Latest & greatest articles for traumatic brain injury

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Top results for traumatic brain injury

101. Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumatic brain injury outcomes

Meta-analysis of Glasgow Coma Scale and Simplified Motor Score in predicting traumatic brain injury outcomes Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2013 DARE.

102. Traumatic intracranial injury in intoxicated patients with minor head trauma (Abstract)

Traumatic intracranial injury in intoxicated patients with minor head trauma Studies focusing on minor head injury in intoxicated patients report disparate prevalences of intracranial injury. It is unclear if the typical factors associated with intracranial injury in published clinical decision rules for computerized tomography (CT) acquisition are helpful in differentiating patients with and without intracranial injuries, as intoxication may obscure particular features of intracranial injury (...) such as headache and mimic other signs of head injury such as altered mental status. This study aimed to estimate the prevalence of intracranial injury following minor head injury (Glasgow Coma Scale [GCS] score ≥14) in intoxicated patients and to assess the performance of established clinical decision rules in this population.This was a prospective cohort study of consecutive intoxicated adults presenting to the emergency department (ED) following minor head injury. Historical and physical examination

2013 EvidenceUpdates

103. A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury Full Text available with Trip Pro

A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury Preclinical and clinical investigations indicate that the positive effect of hyperbaric oxygen (HBO2) for severe traumatic brain injury (TBI) occurs after rather than during treatment. The brain appears better able to use baseline O2 levels following HBO2 (...) consecutive days. Intracranial pressure, surrogate markers for cerebral metabolism, and O2 toxicity were monitored. Clinical outcome was assessed at 6 months using the sliding dichotomized Glasgow Outcome Scale (GOS) score. Mixed-effects linear modeling was used to statistically test differences between the treatment and control groups. Functional outcome and mortality rates were compared using chi-square tests.There were no significant differences in demographic characteristics between the 2 groups

2013 EvidenceUpdates Controlled trial quality: uncertain

104. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial Full Text available with Trip Pro

Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial On the basis of mixed results from previous trials, we assessed whether therapeutic hypothermia for 48-72 h with slow rewarming improved mortality in children after brain injury.In this phase 3, multicenter, multinational, randomised controlled trial, we included patients with severe traumatic brain injury who were younger than 18 years and could (...) of adverse events or serious adverse events.Hypothermia for 48 h with slow rewarming does not reduce mortality of improve global functional outcome after paediatric severe traumatic brain injury.National Institute of Neurological Disorders and Stroke and National Institutes of Health.Copyright © 2013 Elsevier Ltd. All rights reserved.

2013 EvidenceUpdates Controlled trial quality: predicted high

105. Interventions provided in the acute phase for mild traumatic brain injury: a systematic review

Interventions provided in the acute phase for mild traumatic brain injury: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2013 DARE.

106. Mannitol for acute traumatic brain injury. Full Text available with Trip Pro

Mannitol for acute traumatic brain injury. Mannitol is sometimes effective in reversing acute brain swelling, but its effectiveness in the ongoing management of severe head injury remains unclear. There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause increased intracranial pressure.To assess the effects of different mannitol therapy regimens, of mannitol compared to other intracranial pressure (ICP) lowering agents, and to quantify (...) the effectiveness of mannitol administration given at other stages following acute traumatic brain injury.We searched the Cochrane Injuries Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE (OvidSP), EMBASE (OvidSP), ISI Web of Science (SCI-EXPANDED & CPCI-S) and PubMed. We checked reference lists of trials and review articles, and contacted authors of trials. The search was updated on the 20th April 2009.Randomised controlled trials of mannitol, in patients with acute traumatic brain injury

2013 Cochrane

107. A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury

A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2013 PedsCCM Evidence-Based Journal Club

108. Disparities in Disability After Traumatic Brain Injury Among Hispanic Children and Adolescents Full Text available with Trip Pro

Disparities in Disability After Traumatic Brain Injury Among Hispanic Children and Adolescents To compare the extent of disability in multiple areas of functioning after mild, moderate, and severe traumatic brain injury (TBI) between Hispanic and non-Hispanic white (NHW) children.This was a prospective cohort study of children aged <18 years treated for a TBI between March 1, 2007, and September 30, 2008. Hispanic (n = 74) and NHW (n = 457) children were included in the study. Outcome measures (...) were disability in health-related quality of life, adaptive skills, and participation in activities 3, 12, 24, and 36 months after injury compared with preinjury functioning. We compared change in outcome scores between Hispanic and NHW children at each follow-up time. All analyses were adjusted for age, gender, severity and intent of injury, insurance, family function at baseline, parental education, and income.The health-related quality of life for all children was lower at all follow-up times

2013 EvidenceUpdates

109. Complications of Mild Traumatic Brain Injury in Veterans and Military Personnel

Complications of Mild Traumatic Brain Injury in Veterans and Military Personnel Management Briefs Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs Health Services Research & Development Management Briefs Management eBriefs: Provide VA senior managers with results from VA Health Services Research in a concise and timely manner. , April 2019, Issue 152 , March 2019, Issue 151 , March

2013 Veterans Affairs - R&D

110. Cognitive function and other risk factors for mild traumatic brain injury in young men: nationwide cohort study. Full Text available with Trip Pro

Cognitive function and other risk factors for mild traumatic brain injury in young men: nationwide cohort study. To investigate cognitive function and other risk factors for mild traumatic brain injury in young men.Nationwide prospective cohort study.Sweden.305 885 men conscripted for military service from 1989 to 1994.mild traumatic brain injuries in relation to cognitive function and other potential risk factors assessed at conscription and follow-up.Men with one mild traumatic brain injury (...) within two years before (n=1988) or after cognitive testing (n=2214) had about 5.5% lower overall cognitive function scores than did men with no mild traumatic brain injury during follow up (P<0.001 for both). Moreover, men with at least two mild traumatic brain injuries after cognitive testing (n=795) had 15% lower overall cognitive function scores compared with those with no such injury (P<0.001). Independent strong risk factors (P<1×10(-10)) for at least one mild traumatic brain injury after

2013 BMJ

111. Postconcussive Complaints, Anxiety, and Depression Related to Vocational Outcome in Minor to Severe Traumatic Brain Injury (Abstract)

Postconcussive Complaints, Anxiety, and Depression Related to Vocational Outcome in Minor to Severe Traumatic Brain Injury To investigate the relation of postconcussive complaints, anxiety, and depression with vocational outcome in patients with traumatic brain injury (TBI) of various severities and to assess sex differences.A prospective cross-sectional cohort study.Level I trauma center.Adults (N=242) with TBI of various severity.Not applicable.Extended Glasgow Outcome Scale, return to work (...) (RTW), Head Injury Symptom Checklist, and Hospital Anxiety and Depression Scale.In 67% of the patients, complaints were present; 22% were anxious, and 18% were depressed. The frequency of complaints increased significantly with injury severity, in contrast to anxiety and depression. Frequencies of patients with anxiety and depression (9% and 5%) were lower with complete RTW than with incomplete RTW (42% and 37%; P<.001). Patients with minor TBI with complaints were more anxious (50% vs 27%; P<.05

2013 EvidenceUpdates

112. BHR-100 for severe traumatic brain injury ? first line

BHR-100 for severe traumatic brain injury ? first line BHR-100 for severe traumatic brain injury – first line BHR-100 for severe traumatic brain injury – first line NIHR HSC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSC. BHR-100 for severe traumatic brain injury – first line. Birmingham: NIHR Horizon Scanning Centre (NIHR HSC (...) ). Horizon Scanning Review. 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Brain Injuries; Progesterones Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence The NIHR Horizon Scanning Centre, Department of Public Health, Epidemiology, and Biostatistics, School of Health&Population Sciences, University of Birmingham, 90 Vincent Drive, Edgbaston, Birmingham, B15 2SP. United Kingdom

2013 Health Technology Assessment (HTA) Database.

113. Reliable Change in Postconcussive Symptoms and Its Functional Consequences Among Children With Mild Traumatic Brain Injury Full Text available with Trip Pro

Reliable Change in Postconcussive Symptoms and Its Functional Consequences Among Children With Mild Traumatic Brain Injury OBJECTIVE To examine reliable change in postconcussive symptoms and its functional consequences among children with mild traumatic brain injury (TBI) over the first year postinjury as compared with children with orthopedic injuries. DESIGN Prospective, longitudinal cohort. SETTING Emergency departments at 2 children's hospitals. PARTICIPANTS Eight- to 15-year-old children (...) with mild TBI (n = 186) or orthopedic injuries (n = 99). MAIN EXPOSURE Closed-head or orthopedic trauma. MAIN OUTCOME MEASURES Parents rated preinjury symptoms retrospectively shortly after injury and postconcussive symptoms at 2 weeks and 3 and 12 months postinjury. A regression-based approach was used to determine whether each child displayed reliable increases in postconcussive symptoms at each postinjury occasion. Health-related quality of life was assessed at 3 and 12 months postinjury. Information

2013 EvidenceUpdates

114. A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury Full Text available with Trip Pro

A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury Pieracci FM, Moore EE, Beauchamp K, Tebockhorst S, Barnett CC, Bensard DD, Burlew CC, Biffl WL, Stoval RT (...) , Johnson JL Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study examined the clinical and economic impact of levetiracetam, compared with phenytoin, to prevent early seizures after traumatic brain injury. The authors concluded

2013 NHS Economic Evaluation Database.

115. A prospective study on employment outcome 3 years after moderate to severe traumatic brain injury (Abstract)

A prospective study on employment outcome 3 years after moderate to severe traumatic brain injury To evaluate the employment outcome in patients with moderate to severe traumatic brain injury (TBI) and to identify which patients are at risk of unemployment 3 years after injury.Prospective cohort study.Patients with moderate and severe TBI discharged from the neurosurgery departments of 3 level 1 trauma centers in The Netherlands.Patients aged 18 to 65 years (N=113; mean age ± SD, 33.2±13.1y; 73 (...) % men) who were hospitalized with moderate (26% of patients) to severe (74% of patients) TBI.Not applicable.The main outcome measure was employment status. Potential predictors included patient characteristics, injury severity factors, functional outcome measured at discharge from the acute hospital with the Glasgow Outcome Scale (GOS), Barthel Index (BI), and FIM, and cognitive functioning measured with the Functional Assessment Measure (FAM).Ninety-four patients (83%) completed the 3-year follow

2012 EvidenceUpdates

116. Early management of severe traumatic brain injury. (Abstract)

Early management of severe traumatic brain injury. Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury, this has not yet led to substantial improvements in outcome. In this report, we address present knowledge and its limitations, research innovations, and clinical implications. Improved outcomes for patients with severe traumatic brain injury could result from progress (...) in pharmacological and other treatments, neural repair and regeneration, optimisation of surgical indications and techniques, and combination and individually targeted treatments. Expanded classification of traumatic brain injury and innovations in research design will underpin these advances. We are optimistic that further gains in outcome for patients with severe traumatic brain injury will be achieved in the next decade.Copyright © 2012 Elsevier Ltd. All rights reserved.

2012 Lancet

117. Specialized neurocritical care units for traumatic brain injury

Specialized neurocritical care units for traumatic brain injury Specialized neurocritical care units for traumatic brain injury Specialized neurocritical care units for traumatic brain injury Mitchell MD, Williams K Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mitchell MD, Williams K. Specialized neurocritical care units for traumatic brain injury (...) . Philadelphia: Center for Evidence-based Practice (CEP). 2012 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Brain Injuries; Critical Cares; Intensive Care Units; Outcome and Process Assessment (Health Care) Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence Center for Evidence-based Practice, University of Pennsylvania Health System, 3535 Market St. Suite 50, Philadelphia PA 19104

2012 Health Technology Assessment (HTA) Database.

118. WITHDRAWN: Antiepileptic drugs for preventing seizures following acute traumatic brain injury. Full Text available with Trip Pro

WITHDRAWN: Antiepileptic drugs for preventing seizures following acute traumatic brain injury. Seizure activity in the early post-traumatic period following head injury may cause secondary brain damage as a result of increased metabolic demands, raised intracranial pressure and excess neurotransmitter release.To determine the effects of prophylactic anti-epileptic agents for acute traumatic head injury.We searched the Cochrane Injuries Group specialised register, MEDLINE and the registers (...) of the Cochrane Stroke Group and Cochrane Epilepsy Group. We contacted pharmaceutical companies who manufacture anti-epileptic agents, the National Institute of Neurological Disorders and Stroke, Epilepsy Division, and the United States' National Institute of Health.All randomised trials of anti-epileptic agents, in which study participants had a clinically defined acute traumatic head injury of any severity. Trials in which the intervention was started more than eight weeks after injury were excluded.Two

2012 Cochrane

119. Performance of the Canadian CT Head Rule and the New Orleans Criteria for predicting any traumatic intracranial injury on computed tomography in a United States Level I trauma center Full Text available with Trip Pro

with GCS 15. The primary outcome was prediction of "any traumatic intracranial injury" on CT. Secondary outcomes included "clinically important brain injury" on CT and need for neurosurgical intervention.Among the 431 enrolled patients, 314 patients (73%) had a GCS of 15, and 22 of the 314 (7%) had evidence of a traumatic intracranial lesion on CT. There were 11 of 314 (3.5%) who had "clinically important" brain injury, and 3 of 314 (1.0%) required neurosurgical intervention. The NOC and CCHR both had (...) -injured patients, the CCHR and the NOC had equivalently high sensitivities for detecting any traumatic intracranial lesion on CT, clinically important brain injury, and neurosurgical intervention, but the CCHR was more specific. A larger cohort will be needed to validate these findings.© 2012 by the Society for Academic Emergency Medicine.

2012 EvidenceUpdates

120. Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges

Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges Use of a mild traumatic brain injury guideline to reduce inpatient hospital imaging and charges Goldberg J, McClaine RJ, Cook B, Garcia VF, Brown RL, Crone K, Falcone RA Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract (...) contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study evaluated the impact of guidelines for the treatment of mild traumatic brain injury in paediatric patients, in reducing hospital charges and computed tomography (CT) scans. The implementation of the guideline resulted in a significant reduction in CT scans, length of stay, and patient charges. There were

2012 NHS Economic Evaluation Database.