Latest & greatest articles for tuberculosis

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Top results for tuberculosis

1. Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults. (Abstract)

Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults. In regions with high burdens of tuberculosis and human immunodeficiency virus (HIV), many HIV-infected adults begin antiretroviral therapy (ART) when they are already severely immunocompromised. Mortality after ART initiation is high in these patients, and tuberculosis and invasive bacterial diseases are common causes of death.We conducted a 48-week trial of empirical treatment for tuberculosis as compared (...) with treatment guided by testing in HIV-infected adults who had not previously received ART and had CD4+ T-cell counts below 100 cells per cubic millimeter. Patients recruited in Ivory Coast, Uganda, Cambodia, and Vietnam were randomly assigned in a 1:1 ratio to undergo screening (Xpert MTB/RIF test, urinary lipoarabinomannan test, and chest radiography) to determine whether treatment for tuberculosis should be started or to receive systematic empirical treatment with rifampin, isoniazid, ethambutol

2020 NEJM

2. Health System Costs of Treating Latent Tuberculosis Infection With Four Months of Rifampin Versus Nine Months of Isoniazid in Different Settings. (Abstract)

Health System Costs of Treating Latent Tuberculosis Infection With Four Months of Rifampin Versus Nine Months of Isoniazid in Different Settings. Four months of rifampin treatment for latent tuberculosis infection is safer, has superior treatment completion rates, and is as effective as 9 months of isoniazid. However, daily medication costs are higher for a 4-month rifampin regimen than a 9-month isoniazid regimen.To compare health care use and associated costs of 4 months of rifampin and 9 (...) months of isoniazid.Health system cost comparison using all health care activities recorded during 2 randomized clinical trials. (ClinicalTrials.gov: NCT00931736 and NCT00170209).High-income countries (Australia, Canada, Saudi Arabia, and South Korea), middle-income countries (Brazil and Indonesia), and African countries (Benin, Ghana, and Guinea).Adults and children with clinical or epidemiologic factors associated with increased risk for developing tuberculosis that warranted treatment for latent

2020 Annals of Internal Medicine

3. Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Development Goal 3. Full Text available with Trip Pro

Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health: progress towards Sustainable Development Goal 3. Sustainable Development Goal (SDG) 3 aims to "ensure healthy lives and promote well-being for all at all ages". While a substantial effort has been made to quantify progress towards SDG3, less research has focused on tracking spending towards this goal. We used spending estimates to measure progress in financing the priority areas (...) of SDG3, examine the association between outcomes and financing, and identify where resource gains are most needed to achieve the SDG3 indicators for which data are available.We estimated domestic health spending, disaggregated by source (government, out-of-pocket, and prepaid private) from 1995 to 2017 for 195 countries and territories. For disease-specific health spending, we estimated spending for HIV/AIDS and tuberculosis for 135 low-income and middle-income countries, and malaria in 106 malaria

2020 Lancet

4. Treatment of Highly Drug-Resistant Pulmonary Tuberculosis. Full Text available with Trip Pro

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis. Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically have had poor outcomes.In an open-label, single-group study in which follow-up is ongoing at three South African sites, we investigated treatment with three oral drugs - bedaquiline, pretomanid, and linezolid - that have bactericidal activity against tuberculosis and to which there is little preexisting resistance. We evaluated (...) the safety and efficacy of the drug combination for 26 weeks in patients with extensively drug-resistant tuberculosis and patients with multidrug-resistant tuberculosis that was not responsive to treatment or for which a second-line regimen had been discontinued because of side effects. The primary end point was the incidence of an unfavorable outcome, defined as treatment failure (bacteriologic or clinical) or relapse during follow-up, which continued until 6 months after the end of treatment. Patients

2020 NEJM

5. Current and future treatments for tuberculosis. Full Text available with Trip Pro

Current and future treatments for tuberculosis. Guidelines on the treatment of tuberculosis (TB) have essentially remained the same for the past 35 years, but are now starting to change. Ongoing clinical trials will hopefully transform the landscape for treatment of drug sensitive TB, drug resistant TB, and latent TB infection. Multiple trials are evaluating novel agents, repurposed agents, adjunctive host directed therapies, and novel treatment strategies that will increase the probability

2020 BMJ

6. Tuberculosis among First Nations, Inuit and Métis children and youth in Canada: Beyond medical management

Tuberculosis among First Nations, Inuit and Métis children and youth in Canada: Beyond medical management First Nations, Inuit and Métis people in Canada continue to be disproportionately affected by tuberculosis (TB), a disparity rooted primarily in factors such as poverty, crowded and inadequate housing, food insecurity, and inequitable health care access. Historical TB control practices in Canada have contributed to stigma and discrimination toward those with the disease, as well (...) , improve the quality and uptake of services for treatment and prevention in families and communities at risk. They can also advocate for sustainable, community-driven TB elimination strategies that incorporate First Nations, Inuit and Métis principles of wellness, healing and self-determination.   Key words: First Nations, Inuit, Métis, Indigenous, child health, tuberculosis, LTBI, social determinants

2020 Canadian Paediatric Society

7. Tuberculosis and pregnant women

Tuberculosis and pregnant women Tuberculosis and pregnant women - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Tuberculosis and pregnant women Guidance for patients and the public and for clinical staff involved in treating pregnant women. Published 1 November 2013 Last (...) . Please tell us what format you need. It will help us if you say what assistive technology you use. Details One set of guidance is for pregnant women and members of the public. The other is for clinical staff treating pregnant women who have had contact with a person with infectious tuberculosis ( 17 December 2019 Updated to reflect changes in national guidance and availability of services. 1 November 2013 First published. Related content Collection Explore the topic Is this page useful? Thank you

2020 Public Health England

8. Tuberculosis: information for prison and immigration removal centre staff

Tuberculosis: information for prison and immigration removal centre staff Tuberculosis: information for prison and immigration removal centre staff - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Tuberculosis: information for prison and immigration removal centre staff Advice (...) information for prison and immigration removal centre staff on: spotting symptoms of 17 December 2019 Updated 'Tuberculosis: information for prisons and immigration removal centre staff'. 22 March 2019 Updated guidance on 'Tuberculosis (TB): information for discipline and wing staff'. 1 November 2013 First published. Related content Collection Explore the topic Is this page useful? Thank you for your feedback Help us improve GOV.UK Don’t include personal or financial information like your National

2020 Public Health England

9. Tuberculosis (TB) and homelessness

Tuberculosis (TB) and homelessness Tuberculosis (TB) and homelessness - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Tuberculosis (TB) and homelessness Advice for people who work in the homeless sector. Published 1 November 2013 Last updated 16 December 2019 — From: Documents (...) . It will help us if you say what assistive technology you use. Details People who work in the homelessness sector can use this information to help them to recognise 16 December 2019 Updated documents. 7 January 2016 Added 'Tuberculosis (TB) and homelessness: information for homelessness service managers'. 1 November 2013 First published. Related content Collection Explore the topic Is this page useful? Thank you for your feedback Help us improve GOV.UK Don’t include personal or financial information like

2020 Public Health England

10. Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline Full Text available with Trip Pro

Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S (...) Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Am J Respir Crit Care Med Actions , 200 (10), e93-e142 2019 Nov 15 Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , PMID: 31729908 PMCID: DOI: Item in Clipboard Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA

2020 EvidenceUpdates

11. Final Analysis of a Trial of M72/AS01<sub>E</sub> Vaccine to Prevent Tuberculosis. Full Text available with Trip Pro

Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis. Results of an earlier analysis of a trial of the M72/AS01E candidate vaccine against Mycobacterium tuberculosis showed that in infected adults, the vaccine provided 54.0% protection against active pulmonary tuberculosis disease, without evident safety concerns. We now report the results of the 3-year final analysis of efficacy, safety, and immunogenicity.From August 2014 through November 2015, we enrolled adults (...) 18 to 50 years of age with M. tuberculosis infection (defined by positive results on interferon-γ release assay) without evidence of active tuberculosis disease at centers in Kenya, South Africa, and Zambia. Participants were randomly assigned in a 1:1 ratio to receive two doses of either M72/AS01E or placebo, administered 1 month apart. The primary objective was to evaluate the efficacy of M72/AS01E to prevent active pulmonary tuberculosis disease according to the first case definition

2019 NEJM

12. Tuberculosis (TB) and children

Tuberculosis (TB) and children Tuberculosis (TB) and children - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Tuberculosis (TB) and children Guidance for all of those who work with children. Explains how (...) Updated 'Tuberculosis and children: information for all of those who work with children'. 1 November 2013 First published. Related content Collection Explore the topic Is this page useful? Thank you for your feedback Help us improve GOV.UK Don’t include personal or financial information like your National Insurance number or credit card details. What were you doing? What went wrong? Send Help us improve GOV.UK To help us improve GOV.UK, we’d like to know more about your visit today. We’ll send you

2019 Public Health England

13. Transmissibility and potential for disease progression of drug resistant <i>Mycobacterium tuberculosis</i>: prospective cohort study. Full Text available with Trip Pro

Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. To measure the association between phenotypic drug resistance and the risk of tuberculosis infection and disease among household contacts of patients with pulmonary tuberculosis.106 district health centers in Lima, Peru between September 2009 and September 2012.Prospective cohort study.10 160 household contacts of 3339 index patients with tuberculosis were (...) classified on the basis of the drug resistance profile of the patient: 6189 were exposed to drug susceptible strains of Mycobacterium tuberculosis, 1659 to strains resistant to isoniazid or rifampicin, and 1541 to strains that were multidrug resistant (resistant to isoniazid and rifampicin).Tuberculosis infection (positive tuberculin skin test) and the incidence of active disease (diagnosed by positive sputum smear or chest radiograph) after 12 months of follow-up.Household contacts exposed to patients

2019 BMJ

14. Community-wide Screening for Tuberculosis in a High-Prevalence Setting. Full Text available with Trip Pro

Community-wide Screening for Tuberculosis in a High-Prevalence Setting. The World Health Organization has set ambitious targets for the global elimination of tuberculosis. However, these targets will not be achieved at the current rate of progress.We performed a cluster-randomized, controlled trial in Ca Mau Province, Vietnam, to evaluate the effectiveness of active community-wide screening, as compared with standard passive case detection alone, for reducing the prevalence of tuberculosis (...) . Persons 15 years of age or older who resided in 60 intervention clusters (subcommunes) were screened for pulmonary tuberculosis, regardless of symptoms, annually for 3 years, beginning in 2014, by means of rapid nucleic acid amplification testing of spontaneously expectorated sputum samples. Active screening was not performed in the 60 control clusters in the first 3 years. The primary outcome, measured in the fourth year, was the prevalence of microbiologically confirmed pulmonary tuberculosis among

2019 NEJM

15. Interventions for the Diagnosis of Tuberculosis: Clinical Effectiveness and Guidelines

Interventions for the Diagnosis of Tuberculosis: Clinical Effectiveness and Guidelines Interventions for the Diagnosis of Tuberculosis: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Interventions for the Diagnosis of Tuberculosis: Clinical Effectiveness and Guidelines Interventions for the Diagnosis of Tuberculosis: Clinical Effectiveness and Guidelines Last updated: July 2, 2019 Project Number: RA1044-000 Product Line: Research Type: Devices and Systems Report (...) Type: Reference List Result type: Report Question What is the clinical effectiveness of interventions used for the diagnosis of tuberculosis? What are the evidence-based guidelines regarding the diagnosis of tuberculosis? Key Message One health technology assessment and fourteen systematic reviews (twelve with meta-analysis) were identified regarding the clinical effectiveness of interventions used to diagnose tuberculosis. In addition, seven evidence-based guidelines were identified regarding

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

16. Interventions for the Treatment or Management of Tuberculosis: Clinical Effectiveness and Guidelines

Interventions for the Treatment or Management of Tuberculosis: Clinical Effectiveness and Guidelines Interventions for the Treatment or Management of Tuberculosis: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Interventions for the Treatment or Management of Tuberculosis: Clinical Effectiveness and Guidelines Interventions for the Treatment or Management of Tuberculosis: Clinical Effectiveness and Guidelines Last updated: July 8, 2019 Project Number: RA1045-000 (...) Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of interventions used to treat or manage individuals with tuberculosis? What are the evidence-based guidelines regarding the treatment or management of individuals with tuberculosis? Key Message Nine systematic reviews (eight with meta-analysis) and four evidence-based guidelines were identified regarding the treatment or management of individuals

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

17. Interventions Used to Screen for Tuberculosis: Clinical Effectiveness and Guidelines

Interventions Used to Screen for Tuberculosis: Clinical Effectiveness and Guidelines Interventions Used to Screen for Tuberculosis: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Interventions Used to Screen for Tuberculosis: Clinical Effectiveness and Guidelines Interventions Used to Screen for Tuberculosis: Clinical Effectiveness and Guidelines Last updated: June 24, 2019 Project Number: RA1043-000 Product Line: Research Type: Devices and Systems Report Type (...) : Reference List Result type: Report Question What is the clinical effectiveness of interventions used to screen individuals for tuberculosis? What are the evidence-based guidelines regarding the screening of individuals for tuberculosis? Key Message Twelve systematic reviews (eight with meta-analysis) were identified regarding the clinical effectivenessof interventions used to screen individuals for tuberculosis. In addition, four evidence-based guidelines were identified regarding the screening

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

18. Pretomanid - For treatment-resistant forms of tuberculosis

Pretomanid - For treatment-resistant forms of tuberculosis Drug Approval Package: Pretomanid U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: Pretomanid Company: The Global Alliance for TB Drug Development, Inc. (TB Alliance) Application Number: 212862 Approval Date: 08/14/2019 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application

2019 FDA - Drug Approval Package

19. Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals. (Abstract)

Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals. Accurate diagnosis of tuberculosis in people living with HIV is difficult. HIV-positive individuals have higher rates of extrapulmonary tuberculosis and the diagnosis of tuberculosis is often limited to imaging results. Ultrasound is such an imaging test that is widely used as a diagnostic tool (including point-of-care) in people suspected of having (...) abdominal tuberculosis or disseminated tuberculosis with abdominal involvement.To determine the diagnostic accuracy of abdominal ultrasound for detecting abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals.To investigate potential sources of heterogeneity in test accuracy, including clinical setting, ultrasound training level, and type of reference standard.We searched for publications in any language up to 4 April 2019 in the following databases

2019 Cochrane

20. Management of drug-resistant tuberculosis. (Abstract)

Management of drug-resistant tuberculosis. Drug-resistant tuberculosis is a major public health concern in many countries. Over the past decade, the number of patients infected with Mycobacterium tuberculosis resistant to the most effective drugs against tuberculosis (ie, rifampicin and isoniazid), which is called multidrug-resistant tuberculosis, has continued to increase. Globally, 4·6% of patients with tuberculosis have multidrug-resistant tuberculosis, but in some areas, like Kazakhstan (...) , Kyrgyzstan, Moldova, and Ukraine, this proportion exceeds 25%. Treatment for patients with multidrug-resistant tuberculosis is prolonged (ie, 9-24 months) and patients with multidrug-resistant tuberculosis have less favourable outcomes than those treated for drug-susceptible tuberculosis. Individualised multidrug-resistant tuberculosis treatment with novel (eg, bedaquiline) and repurposed (eg, linezolid, clofazimine, or meropenem) drugs and guided by genotypic and phenotypic drug susceptibility testing

2019 Lancet