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Latest & greatest articles for type 2 diabetes
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on type 2 diabetes or other clinical topics then use Trip today.
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Risk and protective factors of co-morbid depression in patients with type2diabetes mellitus: a meta analysis. The aim from this paper is to identify the main influencing factors of co-morbid depression among T2DM (Type2Diabetes Mellitus) patients and to provide reliable evidence for relative researches. A systematic review and meta-analysis of risk factors for co-morbid depression in T2DM was performed on all retrieved studies through an observational research of network database. Data were (...) analyzed by Review Manager 5.3 from the extracted results, the heterogeneity index of the studies was determined using Chi-squared I2 tests and on the basis of heterogeneity, a fixed or random effect model was used to estimates the pooled effect of each influencing factor. Fourteen observational studies containing total of 82,239,298 cases that have been identified. Diabetic complications (OR = 2.91; 95%CI, 1.76-4.82, p < 0.0001), insulin use (OR = 1.71; 95%CI, 1.18-2.48, p = 0.005), education status
Evidence of heterogeneity in statin-associated type2diabetes mellitus risk: A meta-analysis of randomized controlled trials and observational studies. To conduct a meta-analysis of statin-associated type2diabetes mellitus (T2D) risk among randomized controlled trials (RCTs) and observational studies (OBSs), excluding studies conducted among secondary prevention populations.Studies were identified by searching PubMed (1994-present) and EMBASE (1994-present). Articles had to meet (...) the following criteria: (1) follow-up >one year; (2) >50% of participants free of clinically diagnosed ASCVD; (3) adult participants ≥30 years old; (4) reported statin-associated T2D effect estimates; and (5) quantified precision using 95% confidence interval. Data were pooled using random-effects model.We identified 23 studies (35% RCTs) of n = 4,012,555 participants. OBS participants were on average younger (mean difference = 6.2 years) and had lower mean low-density lipoprotein cholesterol (LDL-C, mean
Association between type 1 and type2diabetes and risk of non-Hodgkin's lymphoma: A meta-analysis of cohort studies. Diabetes mellitus (DM) is thought to be associated with an increased risk of non-Hodgkin's lymphoma (NHL), although the evidence so far remains inconsistent. Thus, our study aimed to further assess this association.Electronic searches were performed of the PubMed, Web of Science and Embase databases up to 11 March 2019. A random-effects model was used to calculate summary (...) relative risks (RRs) with corresponding 95% confidence intervals (CIs).A total of 20 articles including data from 35 cohort studies matched our inclusion criteria, and 31 RRs were calculated for type2DM; the summary RR was 1.20 (95% CI: 1.12-1.30, I2 = 84.7%). Also, four RRs were calculated for type 1 DM, and the result was significant (RR: 1.55, 95% CI: 1.15-2.08, I2 = 0.0%). The results of subgroup analyses demonstrated that the association between DM and NHL was much more substantial in an Asian
Different Effects of Structured Education on Glycemic Control and Psychological Outcomes in Adolescent and Adult Patients with Type 1 Diabetes: A Systematic Review and Meta-Analysis. This systematic review aimed at investigating the effectiveness of structured education (SE) in improving glycemic control and psychological outcomes in adolescent and adult patients with type 1 diabetes.Electronic databases (EMBASE, Medline, PubMed, and the Cochrane Library) and the reference lists of included (...) studies were searched from the beginning of the database through April 2019. Randomized controlled trials comparing SE with a control condition and reporting a change in glycosylated hemoglobin (HbA1c) level were included. The primary outcome was glycemic control measured by HbA1c. Secondary outcomes were diabetes-related distress, well-being, depression, and quality of life.Eighteen studies representing 2759 patients were included. Twelve studies targeted adolescents and six targeted adults
Apical Periodontitis and Diabetes Mellitus Type2: A Systematic Review and Meta-Analysis. Investigate if there is an association between apical periodontitis and diabetes mellitus.A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical (...) analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM).Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM
Long-term outcomes of macrovascular diseases and metabolic indicators of bariatric surgery for severe obesity type2diabetes patients with a meta-analysis. There is currently no detailed evidence for the long-term effects of bariatric surgery on severely obese with type2diabetes, such as the risk of myocardial infarction and stroke. In order to provide evidence on the risks of macrovascular diseases and metabolic indicators of bariatric surgery follow-up for more than five years, we searched
Factors associated with high oxidative stress in patients with type2diabetes: a meta-analysis of two cohort studies. Our objective is to identify the potential factors associated with serum Diacron's reactive oxygen metabolites test (D-ROM) levels of patients with type2diabetes mellitus (T2DM) by conducting cross-sectional and longitudinal analyses in two large cohorts and further strengthening these results by performing a meta-analysis.Serum D-ROM concentrations were measured in 1045 (...) and 1101 patients with T2DM from two independent cohort studies from Germany at baseline and repeatedly 3-4 years later. The cross-sectional and longitudinal associations of various potential determinants with D-ROM levels were assessed with a backwards selection algorithm in multivariable adjusted models.In the meta-analysis of the cross-sectional analysis, female sex, low education, obesity, smoking, high total cholesterol, hemoglobin A1c ≥7%, no diabetes medication, a history of myocardial
Psychological interventions for adherence, metabolic control, and coping with stress in adolescents with type 1 diabetes: a systematic review. The aim of this review was to summarize and identify the variations in the effectiveness of psychological interventions on adherence, metabolic control, and coping with stress in adolescents with type 1 diabetes (T1D).An electronic search of literature was performed using PubMed (NLM), Embase (Ovid), CINAHL Plus (EBSCOhost), PsycINFO (Ovid), and Google (...) control, and coping with stress in adolescents with T1D. Behavioral interventions using principles of CBT appear to have a superior positive effect on regimen adherence compared with other types of psychological protocols. In contrast, metabolic control was significantly improved with the implementation of CST and some forms of CBT. Stress management and psychotherapy interventions showed significant promises for adolescents to cope with their diabetes-related daily stressors.However, the findings may
Effect of conventional medical treatment plus Qigong exercise on type2diabetes mellitus in Chinese patients: A Meta-analysis. To systematically evaluate the effect of conventional medical treatment plus Qigong exercise on type2diabetes mellitus (T2DM) in Chinese patients.A literature search was conducted in PubMed, Medline, Embase, China National Knowledge Infrastructure Database, Wanfang and China Science and Technology Journal Database until on January 2017. In this Meta-analysis (...) , enrolled were the studies, including experimental group (with conventional medical treatment plus Qigong therapy) and control group (with conventional medical treatment plus diet control or other exercises). Then, the standardized mean differences (SMDs) of fasting blood-glucose (FBG), 2-hplasmaglucose (2hPG), hemoglobinAlc (HbAlc), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low density lipoprotein (LDL), as well as their 95% confidence interval (CIs) were calculated
The Effect of Diacerein on Type2Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis. To figure out the effect of diacerein supplementation on type2diabetes mellitus (T2DM).An electronic search was processed on Pubmed, Embase, and Cochrane library for randomized controlled trials (RCTs) comparing the efficacy of diacerein with placebo on T2DM. The primary outcome was fasting blood glucose (FBG). Trial sequential analysis
Cost-effectiveness of intensive interventions compared to standard care in individuals with type2diabetes: A systematic review and critical appraisal of decision-analytic models. The objective of this systematic review is to identify and assess the quality of published decision-analytic models evaluating the long-term cost-effectiveness of target-driven intensive interventions for single and multifactorial risk factor control compared to standard care in people with type2 diabetes.We (...) searched the electronic databases MEDLINE, the National Health Service Economic Evaluation Database, Web of Science and the Cochrane Library from inception to October 31, 2019. Articles were eligible for inclusion if the studies had used a decision-analytic model evaluating both the long-term costs and benefits associated with intensive interventions for risk factor control compared to standard care in people with type2diabetes. Data were extracted using a standardised form, while quality
Screening and identification of disordered eating in people with type 1 diabetes: A systematic review. People with Type 1 diabetes (T1D) have been shown to be an at-risk group for the development of disordered eating behaviours, however, the validity of tools used to assess disordered eating behaviours in T1D is unclear. This review aimed to identify tools used to screen or identify disordered eating behaviours and eating disorders in people with T1D, and evaluate the validity and reliability
Metformin therapy and cognitive dysfunction in patients with type2diabetes: A meta-analysis and systematic review. Type2diabetes (T2D) is a risk factor for cognitive dysfunction. The relationship between metformin therapy and cognitive function in patients with T2D is unknown. Therefore, we determined the relationship between metformin therapy and cognitive function in patients with T2D using a meta-analysis.We systematically searched the Cochrane library, PubMed, and Embase to identify (...) of insulin aggravated cognitive dysfunction (HR 1.34; 95% CI [1.24, 1.43]). In the subgroup analysis of various regions controlling for age, gender, education, diabetes course, complications, metformin administration and dosage, and follow-up time, metformin significantly improved cognitive dysfunction in patients in the Americas and Europe (HR 0.69; 95% CI [0.63, 0.74]), (HR 0.71; 95% CI [0.66, 0.76], respectively), while metformin did not significantly improve cognitive dysfunction in Asian patients
Effect of peer support intervention on diabetes distress in people with type2diabetes: A systematic review and meta-analysis. To assess the effect of peer support intervention on diabetes distress in people with type2 diabetes.Diabetes distress may be decreased by peer support intervention, but findings about the effect of peer support on diabetes distress have been mixed.A systematic review and meta-analysis of randomized controlled studies.PubMed, Embase, CENTRAL, PsycINFO, Web of Science (...) , and CINAHL databases were searched for randomized controlled trials from inception to 30 June 2018.Investigators assessed eligibility, extracted data, and assessed methodological quality. Standardized mean difference and 95% confidence intervals were calculated for pooled effect size.A total of 13 studies included in systematic review and 10 in meta-analysis. In the random-effects model, the pooled effect size showed current peer support intervention did not significantly reduce diabetes distress in type
Sex-specific association between type 1 diabetes and the risk of end-stage renal disease: a systematic review and meta-analysis. This meta-analysis was conducted given the inconsistent findings of studies regarding the sex discrepancy in the relationship between type 1 diabetes (T1D) and the risk of end-stage renal disease (ESRD).Articles published on PubMed between January 1, 1966 and March 31, 2019 were systematically retrieved without language restrictions. The included articles all
Surgical outcome of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass for resolution of type2diabetes mellitus: A systematic review and meta-analysis. Bariatric procedures are considered superior to medical therapies in managing type2diabetes mellitus (T2DM). Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are the most commonly used procedures for weight loss and comorbidity resolution worldwide. However, it is not yet known whether (...) nine studies for this research. We found insignificant differences for T2DM resolution by LRYGB and LSG, with an odds ratio of 0.93 (95%CI: 0.64-1.35, Z statistics = 0.38, P = 0.71). Additionally, subset analyses for T2DM resolution showed insignificant differences after 24 mo (χ2 = 1.24, df = 4, P = 0.87, overall Z effect = 0.23), 36 mo (χ2 = 0.41, df = 2, P = 0.81, overall Z effect = 0.51), and 60 mo (χ2 = 4.75, df = 3, P = 0.19, overall Z effect = 1.20) by LRYGB and LSG. This study reports
Physiologic Mechanisms of Type II Diabetes Mellitus Remission Following Bariatric Surgery: a Meta-analysis and Clinical Implications. As obesity prevalence grows in the USA, metabolic syndrome is becoming increasingly more common. Current theories propose that insulin resistance is responsible for the hypertension, dyslipidemia, type II diabetes mellitus (T2DM), and low HDL that comprise metabolic syndrome. Bariatric surgery is one potential treatment, and its effects include permanently
Metabolomics Signatures in Type2Diabetes: A Systematic Review and Integrative Analysis. Metabolic signatures have emerged as valuable signaling molecules in the biochemical process of type2diabetes (T2D). To summarize and identify metabolic biomarkers in T2D, we performed a systematic review and meta-analysis of the associations between metabolites and T2D using high-throughput metabolomics techniques.We searched relevant studies from MEDLINE (PubMed), Embase, Web of Science, and Cochrane (...) , valine, tyrosine, phenylalanine, glutamate, alanine, valerylcarnitine (C5), palmitoylcarnitine (C16), palmitic acid, and linoleic acid were associated with higher T2D risk. Conversely, serine, glutamine, and lysophosphatidylcholine C18:2 decreased risk of T2D. Arginine and glycine increased risk of T2D in the Western countries subgroup, and betaine was negatively correlated with T2D in nested case-control subgroup. In addition, slight improvements in T2D prediction beyond traditional risk factors
Type 1 diabetes mellitus and educational attainment in childhood: a systematic review. The primary objective of this systematic review was to evaluate available literature on whether type 1 diabetes mellitus (T1DM) has an impact on educational attainment in individuals undertaking high stakes standardised testing at the end of compulsory schooling.A systematic review was undertaken comparing educational attainment for individuals with and without T1DM who have undertaken high stakes testing (...) linked administrative data) meeting final inclusion criteria. A small but statistically significant difference was reported in mean final grades, with children with T1DM found to have lower mean grades than their non-diabetic counterparts (adjusted mean difference 0.07-0.08).More contemporary research is required to evaluate the impact of T1DM in childhood on educational attainment in individuals undertaking high stakes standardised testing at the end of compulsory schooling, taking