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Latest & greatest articles for type 2 diabetes
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on type 2 diabetes or other clinical topics then use Trip today.
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Pharmaceutical care-based interventions in type2diabetes mellitus : a systematic review and meta-analysis of randomized clinical trials. To investigate the impact of pharmaceutical care-based interventions on type2diabetes mellitus .PubMed®, Cochrane and Web of Science data bases were searched for randomized controlled clinical trials. Studies evaluating pharmaceutical care-based interventions in type2diabetes mellitus published between 2012 and 2017 were included. Glycated hemoglobin (...) : -8.9; -0.4; p=0.032) levels, and increased HDL levels (4.43mg/dL; 95%CI: 0.16; 8.70; p=0.042).Pharmaceutical care-based clincal and education interventions have significant impact on type2diabetes mellitus . The tools Summary of Diabetes Self-Care Activities and the Morisky Medication Adherence Scale may be useful to monitor patients.
Anthropometric, Cardiopulmonary and Metabolic Benefits of the High-Intensity Interval Training Versus Moderate, Low-Intensity or Control for Type2Diabetes: Systematic Review and Meta-Analysis. Abstract: This study aims to evaluate the effectiveness of high-intensity interval training compared with no intervention and other types of training interventions for people with Type2Diabetes. A systematic review and meta-analysis of randomized controlled trials that used high-interval intensity (...) 95%: (-2.80; -1.31); body-mass index: SMD = -3.04; CI 95%: (-5.16; -0.92); systolic blood pressure: SMD = -2.17; CI 95%: (-3.93; -0.41); HbA1c: SMD = -1.58; CI 95%: (-1.84; -1.33)]. The results show that high-intensity interval training can be a useful strategy in order to improve anthropometric, cardiopulmonary and metabolic parameters in people with Type2diabetes. Despite this, it could be essential to clarify and unify criteria in the intervention protocols, being necessary new lines
Efficacy and Safety of Pioglitazone Monotherapy in Type2Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Pioglitazone, the only thiazolidinedione drug in clinical practice is under scrutiny due to reported adverse effects, it's unique insulin sensitising action provides rationale to remain as a therapeutic option for managing type2diabetes mellitus (T2DM). We conducted a systematic review and meta-analysis comparing pioglitazone monotherapy
Aspirin Versus Clopidogrel Monotherapy for the Secondary Prevention of Recurrent Cerebrovascular Attack Following Previous Ischemic Stroke in Patients with Type2Diabetes Mellitus: A Systematic Review and Meta-Analysis. Type2diabetes mellitus (T2DM) and stroke are two different diseases, but have many aspects in common. Aspirin is recommended as an initial treatment for the secondary prevention of recurrent ischemic stroke in patients with T2DM. However, clopidogrel is an oral antiplatelet
A Systematic Review of Cost-Effectiveness of Sodium-Glucose Cotransporter Inhibitors for Type2Diabetes. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are the most recently approved class of drugs (since 2012) for type2diabetes mellitus (T2DM), but their economic merits have yet been fully confirmed. The objective of this review was to evaluate the most updated evidence that examined the cost-effectiveness of SGLT2i for T2DM.We systematically searched Medline (PubMed), EMBASE, and Web (...) Reporting Standards (CHEERS) checklist. A total of 24 studies were included in the final review. All studies showed good quality according to the CHEERS checklist (scored 21-24). Seven studies compared SGLT2i vs. dipeptidyl peptidase-4 inhibitors (DPP-4i), 3 studies compared SGLT2i vs. sulfonylureas (SU), 3 compared SGLT2i vs. glucagon-like peptide-1 receptor agonist (GLP-1 RA), 2 compared SGLT2i vs. SGLT2i, 3 compared SGLT2i vs. other antidiabetic therapies including thiazolidinediones (TZD), alpha
Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type2Diabetes: A Randomized Clinical Trial. Bromodomain and extraterminal proteins are epigenetic regulators of gene transcription. Apabetalone is a selective bromodomain and extraterminal protein inhibitor targeting bromodomain 2 and is hypothesized to have potentially favorable effects on pathways related to atherothrombosis. Pooled phase 2 data suggest (...) favorable effects on clinical outcomes.To test whether apabetalone significantly reduces major adverse cardiovascular events.A randomized, double-blind, placebo-controlled trial, conducted at 190 sites in 13 countries. Patients with an acute coronary syndrome in the preceding 7 to 90 days, type2diabetes, and low high-density lipoprotein cholesterol levels were eligible for enrollment, which started November 11, 2015, and ended July 4, 2018, with end of follow-up on July 3, 2019.Patients were
A systematic review and meta-analysis of randomized controlled trials, juxtaposing the control of glycemia and blood pressure between large dose empagliflozin and placebo among type 1 diabetes patients. While empagliflozin (25 mg) is used to treat type-2diabetes mellitus patients with optimum renal functioning, its efficacy and safety in type-1 diabetes mellitus (T1DM) is not yet established. Therefore, this study aimed to compare insulin-treated T1DM patients' (with adequate renal functioning
Effect of Exercise Intervention on Cardiac Function in Type2Diabetes Mellitus: A Systematic Review. The effect of exercise on cardiac function/structure in type2diabetes mellitus (T2DM) with or without diabetic cardiomyopathy (DCM) is not yet completely understood. To date, results of studies have been controversial with variable outcomes due to the variety of exercise modalities.The aim of the present review was to examine the impact of exercise intervention, and different types (...) of exercise, on cardiac function and structure in T2DM through a systematic literature review, combining both pre-clinical and clinical studies.A systematic literature search was performed on PubMed, Web of Science, and PEDro to identify studies up to 2 April 2018. Articles were included when well-defined exercise protocols were provided, and cardiac function in T2DM patients or validated animal models was examined.In diabetic animals, improvements in both diastolic and systolic function through exercise
Effects of sodium-glucose cotransporterÂ 2 inhibitors on non-alcoholic fatty liver disease in patients with typeÂ 2diabetes: A meta-analysis of randomized controlled trials. Non-alcoholic fatty liver disease (NAFLD) is increasingly common in patients with type2diabetes mellitus. Currently, some studies have found that sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new hypoglycemic drug, can improve non-alcoholic fatty liver in addition to its hypoglycemic effect. Thus, we undertook (...) a meta-analysis of randomized controlled trials to evaluate the efficacy of SGLT2 inhibitors on the treatment of NAFLD.PubMed, Embase and the Cochrane Library were searched for randomized controlled trials of SGLT2 inhibitors in patients with NAFLD and type2diabetes mellitus up to 1 October 2019. Differences were expressed as weight mean difference (WMD) with 95% confidence interval (CI) for continuous outcomes. The I2 statistic was applied to evaluate the heterogeneity of studies.A total of six
Systematic Review of Polygenic Risk Scores for Type 1 and Type2Diabetes. Recent studies have led to considerable advances in the identification of genetic variants associated with type 1 and type2diabetes. An approach for converting genetic data into a predictive measure of disease susceptibility is to add the risk effects of loci into a polygenic risk score. In order to summarize the recent findings, we conducted a systematic review of studies comparing the accuracy of polygenic risk (...) scores developed during the last two decades. We selected 15 risk scores from three databases (Scopus, Web of Science and PubMed) enrolled in this systematic review. We identified three polygenic risk scores that discriminate between type 1 diabetes patients and healthy people, one that discriminate between type 1 and type2diabetes, two that discriminate between type 1 and monogenic diabetes and nine polygenic risk scores that discriminate between type2diabetes patients and healthy people
Epidemiology of Type2Diabetes in the Greater Maghreb. Example of Tunisia. Systematic review of the literature. Describe epidemiologic profile of DiabetesType2 (DT2) in the Tunisian population, through published and indexed studies in Medline.We carried out a systematic review, through the Medline database, of the main publications related to DT2 among Tunisian patients. This research included prevalence, risk factors, clinical and biological characteristics, and complications of DT2 (...) .The prevalence of DT2 varied from 9.9% in 1996 to 15.1% in 2005 and would reach 26.6% in 2027. It was significantly associated with age and urbanization. The genetic factor was incremented in 58.9 to 75% of cases and obesity in a quarter or more. Neuropathy and diabetic retinopathy were the main degenerative complications affecting the Tunisian diabetic patient in more than half of the cases. Poor compliance was observed in 41% of diabetics and only 16.7% of patients were well controlled.The epidemiological
Adding exercise to usual care in patients with hypertension, type2diabetes mellitus and/or cardiovascular disease: a protocol for a systematic review with meta-analysis and trial sequential analysis. Hypertension, type2diabetes mellitus and cardiovascular disease are among the leading causes of mortality globally. Exercise is one of the commonly recommended interventions/preventions for hypertension, type2diabetes mellitus and cardiovascular disease. However, the previous reviews have (...) shown conflicting evidence on the effects of exercise. Our objective is to assess the beneficial and harmful effects of adding exercise to usual care for people with hypertension, type2diabetes mellitus and/or cardiovascular disease.This protocol for a systematic review was undertaken using the recommendations of The Cochrane Collaboration, the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) and the eight-step assessment procedure suggested by Jakobsen et al
Pioglitazone for the Primary and Secondary Prevention of Cardiovascular and Renal Outcomes in Patients with or at High Risk of Type2Diabetes Mellitus: A Meta-Analysis. The goal of the meta-analysis was to evaluate the effect of pioglitazone on the primary and secondary prevention of cardiovascular diseases (CVDs) and renal adverse events in patients with or at high risk of type2diabetes mellitus (T2DM).Randomized controlled trials (RCTs) comparing pioglitazone with any control were
The Effects of Prebiotics and Substances with Prebiotic Properties on Metabolic and Inflammatory Biomarkers in Individuals with Type2Diabetes Mellitus: A Systematic Review. Intestinal bacteria composition and prebiotics may play a role in the management of type2diabetes mellitus (T2DM).The objective of this systematic review was to evaluate the effect of prebiotics and substances with prebiotic properties on the metabolic and inflammatory biomarkers of individuals with T2DM compared (...) of these publications reported a beneficial effect on metabolic and/or inflammatory biomarkers. Interventions included mostly women, lasted 4 days to 12 weeks, and diabetes duration ranged from 6 months to 11 years. Nineteen publications reported improvements in glycemia, 15 in cardiovascular markers, nine in body weight, and nine in inflammatory markers. Benefits from resistant starch, resistant dextrin, and oligofructose-enriched inulin were most frequent. A smaller number of studies utilizing other substances
Effect of cinnamon supplementation on blood pressure and anthropometric parameters in patients with type2diabetes: A systematic review and meta-analysis of clinical trials. The present systematic review and meta-analysis was conducted to investigate the effect of cinnamon supplementation on blood pressure and anthropometric indices in patients with type2 diabetes.PubMed, Embase, Scopus, Web of Science and Cochrane Library were systematically searched to find relevant records up to 22 August (...) pressure (DBP) (SMD: -0.681, 95% CI: [-1.297, -0.065], P = 0.030) of patients with type2diabetes following cinnamon supplementation. Based on the results of the present study, cinnamon supplementation had no significant effect on the body weight (BW) (SMD: -0.309, 95% CI: [-0.793, 0.175], P = 0.211), body mass index (BMI) (SMD: -0.550, 95% CI: [-1.244, 0.144], P = 0.120). and waist circumference (WC) (SMD: -0.235, 95% CI: [-0.518, 0.047], P = 0.103).Cinnamon supplementation significantly decreased
Association between reduced serum levels of magnesium and the presence of poor glycemic control and complications in type 1 diabetes mellitus: A systematic review and meta-analysis. To evaluate the association between reduced serum magnesium levels and poor glycemic control and/or complications in patients with type 1 diabetes mellitus through a systematic review and meta-analysis.The articles were selected using the Medline/PubMed, Web of Science, Scopus and Scielo databases. Eligibility (...) criteria were cross-sectional, cohort or case-control observational studies that assessed the association between reduced magnesium levels and poor glycemic control and/or complications in patients with type 1 diabetes mellitus.Nine articles were included in the systematic review and two in the meta-analysis, all articles being cross-sectional. Among the seven studies that were designed to evaluate glycemic control, five showed an association between reduced levels of magnesium and poor glycemic
Cultural Influences on Dietary Self-Management of Type2Diabetes in East Asian Americans: A Mixed-Methods Systematic Review. Purpose: Many East Asian Americans (EAAs) (populations originating from China, Korea, Japan, and Taiwan) with type2diabetes mellitus (T2DM) experience unique challenges in managing their disease, including language barriers and traditional cultural beliefs, particularly among first-generation immigrants.. The purpose of this mixed-methods systematic review (...) was to examine cultural perspectives of EAAs that influence dietary self-management of T2DM and identify education interventions and their approaches to enhance EAAs' dietary self-management of diabetes. Methods: A mixed-methods systematic review was conducted to examine EAAs' perspectives from qualitative studies and to identify education interventions and their approaches from quantitative studies. A literature search was conducted using PubMed/MEDLINE, SCOPUS, CINAHL, and Web of Science from 1995 to 2018
Clinical relevance between sodium-glucose co-transporter 2 inhibitors and lipid profiles in Asian patients with type2diabetes mellitus: a systematic review with a meta-analysis of randomized controlled trials. Few systematic reviews have examined the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2is) on lipid profiles in Asian patients with type2diabetes mellitus. We conducted a systematic review with a meta-analysis to summarize the available literature and confirm the effects (...) of SGLT2is on lipid profiles in these patients.We searched the electronic databases MEDLINE, CENTRAL, and Ichushi-web for studies from the dates of their earliest publication to July 2018, and there was no language restriction. Trials were included if they were randomized controlled trials (RCTs) (1) comparing the effects of SGLT2is with a placebo in Asian patients with type2diabetes mellitus (18 years or older), and (2) reporting HbA1c and at least one lipid parameter, such as triglycerides (TG), high
The impact of online self-management interventions on midlife adults with type2diabetes: a systematic review. Online self-management education programmes are now recommended for people with type2diabetes to improve self-management capacities. There is limited evidence to determine whether such programmes improve the health outcomes for midlife adults with diabetes.The purpose of this systematic review was to assess the impact of online self-management interventions with digital consulting (...) on glycated haemoglobin (HbA1c), total cholesterol, blood pressure, diabetes distress, self-efficacy, and depression in midlife adults.A systematic review was undertaken searching Medline, Embase and CINAHL. Studies were appraised using the Cochrane Collaboration's tool.Eight studies were included. Online interventions resulted in the improvement of HbA1c (pooled mean difference on HbA1c: -0.35%, 95% CI (-0.52, -0.18), P<0.001). A narrative synthesis was conducted for all secondary outcomes