Latest & greatest articles for testosterone

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on testosterone or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on testosterone and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for testosterone

1. Testosterone deficiency in men

Testosterone deficiency in men CUAJ – CUA Guideline Grober et al Guideline: Testosterone deficiency in men 1 © 2021 Canadian Urological Association Canadian Urological Association clinical practice guideline on testosterone deficiency in men: Evidence-based Q&A Ethan D. Grober, MD 1 ; Yonah Krakowsky, MD 2 ; Mohit Khera, MD 3 ; Daniel T. Holmes, MD 4 ; Jay C. Lee, MD 5 ; John E. Grantmyre, MD 6 ; Premal Patel, MD 7 ; Richard A. Bebb, MD 8 ; Ryan Fitzpatrick, MD 9 ; Jeffrey D. Campbell, MD 10 (...) , Toronto, ON, Canada; 10 Division of Urology, Department of Surgery, University of Western Ontario, London, ON, Canada 11 Division of Urology, Department of Surgery, McGill University, Montreal, QC, Canada; 12 Department of Urology, Harvard Medical School, Boston, MA, United States Cite as: Grober ED, Krakowsky Y, Khera M, et al. Canadian Urological Association clinical practice guideline: Testosterone deficiency in men — evidence-based Q&A. Can Urol Assoc J 2021 February 23; Epub ahead of print. http

2021 Canadian Urological Association

2. Rapid Changes in Serum Testosterone in Men with Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin

Rapid Changes in Serum Testosterone in Men with Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation (...) of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Diabetes Care Actions . 2021 Apr;44(4):1059-1061. doi: 10.2337/dc20-1558. Epub 2021 Feb 3. Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin , , , , , , , , Affiliations Expand Affiliations 1 Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China. 2

2021 EvidenceUpdates

3. Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials

Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Thromb Res Actions . 2021 Mar;199:123-131. doi: 10.1016/j.thromres.2020.12.029. Epub 2021 Jan 6. Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials , , , , Affiliations Expand Affiliations 1 Department

2021 EvidenceUpdates

4. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search (...) Permalink Copy Page navigation Lancet Diabetes Endocrinol Actions . 2021 Jan;9(1):32-45. doi: 10.1016/S2213-8587(20)30367-3. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, Australia; South Australian Health and Medical

2021 EvidenceUpdates

5. Risks of Serious Injury with Testosterone Treatment Full Text available with Trip Pro

Risks of Serious Injury with Testosterone Treatment Risks of Serious Injury with Testosterone Treatment - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: Get the latest research information from NIH: Find NCBI SARS-CoV-2 literature (...) in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Am J Med Actions . 2020 Sep 12;S0002-9343(20)30775-0. doi: 10.1016/j.amjmed.2020.07.037. Online ahead of print. Risks of Serious Injury with Testosterone Treatment , , Affiliations Expand Affiliations 1 Interdepartmental Division

2020 EvidenceUpdates

6. Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study

Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) : 10.1176/appi.ajp.2020.19080844. Online ahead of print. Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study , , , , , , , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliation 1 Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (Dichtel, Kimball, Miller); Depression Clinical and Research Program, Department of Psychiatry

2020 EvidenceUpdates

7. Faculty Opinions recommendation of Testosterone Supplementation in Patients With Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials. Full Text available with Trip Pro

Faculty Opinions recommendation of Testosterone Supplementation in Patients With Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials. Testosterone Supplementation in Patients With Chronic... | Faculty Opinions On April 12th, 2020, F1000Prime became Faculty Opinions. See our to learn more. Welcome Guest 1 Recommendations info_outline Systematic Review / Meta-analysis New Finding close Classified As New Finding 1 Article Type Systematic Review / Meta-analysis More more_vert (...) close Download article Export article Sciwheel Download citation BibTeX RIS Share Email Testosterone Supplementation in Patients With Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials. ARTICLE PUBLISHED: 2020 CITE AS: Front Endocrinol (Lausanne). 2020 ; 11 : 110 Recommendations Abstract Comments You have reached your article limit. Register for 30-day free trial Registration is free and only takes a moment, or subscribe for unlimited access. Already registered with Faculty

2020 Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

8. Effects of testosterone on serum concentrations, fat-free mass, and physical performance by population: a meta-analysis Full Text available with Trip Pro

Effects of testosterone on serum concentrations, fat-free mass, and physical performance by population: a meta-analysis Effects of Testosterone on Serum Concentrations, Fat-free Mass, and Physical Performance by Population: A Meta-analysis | Journal of the Endocrine Society | Oxford Academic ') We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Advertisement Navbar (...) Search Filter Mobile Microsite Search Term search filter search input Article Navigation Close mobile search navigation Article Navigation September 2020 Article Contents Article Navigation Effects of Testosterone on Serum Concentrations, Fat-free Mass, and Physical Performance by Population: A Meta-analysis , Alyssa N Varanoske Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine , Natick, Massachusetts Oak Ridge Institute for Science and Education , Oak Ridge

2020 Journal of the Endocrine Society

9. Efficacy and Safety of Testosterone Treatment in Men: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians

Efficacy and Safety of Testosterone Treatment in Men: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians Efficacy and Safety of Testosterone Treatment in Men | Annals of Internal Medicine | American College of Physicians '); } '); })(); Sign in below to access your subscription for full content INDIVIDUAL SIGN IN | You will be directed to acponline.org to register and create your Annals account INSTITUTIONAL SIGN IN | | Subscribe to Annals of Internal (...) Medicine . You will be directed to acponline.org to complete your purchase. Search Reviews | 21 January 2020 Efficacy and Safety of Testosterone Treatment in Men: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians Susan J. Diem, MD, MPH; Nancy L. Greer, PhD; Roderick MacDonald, MS; Lauren G. McKenzie, MPH; Philipp Dahm, MD, MHSc; Nacide Ercan-Fang, MD; Allison Estrada, MD; Laura S. Hemmy, PhD; Christina E. Rosebush, MPH; Howard A. Fink, MD, MPH; Timothy J. Wilt

2020 American College of Physicians

10. SAT-LB8 The Testosterone-To-Estradiol Ratio, Rather Than Testosterone or Estradiol Alone, Is a More Precise Marker of Metabolic-Related Outcomes in Males: Insights From a Systematic Review Full Text available with Trip Pro

SAT-LB8 The Testosterone-To-Estradiol Ratio, Rather Than Testosterone or Estradiol Alone, Is a More Precise Marker of Metabolic-Related Outcomes in Males: Insights From a Systematic Review Validate User We are sorry, but we are experiencing unusual traffic at this time. Please help us confirm that you are not a robot and we will take you to your content. Could not validate captcha. Please try again. Take me to my Content

2020 Journal of the Endocrine Society

11. Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial Full Text available with Trip Pro

Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial Testosterone Replacement in Young Male Cancer Survivors: A 6-month Double-Blind Randomised Placebo-Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable (...) your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Randomized Controlled Trial PLoS Med Actions , 16 (11), e1002960 2019 Nov 12 eCollection Nov 2019 Testosterone Replacement in Young Male Cancer Survivors: A 6-month Double-Blind Randomised Placebo-Controlled Trial , , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Oncology and Metabolism

2020 EvidenceUpdates

12. Testosterone Treatment in Adult Men with Age-Related Low Testosterone Full Text available with Trip Pro

Testosterone Treatment in Adult Men with Age-Related Low Testosterone Testosterone Treatment in Adult Men With Age-Related Low Testosterone | Annals of Internal Medicine | American College of Physicians '); } '); })(); Sign in below to access your subscription for full content INDIVIDUAL SIGN IN | You will be directed to acponline.org to register and create your Annals account INSTITUTIONAL SIGN IN | | Subscribe to Annals of Internal Medicine . You will be directed to acponline.org to complete (...) your purchase. Search Clinical Guidelines | 21 January 2020 Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians Free Amir Qaseem, MD, PhD, MHA; Carrie A. Horwitch, MD, MPH; Sandeep Vijan, MD, MS; Itziar Etxeandia-Ikobaltzeta, PhD; Devan Kansagara, MD, MCR; for the Clinical Guidelines Committee of the American College of Physicians Amir Qaseem, MD, PhD, MHA American College of Physicians, Philadelphia, Pennsylvania (A.Q

2020 American College of Physicians

13. Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians. (Abstract)

Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians. The American College of Physicians (ACP) developed this guideline to provide clinical recommendations based on the current evidence of the benefits and harms of testosterone treatment in adult men with age-related low testosterone. This guideline is endorsed by the American Academy of Family Physicians.The ACP Clinical Guidelines Committee based (...) these recommendations on a systematic review on the efficacy and safety of testosterone treatment in adult men with age-related low testosterone. Clinical outcomes were evaluated by using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system and included sexual function, physical function, quality of life, energy and vitality, depression, cognition, serious adverse events, major adverse cardiovascular events, and other adverse events.The target audience includes all clinicians

2020 Annals of Internal Medicine

14. What is the role of free testosterone testing in the workup of suspected male hypogonadism?

What is the role of free testosterone testing in the workup of suspected male hypogonadism? Chiefs’ Inquiry Corner – 9/16/19 – Clinical Correlations Search Chiefs’ Inquiry Corner – 9/16/19 September 16, 2019 2 min read Free testosterone is generally not needed in the workup of male hypogonadism, as total testosterone is generally a good proxy, and a more reliable test (with some caveats- see below!). One exception to this rule is in patients with a suspected sex hormone binding globulin (...) deficiency (as in the case of obesity, type 2 diabetes or steroid exposure), in whom total testosterone can be low while the free fraction remains normal. If measuring free testosterone, be aware that the most commonly used assay, the direct immunoassay (or analog assay), is notoriously unreliable. Instead, order free testosterone by equilibrium dialysis, a test which is only available in a few specialized endocrinology labs. References: In men with signs and symptoms of possible hypogonadism

2019 Clinical Correlations

15. Testosterone replacement in menopause

Testosterone replacement in menopause BRITISH MENOPAUSE SOCIETY T ool for clinicians Information for GPs and other health professionals 1 of 4 1 How much and where does it come from? Testosterone is an important female hormone. Healthy young women produce approximately 100 – 400 mcg per day. This represents three to four times the amount of estrogen produced by the ovaries. Approximately half of endogenous testosterone and precursors are derived from the ovaries e.g. androstenedione and half (...) from the adrenal glands e.g. dehydroepiandrosterone. Some of the effects are direct and some due to peripheral conversion to estrogen by aromatase. Testosterone levels naturally decline throughout a woman’s lifespan. Loss of testosterone is particularly profound after iatrogenic i.e. surgical and medical menopause and premature ovarian insufficiency when testosterone production decreases by more than 50%. 2 What is its role in women? Testosterone contributes to libido, sexual arousal and orgasm

2019 British Menopause Society

16. Testosterone Replacement Guidelines

Testosterone Replacement Guidelines Page | 1 BSPED Guideline: Testosterone Therapy in Infancy and Adolescence Initial authors: R El-Khairi, N Shaw, EC Crowne (November 2016) Revision: A Chinoy, EC Crowne, M Skae (January 2018) Scope This guideline is intended for general paediatricians and paediatric endocrinologists who are regularly managing boys with absent/delayed puberty requiring exogenous testosterone therapy. This includes boys with hypogonadotrophic hypogonadism (HH) of various (...) aetiology, androgen deficiency secondary to testicular failure (hypergonadotrophic hypogonadism) of various aetiology, and constitutional delay of growth and puberty (CDGP). The aim of testosterone replacement therapy is to mimic the normal pattern of puberty and mimic requirements at different stages of pubertal development 1 . This guideline aims to provide the clinician with testosterone dosing regimens for pubertal induction, progression and post-pubertal maintenance, as well as for penile growth

2019 British Society for Paediatric Endocrinology and Diabetes

17. Testosterone (Testavan) - testosterone replacement therapy for adult male hypogonadism

Testosterone (Testavan) - testosterone replacement therapy for adult male hypogonadism Published 08 April 2019 1 www.scottishmedicines.org.uk Product update SMC2152 testosterone 20mg/g transdermal gel (Testavan®) Ferring Pharmaceuticals Ltd 8 March 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following (...) an abbreviated submission testosterone gel (Testavan ® ) is accepted for restricted use within NHSScotland. Indication under review: testosterone replacement therapy for adult male hypogonadism, when testosterone deficiency has been confirmed by clinical features and biochemical tests. SMC restriction: patients requiring a transdermal delivery system. Testosterone (Testavan ® ) is bioequivalent to another testosterone transdermal preparation and costs less. Advice context: No part of this advice may be used

2019 Scottish Medicines Consortium

18. Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank. Full Text available with Trip Pro

Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank. To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction.Two sample mendelian randomisation study using genetic variants as instrumental variables, randomly allocated at conception, to infer causality as additional randomised evidence.Reduction by Dutasteride of Prostate (...) participants, 13 691 had thromboembolism (6208 men, 7483 women), 1688 had heart failure (1186, 502), and 12 882 had myocardial infarction (10 136, 2746). In men, endogenous testosterone genetically predicted by variants in the JMJD1C gene region was positively associated with thromboembolism (odds ratio per unit increase in log transformed testosterone (nmol/L) 2.09, 95% confidence interval 1.27 to 3.46) and heart failure (7.81, 2.56 to 23.8), but not myocardial infarction (1.17, 0.78 to 1.75

2019 BMJ

19. Testosterone Testing - Protocol

Testosterone Testing - Protocol Testosterone Testing - Protocol - Province of British Columbia theme_3_collection theme_3_frontend theme_3_collection theme_3_frontend Birth, Adoption, Death, Marriage & Divorce theme_1_collection theme_1_frontend theme_1_collection theme_1_frontend British Columbians & Our Governments theme_data_collection data_frontend theme_data_collection data_frontend Data theme_5_collection theme_5_frontend theme_5_collection theme_5_frontend Driving & Transportation (...) & Culture theme_8_collection theme_8_frontend theme_8_collection theme_8_frontend Taxes & Tax Credits theme_14_collection theme_14_frontend theme_14_collection theme_14_frontend Tourism & Immigration Search default_collection default_frontend Section Navigation Testosterone Testing - Protocol Effective Date: September 19, 2018 Recommendations and Topics Scope This protocol reviews the appropriate use of serum testosterone testing in men and women aged ≥ 19 years. This document is intended to direct

2019 Clinical Practice Guidelines and Protocols in British Columbia

20. Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate. Full Text available with Trip Pro

Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate. Can injectable testosterone undecanoate (TU) be administered effectively and acceptably by the subcutaneous (SC) route?To investigate the acceptability and pharmacokinetics (PK) of SC injection of TU.Randomized sequence, crossover clinical study of SC vs IM TU injections.Ambulatory clinic of an academic andrology center.Twenty men (11 hypogonadal, 9 transgender men) who were long-term users of TU (...) . injections. Intervention: Injection of 1000 mg TU (in 4 mL castor oil vehicle) by SC or IM route. Main Outcome Measures: Patient-reported pain, acceptability, and preference scales. PK by measurement of serum testosterone, dihydrotestosterone (DHT), and estradiol (E2) concentrations with application of population PK methods and dried blood spot (DBS) sampling.Pain was greater after SC compared with IM injection 24 hours (but not immediately) after injection but both routes were equally acceptable

2019 Journal of the Endocrine Society Controlled trial quality: uncertain