueurer might have punched you, you turn around swiftly and see (...) wonder if there is any real efficacy. When you get home, you decide to do a literature search and see what the evidence shows. PICO Question Population: Adult patients with ureteral stones not requiring urgent surgical intervention Intervention: Tamsulosin Comparison: Usual treatment (oral hydration, pain control, etc.) Outcome: Time to stone passage, pain level, need for surgical intervention, quality of life, patient satisfaction Search Strategy The articles chosen for the 2008 journal club were
COMBODART (dutasteride + tamsulosin), 5-? reductase inhibitor + alpha-blocker Haute Autorité de Santé - COMBODART (dutastéride + tamsulosine), inhibiteur de la 5-α réductase + alpha-bloquant Développer la qualité dans le champ sanitaire, social et médico-social Recherche Évaluation & Recommandation La HAS Accréditation & Certification Outils, Guides & Méthodes Agenda Avis sur les Médicaments COMBODART (dutastéride + tamsulosine), inhibiteur de la 5-α réductase + alpha-bloquant Substance active (...) (DCI) dutastéride tamsulosine (chlorhydrate de) UROLOGIE - Mise au point Nature de la demande Réévaluation SMR Avis de la CT du 14 décembre 2016 Intérêt clinique faible de COMBODART en remplacement de la prise séparée de tamsulosine et de dutastéride, si cette association en prise séparée est bien tolérée durant au moins 6 mois de traitement. COMBODART a l’AMM dans le traitement des symptômes modérés à sévères de l'hypertrophie bénigne de la prostate (HBP) et pour la réduction du risque de
Distal Ureteric Stones and Tamsulosin: A Double-Blind, Placebo-Controlled, Randomized, Multicenter Trial We assess the efficacy and safety of tamsulosin compared with placebo as medical expulsive therapy in patients with distal ureteric stones less than or equal to 10 mm in diameter.This was a randomized, double-blind, placebo-controlled, multicenter trial of adult participants with calculus on computed tomography (CT). Patients were allocated to 0.4 mg of tamsulosin or placebo daily for 28 (...) days. The primary outcomes were stone expulsion on CT at 28 days and time to stone expulsion.There were 403 patients randomized, 81.4% were men, and the median age was 46 years. The median stone size was 4.0 mm in the tamsulosin group and 3.7 mm in the placebo group. Of 316 patients who received CT at 28 days, stone passage occurred in 140 of 161 (87.0%) in the tamsulosin group and 127 of 155 (81.9%) with placebo, a difference of 5.0% (95% confidence interval -3.0% to 13.0%). In a prespecified
Effect of tamsulosin in medical expulsive therapy for proximal ureteral calculi after ureteroscopic holmium laser lithotripsy. 24998239 2014 08 25 2018 12 02 1001-9294 29 2 2014 Jun Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih Chin. Med. Sci. J. Effect of tamsulosin in medical expulsive therapy for proximal ureteral calculi after ureteroscopic holmium laser lithotripsy. 128-30 Wang Zhi-Qiang ZQ Department of Urology, Shouguang Hospital of Traditional Chinese Medicine (...) Department of Urology, Shouguang Hospital of Traditional Chinese Medicine, Shouguang 262700, China. eng Journal Article Randomized Controlled Trial China Chin Med Sci J 9112559 1001-9294 0 Sulfonamides 0 Urological Agents G3P28OML5I Tamsulosin IM Humans Lithotripsy, Laser methods Prospective Studies Sulfonamides therapeutic use Tamsulosin Treatment Outcome Ureteral Calculi surgery Urological Agents therapeutic use 2014 7 8 6 0 2014 7 8 6 0 2014 8 26 6 0 ppublish 24998239 10325
Tamsulosin USE OF TAMSULOSIN IN PREGNANCY 0344 892 0909 USE OF TAMSULOSIN IN PREGNANCY (Date of issue: March 2018 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . Summary Tamsulosin is an alpha 1A selective adrenoceptor-blocking drug used in the treatment of benign prostatic hypertrophy. While the drug (...) is not licensed for use in women, it is used off-license in the treatment of renal calculi, renal colic, glomerulonephritis and other disorders of the urinary tract. The published data concerning gestational exposure to tamsulosin are limited to a single study including 27 tamsulosin-exposed pregnancies. Due to the lack of safety data, it is not currently possible to provide an evidence-based risk assessment for exposure during pregnancy. Where exposure during the first trimester has occurred, it is generally
Combination Therapy with Solifenacin and Tamsulosin Oral Controlled Absorption System in a Single Tablet for Lower Urinary Tract Symptoms in Men: Efficacy and Safety Results from the Randomised Controlled NEPTUNE Trial Storage symptoms are particularly bothersome in men with lower urinary tract symptoms (LUTS) but may not be adequately treated by α-blocker monotherapy.To assess the efficacy and safety of a fixed-dose combination (FDC) of solifenacin and an oral controlled absorption system (...) (OCAS) formulation of tamsulosin compared with placebo and compared with tamsulosin OCAS (TOCAS) monotherapy in men with moderate to severe storage symptoms and voiding symptoms.A double-blind 12-wk phase 3 study in 1334 men with storage and voiding LUTS: total International Prostate Symptom Score (IPSS) ≥ 13, maximum urinary flow rate (Qmax) 4.0-12.0 ml/s, two or more urgency episodes per 24 h of Patient Perception of Intensity of Urgency Scale grade 3 or 4, and eight or more micturitions per
Efficacy and Safety of Solifenacin Plus Tamsulosin OCAS in Men with Voiding and Storage Lower Urinary Tract Symptoms: Results from a Phase 2, Dose-finding Study (SATURN) Storage symptoms are often undertreated in men with lower urinary tract symptoms (LUTS).To evaluate the combination of an antimuscarinic (solifenacin) with an α-blocker (tamsulosin) versus tamsulosin alone in the treatment of men with LUTS.A double-blind, 12-wk, phase 2 study in 937 men with LUTS (≥ 3 mo, total International (...) Prostate Symptom Score [IPSS] ≥ 13, and maximum urinary flow rate 4.0-15.0 ml/s).Eight treatment groups: tamsulosin oral controlled absorption system (OCAS) 0.4 mg; solifenacin 3, 6, or 9 mg; solifenacin 3, 6 or 9 mg plus tamsulosin OCAS 0.4 mg; or placebo.The primary efficacy end point was change from baseline in total IPSS. Secondary end points included micturition diary and quality-of-life (QoL) parameters. Post hoc subgroup analyses were performed by severity of baseline storage symptoms
Cost-effectiveness of combination therapy for treatment of benign prostatic hyperplasia: a model based on the findings of the Combination of Avodart and Tamsulosin trial Cost-effectiveness of combination therapy for treatment of benign prostatic hyperplasia: a model based on the findings of the Combination of Avodart and Tamsulosin trial Cost-effectiveness of combination therapy for treatment of benign prostatic hyperplasia: a model based on the findings of the Combination of Avodart (...) and Tamsulosin trial Bjerklund Johansen TE, Baker TM, Black LK Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study examined the cost-effectiveness of fixed-dose combination therapy (tamsulosin plus dutasteride) for benign prostatic
Randomized Controlled Trial of Tamsulosin for Prevention of Acute Voiding Difficulty After Rectal Cancer Surgery We conducted a randomized clinical trial to investigate the efficacy of the selective α(1A)-adrenoceptor antagonist tamsulosin in preventing acute voiding difficulty after rectal cancer surgery.A total of 94 rectal cancer patients with an International Prostate Symptom Score (IPSS) of ≤7 were randomly assigned (1:1) to the tamsulosin group (0.2 mg/day orally for 7 days) (n = 47 (...) ) or the control group (n = 47). The primary endpoint was the reinsertion rate of the urinary catheter after its removal on postoperative day (POD) 3. The secondary endpoints included the maximum (Qmax) and average (Qavg) urinary flow rates on POD 3, and the voided volume (VV), residual urine volume (RU), and IPSS on POD 7. Analyses were based on an intention-to-treat population.The reinsertion rate of the urinary catheter in the tamsulosin group was similar to that in the control group (23.4 vs. 21.3
Tamsulosin for voiding dysfunction in women Tamsulosin for voiding dysfunction in women Tamsulosin for voiding dysfunction in women Meyer LE, Brown JN CRD summary The review concluded that consistent positive findings across multiple clinical trials suggested that in women with lower urinary tract symptoms (particularly those with voiding dysfunction) tamsulosin may be an effective and safe treatment option. The authors’ conclusions reflect the evidence presented but limitations in the evidence (...) base make the reliability of the conclusions uncertain. Authors' objectives To evaluate the effectiveness of tamsulosin for lower urinary tract symptoms in women. Searching MEDLINE and EMBASE databases were searched to May 2012 for articles in English. Search terms were reported. Reference lists of retrieved articles were searched manually. Study selection Clinical trials that evaluated tamsulosin for the treatment of lower urinary tract symptoms in women were eligible for inclusion. Trials
Dutasteride/Tamsulosin (Duodart) in benign prostatichyperplasia. Why associate? 2011. DAR No 9. Dutasteride/Tamsulosin (Duodart®) in hiperplasia benign prostatic hyperplasia - navarra.es Castellano | Euskara | Français | English Use the search tool! Search engine : : : : : : DAR No 9. Dutasteride/Tamsulosin (Duodart®) in hiperplasia benign prostatic hyperplasia DAR No 9. Dutasteride/Tamsulosin (Duodart®) in hiperplasia benign prostatic hyperplasia Content tools Share it Why associate (...) ? The combination dutasteride/tamsulosin is indicated in the management of moderate to severe symptoms of BPH and in the reduction of the risk of acute urinary retention and surgery in these patients. In the only published study, the combination did not clearly demonstrate the superiority of the combination when compared to dutasteride in monotherapy with regard to the reduction of acute urinary retention or the need for surgery. Adverse reactions were more frequent in the group under combined therapy compared
WITHDRAWN: Tamsulosin for benign prostatic hyperplasia. Benign prostatic hyperplasia (BPH) is a nonmalignant enlargement of the prostate which can result in bothersome lower urinary tract symptoms. The treatment goal for men with BPH is to relieve these bothersome symptoms.This systematic review assessed the effects of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) compatible with BPH.Trials were searched in computerized general and specialized databases (MEDLINE, EMBASE (...) , Cochrane Library), by checking bibliographies, and by contacting manufacturers and researchers.Trials were eligible if they (1) randomized men with BPH to receive tamsulosin in comparison with placebo, other BPH medications or surgical interventions and (2) included clinical outcomes such as urologic symptom scales, symptoms, or urodynamic measurements, and (3) had a treatment duration of 30 days or longer. Eligibility was assessed by at least two independent observers.Information on patients
Efficacy and safety of tamsulosin for the treatment of benign prostatic hyperplasia: a meta analysis Efficacy and safety of tamsulosin for the treatment of benign prostatic hyperplasia: a meta analysis Efficacy and safety of tamsulosin for the treatment of benign prostatic hyperplasia: a meta analysis Ren RM, Kou M, Lan XX CRD summary This review concluded that in comparison with placebo, tamsulosin improved international prostate symptom scores and maximum flow rates for patients with benign (...) prostatic hyperplasia with no significant difference in adverse events. A risk of missing data, paucity of evidence and a lack of information regarding study quality suggest that the findings should be interpreted with caution. Authors' objectives To determine the safety and efficacy of tamsulosin compared with placebo for the treatment of benign prostatic hyperplasia (BPH). Searching PubMed, EBSCO, CBM and CNKI were searched up to 2008. Search terms were reported. Science Direct and four relevant
Tamsulosin versus terazosin for benign prostatic hyperplasia: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Efficacy of tamsulosin with extracorporeal shock wave lithotripsy for passage of renal and ureteral calculi Efficacy of tamsulosin with extracorporeal shock wave lithotripsy for passage of renal and ureteral calculi Efficacy of tamsulosin with extracorporeal shock wave lithotripsy for passage of renal and ureteral calculi Losek RL, Mauro LS CRD summary This review concluded that tamsulosin adjunctive to extracorporeal shock wave lithotripsy was safe and effective in treating patients with renal (...) stones of 10 to 24mm diameter; evidence was inconclusive for ureteral stone clearance. Given the poor reporting of the review process and lack of adequate primary trial information, the authors' conclusions should be treated with caution. Authors' objectives To evaluate the safety and efficacy of tamsulosin as an adjunct to extracorporeal shock wave lithotripsy (ESWL) in improving renal and ureteral stone clearance Searching MEDLINE(1950 to January 2008) and Iowa Drug Information System (1966