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Latest & greatest articles for type 2 diabetes
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on type 2 diabetes or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on type 2 diabetes and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
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Combination Therapy with an SGLT2 Inhibitor as Initial Treatment for Type2Diabetes: A Systematic Review and Meta-Analysis. Guidelines differ with regard to indications for initial combination pharmacotherapy for type2 diabetes.To compare the efficacy and safety of (i) sodium-glucose cotransporter 2 (SGLT2) inhibitor combination therapy in treatment-naïve type2diabetes adults; (ii) initial high and low dose SGLT2 inhibitor combination therapy.PubMed, Embase and Cochrane Library were
Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis. Strict glucose control using multiple doses of insulin is the standard treatment for type 1 diabetes mellitus (T1DM), but increased risk of hypoglycemia is a frequent drawback. Regular insulin in multiple doses is important for achieving strict glycemic control for T1DM, but short-acting insulin analogues may be better
Effects of exercise training on Fetuin-a in obese, type2diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis. Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type2diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults.We searched clinical trials that objectively assessed fetuin-A and included study arms with exercise (...) intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges' g using random-effects models.The overall Hedges' g for fetuin-A in all included interventions was - 0.640 (95%CI - 1.129 to - 0.151; n = 9), but this effect was not observed in obese (g = - 0.096; 95%CI, - 0.328 to 0.135) and type2diabetes/dysglycemia (g = - 0.56; 95%CI, - 1.348 to 0.236) individuals
Association between sarcopenic obesity and higher risk of type2diabetes in adults: A systematic review and meta-analysis. The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity (SO) and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its potential negative effects on health outcomes.To conduct a systematic review to determine (...) the prevalence of sarcopenia among adults with overweight and obesity and to investigate whether SO was associated with a higher risk of type2diabetes (T2D).This study was conducted in adherence with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Literature searches, study selection, methodology development and quality appraisal were performed independently by two authors and the data were collated by means of meta-analysis and narrative synthesis.Of the 606 articles
Comparison of the Effectiveness of Lifestyle Modification with Other Treatments on the Incidence of Type2Diabetes in People at High Risk: A Network Meta-Analysis. Many clinical trials have been conducted to verify the effects of interventions for prevention of type2diabetes (T2D) using different treatments and outcomes. The aim of this study was to compare the effectiveness of lifestyle modifications (LM) with other treatments in persons at high risk of T2D by a network meta-analysis (NMA
SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type2diabetes mellitus: A systematic review. Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity with type2diabetes. The existing therapeutic options for NAFLD are not adequate. Hypocaloric diet and exercise is the cornerstone of therapy in NAFLD. Pioglitazone is the only drug recommended in diabetes patients with biopsy proven non-alcoholic steatohepatitis. The frequent coexistence of NAFLD and type2 (...) diabetes with their combined adverse health consequences and inadequate therapeutic options makes it necessary to search for newer alternatives.To assess the effect of sodium glucose cotransporter-2 (SGLT-2) inhibitors on liver enzymes in type2diabetes patients with NAFLD.We searched PubMed/MEDLINE, Cochrane library, Google scholar, and Clinicaltrials.gov for the relevant articles to be included in this systematic review. Human studies done in type2diabetes patients with NAFLD treated with SGLT-2
Short-Term Versus Long-Term Adverse Cardiovascular Outcomes Post Percutaneous Coronary Intervention in Patients with Insulin-Treated Type2Diabetes Mellitus: A Simple Meta-Analysis. Type2diabetes mellitus (T2DM) is a major health issue, especially in patients with coexisting coronary artery disease (CAD). Patients with insulin-treated T2DM (ITDM) have worse outcomes than those with non-insulin-treated T2DM. Very few studies have compared short-term to long-term adverse cardiovascular
Meta-analysis of the efficacy of liraglutide in patients with type2diabetes accompanied by incipient nephropathy. The efficacy of liraglutide in patients with type2diabetes accompanied by early-stage nephropathy has remained to be fully elucidated. The present meta-analysis was performed to determine the clinical outcomes associated with liraglutide treatment. The PubMed, Ovid, Cochrane Library, Chinese National Knowledge Infrastructure and Wanfang databases were searched in October 2018 (...) to identify randomized controlled trials of liraglutide for diabetes patients with early-stage nephropathy. The treatment effect was estimated by calculating the mean difference (MD). Heterogeneity was assessed using χ2 and I2 tests. In addition, risk of bias graphs and summaries were used to assess the quality of the trials included. A total of 13 randomized controlled trials were included in the present meta-analysis. In subjects with stage I-II diabetic nephropathy (DN), liraglutide had obvious
Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type2Diabetes: A Meta-Analysis of Randomized Controlled Trials. Purpose: Diabetes Mellitus (T2DM) as a chronic disease, is on rise in parallel with other non-communicable diseases. Several studies have shown that probiotics and prebiotics might exert beneficial effects in chronic diseases including diabetes. Because of controversial results from different trials, the present study aims to assess the effects (...) and HbA1c (prebiotic group) compared with placebo. In another subgroup analysis, high quality studies showed significant reductions in TG, TC, FBG and HbA1c in intervention group compared with placebo group. Conclusion: In summary, diets supplemented with either prebiotics or synbiotics can result in improvements in lipid metabolism and glucose homeostasis in type2diabetic patients.
Spousal diabetes status as a risk factor for incident type2diabetes: a prospective cohort study and meta-analysis. It is unclear if the presence of type-2diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis.We conducted a prospective cohort analysis of ARIC data from 8077 (...) married men and women (mean age 54 years) without diabetes at baseline (1987-1989). Complementary log-log models that accounted for interval censoring was used to model the hazard ratio (HR) for the association of spousal diabetes status with the incidence of diabetes. For the meta-analysis, we searched MEDLINE and EMBASE for observational studies published through December 2018 that evaluated spousal concordance for diabetes.During a median follow-up of 22 years, 2512 incident cases of diabetes were
Systematic review of community pharmacy-based and pharmacist-led foot care interventions for adults with type2diabetes. To prevent diabetic foot disease, proper foot care is essential for early detection and treatment. Pharmacists are well suited to provide accessible foot care to adults with type2diabetes. Limited research has examined this role.We conducted a systematic review of community pharmacy-based and pharmacist-led foot care interventions for adults with type2diabetes compared (...) to usual care. Data sources included MEDLINE, EMBASE, the Cochrane Library, CINAHL, Academic Search Complete and Health Source: Nursing/Academic Edition and Google Scholar, plus Google and hand-searching. Original research studies reported in English, focused on community pharmacy-based or pharmacist-led foot care interventions were eligible for review. Participants were adults with type2diabetes. Studies were summarized narratively; pooled data were not possible.Seven studies were included
Systematic review: associations of calcium intake, vitamin D intake, and physical activity with skeletal outcomes in people with Type 1 diabetes mellitus. The skeletal complications of type 1 diabetes (T1D) include low bone density, poor bone quality and fractures. Greater calcium intake, vitamin D intake, and physical activity are commonly recommended to improve bone health in patients with T1D. However, it is not clear whether these factors are affected by T1D or improve clinical outcomes.The
Tailored mobile text messaging interventions targeting type2diabetes self-management: A systematic review and a meta-analysis. This study aimed to identify, assess and summarize available scientiﬁc evidence on tailored text messaging interventions focused on type2diabetes self-management. The systematic review concentrated on message design and delivery features, and tailoring strategies. The meta-analysis assessed the moderators of the effectiveness of tailored text messaging (...) = 0.001), message direction (QB = 5.26, df = 1, p = 0.022), message frequency (QB = 18.72, df = 1, p = 0.000) and using multi-modalities (QB = 6.18, df = 1, p = 0.013).Tailored mobile text messaging interventions can improve glycemic control in type2diabetes patients. However, more rigorous interventions with larger samples and longer follow-ups are required to confirm these findings and explore the effects of tailored text messaging on other self-management outcomes.
Sodium-Glucose Co-Transporter 2 Inhibitors Compared with Sulfonylureas in Patients with Type2Diabetes Inadequately Controlled on Metformin: A Meta-Analysis of Randomized Controlled Trials. When metformin is insufficient for patients with type2diabetes mellitus (T2DM), the optimal adjunctive therapy is unclear. This meta-analysis was to compare the efficacy and safety of sodium-glucose co-transporter 2 (SGLT2) inhibitors with sulfonylureas (SUs) as second-line therapy in patients with T2DM
The role of concordant and discordant comorbidities on performance of self-care behaviors in adults with type2diabetes: a systematic review. Background: Most patients with Type2diabetes (T2D) have high number of comorbid chronic conditions that can affect their self-care abilities. Guidelines for diabetes self-care behaviors are disease specific with little attention given to managing T2D with other comorbidities. Identifying comorbidities that either improve or potentially diminish (...) the individual's capacity to perform effective self-care behaviors is essential to enhance clinical outcomes. One such framework conceptualizes comorbidities as concordant or discordant with diabetes pathophysiological pathways and care goals. Objective: The purpose of this systematic review was to examine the role of diabetes-concordant and discordant chronic conditions on the performance of self-care behaviors in adults with T2D. Methods: A comprehensive literature search was undertaken to identify published
Cangrelor or Clopidogrel in Patients with Type2Diabetes Mellitus Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials. With recent advances in interventional cardiology where percutaneous coronary intervention (PCI) has become the most preferred invasive strategy and with advances in adjunctive pharmacotherapy, several newer oral P2Y12 inhibitors have reached the market. In this analysis, we aimed to compare the cardiovascular outcomes and bleeding (...) events which were associated with the use of cangrelor versus clopidogrel in patients with type2diabetes mellitus (T2DM) 48 h after PCI.The electronic databases MEDLINE (PubMed), www.ClinicalTrials.gov , EMBASE, and Cochrane central were searched for relevant publications comparing canagrelor with clopidogrel during PCI. Patients with T2DM were extracted. Adverse cardiovascular outcomes and bleeding events at 48 h follow-up were considered as the end points. This meta-analysis was carried out
Dietary Glycemic Index and Load and the Risk of Type2Diabetes: Assessment of Causal Relations. While dietary factors are important modifiable risk factors for type2diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-analyses indicate significant relations but consideration of causality has been (...) minimal. Here, the results of our recent meta-analyses of prospective cohort studies of 4 to 26-y follow-up are interpreted in the context of the nine Bradford-Hill criteria for causality, that is: (1) Strength of Association, (2) Consistency, (3) Specificity, (4) Temporality, (5) Biological Gradient, (6) Plausibility, (7) Experimental evidence, (8) Analogy, and (9) Coherence. These criteria necessitated referral to a body of literature wider than prospective cohort studies alone, especially
Use of Dental Practices for the Identification of Adults With Undiagnosed Type2Diabetes Mellitus or Nondiabetic Hyperglycemia: Protocol for a Systematic Review. Type2diabetes mellitus (T2DM) is a growing global health burden and is expected to affect more than 590 million people by the year 2035. Evidence exists to demonstrate that dental settings have been used for risk assessment and identification of individuals who may be at high risk for T2DM or who may already unknowingly have
Cardiovascular and mortality events in type2diabetes cardiovascular outcomes trials: a systematic review with trend analysis. To investigate cardiovascular disease and mortality trends in control arm participants of diabetes cardiovascular outcome trials (CVOTs).We electronically searched CVOTs published before October 2017. Data on all-cause mortality, cardiovascular mortality and events, and baseline characteristics were collected, along with study calendar years. Trends were estimated (...) , there was no evidence of an improvement in all-cause and cardiovascular mortality in type2diabetes participants included in control arms of randomised clinical trials across 5 decades. Further studies should investigate whether and how dissimilarities in populations, procedures, and assessments of exposures and outcomes explain the differences between real-world setting and clinical trials.
Efficacy of Autologous Bone Marrow Mononuclear Cell Transplantation Therapy for Type2Diabetes Mellitus: An Updated Meta-Analysis. Studies of the effects of stem cell therapy on type2diabetes mellitus (T2DM) have not reached consistent results. Our meta-analysis aimed to systematically evaluate the efficacy of autologous bone marrow-derived stem cells (ABM-MNCs) on T2DM.We systematically searched PubMed, EMBASE, Web of Science, and the Cochrane Library for studies published between 1980