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Latest & greatest articles for type 2 diabetes
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on type 2 diabetes or other clinical topics then use Trip today.
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Factors affecting follow-up non-attendance in patients with Type2diabetes mellitus and hypertension: a systematic review. This is a systematic review of the factors and reasons associated with follow-up non-attendance (FUNA) in patients with Type2diabetes mellitus and hypertension in an outpatient setting. We performed a systematic literature search using electronic databases and related keywords with the PRISMA-P checklist, focusing on the factors, types of studies and number of studies
A Meta-analysis of the Types and Outcomes of Conservative Excisional Surgery for Recalcitrant or Infected Diabetic Toe Ulcers. Although they occur frequently, diabetic toe ulcers (DTUs) are poorly investigated. Long-term antibiotics or toe amputation are the usual indications for complicated DTU treatment. Some authors reported good to excellent results following conservative surgery (CS) for recalcitrant or infected wounds; yet no systematic review has been published. Seven studies, comprising (...) 290 patients with 317 ulcers, met the inclusion criteria of this meta-analysis. Three types of CS were found: resection arthroplasty of the interphalangeal joint, toe-sparing bone excision (internal pedal amputation), and distal Symes amputation. The meta-analytical results were as follows: healing rate of 98.3%, healing time of 6.8 ± 3.9 weeks, recurrence rate of 2.3%, wound dehiscence/recurrent infection rate of 6.4%, skin necrosis rate of 2.8%, and revision surgery rate of 7.4%. Subgroup
Comparative effectiveness of bariatric surgeries in patients with obesity and type2diabetes mellitus: A network meta-analysis of randomized controlled trials. A network meta-analysis of randomized controlled trials (RCTs) was performed to determine the hierarchies of different bariatric surgeries in patients with obesity and type2diabetes mellitus (T2DM), in terms of diabetes remission and cardiometabolic outcomes. Seventeen RCTs and six bariatric surgeries, including single anastomosis (...) (from best to worst) were significantly superior to NST in achieving the remission of T2DM. For secondary outcomes, the overall ranking for bariatric surgeries was RYGBP > BPD > LSG > LAGB after comprehensively weighting glucose, weight, systolic and diastolic pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Mini-GBP has the greatest probability of achieving diabetes remission in adults with obesity and T2DM
Response to: Update on "Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type2Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis". 31945793 2020 04 14 2020 04 14 1439-4286 52 1 2020 01 Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme Horm. Metab. Res. Response to: Update on "Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type2Diabetes Mellitus and Metabolic Syndrome: A Systematic Review (...) and Meta-Analysis". 71 10.1055/a-1063-6405 Yang Jiajia J Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, China. Pan Faming F Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, China. eng Letter Comment 2020 01 16 Germany Horm Metab Res 0177722 0018-5043 0 Estrogen Receptor alpha IM Horm Metab Res. 2020 Jan;52(1):67-70 31945792 Diabetes Mellitus, Type2 Estrogen Receptor alpha genetics Genetic Predisposition to Disease Humans Metabolic Syndrome
Associations of serum low-density lipoprotein and systolic blood pressure levels with type2diabetic patients with and without peripheral neuropathy: systemic review, meta-analysis and meta-regression analysis of observational studies. Compositional abnormalities in lipoproteins and cardiovascular risk factors play an important role in the progression of diabetic peripheral neuropathy (DPN). This systematic review aimed to estimate the predicting value of low-density lipoprotein (LDL (...) ) and systolic blood pressure (SBP) level in type-2diabetes mellitus (T2DM) patients with and without peripheral neuropathy. We also tried to determine whether LDL and SBP are associated with an increased collision risk of DPN.A systematic search was conducted for eligible publications which explored the LDL and SBP level in T2DM patients with and without peripheral neuropathy. The quality of the included studies was assessed by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL
[Psychological interventions for patients with type2diabetes mellitus. A systematic review and meta-analysis]. Background Affordable interventions to improve metabolic control of Type2-Diabetes Mellitus are increasingly necessary. Aim To review systematically the existing literature on the effects of psychological interventions on Type-2Diabetes Mellitus compensation. Material and Methods We performed a systematic literature review and meta-analysis on the effectiveness of psychological (...) interventions implemented for Type-2Diabetes Mellitus patients. Research included the following electronic databases: PubMed, Bireme, Web of Science, SciELO, Embase, EBSCOhost, SCOPUS, Psychology Database. Results Most studies showed a decrease in the level of glycated hemoglobin after interventions, which applied different initiatives complementary to standard medical treatment. Mainly, these interventions encompassed training for self-monitoring and control of diabetes based on cognitive behavioral
Empagliflozin reduces blood pressure and uric acid in patients with type2diabetes mellitus: a systematic review and meta-analysis. The antidiabetic effect of empagliflozin in patients with type2diabetes mellitus has been explored in several trials. We performed this meta-analysis determining the effects of empagliflozin on blood pressure, uric acid, estimated glomerular filtration rate, blood lipids, blood glucose, and body weight in patients with type2diabetes mellitus. We searched three (...) electronic databases (Pubmed, Web of Science, and Cochrane Central) for all published articles evaluating the effects of empagliflozin on blood glucose or blood pressure in subjects with type2diabetes mellitus. Total 5781 patients were included in 12 randomized controlled trials with a follow-up of 28 ± 22 weeks. Empagliflozin 10 or 25 mg reduced systolic and diastolic blood pressure, uric acid, hemoglobin A1c, fasting plasma glucose, and body weight in patients with type2diabetes mellitus (all p
Relationship between bullying and type 1 diabetes mellitus in children and adolescents: a systematic review. To carry out a systematic review on the relationship of bullying with type 1 diabetes in children and adolescents.Systematic review, according to the PRISMA methodology, in which the databases PubMed, Web of Science, Scopus, Thomson Reuters, Eighteenth Century Collections Online, Begell House Digital Library, LILACS, and SciELO were searched using the terms "bullied", "aggression", "peer (...) victimization", "victimization", "school violence", "diabetes mellitus", "type 1 diabetes mellitus", "autoimmune diabetes", "children" and "adolescents." The authors included original studies, involving bullying associated with type 1 diabetes, with children and adolescents, without language restriction and publication period, with texts available in full.Of the 32 articles found, four studies met the selection criteria. Of these studies 85.7% identified occurrence of victimization in diabetics or found
The prevalence of retinopathy among type2diabetic patients in Iran: A systematic review and meta-analysis. Diabetic retinopathy is one of the most major causes of blindness and disability in diabetic patients and imposes very high cost on Health Care System. Studies conducted in the country showed different and inconsistent prevalence of the disease. The study aims to determine the overall prevalence of retinopathy in patients with type2diabetes in Iran through a systematic review and meta (...) of retinopathy for type2diabetic patients in Iran and on the basis of meta-analysis, was obtained that was 37.8% (32.84-43%, 95% confidence interval); the highest prevalence of retinopathy for type2diabetic patients was in Tehran province with 78% (68.8-85.1%, 95% confidence interval) in 2006 and the lowest prevalence of retinopathy for type2diabetic patients was in Isfahan province with 9% (7.1-11.4, 95% confidence interval) in 2006; furthermore, the prevalence of retinopathy for type2diabetic
A systematic review of the behaviour change techniques and digital features in technology-driven type2diabetes prevention interventions. Our aim was to conduct a systematic review to determine which technology-driven diabetes prevention interventions were effective in producing clinically significant weight loss, and to identify the behaviour change techniques and digital features frequently used in effective interventions.We searched five databases (CINAHL, EMBASE, MEDLINE, PsychINFO (...) , and Pubmed) from inception to September 2018 and reviewed 19 experimental and non-experimental studies of 21 technology-driven diet plus physical activity interventions for adults (≥18 years) at risk of developing type2diabetes. Behaviour change techniques were coded using the BCT taxonomy v1, and digital features were identified via thematic analysis of intervention descriptions.Sixty-three per cent of interventions were effective in the short term (achieving ≥3% weight loss at ≤6 months), using
Psychological interventions to improve glycemic control in adults with type2diabetes: a systematic review and meta-analysis. The quality of evidence that psychological interventions are effective in improving glycemic control in adults with type2diabetes (T2D) is weak.We conducted a systematic review and meta-analysis of psychological interventions in T2D to assess whether their effectiveness in improving glycemic levels has improved over the past 30 years. We applied the protocol (...) of a systematic review and aggregate meta-analysis conducted to January 2003. We added network meta-analysis (NMA) to compare intervention and control group type against usual care. MEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, EMBASE, Cochrane Controlled Trials Database, Web of Science, and Dissertation Abstracts International were searched from January 2003 to July 2018. Only randomized controlled trials (RCT) of psychological interventions for adults with T2D reported in any
Efficacy and Safety of Dulaglutide Compared to Liraglutide: A Systematic Review and Meta-analysis in Patients with Type2Diabetes Mellitus. Diabetes mellitus has been always one of the most prevalent chronic diseases in the last decades. There exist a wide range of pharmacological agents for controlling this disease. However, these agents fare differently in terms of efficacy and safety. Hence, the aim of this study was to compare dulaglutide and liraglutide, two glucagon-like peptide-1
A systematic review and meta-analysis on the efficacy and safety of traditional Chinese patent medicine Jinqi Jiangtang Tablet in the treatment of type2diabetes. At present, a large number of people in the world are suffering from type2diabetes (T2DM), so it is urgent to develop effective treatment measures of T2DM. In China, many clinical studies have shown that Jinqi Jiangtang Tablet (JQJTT), a traditional Chinese patent medicine (TCPM), has a good effect in the treatment of T2DM (...) . For different variable types, the outcome measures were expressed as risk ratios (RRs) or mean differences (MDs). According to the value of I2, a fixed or random effect model was used for statistical analysis.Seventeen studies conducted in China were identified in this systematic review, which included 1,425 participants. The meta-analysis on the effective rate of the comparison groups showed a significant difference in favor of the JQJTT group (RR 1.34; 95%CI [1.02, 1.75]; p = 0.04). In addition
Plasma metabolomics identifies markers of impaired renal function: A meta-analysis of 3,089 persons with type2diabetes. There is a need for novel biomarkers and better understanding of the pathophysiology of diabetic kidney disease.To investigate associations between plasma metabolites and kidney function in people with type2diabetes (T2D).3,089 samples from individuals with T2D, collected between 1999 and 2015, from five independent Dutch cohort studies were included. Up to 7 years follow
Dipeptidyl Peptidase 4 Inhibitors and Risk of Inflammatory Bowel Disease Among Patients With Type2Diabetes: A Meta-analysis of Randomized Controlled Trials. 31221707 2020 04 09 1935-5548 42 7 2019 07 Diabetes care Diabetes Care Dipeptidyl Peptidase 4 Inhibitors and Risk of Inflammatory Bowel Disease Among Patients With Type2Diabetes: A Meta-analysis of Randomized Controlled Trials. e119-e121 10.2337/dc18-1578 Li Guangyao G Department of Pharmacy Administration and Clinical Pharmacy, School (...) /dc18-1578 PMC7118251 Diabetes Obes Metab. 2014 Dec;16(12):1239-46 25132212 N Engl J Med. 2013 Oct 3;369(14):1327-35 23992602 Cardiovasc Diabetol. 2017 Sep 11;16(1):112 28893244 Diabetes Obes Metab. 2007 Mar;9(2):194-205 17300595 N Engl J Med. 2013 Oct 3;369(14):1317-26 23992601 Lancet. 2012 Aug 4;380(9840):475-83 22748821 Curr Med Res Opin. 2012 Apr;28(4):513-23 22313154 Diabetes Obes Metab. 2010 Jul;12(7):613-22 20590736 Diabetes Care. 2015 Nov;38(11):2018-24 26324329 Lancet Diabetes Endocrinol
Effect of probiotics supplementation on glucose and oxidative stress in type2diabetes mellitus: a meta-analysis of randomized trials. The role of oxidative stress in pathogenesis of diabetes is well established. In addition, an association between gut microbiota and type2diabetes mellitus (T2DM) is widely observed in previously published reports. This meta-analysis critically examines the association between gut microbiota, and oxidative stress in T2DM.A systematic search for clinical (...) trials was performed in PubMed, Web of Science and Scopus web databases up to 1 Jan 2019. Primary search terms include "microbiota", "diabetes", and "oxidative stress". Study was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. All clinical trials that compared the effects of probiotic supplementations with a control group using end points serum levels of fasting blood sugar (FBS), hemoglobin A1C (HbA1C) and oxidative stress biomarkers
Sodium-glucose co-transporter 2 inhibitors for the prevention of heart failure in type2diabetes: A systematic review and meta-analysis. 30966822 2020 04 09 2047-4881 27 6 2020 Apr European journal of preventive cardiology Eur J Prev Cardiol Sodium-glucose co-transporter 2 inhibitors for the prevention of heart failure in type2diabetes: A systematic review and meta-analysis. 667-670 10.1177/2047487319841936 Yamani Naser N Internal Medicine, John H Stroger Jr Hospital of Cook County, USA
Systematic Review and Meta-Analysis of the Effects of Soy on Glucose Metabolism in Patients with Type2Diabetes. This study aimed to assess the effects of soy consumption on glucose metabolism in patients with type2 diabetes.A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review (PRISMA) principles. Literature published between 1990 and 2019 was searched. Primary outcomes were the effect of soy on fasting plasma glucose (FPG), insulin (...) indicated no beneficial effects of soy consumption on FPG, insulin, and HbA1c in patients with type2diabetes, pooling of parallel studies showed different results from crossover studies. The quality of evidence revealed low levels of confidence for primary outcomes. Therefore, further research is recommended.
Association of magnesium consumption with type2diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis. Prevention of type2diabetes (T2D) with diet or diet supplementation is challenging. This article aims to draw conclusive associations between magnesium intake and T2D incidence and evaluate the effect of magnesium supplementation on glucose metabolism. Databases were searched for related articles from inception to May 15, 2019. Prospective (...) magnesium intake. Additional analysis of 26 RCTs (1168 participants) was performed, revealing that magnesium supplementation significantly reduced the fasting plasma glucose (FPG) level (SMD, -0.32 [95% CI, -0.59 to -0.05], 2-hour oral glucose tolerance test (2-h OGTT) result (SMD, -0.30 [-0.58 to -0.02]), fasting insulin level (SMD, -0.17 [-0.30 to -0.04]), homeostatic model assessment-insulin resistance (HOMA-IR) score (SMD, -0.41 [-0.71 to -0.11]), triglyceride (TG) level, systolic blood pressure
Risk of type2diabetes in metabolically healthy people in different categories of body mass index: an updated network meta-analysis of prospective cohort studies. Introduction: Risk of diabetes mellitus type2 (T2DM) is variable between individuals due to different metabolic phenotypes. In present network meta-analysis, we aimed to evaluate the risk of T2DM related with current definitions of metabolic health in different body mass index (BMI) categories. Methods: Relevant articles were (...) collected by systematically searching PubMed and Scopus databases up to 20 March 2018 and for analyses we used a random-effects model. Nineteen prospective cohort studies were included in the analyses and metabolically healthy normal weight (MHNW) was considered as the reference group in direct comparison for calculating indirect comparisons in difference type of BMI categories. Results: Total of 199403 participants and 10388 cases from 19 cohort studies, were included in our network meta-analysis