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Latest & greatest articles for traumatic brain injury
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Paediatric TraumaticBrainInjury Consortium. Comparison of hypothermia and normothermia after severe traumaticbraininjury in children (Cool Kids): a phase 3, randomised controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumaticbraininjury outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Traumaticintracranialinjury in intoxicated patients with minor head trauma Studies focusing on minor head injury in intoxicated patients report disparate prevalences of intracranialinjury. It is unclear if the typical factors associated with intracranialinjury in published clinical decision rules for computerized tomography (CT) acquisition are helpful in differentiating patients with and without intracranialinjuries, as intoxication may obscure particular features of intracranialinjury (...) such as headache and mimic other signs of head injury such as altered mental status. This study aimed to estimate the prevalence of intracranialinjury following minor head injury (Glasgow Coma Scale [GCS] score ≥14) in intoxicated patients and to assess the performance of established clinical decision rules in this population.This was a prospective cohort study of consecutive intoxicated adults presenting to the emergency department (ED) following minor head injury. Historical and physical examination
A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumaticbraininjury Preclinical and clinical investigations indicate that the positive effect of hyperbaric oxygen (HBO2) for severe traumaticbraininjury (TBI) occurs after rather than during treatment. The brain appears better able to use baseline O2 levels following HBO2 (...) consecutive days. Intracranial pressure, surrogate markers for cerebral metabolism, and O2 toxicity were monitored. Clinical outcome was assessed at 6 months using the sliding dichotomized Glasgow Outcome Scale (GOS) score. Mixed-effects linear modeling was used to statistically test differences between the treatment and control groups. Functional outcome and mortality rates were compared using chi-square tests.There were no significant differences in demographic characteristics between the 2 groups
Interventions provided in the acute phase for mild traumaticbraininjury: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.
Mannitol for acute traumaticbraininjury. Mannitol is sometimes effective in reversing acute brain swelling, but its effectiveness in the ongoing management of severe head injury remains unclear. There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.To assess the effects of different mannitol therapy regimens, of mannitol compared to other intracranial pressure (ICP) lowering agents, and to quantify (...) the effectiveness of mannitol administration given at other stages following acute traumaticbrain injury.We searched the Cochrane Injuries Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE (OvidSP), EMBASE (OvidSP), ISI Web of Science (SCI-EXPANDED & CPCI-S) and PubMed. We checked reference lists of trials and review articles, and contacted authors of trials. The search was updated on the 20th April 2009.Randomised controlled trials of mannitol, in patients with acute traumaticbraininjury
Disparities in Disability After TraumaticBrainInjury Among Hispanic Children and Adolescents To compare the extent of disability in multiple areas of functioning after mild, moderate, and severe traumaticbraininjury (TBI) between Hispanic and non-Hispanic white (NHW) children.This was a prospective cohort study of children aged <18 years treated for a TBI between March 1, 2007, and September 30, 2008. Hispanic (n = 74) and NHW (n = 457) children were included in the study. Outcome measures (...) were disability in health-related quality of life, adaptive skills, and participation in activities 3, 12, 24, and 36 months after injury compared with preinjury functioning. We compared change in outcome scores between Hispanic and NHW children at each follow-up time. All analyses were adjusted for age, gender, severity and intent of injury, insurance, family function at baseline, parental education, and income.The health-related quality of life for all children was lower at all follow-up times
Complications of Mild TraumaticBrainInjury in Veterans and Military Personnel Management Briefs Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs Health Services Research & Development Management Briefs Management eBriefs: Provide VA senior managers with results from VA Health Services Research in a concise and timely manner. , April 2019, Issue 152 , March 2019, Issue 151 , March
Cognitive function and other risk factors for mild traumaticbraininjury in young men: nationwide cohort study. To investigate cognitive function and other risk factors for mild traumaticbraininjury in young men.Nationwide prospective cohort study.Sweden.305 885 men conscripted for military service from 1989 to 1994.mild traumaticbraininjuries in relation to cognitive function and other potential risk factors assessed at conscription and follow-up.Men with one mild traumaticbraininjury (...) within two years before (n=1988) or after cognitive testing (n=2214) had about 5.5% lower overall cognitive function scores than did men with no mild traumaticbraininjury during follow up (P<0.001 for both). Moreover, men with at least two mild traumaticbraininjuries after cognitive testing (n=795) had 15% lower overall cognitive function scores compared with those with no such injury (P<0.001). Independent strong risk factors (P<1×10(-10)) for at least one mild traumaticbraininjury after
Postconcussive Complaints, Anxiety, and Depression Related to Vocational Outcome in Minor to Severe TraumaticBrainInjury To investigate the relation of postconcussive complaints, anxiety, and depression with vocational outcome in patients with traumaticbraininjury (TBI) of various severities and to assess sex differences.A prospective cross-sectional cohort study.Level I trauma center.Adults (N=242) with TBI of various severity.Not applicable.Extended Glasgow Outcome Scale, return to work (...) (RTW), Head Injury Symptom Checklist, and Hospital Anxiety and Depression Scale.In 67% of the patients, complaints were present; 22% were anxious, and 18% were depressed. The frequency of complaints increased significantly with injury severity, in contrast to anxiety and depression. Frequencies of patients with anxiety and depression (9% and 5%) were lower with complete RTW than with incomplete RTW (42% and 37%; P<.001). Patients with minor TBI with complaints were more anxious (50% vs 27%; P<.05
BHR-100 for severe traumaticbraininjury ? first line BHR-100 for severe traumaticbraininjury – first line BHR-100 for severe traumaticbraininjury – first line NIHR HSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSC. BHR-100 for severe traumaticbraininjury – first line. Birmingham: NIHR Horizon Scanning Centre (NIHR HSC (...) ). Horizon Scanning Review. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH BrainInjuries; Progesterones Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health&Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom
Reliable Change in Postconcussive Symptoms and Its Functional Consequences Among Children With Mild TraumaticBrainInjury OBJECTIVE To examine reliable change in postconcussive symptoms and its functional consequences among children with mild traumaticbraininjury (TBI) over the first year postinjury as compared with children with orthopedic injuries. DESIGN Prospective, longitudinal cohort. SETTING Emergency departments at 2 children's hospitals. PARTICIPANTS Eight- to 15-year-old children (...) with mild TBI (n = 186) or orthopedic injuries (n = 99). MAIN EXPOSURE Closed-head or orthopedic trauma. MAIN OUTCOME MEASURES Parents rated preinjury symptoms retrospectively shortly after injury and postconcussive symptoms at 2 weeks and 3 and 12 months postinjury. A regression-based approach was used to determine whether each child displayed reliable increases in postconcussive symptoms at each postinjury occasion. Health-related quality of life was assessed at 3 and 12 months postinjury. Information
A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumaticbraininjury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumaticbraininjury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumaticbraininjury Pieracci FM, Moore EE, Beauchamp K, Tebockhorst S, Barnett CC, Bensard DD, Burlew CC, Biffl WL, Stoval RT (...) , Johnson JL Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the clinical and economic impact of levetiracetam, compared with phenytoin, to prevent early seizures after traumaticbraininjury. The authors concluded
A prospective study on employment outcome 3 years after moderate to severe traumaticbraininjury To evaluate the employment outcome in patients with moderate to severe traumaticbraininjury (TBI) and to identify which patients are at risk of unemployment 3 years after injury.Prospective cohort study.Patients with moderate and severe TBI discharged from the neurosurgery departments of 3 level 1 trauma centers in The Netherlands.Patients aged 18 to 65 years (N=113; mean age ± SD, 33.2±13.1y; 73 (...) % men) who were hospitalized with moderate (26% of patients) to severe (74% of patients) TBI.Not applicable.The main outcome measure was employment status. Potential predictors included patient characteristics, injury severity factors, functional outcome measured at discharge from the acute hospital with the Glasgow Outcome Scale (GOS), Barthel Index (BI), and FIM, and cognitive functioning measured with the Functional Assessment Measure (FAM).Ninety-four patients (83%) completed the 3-year follow
Specialized neurocritical care units for traumaticbraininjury Specialized neurocritical care units for traumaticbraininjury Specialized neurocritical care units for traumaticbraininjury Mitchell MD, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Williams K. Specialized neurocritical care units for traumaticbraininjury (...) . Philadelphia: Center for Evidence-based Practice (CEP). 2012 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH BrainInjuries; Critical Cares; Intensive Care Units; Outcome and Process Assessment (Health Care) Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104
WITHDRAWN: Antiepileptic drugs for preventing seizures following acute traumaticbraininjury. Seizure activity in the early post-traumatic period following head injury may cause secondary brain damage as a result of increased metabolic demands, raised intracranial pressure and excess neurotransmitter release.To determine the effects of prophylactic anti-epileptic agents for acute traumatic head injury.We searched the Cochrane Injuries Group specialised register, MEDLINE and the registers (...) of the Cochrane Stroke Group and Cochrane Epilepsy Group. We contacted pharmaceutical companies who manufacture anti-epileptic agents, the National Institute of Neurological Disorders and Stroke, Epilepsy Division, and the United States' National Institute of Health.All randomised trials of anti-epileptic agents, in which study participants had a clinically defined acute traumatic head injury of any severity. Trials in which the intervention was started more than eight weeks after injury were excluded.Two