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Top results for thyroid

1. Thyroid Disease in Pregnancy

Thyroid Disease in Pregnancy Thyroid Disease in Pregnancy | ACOG Clinical Guidance Journals & Publications Patient Education Topics Featured Clinical Topics Hi, Featured Clinical Topics Clinical Guidance Thyroid Disease in Pregnancy Practice Bulletin Number 223 June 2020 Jump to Resources Share By reading this page you agree to ACOG's Terms and Conditions. Nonmembers: Subscribe now to access exclusive ACOG Clinical content, including: ACOG Clinical is designed for easy and convenient access (...) and clinical management issues. Note for Life Fellows: Annual membership dues are waived but there is a discounted annual subscription fee of $95 for access to publications such as the Green Journal, Practice Bulletins, and Committee Opinions. Individual subscriptions include print and online access. . Jump to: Figures & Tables Figure 1. Clinical Algorithm for Management of Thyroid Disease in Pregnancy. Abbreviations: T 3 , triiodothyronine; T 4 , thyroxine; TRAB, thyroid receptor antibodies; TSH, thyroid

2020 American College of Obstetricians and Gynecologists

2. Thyroid hormone treatment: no proof of benefit in asymptomatic subclinical hypothyroidism.

Thyroid hormone treatment: no proof of benefit in asymptomatic subclinical hypothyroidism. Prescrire IN ENGLISH - Spotlight ''Thyroid hormone treatment: no proof of benefit in asymptomatic subclinical hypothyroidism.'', 1 June 2020 {1} {1} {1} | | > > > Thyroid hormone treatment: no proof of benefit in asymptomatic subclinical hypothyroidism. Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |  (...)  |   |   |  Spotlight Thyroid hormone treatment: no proof of benefit in asymptomatic subclinical hypothyroidism. According to a systematic review of comparative trials in approximately 2 000 patients, symptomless hypothyroidism discovered incidentally does not require thyroid hormone treatment (levothyroxine). So-called subclinical hypothyroidism is characterised by an elevated blood level of the pituitary hormone TSH but with a normal blood concentration of the thyroid

2020 Prescrire

3. Clinical Practice Guidelines – Thyroid cancer

Clinical Practice Guidelines – Thyroid cancer SPECIAL ARTICLE Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up † S. Filetti 1 , C. Durante 1 , D. Hartl 2,3 , S. Leboulleux 3,4 , L. D. Locati 5 , K. Newbold 6 , M. G. Papotti 7 & A. Berruti 8 , on behalf of the ESMO Guidelines Committee * 1 Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; 2 Department of Head and Neck Oncology, Gustave Roussy, Villejuif; 3 (...) Civili, Brescia, Italy Key words: papillary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, medullary thyroid cancer, management Introduction The aim of clinical practice guidelines is to provide physicians with the best available evidence on particular issues and recom- mendations for the best standards of care. They help health pro- fessionals weigh the bene?ts and the risks of available diagnostic or therapeutic options. Randomised clinical trial (RCT) data on the management

2020 European Society for Medical Oncology

4. A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery

A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features (...) in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation World J Surg Actions . 2020 Mar 19. doi: 10.1007/s00268-020-05458-6. Online ahead of print. A Double-Blind, Randomized Controlled Trial of Pre-incision Wound Infiltration Using Diclofenac Versus Bupivacaine for Post-operative Pain Relief in Open Thyroid and Parathyroid Surgery , , , Affiliations Expand Affiliations 1 Department of Surgery, University

2020 EvidenceUpdates

5. BTA/SFE statement regarding issues specific to thyroid dysfunction during the COVID -19 pandemic

BTA/SFE statement regarding issues specific to thyroid dysfunction during the COVID -19 pandemic v1 25th March 2020 BTA/SFE statement regarding issues specific to thyroid dysfunction during the COVID -19 pandemic The worldwide spread of the novel coronavirus, COVID-19, has recently been declared a pandemic. This presents many challenges to those of us working in healthcare, and will especially impact individuals with some chronic conditions. Members of the British Thyroid Association (BTA (...) ) and the Society for Endocrinology (SfE) have received numerous queries regarding how this pandemic may affect management of patients with thyroid disease, so we have formulated responses to these questions in order to assist our endocrine and primary care colleagues during this extraordinary time. We acknowledge that the situation is changing rapidly and also that local practice may differ depending on available resources and infrastructure. The British Thyroid Foundation (BTF) and Thyroid Cancer Forum-UK

2020 British Thyroid Association

6. Clinicopathological and prognostic significance of thyroid transcription factor-1 expression in small cell lung cancer: A systemic review and meta-analysis. (Abstract)

Clinicopathological and prognostic significance of thyroid transcription factor-1 expression in small cell lung cancer: A systemic review and meta-analysis. To explore the association of thyroid transcription factor-1 (TTF-1) expression status with clinicopathological characteristics and survival of patients with small cell lung cancer (SCLC).A comprehensive literature search was conducted to identify potentially relevant studies in several electronic databases, including EMBASE, PubMed, Web

2020 Pathology, research and practice

7. Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis. (Abstract)

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis. Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B (...) . The pooled cancer prevalence was 17% in Tir 3A and 47% in Tir 3B. The OR of Tir 3B vs. Tir 3A was 4.24 (95% CI 2.75 to 6.53) with mild heterogeneity and without publication bias. When we considered non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) as non-malignant, cancer rate was lower, and OR of Tir 3B against Tir 3A was 2.93 (95% CI 1.60 to 5.37), with no heterogeneity but with publication bias.The Italian system for thyroid cytology is reliable to assess

2020 Endocrine

8. Radioiodine Ablation of Remaining Thyroid Lobe in Patients with Differentiated Thyroid Cancer Treated by Lobectomy. A systematic review and meta-analysis. (Abstract)

Radioiodine Ablation of Remaining Thyroid Lobe in Patients with Differentiated Thyroid Cancer Treated by Lobectomy. A systematic review and meta-analysis. Purpose: We aimed to conduct a systematic review and meta-analysis of studies reporting the performance of radioactive iodine therapy (131-I therapy) in differentiating thyroid cancer (DTC) patients requiring a completion treatment following lobectomy. We also evaluated the response to 131-I therapy according to 2015ATA guidelines (...) %) in patients receiving higher activities of radioiodine (~3.7 Gbq). Neck pain due to thyroiditis was reported in up to 18% of patients but, in most cases, symptoms resolved after oral paracetamol or a short course of prednisone. Conclusion: Lobar ablation with 131-I is effective especially when high 131I activities are used. However, the rate of incomplete biochemical response to initial treatment appears to be slightly higher than the classical scheme of initial treatment of DTC. "Radioisotopic lobectomy

2020 Journal of nuclear medicine : official publication, Society of Nuclear Medicine

9. Genome-wide association meta-analysis for total thyroid hormone levels in Croatian population. (Full text)

Genome-wide association meta-analysis for total thyroid hormone levels in Croatian population. Thyroid hormones (THs) are key regulators of cellular growth, development, and metabolism. The thyroid gland secretes two THs, thyroxine (T4) and triiodothyronine (T3), into the plasma where they are almost all bound reversibly to plasma proteins. Free forms of THs are metabolically active, however, they represent a very small fraction of total TH levels. No genome-wide studies have been performed

2020 Journal of Human Genetics PubMed abstract

10. Thyroid Hormone (Triiodothyronine) Therapy in Children After Congenital Heart Surgery: A Meta-Analysis. (Abstract)

Thyroid Hormone (Triiodothyronine) Therapy in Children After Congenital Heart Surgery: A Meta-Analysis. Thyroid hormone modifies metabolic, immune and cardiovascular functions and has been administered perioperatively to treat a relative reduction of thyroid function in children following cardiopulmonary bypass (CPB) for correction of congenital heart disease. However, it remains unclear whether its use is associated with improved outcomes. We performed a meta-analysis of studies that evaluated (...) the impact of thyroid hormone supplementation on clinical outcomes in children undergoing repair of congenital heart disease using CPB. A systematic review of published trials was conducted to identify studies of children randomized to thyroid hormone supplementation or placebo undergoing congenital heart surgery. A meta-analysis was then conducted to determine the clinical impact of thyroid hormone replacement on cardiac function and postoperative characteristics. The following outcomes were included

2020 Seminars in thoracic and cardiovascular surgery

11. Clinical and Ultrasonic Risk Factors for Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis. (Full text)

Clinical and Ultrasonic Risk Factors for Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis. Background: Clinical and ultrasonic risk factors for lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC) are not well-defined. Herein, a systematic review and meta-analysis was conducted to investigate clinicopathologic and ultrasonic risk features for LLNM in PTMC. Methods: A systematic search of electronic databases (...) extension (OR, 3.63; 95% CI, 2.28-5.77; P <0.00), tumor multifocality (OR, 2.24; 95% CI, 1.53-3.28; P <0.00), tumor > 0.5 cm (OR, 2.24; 95% CI, 1.53-3.28; P < 0.00), central lymph node metastasis (OR, 5.61; 95% CI, 4.64-6.79; P < 0.00), >25% tumor contact with thyroid capsule (OR, 6.66; 95% CI, 1.96-22.65; P = 0.002), tumor calcification (OR, 2.90; 95% CI, 1.71-4.93; P < 0.00), upper tumor (OR, 3.18; 95% CI, 2.23-4.55; P < 0.00) were significantly associated with increased risk of LLNM in PTMC, while

2020 Frontiers in oncology PubMed abstract

12. Association of Patient Age With Progression of Low-Risk Papillary Thyroid Carcinoma Under Active Surveillance: A Systematic Review and Meta-analysis. (Abstract)

Association of Patient Age With Progression of Low-Risk Papillary Thyroid Carcinoma Under Active Surveillance: A Systematic Review and Meta-analysis. Active surveillance is sometimes considered as a disease management option for individuals with small, low-risk papillary thyroid carcinoma.To assess whether patient age is associated with progression of low-risk papillary thyroid carcinoma (tumor growth or incident metastatic disease) in adults under active surveillance.Eight electronic databases (...) in individuals 40 years or older was 0.22 (95% CI, 0.10-0.47; 1806 patients, 3 studies); however, in a secondary analysis, the risk difference was not significantly different. There was no statistically significant heterogeneity in any of the meta-analyses. There were no thyroid cancer-related deaths nor incident distant metastases.This study suggests that older age may be associated with a reduced risk of primary papillary thyroid carcinoma tumor growth under active surveillance. Incident metastatic disease

2020 JAMA otolaryngology-- head & neck surgery

13. Systematic review and meta-analysis of the effects of iodine supplementation on thyroid function and child neurodevelopment in mildly-to-moderately iodine-deficient pregnant women. (Abstract)

Systematic review and meta-analysis of the effects of iodine supplementation on thyroid function and child neurodevelopment in mildly-to-moderately iodine-deficient pregnant women. Mild-to-moderate iodine deficiency, particularly in pregnancy, is prevalent; this is of concern because observational studies have shown negative associations with child neurodevelopment. Although neither the benefits nor the safety of iodine supplementation in pregnancy in areas of mild-to-moderate deficiency (...) are well researched, such supplementation is increasingly being recommended by health authorities in a number of countries.By reviewing the most recent published data on the effects of iodine supplementation in mildly-to-moderately deficient pregnant women on maternal and infant thyroid function and child cognition, we aimed to determine whether the evidence was sufficient to support recommendations in these areas.A systematic review of randomized controlled trials (RCTs), non-RCT interventions

2020 The American journal of clinical nutrition

14. The Need for Dynamic Clinical Guidelines: A Systematic Review of New Research Published After Release of the 2017 ATA Guidelines on Thyroid Disease During Pregnancy and the Postpartum. (Full text)

The Need for Dynamic Clinical Guidelines: A Systematic Review of New Research Published After Release of the 2017 ATA Guidelines on Thyroid Disease During Pregnancy and the Postpartum. Background: The American Thyroid Association Guidelines on Thyroid Disease During Pregnancy and the Postpartum (ATA Guidelines) were published in 2017, with an update not expected for another 5 years. Since release of the 2017 ATA Guidelines, greater than 500 articles have been published in the field. Furthermore (...) "thyroid" and "pregnancy," a systematic review of literature published in Pubmed from 3/1/2017 to 12/31/2018 was conducted. The titles and/or abstracts of all articles were reviewed. All articles were classified by subject headings used in the 2017 ATA Guidelines. English-text articles classified under "hypothyroidism" or "thyroid autoimmunity" were examined in full-text. Using the questions and recommendations put forth by the previous ATA Guidelines, relevant articles were selected for discussion

2020 Frontiers in endocrinology PubMed abstract

15. Utility of Routine Frozen Section of Thyroid Nodules Classified as Follicular Neoplasm. (Abstract)

Utility of Routine Frozen Section of Thyroid Nodules Classified as Follicular Neoplasm. To evaluate the diagnostic performance of frozen section in thyroid nodules classified as follicular neoplasm.A diagnostic test meta-analysis was designed. Studies that assessed frozen section in patients with thyroid nodules and a fine-needle aspiration biopsy result of Bethesda IV were selected. The outcomes measured were the number of false- and true-positive and -negative results. We used the Quality

2020 American journal of clinical pathology

16. Thyroid hormone treatment in the management of treatment-resistant unipolar depression: a systematic review and meta-analysis. (Abstract)

Thyroid hormone treatment in the management of treatment-resistant unipolar depression: a systematic review and meta-analysis. Treatment with thyroid hormones is occasionally used in the management of treatment-resistant depression. However, the evidence supporting this treatment is not fully established. The aim of this study was to systematically review the literature on the effect of adjunctive thyroid hormone in the management of treatment-resistant unipolar depression and to provide (...) yielded 1355 records. Based on the screening of these records, we identified 10 studies that met the inclusion criteria (total number of patients = 663). The comparison of response to thyroid hormones vs. placebo resulted in an odds ratio of 1.56 (95% CI: 0.50-4.84). Similarly, the comparison of response to thyroid hormones vs. lithium resulted in an odds ratio of 1.91 (95% CI: 0.85-4.26). Thus, adjunctive therapy with thyroid hormones was not superior to placebo or lithium in the management

2020 Acta Psychiatrica Scandinavica

17. Contrast-enhanced ultrasound for the differential diagnosis of thyroid nodules: An updated meta-analysis with comprehensive heterogeneity analysis. (Full text)

Contrast-enhanced ultrasound for the differential diagnosis of thyroid nodules: An updated meta-analysis with comprehensive heterogeneity analysis. The diagnostic accuracy of contrast-enhanced ultrasound (CEUS) for distinguishing malignant thyroid nodules from benign thyroid nodules remains controversial. This meta-analysis was performed to evaluate the overall diagnostic value of CEUS for the characterization of thyroid nodules. Relevant studies were identified by searching PubMed, Embase (...) in the group of variable sizes group (I2 = 69.5%). However, meta-regression analysis revealed that only diagnostic criterion was the major source of heterogeneity (p = 0.0259). The risk of publication bias was negligible (p = 0.35). CEUS exhibited high accuracy for the identification of thyroid nodules and might provide additional perfusion information for the current US imaging reporting systems.

2020 PloS one PubMed abstract

18. Sorafenib and radioiodine-refractory differentiated thyroid cancer (RR-DTC): a systematic review and meta-analysis. (Abstract)

Sorafenib and radioiodine-refractory differentiated thyroid cancer (RR-DTC): a systematic review and meta-analysis. Except conventional treatments, research on medical approach for radioiodine-refractory differentiated thyroid cancer (RR-DTC) was considered particularly challenging. Sorafenib, a novel biological agent, has been widely studied in the treatment of RR-DTC for years. We performed a systematic review and meta-analysis to explore the efficiency and safety of treating RR-DTC patients

2020 Endocrine

19. A systematic review of the incidence of thyroid carcinoma in patients undergoing thyroidectomy for thyrotoxicosis. (Abstract)

A systematic review of the incidence of thyroid carcinoma in patients undergoing thyroidectomy for thyrotoxicosis. Hyperthyroidism (HT) has been associated with no insignificant rates of thyroid malignancy. There are no current specific guidelines that suggest routine preoperative imaging for thyroid nodules in patients with Grave's disease. We therefore performed a systematic review assessing rates of thyroid malignancy in patients undergoing surgery for different causes of HT: Grave's disease (...) (GD), toxic adenoma (TA) and toxic multinodular goitre (TMNG).Major databases (MEDLINE, PubMed and the Cochrane library) were searched to identify eligible studies.After searching and appraising, 33 papers were found to be eligible for analysis. The mean overall rate of malignancy was 8.5% (range 0.8%-32.4%). The mean rates based on histological subtype were as follows: papillary thyroid cancer (PTC), 3.1% (range 0%-13.2%); micropapillary carcinoma (mPTC), 5.1% (range 0%-16.9%); and follicular

2020 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

20. Author Correction: Cerebral glucose metabolism and Cerebral blood flow in thyroid dysfunction: An Activation Likelihood Estimation Meta-analysis. (Full text)

Author Correction: Cerebral glucose metabolism and Cerebral blood flow in thyroid dysfunction: An Activation Likelihood Estimation Meta-analysis. An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2020 Scientific reports PubMed abstract